Abstract

We present a method that is capable of imaging particle size and concentration in heterogeneous turbid media using multispectral diffuse optical tomography (MSDOT). Successful images of mean particle size and particle concentration are achieved for the first time using tissue phantom data obtained from a ten-wavelength MSDOT system.

© 2004 Optical Society of America

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  1. J.R. Mourant, A.H. Hielscher, A.A. Eick, T.M. Johnson, and J.P. Freyer, “Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells,” Cancer Cytopathol 84, 366–374 (1998).
  2. B. Veauvoit, H. Liu, K. Kang, P. D. Kaplan, M. Miwa, and B. Chance, “Characterization of absorption and scattering properties of various yeast strains by time-resolved spectroscopy,” Cell Biophys. 23, 91–109 (1993).
  3. L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
    [Crossref]
  4. A.E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A.J. Berger, D. Hsiang, J. Butler, R.F. Holcombe, and B.J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60–71 (2002).
    [Crossref] [PubMed]
  5. R.S. Cotran, S. Robbins, V. Kumar, and Robbins Pathological Basis of Disease (W.B. Saunders, Philadelphia, Pennsylvania, 1994).
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    [Crossref] [PubMed]
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    [Crossref]
  11. M. Johns and H. Liu, “Limited possibility for quantifying mean particle size by logarithmic light-scattering spectroscopy,” Appl. Opt. 42, 2968–2971 (2003).
    [Crossref] [PubMed]
  12. Y. Xu, X. Gu, T. Khan, and H. Jiang, “Absorption and scattering images of heterogeneous scattering media can be simultaneously reconstructed by use of dc data,” Appl. Opt. 41, 5427–5437 (2002).
    [Crossref] [PubMed]
  13. K.D. Paulsen and H. Jiang, “Spatially varying optical property reconstruction using a finite element diffusion equation approximation,” Med. Phys. 22, 691–701 (1995).
    [Crossref] [PubMed]
  14. N. Iftimia and H. Jiang, “Quantitative optical image reconstruction of turbid media by use of direct-current measurements,” Appl. Opt. 39, 5256–5261 (2000).
    [Crossref]
  15. H. Jiang, J. Pierce, J. Kao, and Eva Sevick-Muraca, “Measurement of particle-size distribution and volume fraction in concentrated suspensions with photon migration techniques,” Appl. Opt. 36, 3310–3318 (1997).
    [Crossref] [PubMed]
  16. H. Jiang, “Enhanced photon-migration methods for particle sizing in concentrated suspensions,” AIChE J. 44, 1740–1744 (1998).
    [Crossref]
  17. H. Jiang, G. Marquez, and L. Wang, “Particle sizing in concentrated suspensions by use of steady-state, continuous-wave photon-migration techniques,” Opt. Lett. 23, 394–396 (1998).
    [Crossref]
  18. M. Bartlett and H. Jiang, “Particle sizing in dense, rapidly flowing KCl suspensions by photon migration techniques,” AIChE J. 47, 60–65 (2001).
    [Crossref]
  19. G. F. Bohren and D. R. Hoffman, Absorption and Scattering of Light by Small Particles (Wiley, New York, 1983)
  20. C. Li and H. Jiang, “A calibration method in diffuse optical tomography,” J. Opt. A: Pure Appl. Opt. 6, 844–852 (2004).
    [Crossref]
  21. C. Li, H. Zhao, and H. Jiang, in Biomedical Topical Meeting on CD-ROM (the Optical Society of America, Washington, DC, 2004), WF19.
  22. E. Shives, Y. Xu, and H. Jiang, “Fluorescence lifetime tomography of turbid media based on an oxygen-sensitive dye,” Opt. Express 10, 1557–1562 (2002), http://www.opticsexpress.org/abstract.cfm?URI=OPEX-10-26-1557.
    [Crossref] [PubMed]
  23. X. Li, Z. Chen, J. Gong, A. Taflove, and V. Backman, “Analytical techniques for addressing forward and inverse problems of light scattering by irregularly shaped particles,” Opt. Lett. 29, 1239–11241(2004).
    [Crossref] [PubMed]

2004 (3)

B.W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T.D. Tosteson, S.P. Poplack, and K.D. Paulsen, “Characterization of hemoglobin, water, and NIR scattering in breast tissue: Analysis of intersubject variability and menstrual cycle changes,” J. Biomed. Opt. 9, 541–552 (2004).
[Crossref] [PubMed]

C. Li and H. Jiang, “A calibration method in diffuse optical tomography,” J. Opt. A: Pure Appl. Opt. 6, 844–852 (2004).
[Crossref]

X. Li, Z. Chen, J. Gong, A. Taflove, and V. Backman, “Analytical techniques for addressing forward and inverse problems of light scattering by irregularly shaped particles,” Opt. Lett. 29, 1239–11241(2004).
[Crossref] [PubMed]

2003 (2)

2002 (3)

2001 (1)

M. Bartlett and H. Jiang, “Particle sizing in dense, rapidly flowing KCl suspensions by photon migration techniques,” AIChE J. 47, 60–65 (2001).
[Crossref]

2000 (1)

1998 (5)

H. Jiang, “Enhanced photon-migration methods for particle sizing in concentrated suspensions,” AIChE J. 44, 1740–1744 (1998).
[Crossref]

H. Jiang, G. Marquez, and L. Wang, “Particle sizing in concentrated suspensions by use of steady-state, continuous-wave photon-migration techniques,” Opt. Lett. 23, 394–396 (1998).
[Crossref]

L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
[Crossref]

J.R. Mourant, A.H. Hielscher, A.A. Eick, T.M. Johnson, and J.P. Freyer, “Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells,” Cancer Cytopathol 84, 366–374 (1998).

A.M.K. Nilsson, C. Sturesson, D.L. Liu, and S. Andersson-Engels, “Changes in spectral shape of tissue optical properties in conjunction with laser-induced thermotherapy,” Appl. Opt. 37, 1256–1267 (1998).
[Crossref]

1997 (2)

1995 (1)

K.D. Paulsen and H. Jiang, “Spatially varying optical property reconstruction using a finite element diffusion equation approximation,” Med. Phys. 22, 691–701 (1995).
[Crossref] [PubMed]

1993 (1)

B. Veauvoit, H. Liu, K. Kang, P. D. Kaplan, M. Miwa, and B. Chance, “Characterization of absorption and scattering properties of various yeast strains by time-resolved spectroscopy,” Cell Biophys. 23, 91–109 (1993).

1992 (1)

Aarnoudse, J. G.

Andersson-Engels, S.

Arridge, S.R.

Backman, V.

X. Li, Z. Chen, J. Gong, A. Taflove, and V. Backman, “Analytical techniques for addressing forward and inverse problems of light scattering by irregularly shaped particles,” Opt. Lett. 29, 1239–11241(2004).
[Crossref] [PubMed]

L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
[Crossref]

Bartlett, M.

M. Bartlett and H. Jiang, “Particle sizing in dense, rapidly flowing KCl suspensions by photon migration techniques,” AIChE J. 47, 60–65 (2001).
[Crossref]

Berger, A.J.

A.E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A.J. Berger, D. Hsiang, J. Butler, R.F. Holcombe, and B.J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60–71 (2002).
[Crossref] [PubMed]

Bevilacqua, F.

A.E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A.J. Berger, D. Hsiang, J. Butler, R.F. Holcombe, and B.J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60–71 (2002).
[Crossref] [PubMed]

Bigio, I. J.

Bohren, G. F.

G. F. Bohren and D. R. Hoffman, Absorption and Scattering of Light by Small Particles (Wiley, New York, 1983)

Boyer, J.

Butler, J.

A.E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A.J. Berger, D. Hsiang, J. Butler, R.F. Holcombe, and B.J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60–71 (2002).
[Crossref] [PubMed]

Cerussi, A.E.

A.E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A.J. Berger, D. Hsiang, J. Butler, R.F. Holcombe, and B.J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60–71 (2002).
[Crossref] [PubMed]

Chance, B.

B. Veauvoit, H. Liu, K. Kang, P. D. Kaplan, M. Miwa, and B. Chance, “Characterization of absorption and scattering properties of various yeast strains by time-resolved spectroscopy,” Cell Biophys. 23, 91–109 (1993).

Chen, Z.

Choe, R.

Corlu, A.

Cotran, R.S.

R.S. Cotran, S. Robbins, V. Kumar, and Robbins Pathological Basis of Disease (W.B. Saunders, Philadelphia, Pennsylvania, 1994).

Crawford, J.M.

L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
[Crossref]

de Mul, F. F. M.

Dehghani, H.

B.W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T.D. Tosteson, S.P. Poplack, and K.D. Paulsen, “Characterization of hemoglobin, water, and NIR scattering in breast tissue: Analysis of intersubject variability and menstrual cycle changes,” J. Biomed. Opt. 9, 541–552 (2004).
[Crossref] [PubMed]

Durduran, T.

Eick, A.A.

J.R. Mourant, A.H. Hielscher, A.A. Eick, T.M. Johnson, and J.P. Freyer, “Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells,” Cancer Cytopathol 84, 366–374 (1998).

Feld, M.S.

L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
[Crossref]

Freyer, J.P.

J.R. Mourant, A.H. Hielscher, A.A. Eick, T.M. Johnson, and J.P. Freyer, “Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells,” Cancer Cytopathol 84, 366–374 (1998).

Fuselier, T.

Gong, J.

Graaff, R.

Greve, J.

Gu, X.

Hamano, T.

L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
[Crossref]

Hielscher, A.H.

J.R. Mourant, A.H. Hielscher, A.A. Eick, T.M. Johnson, and J.P. Freyer, “Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells,” Cancer Cytopathol 84, 366–374 (1998).

Hillman, E.M.C.

Hoffman, D. R.

G. F. Bohren and D. R. Hoffman, Absorption and Scattering of Light by Small Particles (Wiley, New York, 1983)

Holcombe, R.F.

A.E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A.J. Berger, D. Hsiang, J. Butler, R.F. Holcombe, and B.J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60–71 (2002).
[Crossref] [PubMed]

Hsiang, D.

A.E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A.J. Berger, D. Hsiang, J. Butler, R.F. Holcombe, and B.J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60–71 (2002).
[Crossref] [PubMed]

Iftimia, N.

Itzkan, I.

L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
[Crossref]

Jakubowski, D.

A.E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A.J. Berger, D. Hsiang, J. Butler, R.F. Holcombe, and B.J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60–71 (2002).
[Crossref] [PubMed]

Jiang, H.

C. Li and H. Jiang, “A calibration method in diffuse optical tomography,” J. Opt. A: Pure Appl. Opt. 6, 844–852 (2004).
[Crossref]

Y. Xu, X. Gu, T. Khan, and H. Jiang, “Absorption and scattering images of heterogeneous scattering media can be simultaneously reconstructed by use of dc data,” Appl. Opt. 41, 5427–5437 (2002).
[Crossref] [PubMed]

E. Shives, Y. Xu, and H. Jiang, “Fluorescence lifetime tomography of turbid media based on an oxygen-sensitive dye,” Opt. Express 10, 1557–1562 (2002), http://www.opticsexpress.org/abstract.cfm?URI=OPEX-10-26-1557.
[Crossref] [PubMed]

M. Bartlett and H. Jiang, “Particle sizing in dense, rapidly flowing KCl suspensions by photon migration techniques,” AIChE J. 47, 60–65 (2001).
[Crossref]

N. Iftimia and H. Jiang, “Quantitative optical image reconstruction of turbid media by use of direct-current measurements,” Appl. Opt. 39, 5256–5261 (2000).
[Crossref]

H. Jiang, “Enhanced photon-migration methods for particle sizing in concentrated suspensions,” AIChE J. 44, 1740–1744 (1998).
[Crossref]

H. Jiang, G. Marquez, and L. Wang, “Particle sizing in concentrated suspensions by use of steady-state, continuous-wave photon-migration techniques,” Opt. Lett. 23, 394–396 (1998).
[Crossref]

H. Jiang, J. Pierce, J. Kao, and Eva Sevick-Muraca, “Measurement of particle-size distribution and volume fraction in concentrated suspensions with photon migration techniques,” Appl. Opt. 36, 3310–3318 (1997).
[Crossref] [PubMed]

K.D. Paulsen and H. Jiang, “Spatially varying optical property reconstruction using a finite element diffusion equation approximation,” Med. Phys. 22, 691–701 (1995).
[Crossref] [PubMed]

C. Li, H. Zhao, and H. Jiang, in Biomedical Topical Meeting on CD-ROM (the Optical Society of America, Washington, DC, 2004), WF19.

Jiang, S.

B.W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T.D. Tosteson, S.P. Poplack, and K.D. Paulsen, “Characterization of hemoglobin, water, and NIR scattering in breast tissue: Analysis of intersubject variability and menstrual cycle changes,” J. Biomed. Opt. 9, 541–552 (2004).
[Crossref] [PubMed]

Johns, M.

Johnson, T. M.

Johnson, T.M.

J.R. Mourant, A.H. Hielscher, A.A. Eick, T.M. Johnson, and J.P. Freyer, “Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells,” Cancer Cytopathol 84, 366–374 (1998).

Kang, K.

B. Veauvoit, H. Liu, K. Kang, P. D. Kaplan, M. Miwa, and B. Chance, “Characterization of absorption and scattering properties of various yeast strains by time-resolved spectroscopy,” Cell Biophys. 23, 91–109 (1993).

Kao, J.

Kaplan, P. D.

B. Veauvoit, H. Liu, K. Kang, P. D. Kaplan, M. Miwa, and B. Chance, “Characterization of absorption and scattering properties of various yeast strains by time-resolved spectroscopy,” Cell Biophys. 23, 91–109 (1993).

Khan, T.

Koelink, M. H.

Kogel, C.

B.W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T.D. Tosteson, S.P. Poplack, and K.D. Paulsen, “Characterization of hemoglobin, water, and NIR scattering in breast tissue: Analysis of intersubject variability and menstrual cycle changes,” J. Biomed. Opt. 9, 541–552 (2004).
[Crossref] [PubMed]

Kumar, V.

R.S. Cotran, S. Robbins, V. Kumar, and Robbins Pathological Basis of Disease (W.B. Saunders, Philadelphia, Pennsylvania, 1994).

Lanning, R.

A.E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A.J. Berger, D. Hsiang, J. Butler, R.F. Holcombe, and B.J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60–71 (2002).
[Crossref] [PubMed]

Li, C.

C. Li and H. Jiang, “A calibration method in diffuse optical tomography,” J. Opt. A: Pure Appl. Opt. 6, 844–852 (2004).
[Crossref]

C. Li, H. Zhao, and H. Jiang, in Biomedical Topical Meeting on CD-ROM (the Optical Society of America, Washington, DC, 2004), WF19.

Li, X.

Lima, C.

L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
[Crossref]

Liu, D.L.

Liu, H.

M. Johns and H. Liu, “Limited possibility for quantifying mean particle size by logarithmic light-scattering spectroscopy,” Appl. Opt. 42, 2968–2971 (2003).
[Crossref] [PubMed]

B. Veauvoit, H. Liu, K. Kang, P. D. Kaplan, M. Miwa, and B. Chance, “Characterization of absorption and scattering properties of various yeast strains by time-resolved spectroscopy,” Cell Biophys. 23, 91–109 (1993).

Manoharan, R.

L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
[Crossref]

Marquez, G.

Miwa, M.

B. Veauvoit, H. Liu, K. Kang, P. D. Kaplan, M. Miwa, and B. Chance, “Characterization of absorption and scattering properties of various yeast strains by time-resolved spectroscopy,” Cell Biophys. 23, 91–109 (1993).

Mourant, J. R.

Mourant, J.R.

J.R. Mourant, A.H. Hielscher, A.A. Eick, T.M. Johnson, and J.P. Freyer, “Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells,” Cancer Cytopathol 84, 366–374 (1998).

Nilsson, A.M.K.

Nusrat, A.

L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
[Crossref]

Paulsen, K.D.

B.W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T.D. Tosteson, S.P. Poplack, and K.D. Paulsen, “Characterization of hemoglobin, water, and NIR scattering in breast tissue: Analysis of intersubject variability and menstrual cycle changes,” J. Biomed. Opt. 9, 541–552 (2004).
[Crossref] [PubMed]

K.D. Paulsen and H. Jiang, “Spatially varying optical property reconstruction using a finite element diffusion equation approximation,” Med. Phys. 22, 691–701 (1995).
[Crossref] [PubMed]

Perelman, L.T.

L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
[Crossref]

Pierce, J.

Pogue, B.W.

B.W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T.D. Tosteson, S.P. Poplack, and K.D. Paulsen, “Characterization of hemoglobin, water, and NIR scattering in breast tissue: Analysis of intersubject variability and menstrual cycle changes,” J. Biomed. Opt. 9, 541–552 (2004).
[Crossref] [PubMed]

Poplack, S.P.

B.W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T.D. Tosteson, S.P. Poplack, and K.D. Paulsen, “Characterization of hemoglobin, water, and NIR scattering in breast tissue: Analysis of intersubject variability and menstrual cycle changes,” J. Biomed. Opt. 9, 541–552 (2004).
[Crossref] [PubMed]

Robbins,

R.S. Cotran, S. Robbins, V. Kumar, and Robbins Pathological Basis of Disease (W.B. Saunders, Philadelphia, Pennsylvania, 1994).

Robbins, S.

R.S. Cotran, S. Robbins, V. Kumar, and Robbins Pathological Basis of Disease (W.B. Saunders, Philadelphia, Pennsylvania, 1994).

Schweiger, M.

Seiler, M.

L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
[Crossref]

Sevick-Muraca, Eva

Shah, N.

A.E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A.J. Berger, D. Hsiang, J. Butler, R.F. Holcombe, and B.J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60–71 (2002).
[Crossref] [PubMed]

Shields, S.

L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
[Crossref]

Shives, E.

Sloot, P. M. A.

Soho, S.

B.W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T.D. Tosteson, S.P. Poplack, and K.D. Paulsen, “Characterization of hemoglobin, water, and NIR scattering in breast tissue: Analysis of intersubject variability and menstrual cycle changes,” J. Biomed. Opt. 9, 541–552 (2004).
[Crossref] [PubMed]

Song, X.

B.W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T.D. Tosteson, S.P. Poplack, and K.D. Paulsen, “Characterization of hemoglobin, water, and NIR scattering in breast tissue: Analysis of intersubject variability and menstrual cycle changes,” J. Biomed. Opt. 9, 541–552 (2004).
[Crossref] [PubMed]

Srinivasan, S.

B.W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T.D. Tosteson, S.P. Poplack, and K.D. Paulsen, “Characterization of hemoglobin, water, and NIR scattering in breast tissue: Analysis of intersubject variability and menstrual cycle changes,” J. Biomed. Opt. 9, 541–552 (2004).
[Crossref] [PubMed]

Sturesson, C.

Taflove, A.

Tosteson, T.D.

B.W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T.D. Tosteson, S.P. Poplack, and K.D. Paulsen, “Characterization of hemoglobin, water, and NIR scattering in breast tissue: Analysis of intersubject variability and menstrual cycle changes,” J. Biomed. Opt. 9, 541–552 (2004).
[Crossref] [PubMed]

Tromberg, B.J.

A.E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A.J. Berger, D. Hsiang, J. Butler, R.F. Holcombe, and B.J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60–71 (2002).
[Crossref] [PubMed]

Van Dam, J.

L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
[Crossref]

Veauvoit, B.

B. Veauvoit, H. Liu, K. Kang, P. D. Kaplan, M. Miwa, and B. Chance, “Characterization of absorption and scattering properties of various yeast strains by time-resolved spectroscopy,” Cell Biophys. 23, 91–109 (1993).

Wallace, M.

L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
[Crossref]

Wang, L.

Xu, Y.

Yodh, A.G.

Zhao, H.

C. Li, H. Zhao, and H. Jiang, in Biomedical Topical Meeting on CD-ROM (the Optical Society of America, Washington, DC, 2004), WF19.

Zijp, J. R.

Zonios, G.

L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
[Crossref]

AIChE J. (2)

M. Bartlett and H. Jiang, “Particle sizing in dense, rapidly flowing KCl suspensions by photon migration techniques,” AIChE J. 47, 60–65 (2001).
[Crossref]

H. Jiang, “Enhanced photon-migration methods for particle sizing in concentrated suspensions,” AIChE J. 44, 1740–1744 (1998).
[Crossref]

Appl. Opt. (7)

R. Graaff, J. G. Aarnoudse, J. R. Zijp, P. M. A. Sloot, F. F. M. de Mul, J. Greve, and M. H. Koelink, “Reduced light-scattering properties fro mixtures of spherical-particles-a simple approximation derived from MIE calculations,” Appl. Opt. 31, 1370–1376 (1992).
[Crossref] [PubMed]

H. Jiang, J. Pierce, J. Kao, and Eva Sevick-Muraca, “Measurement of particle-size distribution and volume fraction in concentrated suspensions with photon migration techniques,” Appl. Opt. 36, 3310–3318 (1997).
[Crossref] [PubMed]

A.M.K. Nilsson, C. Sturesson, D.L. Liu, and S. Andersson-Engels, “Changes in spectral shape of tissue optical properties in conjunction with laser-induced thermotherapy,” Appl. Opt. 37, 1256–1267 (1998).
[Crossref]

N. Iftimia and H. Jiang, “Quantitative optical image reconstruction of turbid media by use of direct-current measurements,” Appl. Opt. 39, 5256–5261 (2000).
[Crossref]

J. R. Mourant, T. Fuselier, J. Boyer, T. M. Johnson, and I. J. Bigio, “Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms,” Appl. Opt. 36, 949–957 (1997).
[Crossref] [PubMed]

Y. Xu, X. Gu, T. Khan, and H. Jiang, “Absorption and scattering images of heterogeneous scattering media can be simultaneously reconstructed by use of dc data,” Appl. Opt. 41, 5427–5437 (2002).
[Crossref] [PubMed]

M. Johns and H. Liu, “Limited possibility for quantifying mean particle size by logarithmic light-scattering spectroscopy,” Appl. Opt. 42, 2968–2971 (2003).
[Crossref] [PubMed]

Cancer Cytopathol (1)

J.R. Mourant, A.H. Hielscher, A.A. Eick, T.M. Johnson, and J.P. Freyer, “Evidence of intrinsic differences in the light scattering properties of tumorigenic and nontumorigenic cells,” Cancer Cytopathol 84, 366–374 (1998).

Cell Biophys. (1)

B. Veauvoit, H. Liu, K. Kang, P. D. Kaplan, M. Miwa, and B. Chance, “Characterization of absorption and scattering properties of various yeast strains by time-resolved spectroscopy,” Cell Biophys. 23, 91–109 (1993).

J. Biomed. Opt. (2)

A.E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A.J. Berger, D. Hsiang, J. Butler, R.F. Holcombe, and B.J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J. Biomed. Opt. 7, 60–71 (2002).
[Crossref] [PubMed]

B.W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, S. Srinivasan, X. Song, T.D. Tosteson, S.P. Poplack, and K.D. Paulsen, “Characterization of hemoglobin, water, and NIR scattering in breast tissue: Analysis of intersubject variability and menstrual cycle changes,” J. Biomed. Opt. 9, 541–552 (2004).
[Crossref] [PubMed]

J. Opt. A: Pure Appl. Opt. (1)

C. Li and H. Jiang, “A calibration method in diffuse optical tomography,” J. Opt. A: Pure Appl. Opt. 6, 844–852 (2004).
[Crossref]

Med. Phys. (1)

K.D. Paulsen and H. Jiang, “Spatially varying optical property reconstruction using a finite element diffusion equation approximation,” Med. Phys. 22, 691–701 (1995).
[Crossref] [PubMed]

Opt. Express (1)

Opt. Lett. (3)

Phys. Rev. Lett. (1)

L.T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J.M. Crawford, and M.S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: A new technique for measuring nuclear size distribution,” Phys. Rev. Lett. 80, 627–630 (1998).
[Crossref]

Other (3)

R.S. Cotran, S. Robbins, V. Kumar, and Robbins Pathological Basis of Disease (W.B. Saunders, Philadelphia, Pennsylvania, 1994).

G. F. Bohren and D. R. Hoffman, Absorption and Scattering of Light by Small Particles (Wiley, New York, 1983)

C. Li, H. Zhao, and H. Jiang, in Biomedical Topical Meeting on CD-ROM (the Optical Society of America, Washington, DC, 2004), WF19.

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Figures (3)

Fig. 1.
Fig. 1.

(a) The µ′s spectra generated by Eq. (1) and the Mie fittings using recovered particle parameters from simulated data (5% noise) with 10, 20, and 50 wavelengths, respectively. (b) Experimental µ′s spectra DOT reconstructed at a typical node in the target area and the corresponding Mie fitting using recovered particle parameters for the 2.06 µm polystyrene case.

Fig. 2.
Fig. 2.

The DOT reconstructed absorption images (a1 to a10) and reduced scattering images (b1 to b10) at 10 different wavelengths: a1/b1 at 638nm; a2/b2 at 673nm; a3/b3 at 690nm; a4/b4 at 733nm; a5/b5 at 775nm; a6/b6 at 808nm; a7/b7 at 840nm; a8/b8 at 915nm; a9/b9 at 922nm and a10/b10 at 965nm for the 2.06 µ m polystyrene case for all ten wavelengths.

Fig. 3.
Fig. 3.

Reconstructed images of mean particle size (a, c) and concentration (b, d) for the 2.06 µ m (a, b) and 5.66 µ m (c, d) polystyrene cases, respectively. The axes (left and bottom) indicate the spatial scale, in millimeters, whereas the colorful scale (right) records the mean particle size or concentration, in micrometers or percentage.

Equations (4)

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μ s ( λ ) = 0 3 Q scat ( x , n , λ ) [ 1 g ( x, n , λ ) ] 2 x ϕ f ( x ) dx
χ 2 = j = λ 1 λ 10 [ ( μ s ) j o ( μ s ) j c ] 2
f ( x ) = 1 2 π b 2 e ( x a ) 2 2 b 2
μ s ( λ ) = 0 3 Q scat ( x , n , λ ) [ 1 g ( x , n , λ ) ] 2 x ϕ 1 2 π b 2 e ( x a ) 2 b 2 2 dx

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