Abstract

We report on the measurement of morphology-dependent resonance within a laser-trapped micro-sphere excited under two-photon absorption. Both trapping and two-photon excitation are simultaneously achieved by a single femtosecond pulsed laser beam. The effect of the laser power as well as the pulse width on the transverse trapping force is first investigated. The dependence of two-photon-induced morphology-dependent resonance on the scanning velocity of a trapped particle is then experimentally determined.

© 2004 Optical Society of America

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  1. A. Ashkin and J.M. Dziedzic, “Optical trapping and manipulation of viruses and bacteria,” Science. 235, 1517–1521 (1987).
    [CrossRef] [PubMed]
  2. K. Svoboda, C.F. Schmidt, B.J. Schnapp, and S.M. Block, “Direct observation of kinesin stepping by optical trapping interferometry,” Nature 365, 721–727 (1993).
    [CrossRef] [PubMed]
  3. S. B. Smith, Y. Cui, and C. Bustamante, “Overstretching B-DNA: the elastic response of individual double-stranded and single-stranded DNA molecules,” Science 271, 795–799 (1996).
    [CrossRef] [PubMed]
  4. M. Gu and P. Ke, “Image enhancement in near-field scanning optical microscopy with laser-trapped metallic particles,” Opt. Lett. 24, 74–76 (1999).
    [CrossRef]
  5. M. Gu and P. Ke, “Effect of depolarization of scattered evanescent waves on particle-trapped near-field scanning optical microscopy,” Appl. Phys. Lett. 75, 175–178 (1999).
    [CrossRef]
  6. R. E. Benner, P. W. Barber, J. F. Owen, and R. K. Chang, “Observation of structure resonances in the fluorescence spectra from microspheres,” Phys. Rev. Lett. 44, 475–478 (1980).
    [CrossRef]
  7. A. Ashkin and J. M. Dziedzic, “Observation of optical resonances of dielectric spheres by light scattering,” Appl. Opt. 20, 1803–1814 (1981).
    [CrossRef] [PubMed]
  8. A. J. Campillo, J. D. Eversole, and H-B. “Cavity quantum electrodynamic enhancement of stimulated emission in microdroplets,” Lin, Phys. Rev. Lett. 67, 437–440 (1991).
    [CrossRef] [PubMed]
  9. H.-M. Tzeng, K. F. Wall, M. B. Long, and R. K. Chang, “Laser emission from individual droplets at wavelengths corresponding to morphology-dependent resonances,” Opt. Lett. 9, 499–501 (1984).
    [CrossRef] [PubMed]
  10. K. Sasaki, H. Fujiwara, and H. Masuhara, “Photon tunneling from an optically manipulated microsphere to a surface by lasing spectral analysis,” Appl. Phys. Lett. 70, 2647–2650 (1997).
    [CrossRef]
  11. D. Morrish, X. Gan, and M. Gu, “Observation of orthogonally polarized transverse electric and transverse magnetic oscillation modes in a microcavity excited by localized two-photon absorption,” Appl. Phys. Lett. 81, 5132–5135 (2002).
    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef]
  14. B. Agate, C. T. A. Brown, W. Sibbett, and K. Dholakia, “Femtosecond optical tweezers for in-situ control of two-photon fluorescence,” Opt. Express 12, 3011–3017 (2004), http://www.opticsexpress.org/abstract.cfm?URI=OPEX-12-13-3011
    [CrossRef] [PubMed]
  15. H. Misawa, R. Fujisawa, K. Sasaki, N. Kitamura, and H. Masuhara, “Simultaneous manipulation and lasing of a polymer microparticle using a CW 1064 nm laser beam,” Jpn. J. Appl. Phys. 32, L788–L790 (1993).
    [CrossRef]
  16. M. Gu, D. Morrish, and P. Ke, “Enhancement of transverse trapping efficiency for a metallic particle using an obstructed laser beam,” Appl. Phys. Lett. 77, 34–36 (2000).
    [CrossRef]
  17. A. Ashkin, “Forces of a single-beam gradient laser trap on a dielectric sphere in the ray optics regime,” Biophys. J. 61, 569–581 (1992).
    [CrossRef] [PubMed]

2004 (1)

2002 (1)

D. Morrish, X. Gan, and M. Gu, “Observation of orthogonally polarized transverse electric and transverse magnetic oscillation modes in a microcavity excited by localized two-photon absorption,” Appl. Phys. Lett. 81, 5132–5135 (2002).
[CrossRef]

2000 (1)

M. Gu, D. Morrish, and P. Ke, “Enhancement of transverse trapping efficiency for a metallic particle using an obstructed laser beam,” Appl. Phys. Lett. 77, 34–36 (2000).
[CrossRef]

1999 (2)

M. Gu and P. Ke, “Image enhancement in near-field scanning optical microscopy with laser-trapped metallic particles,” Opt. Lett. 24, 74–76 (1999).
[CrossRef]

M. Gu and P. Ke, “Effect of depolarization of scattered evanescent waves on particle-trapped near-field scanning optical microscopy,” Appl. Phys. Lett. 75, 175–178 (1999).
[CrossRef]

1997 (1)

K. Sasaki, H. Fujiwara, and H. Masuhara, “Photon tunneling from an optically manipulated microsphere to a surface by lasing spectral analysis,” Appl. Phys. Lett. 70, 2647–2650 (1997).
[CrossRef]

1996 (2)

E. Florin, J. Hörber, and E. H. K. Stelzer, “High-resolution axial and lateral position sensing using two-photon excitation of fluorophores by a continuous-wave Nd:YAG laser,” Appl. Phys. Lett. 69, 446–449 (1996).
[CrossRef]

S. B. Smith, Y. Cui, and C. Bustamante, “Overstretching B-DNA: the elastic response of individual double-stranded and single-stranded DNA molecules,” Science 271, 795–799 (1996).
[CrossRef] [PubMed]

1995 (1)

1993 (2)

H. Misawa, R. Fujisawa, K. Sasaki, N. Kitamura, and H. Masuhara, “Simultaneous manipulation and lasing of a polymer microparticle using a CW 1064 nm laser beam,” Jpn. J. Appl. Phys. 32, L788–L790 (1993).
[CrossRef]

K. Svoboda, C.F. Schmidt, B.J. Schnapp, and S.M. Block, “Direct observation of kinesin stepping by optical trapping interferometry,” Nature 365, 721–727 (1993).
[CrossRef] [PubMed]

1992 (1)

A. Ashkin, “Forces of a single-beam gradient laser trap on a dielectric sphere in the ray optics regime,” Biophys. J. 61, 569–581 (1992).
[CrossRef] [PubMed]

1991 (1)

A. J. Campillo, J. D. Eversole, and H-B. “Cavity quantum electrodynamic enhancement of stimulated emission in microdroplets,” Lin, Phys. Rev. Lett. 67, 437–440 (1991).
[CrossRef] [PubMed]

1987 (1)

A. Ashkin and J.M. Dziedzic, “Optical trapping and manipulation of viruses and bacteria,” Science. 235, 1517–1521 (1987).
[CrossRef] [PubMed]

1984 (1)

1981 (1)

1980 (1)

R. E. Benner, P. W. Barber, J. F. Owen, and R. K. Chang, “Observation of structure resonances in the fluorescence spectra from microspheres,” Phys. Rev. Lett. 44, 475–478 (1980).
[CrossRef]

Agate, B.

Ashkin, A.

A. Ashkin, “Forces of a single-beam gradient laser trap on a dielectric sphere in the ray optics regime,” Biophys. J. 61, 569–581 (1992).
[CrossRef] [PubMed]

A. Ashkin and J.M. Dziedzic, “Optical trapping and manipulation of viruses and bacteria,” Science. 235, 1517–1521 (1987).
[CrossRef] [PubMed]

A. Ashkin and J. M. Dziedzic, “Observation of optical resonances of dielectric spheres by light scattering,” Appl. Opt. 20, 1803–1814 (1981).
[CrossRef] [PubMed]

Barber, P. W.

R. E. Benner, P. W. Barber, J. F. Owen, and R. K. Chang, “Observation of structure resonances in the fluorescence spectra from microspheres,” Phys. Rev. Lett. 44, 475–478 (1980).
[CrossRef]

Benner, R. E.

R. E. Benner, P. W. Barber, J. F. Owen, and R. K. Chang, “Observation of structure resonances in the fluorescence spectra from microspheres,” Phys. Rev. Lett. 44, 475–478 (1980).
[CrossRef]

Berns, M. W.

Block, S.M.

K. Svoboda, C.F. Schmidt, B.J. Schnapp, and S.M. Block, “Direct observation of kinesin stepping by optical trapping interferometry,” Nature 365, 721–727 (1993).
[CrossRef] [PubMed]

Brown, C. T. A.

Bustamante, C.

S. B. Smith, Y. Cui, and C. Bustamante, “Overstretching B-DNA: the elastic response of individual double-stranded and single-stranded DNA molecules,” Science 271, 795–799 (1996).
[CrossRef] [PubMed]

Campillo, A. J.

A. J. Campillo, J. D. Eversole, and H-B. “Cavity quantum electrodynamic enhancement of stimulated emission in microdroplets,” Lin, Phys. Rev. Lett. 67, 437–440 (1991).
[CrossRef] [PubMed]

Chang, R. K.

H.-M. Tzeng, K. F. Wall, M. B. Long, and R. K. Chang, “Laser emission from individual droplets at wavelengths corresponding to morphology-dependent resonances,” Opt. Lett. 9, 499–501 (1984).
[CrossRef] [PubMed]

R. E. Benner, P. W. Barber, J. F. Owen, and R. K. Chang, “Observation of structure resonances in the fluorescence spectra from microspheres,” Phys. Rev. Lett. 44, 475–478 (1980).
[CrossRef]

Cui, Y.

S. B. Smith, Y. Cui, and C. Bustamante, “Overstretching B-DNA: the elastic response of individual double-stranded and single-stranded DNA molecules,” Science 271, 795–799 (1996).
[CrossRef] [PubMed]

Dholakia, K.

Dziedzic, J. M.

Dziedzic, J.M.

A. Ashkin and J.M. Dziedzic, “Optical trapping and manipulation of viruses and bacteria,” Science. 235, 1517–1521 (1987).
[CrossRef] [PubMed]

Eversole, J. D.

A. J. Campillo, J. D. Eversole, and H-B. “Cavity quantum electrodynamic enhancement of stimulated emission in microdroplets,” Lin, Phys. Rev. Lett. 67, 437–440 (1991).
[CrossRef] [PubMed]

Florin, E.

E. Florin, J. Hörber, and E. H. K. Stelzer, “High-resolution axial and lateral position sensing using two-photon excitation of fluorophores by a continuous-wave Nd:YAG laser,” Appl. Phys. Lett. 69, 446–449 (1996).
[CrossRef]

Fujisawa, R.

H. Misawa, R. Fujisawa, K. Sasaki, N. Kitamura, and H. Masuhara, “Simultaneous manipulation and lasing of a polymer microparticle using a CW 1064 nm laser beam,” Jpn. J. Appl. Phys. 32, L788–L790 (1993).
[CrossRef]

Fujiwara, H.

K. Sasaki, H. Fujiwara, and H. Masuhara, “Photon tunneling from an optically manipulated microsphere to a surface by lasing spectral analysis,” Appl. Phys. Lett. 70, 2647–2650 (1997).
[CrossRef]

Gan, X.

D. Morrish, X. Gan, and M. Gu, “Observation of orthogonally polarized transverse electric and transverse magnetic oscillation modes in a microcavity excited by localized two-photon absorption,” Appl. Phys. Lett. 81, 5132–5135 (2002).
[CrossRef]

Gu, M.

D. Morrish, X. Gan, and M. Gu, “Observation of orthogonally polarized transverse electric and transverse magnetic oscillation modes in a microcavity excited by localized two-photon absorption,” Appl. Phys. Lett. 81, 5132–5135 (2002).
[CrossRef]

M. Gu, D. Morrish, and P. Ke, “Enhancement of transverse trapping efficiency for a metallic particle using an obstructed laser beam,” Appl. Phys. Lett. 77, 34–36 (2000).
[CrossRef]

M. Gu and P. Ke, “Effect of depolarization of scattered evanescent waves on particle-trapped near-field scanning optical microscopy,” Appl. Phys. Lett. 75, 175–178 (1999).
[CrossRef]

M. Gu and P. Ke, “Image enhancement in near-field scanning optical microscopy with laser-trapped metallic particles,” Opt. Lett. 24, 74–76 (1999).
[CrossRef]

H-B.,

A. J. Campillo, J. D. Eversole, and H-B. “Cavity quantum electrodynamic enhancement of stimulated emission in microdroplets,” Lin, Phys. Rev. Lett. 67, 437–440 (1991).
[CrossRef] [PubMed]

Hörber, J.

E. Florin, J. Hörber, and E. H. K. Stelzer, “High-resolution axial and lateral position sensing using two-photon excitation of fluorophores by a continuous-wave Nd:YAG laser,” Appl. Phys. Lett. 69, 446–449 (1996).
[CrossRef]

Ke, P.

M. Gu, D. Morrish, and P. Ke, “Enhancement of transverse trapping efficiency for a metallic particle using an obstructed laser beam,” Appl. Phys. Lett. 77, 34–36 (2000).
[CrossRef]

M. Gu and P. Ke, “Effect of depolarization of scattered evanescent waves on particle-trapped near-field scanning optical microscopy,” Appl. Phys. Lett. 75, 175–178 (1999).
[CrossRef]

M. Gu and P. Ke, “Image enhancement in near-field scanning optical microscopy with laser-trapped metallic particles,” Opt. Lett. 24, 74–76 (1999).
[CrossRef]

Kitamura, N.

H. Misawa, R. Fujisawa, K. Sasaki, N. Kitamura, and H. Masuhara, “Simultaneous manipulation and lasing of a polymer microparticle using a CW 1064 nm laser beam,” Jpn. J. Appl. Phys. 32, L788–L790 (1993).
[CrossRef]

Konig, K.

Liu, Y.

Long, M. B.

Masuhara, H.

K. Sasaki, H. Fujiwara, and H. Masuhara, “Photon tunneling from an optically manipulated microsphere to a surface by lasing spectral analysis,” Appl. Phys. Lett. 70, 2647–2650 (1997).
[CrossRef]

H. Misawa, R. Fujisawa, K. Sasaki, N. Kitamura, and H. Masuhara, “Simultaneous manipulation and lasing of a polymer microparticle using a CW 1064 nm laser beam,” Jpn. J. Appl. Phys. 32, L788–L790 (1993).
[CrossRef]

Misawa, H.

H. Misawa, R. Fujisawa, K. Sasaki, N. Kitamura, and H. Masuhara, “Simultaneous manipulation and lasing of a polymer microparticle using a CW 1064 nm laser beam,” Jpn. J. Appl. Phys. 32, L788–L790 (1993).
[CrossRef]

Morrish, D.

D. Morrish, X. Gan, and M. Gu, “Observation of orthogonally polarized transverse electric and transverse magnetic oscillation modes in a microcavity excited by localized two-photon absorption,” Appl. Phys. Lett. 81, 5132–5135 (2002).
[CrossRef]

M. Gu, D. Morrish, and P. Ke, “Enhancement of transverse trapping efficiency for a metallic particle using an obstructed laser beam,” Appl. Phys. Lett. 77, 34–36 (2000).
[CrossRef]

Owen, J. F.

R. E. Benner, P. W. Barber, J. F. Owen, and R. K. Chang, “Observation of structure resonances in the fluorescence spectra from microspheres,” Phys. Rev. Lett. 44, 475–478 (1980).
[CrossRef]

Sasaki, K.

K. Sasaki, H. Fujiwara, and H. Masuhara, “Photon tunneling from an optically manipulated microsphere to a surface by lasing spectral analysis,” Appl. Phys. Lett. 70, 2647–2650 (1997).
[CrossRef]

H. Misawa, R. Fujisawa, K. Sasaki, N. Kitamura, and H. Masuhara, “Simultaneous manipulation and lasing of a polymer microparticle using a CW 1064 nm laser beam,” Jpn. J. Appl. Phys. 32, L788–L790 (1993).
[CrossRef]

Schmidt, C.F.

K. Svoboda, C.F. Schmidt, B.J. Schnapp, and S.M. Block, “Direct observation of kinesin stepping by optical trapping interferometry,” Nature 365, 721–727 (1993).
[CrossRef] [PubMed]

Schnapp, B.J.

K. Svoboda, C.F. Schmidt, B.J. Schnapp, and S.M. Block, “Direct observation of kinesin stepping by optical trapping interferometry,” Nature 365, 721–727 (1993).
[CrossRef] [PubMed]

Sibbett, W.

Smith, S. B.

S. B. Smith, Y. Cui, and C. Bustamante, “Overstretching B-DNA: the elastic response of individual double-stranded and single-stranded DNA molecules,” Science 271, 795–799 (1996).
[CrossRef] [PubMed]

Sonek, G. J.

Stelzer, E. H. K.

E. Florin, J. Hörber, and E. H. K. Stelzer, “High-resolution axial and lateral position sensing using two-photon excitation of fluorophores by a continuous-wave Nd:YAG laser,” Appl. Phys. Lett. 69, 446–449 (1996).
[CrossRef]

Svoboda, K.

K. Svoboda, C.F. Schmidt, B.J. Schnapp, and S.M. Block, “Direct observation of kinesin stepping by optical trapping interferometry,” Nature 365, 721–727 (1993).
[CrossRef] [PubMed]

Tromberg, B.

Tzeng, H.-M.

Wall, K. F.

Appl. Opt. (1)

Appl. Phys. Lett. (5)

M. Gu and P. Ke, “Effect of depolarization of scattered evanescent waves on particle-trapped near-field scanning optical microscopy,” Appl. Phys. Lett. 75, 175–178 (1999).
[CrossRef]

K. Sasaki, H. Fujiwara, and H. Masuhara, “Photon tunneling from an optically manipulated microsphere to a surface by lasing spectral analysis,” Appl. Phys. Lett. 70, 2647–2650 (1997).
[CrossRef]

D. Morrish, X. Gan, and M. Gu, “Observation of orthogonally polarized transverse electric and transverse magnetic oscillation modes in a microcavity excited by localized two-photon absorption,” Appl. Phys. Lett. 81, 5132–5135 (2002).
[CrossRef]

E. Florin, J. Hörber, and E. H. K. Stelzer, “High-resolution axial and lateral position sensing using two-photon excitation of fluorophores by a continuous-wave Nd:YAG laser,” Appl. Phys. Lett. 69, 446–449 (1996).
[CrossRef]

M. Gu, D. Morrish, and P. Ke, “Enhancement of transverse trapping efficiency for a metallic particle using an obstructed laser beam,” Appl. Phys. Lett. 77, 34–36 (2000).
[CrossRef]

Biophys. J. (1)

A. Ashkin, “Forces of a single-beam gradient laser trap on a dielectric sphere in the ray optics regime,” Biophys. J. 61, 569–581 (1992).
[CrossRef] [PubMed]

Jpn. J. Appl. Phys. (1)

H. Misawa, R. Fujisawa, K. Sasaki, N. Kitamura, and H. Masuhara, “Simultaneous manipulation and lasing of a polymer microparticle using a CW 1064 nm laser beam,” Jpn. J. Appl. Phys. 32, L788–L790 (1993).
[CrossRef]

Nature (1)

K. Svoboda, C.F. Schmidt, B.J. Schnapp, and S.M. Block, “Direct observation of kinesin stepping by optical trapping interferometry,” Nature 365, 721–727 (1993).
[CrossRef] [PubMed]

Opt. Express (1)

Opt. Lett. (3)

Phys. Rev. Lett. (2)

R. E. Benner, P. W. Barber, J. F. Owen, and R. K. Chang, “Observation of structure resonances in the fluorescence spectra from microspheres,” Phys. Rev. Lett. 44, 475–478 (1980).
[CrossRef]

A. J. Campillo, J. D. Eversole, and H-B. “Cavity quantum electrodynamic enhancement of stimulated emission in microdroplets,” Lin, Phys. Rev. Lett. 67, 437–440 (1991).
[CrossRef] [PubMed]

Science (1)

S. B. Smith, Y. Cui, and C. Bustamante, “Overstretching B-DNA: the elastic response of individual double-stranded and single-stranded DNA molecules,” Science 271, 795–799 (1996).
[CrossRef] [PubMed]

Science. (1)

A. Ashkin and J.M. Dziedzic, “Optical trapping and manipulation of viruses and bacteria,” Science. 235, 1517–1521 (1987).
[CrossRef] [PubMed]

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Figures (4)

Fig. 1.
Fig. 1.

Schematic diagram of the experimental setup.

Fig. 2.
Fig. 2.

The dependence of the maximum transverse trapping force on laser power. The inset gives the power range within which a particle can be trapped and scanned without damage.

Fig. 3.
Fig. 3.

MDR spectra of a laser trapped micro-sphere at velocities 4, 9, 14, 19, 26 and 29 μm/s ((a) to (f)), respectively.

Fig. 4.
Fig. 4.

Visibility of peaks 517.8 nm (squares) and 521.2 nm (circles) as a function of the translation velocity of a trapped particle.

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