Abstract

We demonstrate experimentally that selective two-photon probe excitation using phase shaped pulses can be achieved even when the laser propagates through scattering tissue. The pre-optimized phase tailored femtosecond pulses were able to identify acidic and basic solutions of a pH sensitive chromophore hidden behind a slab of scattering tissue. This observation has important implications for future applications of coherent control for biomedical imaging and photodynamic therapy.

© 2004 Optical Society of America

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References

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  1. D. Meshulach and Y. Silberberg, “Coherent quantum control of two-photon transitions by a femtosecond laser pulse,” Nature 396, 239–242 (1998).
    [Crossref]
  2. A. Assion, T. Baumert, M. Bergt, T. Brixner, B. Kiefer, V. Seyfried, M. Strehle, and G. Gerber, “Control of chemical reactions by feedback-optimized phase- shaped femtosecond laser pulses,” Science 282, 919–922 (1998).
    [Crossref] [PubMed]
  3. R. J. Levis, G. M. Menkir, and H. Rabitz, “Selective bond dissociation and rearrangement with optimally tailored, strong-field laser pulses,” Science 292, 709–713 (2001).
    [Crossref] [PubMed]
  4. C. J. Bardeen, V. V. Yakovlev, K. R. Wilson, S. D. Carpenter, P. M. Weber, and W. S. Warren, “Feedback quantum control of molecular electronic population transfer,” Chem. Phys. Lett. 280, 151–158 (1997).
    [Crossref]
  5. T. Brixner, N. H. Damrauer, P. Niklaus, and G. Gerber, “Photoselective adaptive femtosecond quantum control in the liquid phase,” Nature 414, 57–60 (2001).
    [Crossref] [PubMed]
  6. J. L. Herek, W. Wohlleben, R. J. Cogdell, D. Zeidler, and M. Motzkus, “Quantum control of energy flow in light harvesting,” Nature 417, 533–535 (2002).
    [Crossref] [PubMed]
  7. T. C. Weinacht, J. L. White, and P. H. Bucksbaum, “Toward strong field mode-selective chemistry,” J. Phys. Chem. A 103, 10166–10168 (1999).
    [Crossref]
  8. A. M. Weiner, “Femtosecond pulse shaping using spatial light modulators,” Rev. Sci. Instrum. 71, 1929–1960 (2000).
    [Crossref]
  9. R. S. Judson and H. Rabitz, “Teaching Lasers to Control Molecules,” Phys. Rev. Lett. 68, 1500–1503 (1992).
    [Crossref] [PubMed]
  10. R. N. Zare, “Laser control of chemical reactions,” Science 279, 1875–1879 (1998).
    [Crossref] [PubMed]
  11. R. J. Gordon and S. A. Rice, “Active control of the dynamics of atoms and molecules,” Annu. Rev. Phys. Chem. 48, 601–641 (1997).
    [Crossref] [PubMed]
  12. S. A. Rice, “Interfering for the good of a chemical reaction,” Nature 409, 422–426 (2001).
    [Crossref] [PubMed]
  13. S. A. Rice and S. P. Shah, “Active control of product selection in a chemical reaction: a view of the current scene,” Phys. Chem. Chem. Phys. 4, 1683–1700 (2002).
    [Crossref]
  14. H. Rabitz, “Shaped laser pulses as reagents,” Science 299, 525–527 (2003).
    [Crossref] [PubMed]
  15. M. Dantus and V. V. Lozovoy, “Experimental Coherent Laser Control of Physicochemical Processes,” Chem. Rev. 104, 1813–1860 (2004).
    [Crossref] [PubMed]
  16. K. A. Walowicz, I. Pastirk, V. V. Lozovoy, and M. Dantus, “Multiphoton intrapulse interference. 1. Control of multiphoton processes in condensed phases,” J. Phys. Chem. A 106, 9369–9373 (2002).
    [Crossref]
  17. V. V. Lozovoy, I. Pastirk, K. A. Walowicz, and M. Dantus, “Multiphoton intrapulse interference. II. Control of two- and three-photon laser induced fluorescence with shaped pulses,” J. Chem. Phys. 118, 3187–3196 (2003).
    [Crossref]
  18. J. M. Dela Cruz, I. Pastirk, V. V. Lozovoy, K. A. Walowicz, and M. Dantus, “Multiphoton intrapulse interference 3: Probing microscopic chemical environments,” J. Phys. Chem. A 108, 53–58 (2004).
    [Crossref]
  19. N. Dudovich, D. Oron, and Y. Silberberg, “Single-pulse coherently controlled nonlinear Raman spectroscopy and microscopy,” Nature 418, 512–514 (2002).
    [Crossref] [PubMed]
  20. I. Pastirk, J. M. Dela Cruz, K. A. Walowicz, V. V. Lozovoy, and M. Dantus, “Selective two-photon microscopy with shaped femtosecond pulses,” Opt. Express 11, 1695–1701 (2003).
    [Crossref] [PubMed]
  21. W. Denk, J. H. Strickler, and W. W. Webb, “2-Photon Laser Scanning Fluorescence Microscopy,” Science 248, 73–76 (1990).
    [Crossref] [PubMed]
  22. W. Denk, “Two-photon excitation in functional biological imaging,” J. Biomed. Opt. 1, 296–304 (1996).
    [Crossref] [PubMed]
  23. W. G. Fisher, W. P. Partridge, C. Dees, and E. A. Wachter, “Simultaneous two-photon activation of type-I photodynamic therapy agents,” Photochem. Photobiol. 66, 141–155 (1997).
    [Crossref] [PubMed]
  24. V. V. Lozovoy, I. Pastirk, and M. Dantus, “Multiphoton intrapulse interference. 4. Characterization of the phase of ultrashort laser pulses.,” Opt. Lett. 7, 775–777 (2004).
    [Crossref]
  25. M. Comstock, V. V. Lozovoy, I. Pastirk, and M. Dantus, “Multiphoton intrapulse interference 6; binary phase shaping,” Opt. Express 12, 1061–1066 (2004).
    [Crossref] [PubMed]

2004 (4)

M. Dantus and V. V. Lozovoy, “Experimental Coherent Laser Control of Physicochemical Processes,” Chem. Rev. 104, 1813–1860 (2004).
[Crossref] [PubMed]

J. M. Dela Cruz, I. Pastirk, V. V. Lozovoy, K. A. Walowicz, and M. Dantus, “Multiphoton intrapulse interference 3: Probing microscopic chemical environments,” J. Phys. Chem. A 108, 53–58 (2004).
[Crossref]

V. V. Lozovoy, I. Pastirk, and M. Dantus, “Multiphoton intrapulse interference. 4. Characterization of the phase of ultrashort laser pulses.,” Opt. Lett. 7, 775–777 (2004).
[Crossref]

M. Comstock, V. V. Lozovoy, I. Pastirk, and M. Dantus, “Multiphoton intrapulse interference 6; binary phase shaping,” Opt. Express 12, 1061–1066 (2004).
[Crossref] [PubMed]

2003 (3)

V. V. Lozovoy, I. Pastirk, K. A. Walowicz, and M. Dantus, “Multiphoton intrapulse interference. II. Control of two- and three-photon laser induced fluorescence with shaped pulses,” J. Chem. Phys. 118, 3187–3196 (2003).
[Crossref]

I. Pastirk, J. M. Dela Cruz, K. A. Walowicz, V. V. Lozovoy, and M. Dantus, “Selective two-photon microscopy with shaped femtosecond pulses,” Opt. Express 11, 1695–1701 (2003).
[Crossref] [PubMed]

H. Rabitz, “Shaped laser pulses as reagents,” Science 299, 525–527 (2003).
[Crossref] [PubMed]

2002 (4)

S. A. Rice and S. P. Shah, “Active control of product selection in a chemical reaction: a view of the current scene,” Phys. Chem. Chem. Phys. 4, 1683–1700 (2002).
[Crossref]

K. A. Walowicz, I. Pastirk, V. V. Lozovoy, and M. Dantus, “Multiphoton intrapulse interference. 1. Control of multiphoton processes in condensed phases,” J. Phys. Chem. A 106, 9369–9373 (2002).
[Crossref]

J. L. Herek, W. Wohlleben, R. J. Cogdell, D. Zeidler, and M. Motzkus, “Quantum control of energy flow in light harvesting,” Nature 417, 533–535 (2002).
[Crossref] [PubMed]

N. Dudovich, D. Oron, and Y. Silberberg, “Single-pulse coherently controlled nonlinear Raman spectroscopy and microscopy,” Nature 418, 512–514 (2002).
[Crossref] [PubMed]

2001 (3)

R. J. Levis, G. M. Menkir, and H. Rabitz, “Selective bond dissociation and rearrangement with optimally tailored, strong-field laser pulses,” Science 292, 709–713 (2001).
[Crossref] [PubMed]

T. Brixner, N. H. Damrauer, P. Niklaus, and G. Gerber, “Photoselective adaptive femtosecond quantum control in the liquid phase,” Nature 414, 57–60 (2001).
[Crossref] [PubMed]

S. A. Rice, “Interfering for the good of a chemical reaction,” Nature 409, 422–426 (2001).
[Crossref] [PubMed]

2000 (1)

A. M. Weiner, “Femtosecond pulse shaping using spatial light modulators,” Rev. Sci. Instrum. 71, 1929–1960 (2000).
[Crossref]

1999 (1)

T. C. Weinacht, J. L. White, and P. H. Bucksbaum, “Toward strong field mode-selective chemistry,” J. Phys. Chem. A 103, 10166–10168 (1999).
[Crossref]

1998 (3)

D. Meshulach and Y. Silberberg, “Coherent quantum control of two-photon transitions by a femtosecond laser pulse,” Nature 396, 239–242 (1998).
[Crossref]

A. Assion, T. Baumert, M. Bergt, T. Brixner, B. Kiefer, V. Seyfried, M. Strehle, and G. Gerber, “Control of chemical reactions by feedback-optimized phase- shaped femtosecond laser pulses,” Science 282, 919–922 (1998).
[Crossref] [PubMed]

R. N. Zare, “Laser control of chemical reactions,” Science 279, 1875–1879 (1998).
[Crossref] [PubMed]

1997 (3)

R. J. Gordon and S. A. Rice, “Active control of the dynamics of atoms and molecules,” Annu. Rev. Phys. Chem. 48, 601–641 (1997).
[Crossref] [PubMed]

C. J. Bardeen, V. V. Yakovlev, K. R. Wilson, S. D. Carpenter, P. M. Weber, and W. S. Warren, “Feedback quantum control of molecular electronic population transfer,” Chem. Phys. Lett. 280, 151–158 (1997).
[Crossref]

W. G. Fisher, W. P. Partridge, C. Dees, and E. A. Wachter, “Simultaneous two-photon activation of type-I photodynamic therapy agents,” Photochem. Photobiol. 66, 141–155 (1997).
[Crossref] [PubMed]

1996 (1)

W. Denk, “Two-photon excitation in functional biological imaging,” J. Biomed. Opt. 1, 296–304 (1996).
[Crossref] [PubMed]

1992 (1)

R. S. Judson and H. Rabitz, “Teaching Lasers to Control Molecules,” Phys. Rev. Lett. 68, 1500–1503 (1992).
[Crossref] [PubMed]

1990 (1)

W. Denk, J. H. Strickler, and W. W. Webb, “2-Photon Laser Scanning Fluorescence Microscopy,” Science 248, 73–76 (1990).
[Crossref] [PubMed]

Assion, A.

A. Assion, T. Baumert, M. Bergt, T. Brixner, B. Kiefer, V. Seyfried, M. Strehle, and G. Gerber, “Control of chemical reactions by feedback-optimized phase- shaped femtosecond laser pulses,” Science 282, 919–922 (1998).
[Crossref] [PubMed]

Bardeen, C. J.

C. J. Bardeen, V. V. Yakovlev, K. R. Wilson, S. D. Carpenter, P. M. Weber, and W. S. Warren, “Feedback quantum control of molecular electronic population transfer,” Chem. Phys. Lett. 280, 151–158 (1997).
[Crossref]

Baumert, T.

A. Assion, T. Baumert, M. Bergt, T. Brixner, B. Kiefer, V. Seyfried, M. Strehle, and G. Gerber, “Control of chemical reactions by feedback-optimized phase- shaped femtosecond laser pulses,” Science 282, 919–922 (1998).
[Crossref] [PubMed]

Bergt, M.

A. Assion, T. Baumert, M. Bergt, T. Brixner, B. Kiefer, V. Seyfried, M. Strehle, and G. Gerber, “Control of chemical reactions by feedback-optimized phase- shaped femtosecond laser pulses,” Science 282, 919–922 (1998).
[Crossref] [PubMed]

Brixner, T.

T. Brixner, N. H. Damrauer, P. Niklaus, and G. Gerber, “Photoselective adaptive femtosecond quantum control in the liquid phase,” Nature 414, 57–60 (2001).
[Crossref] [PubMed]

A. Assion, T. Baumert, M. Bergt, T. Brixner, B. Kiefer, V. Seyfried, M. Strehle, and G. Gerber, “Control of chemical reactions by feedback-optimized phase- shaped femtosecond laser pulses,” Science 282, 919–922 (1998).
[Crossref] [PubMed]

Bucksbaum, P. H.

T. C. Weinacht, J. L. White, and P. H. Bucksbaum, “Toward strong field mode-selective chemistry,” J. Phys. Chem. A 103, 10166–10168 (1999).
[Crossref]

Carpenter, S. D.

C. J. Bardeen, V. V. Yakovlev, K. R. Wilson, S. D. Carpenter, P. M. Weber, and W. S. Warren, “Feedback quantum control of molecular electronic population transfer,” Chem. Phys. Lett. 280, 151–158 (1997).
[Crossref]

Cogdell, R. J.

J. L. Herek, W. Wohlleben, R. J. Cogdell, D. Zeidler, and M. Motzkus, “Quantum control of energy flow in light harvesting,” Nature 417, 533–535 (2002).
[Crossref] [PubMed]

Comstock, M.

Damrauer, N. H.

T. Brixner, N. H. Damrauer, P. Niklaus, and G. Gerber, “Photoselective adaptive femtosecond quantum control in the liquid phase,” Nature 414, 57–60 (2001).
[Crossref] [PubMed]

Dantus, M.

M. Dantus and V. V. Lozovoy, “Experimental Coherent Laser Control of Physicochemical Processes,” Chem. Rev. 104, 1813–1860 (2004).
[Crossref] [PubMed]

J. M. Dela Cruz, I. Pastirk, V. V. Lozovoy, K. A. Walowicz, and M. Dantus, “Multiphoton intrapulse interference 3: Probing microscopic chemical environments,” J. Phys. Chem. A 108, 53–58 (2004).
[Crossref]

V. V. Lozovoy, I. Pastirk, and M. Dantus, “Multiphoton intrapulse interference. 4. Characterization of the phase of ultrashort laser pulses.,” Opt. Lett. 7, 775–777 (2004).
[Crossref]

M. Comstock, V. V. Lozovoy, I. Pastirk, and M. Dantus, “Multiphoton intrapulse interference 6; binary phase shaping,” Opt. Express 12, 1061–1066 (2004).
[Crossref] [PubMed]

I. Pastirk, J. M. Dela Cruz, K. A. Walowicz, V. V. Lozovoy, and M. Dantus, “Selective two-photon microscopy with shaped femtosecond pulses,” Opt. Express 11, 1695–1701 (2003).
[Crossref] [PubMed]

V. V. Lozovoy, I. Pastirk, K. A. Walowicz, and M. Dantus, “Multiphoton intrapulse interference. II. Control of two- and three-photon laser induced fluorescence with shaped pulses,” J. Chem. Phys. 118, 3187–3196 (2003).
[Crossref]

K. A. Walowicz, I. Pastirk, V. V. Lozovoy, and M. Dantus, “Multiphoton intrapulse interference. 1. Control of multiphoton processes in condensed phases,” J. Phys. Chem. A 106, 9369–9373 (2002).
[Crossref]

Dees, C.

W. G. Fisher, W. P. Partridge, C. Dees, and E. A. Wachter, “Simultaneous two-photon activation of type-I photodynamic therapy agents,” Photochem. Photobiol. 66, 141–155 (1997).
[Crossref] [PubMed]

Dela Cruz, J. M.

J. M. Dela Cruz, I. Pastirk, V. V. Lozovoy, K. A. Walowicz, and M. Dantus, “Multiphoton intrapulse interference 3: Probing microscopic chemical environments,” J. Phys. Chem. A 108, 53–58 (2004).
[Crossref]

I. Pastirk, J. M. Dela Cruz, K. A. Walowicz, V. V. Lozovoy, and M. Dantus, “Selective two-photon microscopy with shaped femtosecond pulses,” Opt. Express 11, 1695–1701 (2003).
[Crossref] [PubMed]

Denk, W.

W. Denk, “Two-photon excitation in functional biological imaging,” J. Biomed. Opt. 1, 296–304 (1996).
[Crossref] [PubMed]

W. Denk, J. H. Strickler, and W. W. Webb, “2-Photon Laser Scanning Fluorescence Microscopy,” Science 248, 73–76 (1990).
[Crossref] [PubMed]

Dudovich, N.

N. Dudovich, D. Oron, and Y. Silberberg, “Single-pulse coherently controlled nonlinear Raman spectroscopy and microscopy,” Nature 418, 512–514 (2002).
[Crossref] [PubMed]

Fisher, W. G.

W. G. Fisher, W. P. Partridge, C. Dees, and E. A. Wachter, “Simultaneous two-photon activation of type-I photodynamic therapy agents,” Photochem. Photobiol. 66, 141–155 (1997).
[Crossref] [PubMed]

Gerber, G.

T. Brixner, N. H. Damrauer, P. Niklaus, and G. Gerber, “Photoselective adaptive femtosecond quantum control in the liquid phase,” Nature 414, 57–60 (2001).
[Crossref] [PubMed]

A. Assion, T. Baumert, M. Bergt, T. Brixner, B. Kiefer, V. Seyfried, M. Strehle, and G. Gerber, “Control of chemical reactions by feedback-optimized phase- shaped femtosecond laser pulses,” Science 282, 919–922 (1998).
[Crossref] [PubMed]

Gordon, R. J.

R. J. Gordon and S. A. Rice, “Active control of the dynamics of atoms and molecules,” Annu. Rev. Phys. Chem. 48, 601–641 (1997).
[Crossref] [PubMed]

Herek, J. L.

J. L. Herek, W. Wohlleben, R. J. Cogdell, D. Zeidler, and M. Motzkus, “Quantum control of energy flow in light harvesting,” Nature 417, 533–535 (2002).
[Crossref] [PubMed]

Judson, R. S.

R. S. Judson and H. Rabitz, “Teaching Lasers to Control Molecules,” Phys. Rev. Lett. 68, 1500–1503 (1992).
[Crossref] [PubMed]

Kiefer, B.

A. Assion, T. Baumert, M. Bergt, T. Brixner, B. Kiefer, V. Seyfried, M. Strehle, and G. Gerber, “Control of chemical reactions by feedback-optimized phase- shaped femtosecond laser pulses,” Science 282, 919–922 (1998).
[Crossref] [PubMed]

Levis, R. J.

R. J. Levis, G. M. Menkir, and H. Rabitz, “Selective bond dissociation and rearrangement with optimally tailored, strong-field laser pulses,” Science 292, 709–713 (2001).
[Crossref] [PubMed]

Lozovoy, V. V.

J. M. Dela Cruz, I. Pastirk, V. V. Lozovoy, K. A. Walowicz, and M. Dantus, “Multiphoton intrapulse interference 3: Probing microscopic chemical environments,” J. Phys. Chem. A 108, 53–58 (2004).
[Crossref]

V. V. Lozovoy, I. Pastirk, and M. Dantus, “Multiphoton intrapulse interference. 4. Characterization of the phase of ultrashort laser pulses.,” Opt. Lett. 7, 775–777 (2004).
[Crossref]

M. Dantus and V. V. Lozovoy, “Experimental Coherent Laser Control of Physicochemical Processes,” Chem. Rev. 104, 1813–1860 (2004).
[Crossref] [PubMed]

M. Comstock, V. V. Lozovoy, I. Pastirk, and M. Dantus, “Multiphoton intrapulse interference 6; binary phase shaping,” Opt. Express 12, 1061–1066 (2004).
[Crossref] [PubMed]

V. V. Lozovoy, I. Pastirk, K. A. Walowicz, and M. Dantus, “Multiphoton intrapulse interference. II. Control of two- and three-photon laser induced fluorescence with shaped pulses,” J. Chem. Phys. 118, 3187–3196 (2003).
[Crossref]

I. Pastirk, J. M. Dela Cruz, K. A. Walowicz, V. V. Lozovoy, and M. Dantus, “Selective two-photon microscopy with shaped femtosecond pulses,” Opt. Express 11, 1695–1701 (2003).
[Crossref] [PubMed]

K. A. Walowicz, I. Pastirk, V. V. Lozovoy, and M. Dantus, “Multiphoton intrapulse interference. 1. Control of multiphoton processes in condensed phases,” J. Phys. Chem. A 106, 9369–9373 (2002).
[Crossref]

Menkir, G. M.

R. J. Levis, G. M. Menkir, and H. Rabitz, “Selective bond dissociation and rearrangement with optimally tailored, strong-field laser pulses,” Science 292, 709–713 (2001).
[Crossref] [PubMed]

Meshulach, D.

D. Meshulach and Y. Silberberg, “Coherent quantum control of two-photon transitions by a femtosecond laser pulse,” Nature 396, 239–242 (1998).
[Crossref]

Motzkus, M.

J. L. Herek, W. Wohlleben, R. J. Cogdell, D. Zeidler, and M. Motzkus, “Quantum control of energy flow in light harvesting,” Nature 417, 533–535 (2002).
[Crossref] [PubMed]

Niklaus, P.

T. Brixner, N. H. Damrauer, P. Niklaus, and G. Gerber, “Photoselective adaptive femtosecond quantum control in the liquid phase,” Nature 414, 57–60 (2001).
[Crossref] [PubMed]

Oron, D.

N. Dudovich, D. Oron, and Y. Silberberg, “Single-pulse coherently controlled nonlinear Raman spectroscopy and microscopy,” Nature 418, 512–514 (2002).
[Crossref] [PubMed]

Partridge, W. P.

W. G. Fisher, W. P. Partridge, C. Dees, and E. A. Wachter, “Simultaneous two-photon activation of type-I photodynamic therapy agents,” Photochem. Photobiol. 66, 141–155 (1997).
[Crossref] [PubMed]

Pastirk, I.

V. V. Lozovoy, I. Pastirk, and M. Dantus, “Multiphoton intrapulse interference. 4. Characterization of the phase of ultrashort laser pulses.,” Opt. Lett. 7, 775–777 (2004).
[Crossref]

J. M. Dela Cruz, I. Pastirk, V. V. Lozovoy, K. A. Walowicz, and M. Dantus, “Multiphoton intrapulse interference 3: Probing microscopic chemical environments,” J. Phys. Chem. A 108, 53–58 (2004).
[Crossref]

M. Comstock, V. V. Lozovoy, I. Pastirk, and M. Dantus, “Multiphoton intrapulse interference 6; binary phase shaping,” Opt. Express 12, 1061–1066 (2004).
[Crossref] [PubMed]

V. V. Lozovoy, I. Pastirk, K. A. Walowicz, and M. Dantus, “Multiphoton intrapulse interference. II. Control of two- and three-photon laser induced fluorescence with shaped pulses,” J. Chem. Phys. 118, 3187–3196 (2003).
[Crossref]

I. Pastirk, J. M. Dela Cruz, K. A. Walowicz, V. V. Lozovoy, and M. Dantus, “Selective two-photon microscopy with shaped femtosecond pulses,” Opt. Express 11, 1695–1701 (2003).
[Crossref] [PubMed]

K. A. Walowicz, I. Pastirk, V. V. Lozovoy, and M. Dantus, “Multiphoton intrapulse interference. 1. Control of multiphoton processes in condensed phases,” J. Phys. Chem. A 106, 9369–9373 (2002).
[Crossref]

Rabitz, H.

H. Rabitz, “Shaped laser pulses as reagents,” Science 299, 525–527 (2003).
[Crossref] [PubMed]

R. J. Levis, G. M. Menkir, and H. Rabitz, “Selective bond dissociation and rearrangement with optimally tailored, strong-field laser pulses,” Science 292, 709–713 (2001).
[Crossref] [PubMed]

R. S. Judson and H. Rabitz, “Teaching Lasers to Control Molecules,” Phys. Rev. Lett. 68, 1500–1503 (1992).
[Crossref] [PubMed]

Rice, S. A.

S. A. Rice and S. P. Shah, “Active control of product selection in a chemical reaction: a view of the current scene,” Phys. Chem. Chem. Phys. 4, 1683–1700 (2002).
[Crossref]

S. A. Rice, “Interfering for the good of a chemical reaction,” Nature 409, 422–426 (2001).
[Crossref] [PubMed]

R. J. Gordon and S. A. Rice, “Active control of the dynamics of atoms and molecules,” Annu. Rev. Phys. Chem. 48, 601–641 (1997).
[Crossref] [PubMed]

Seyfried, V.

A. Assion, T. Baumert, M. Bergt, T. Brixner, B. Kiefer, V. Seyfried, M. Strehle, and G. Gerber, “Control of chemical reactions by feedback-optimized phase- shaped femtosecond laser pulses,” Science 282, 919–922 (1998).
[Crossref] [PubMed]

Shah, S. P.

S. A. Rice and S. P. Shah, “Active control of product selection in a chemical reaction: a view of the current scene,” Phys. Chem. Chem. Phys. 4, 1683–1700 (2002).
[Crossref]

Silberberg, Y.

N. Dudovich, D. Oron, and Y. Silberberg, “Single-pulse coherently controlled nonlinear Raman spectroscopy and microscopy,” Nature 418, 512–514 (2002).
[Crossref] [PubMed]

D. Meshulach and Y. Silberberg, “Coherent quantum control of two-photon transitions by a femtosecond laser pulse,” Nature 396, 239–242 (1998).
[Crossref]

Strehle, M.

A. Assion, T. Baumert, M. Bergt, T. Brixner, B. Kiefer, V. Seyfried, M. Strehle, and G. Gerber, “Control of chemical reactions by feedback-optimized phase- shaped femtosecond laser pulses,” Science 282, 919–922 (1998).
[Crossref] [PubMed]

Strickler, J. H.

W. Denk, J. H. Strickler, and W. W. Webb, “2-Photon Laser Scanning Fluorescence Microscopy,” Science 248, 73–76 (1990).
[Crossref] [PubMed]

Wachter, E. A.

W. G. Fisher, W. P. Partridge, C. Dees, and E. A. Wachter, “Simultaneous two-photon activation of type-I photodynamic therapy agents,” Photochem. Photobiol. 66, 141–155 (1997).
[Crossref] [PubMed]

Walowicz, K. A.

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V. V. Lozovoy, I. Pastirk, K. A. Walowicz, and M. Dantus, “Multiphoton intrapulse interference. II. Control of two- and three-photon laser induced fluorescence with shaped pulses,” J. Chem. Phys. 118, 3187–3196 (2003).
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Figures (5)

Fig. 1.
Fig. 1.

Experimental setup. The shaped laser pulses impinge on the sample from right to left. The sample with or without scattering tissue is scanned in the focal plane of the laser while the two-photon induced fluorescence is detected at each point.

Fig. 2.
Fig. 2.

Optimized phase functions and the resulting SHG after they are tested with a thin SHG crystal. The panel on the left shows the fundamental spectrum of the pulse and the three different pulses evaluated, transform limited (TL), optimized for acidic excitation (BPS06) and optimized for basic excitation (BPS10). The panel on the right shows the SHG spectrum obtained when each of the laser pulses goes through a thin SHG crystal.

Fig. 3.
Fig. 3.

Fluorescence signal obtained from two capillaries with JPTS in buffered solutions. The signal was obtained after excitation with TL and shaped pulses.

Fig. 4.
Fig. 4.

Experimental results obtained with TL (black dots) pulses and difference plot obtained from the shaped laser pulses (red circles). Notice that shaped laser pulses are capable of selective excitation even when the laser transmits through scattering tissue

Fig. 5.
Fig. 5.

SHG spectrum for TL and for shaped pulses (BPS06) in the presence and absence of biological tissue (intensity multiplied x20).

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