Abstract

Time-resolved Stokes vectors of transmitted optical signals were measured to differentiate normal and stunned myocardium tissues. The corresponding Mueller matrices were calculated based on the Stokes-Mueller formalism. Our experimental results indicated that the time-resolved Mueller matrices could provide information about myocardial architectural alteration in stunned myocardium. Thus, the Stokes-Mueller measurement can be a useful method in cardiovascular research.

© 2002 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |

  1. O. M. Hess, J. Schneider, H. Nonogi, J. D. Carroll, K. Schneider, M. Turina and H. P. Krayenbuehl, �??Myocardial structure in patients with exercise-induced ischemia,�?? Circulation 77, 967-977 (1988).
    [CrossRef] [PubMed]
  2. S. A. Rubin, M. C. Fishbein, H. J. Swan, �??Compensatory hypertrophy in the heart after myocardial infarction in the rat,�?? J. Am. Coll. Cardiol. 1, 1435-1441 (1983).
    [CrossRef] [PubMed]
  3. R. A. Kloner and R. B. Jennings, �??Consequences of brief ischemia: stunning, preconditioning, and their clinical implications,�?? Circulation 104, 2981-2989 (2001).
    [CrossRef] [PubMed]
  4. A. Lochner, I. S. Harper, R. Salie, S. Genade, A. R. Coetzee, �??Halothane protects the isolated rat myocardium against excessive total intracellular calcium and structural damage during ischemia and reperfusion,�?? Anesth. Analg. 79, 226-233 (1994).
    [CrossRef] [PubMed]
  5. S. K. Gayen and R. R. Alfano, �??Sensing lesions in tissues with light,�?? Opt. Express 4, 475-480 (1999). <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-4-11-475">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-4-11-475</a>.
    [CrossRef] [PubMed]
  6. D. Grosenick, H. Wabnitz, H. H. Rinneberg, K. T. Moesta, and P. M. Schlag, �??Development of a timedomain optical mammography and first in vivo applications,�?? Appl. Opt. 38, 2927-2943 (1999).
    [CrossRef]
  7. C. -W. Sun, C. -Y. Wang, C. C. Yang, Y. -W Kiang, I -J. Hsu, and C. -W. Lin, �??Polarization gating in ultrafast-optics imaging of skeletal muscle tissues,�?? Opt. Lett. 26, 432-434 (2001).
    [CrossRef]
  8. R. E. Weiss and M. Morad, �??Birefringence signals in mammalian and frog myocardium,�?? J. Gen. Physiol. 82, 79-117 (1983).
    [CrossRef] [PubMed]
  9. C. -W. Sun, C. -Y. Wang, C. C. Yang, Y. -W Kiang, C. -W. Lu, I -J. Hsu, and C. -W. Lin, �??Polarization dependent characteristics and polarization gating in time-resolved optical imaging of skeletal muscle tissues,�?? IEEE J. Sel. Top. Quantum Electron. 7, 924-930 (2001).
    [CrossRef]
  10. T. T. Tower and R. T. Tranquillo, �??Alignment maps of tissues: II. Fast harmonic analysis for imaging,�?? Biophys. J. 81, 2964-2971 (2001).
    [CrossRef] [PubMed]
  11. S. Jiao, G. Yao, and L. V. Wang, �??Depth-resolved two-dimensional Stokes vectors of backscattered light and Mueller matrices of biological tissue measured with optical coherent tomography,�?? Appl. Opt. 39, 6318-6324 (2000).
    [CrossRef]
  12. A. H. Hielscher, A. A. Eick, J. R. Mourant, D. Shen, James. P. Freyer, and I. J. Bigio, �??Diffuse backscattering Mueller matrices of highly scattering media,�?? Opt. Express 1, 441-453 (1997). <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-1-13-441">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-1-13-441</a>.
    [CrossRef] [PubMed]
  13. V. Nigro, Y. Okazaki, A. Belsito, G. Piluso, Y. Matsuda, L. Politano, G. Nigro, C. Ventura, C. Abbondanza, A. M. Molinari, D. Acampora, M. Nishimura, Y. Hayashizaki and G. A. Puca, "Identification of the Syrian hamstercardiomyopathy gene," Human Molecular Genetics 6, 601-607 (1997).
    [CrossRef] [PubMed]

Anesth. Analg.

A. Lochner, I. S. Harper, R. Salie, S. Genade, A. R. Coetzee, �??Halothane protects the isolated rat myocardium against excessive total intracellular calcium and structural damage during ischemia and reperfusion,�?? Anesth. Analg. 79, 226-233 (1994).
[CrossRef] [PubMed]

Appl. Opt.

Biophys. J.

T. T. Tower and R. T. Tranquillo, �??Alignment maps of tissues: II. Fast harmonic analysis for imaging,�?? Biophys. J. 81, 2964-2971 (2001).
[CrossRef] [PubMed]

Circulation

R. A. Kloner and R. B. Jennings, �??Consequences of brief ischemia: stunning, preconditioning, and their clinical implications,�?? Circulation 104, 2981-2989 (2001).
[CrossRef] [PubMed]

O. M. Hess, J. Schneider, H. Nonogi, J. D. Carroll, K. Schneider, M. Turina and H. P. Krayenbuehl, �??Myocardial structure in patients with exercise-induced ischemia,�?? Circulation 77, 967-977 (1988).
[CrossRef] [PubMed]

Human Molecular Genetics

V. Nigro, Y. Okazaki, A. Belsito, G. Piluso, Y. Matsuda, L. Politano, G. Nigro, C. Ventura, C. Abbondanza, A. M. Molinari, D. Acampora, M. Nishimura, Y. Hayashizaki and G. A. Puca, "Identification of the Syrian hamstercardiomyopathy gene," Human Molecular Genetics 6, 601-607 (1997).
[CrossRef] [PubMed]

IEEE J. Sel. Top. Quantum Electron.

C. -W. Sun, C. -Y. Wang, C. C. Yang, Y. -W Kiang, C. -W. Lu, I -J. Hsu, and C. -W. Lin, �??Polarization dependent characteristics and polarization gating in time-resolved optical imaging of skeletal muscle tissues,�?? IEEE J. Sel. Top. Quantum Electron. 7, 924-930 (2001).
[CrossRef]

J. Am. Coll. Cardiol.

S. A. Rubin, M. C. Fishbein, H. J. Swan, �??Compensatory hypertrophy in the heart after myocardial infarction in the rat,�?? J. Am. Coll. Cardiol. 1, 1435-1441 (1983).
[CrossRef] [PubMed]

J. Gen. Physiol.

R. E. Weiss and M. Morad, �??Birefringence signals in mammalian and frog myocardium,�?? J. Gen. Physiol. 82, 79-117 (1983).
[CrossRef] [PubMed]

Opt. Express

Opt. Lett.

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (7)

Fig. 1.
Fig. 1.

Experimental setup. BP: beam splitter; P: polarizer; HW: half-wave plate; QW: quarter-wave plate; D: trigger detector.

Fig. 2.
Fig. 2.

Measured time-resolved polarization components of normal myocardium.

Fig. 3.
Fig. 3.

Microphotographs (under 400X magnification) of (a) normal and (b) stunned myocardium.

Fig. 4.
Fig. 4.

Time-resolved Stokes vectors of (a) normal and (b) stunned myocardium.

Fig. 5.
Fig. 5.

Time-resolved Mueller matrices of (a) normal and (b) stunned myocardium.

Fig. 6.
Fig. 6.

Microphotograph (under 400X magnification) of cardiomyopathic myocardium.

Fig. 7.
Fig. 7.

Time-resolved Mueller matrices of (a) normal and (b) cardiomyopathic myocardium.

Equations (2)

Equations on this page are rendered with MathJax. Learn more.

S = [ S 0 S 1 S 2 S 3 ] = [ H + V H V 2 P H V 2 R H V ] .
M = 1 2 [ S H + S V S H S V 2 S P ( S H + S V ) 2 S R ( S H + S V ) ] .

Metrics