Abstract

First results of endoscopic applications of optical coherence tomography for in vivo studies of human mucosa in respiratory, gastrointestinal, urinary and genital tracts are presented. A novel endoscopic OCT (EOCT) system has been created that is based on the integration of a sampling arm of an all-optical-fiber interferometer into standard endoscopic devices using their biopsy channel to transmit low-coherence radiation to investigated tissue. We have studied mucous membranes of esophagus, larynx, stomach, urinary bladder, uterine cervix and body as typical localization for carcinomatous processes. Images of tumor tissues versus healthy tissues have been recorded and analyzed. Violations of well-defined stratified healthy mucosa structure in cancered tissue are distinctly seen by EOCT, thus making this technique promising for early diagnosis of tumors and precise guiding of excisional biopsy.

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  1. D. Huang, J. Wang, C. P. Lin, J. S. Shuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178 (1991).
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Other

D. Huang, J. Wang, C. P. Lin, J. S. Shuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178 (1991).

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, "In vivo optical coherence tomography," Am. J. Ophthalmol. 116, No. 1, 113-114 (1993).

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. Shutz, C. A. Puliafito, and J. G. Fujimoto, "In vivo retinal imaging by optical coherence tomography," Opt. Lett. 18, 1864 (1993).

A. Sergeev, V. Gelikonov, G. Gelikonov, F. Feldchtein, K. Pravdenko, D. Shabanov, N. Gladkova, V. Pochinko, V. Zhegalov, G. Dmitriev, I. Vazina, G. Petrova, and N. Nikulin, "In Vivo Optical Coherence Tomography of Human Skin Microstructure," in: "Biomedical optoelectronic devices and systems II," Proc. SPIE 2328, 144 (1994).

V. M. Gelikonov, G. V. Gelikonov, R. V. Kuranov, K. I. Pravdenko, A. M. Sergeev, F. I. Feldchtein, Ya. I. Khanin, D. V. Shabanov, N. D. Gladkova, N. K. Nikulin, G. A. Petrova, and V. V. Pochinko, "Coherent optical tomography of microscopic inhomogeneties in biological tissues," JETP Lett. 61, 149 (1995).

A. Sergeev, V. Gelikonov, G. Gelikonov, F. Feldchtein, K. Pravdenko, R. Kuranov, N. Gladkova, V. Pochinko, G. Petrova, and N. Nikulin, "High-spatial-resolution optical coherence tomography of human skin and mucous membranes," in Digest of Conference on Lasers and Electro-Optics (Optical Society of America, Washington, D.C., 1995) p.349.

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat.Med. 1, 970 (1995).

J. A. Izatt, H.-W. Wang, M. Kulkarni, K. Kobayashi, M. I. Canto, and M. V. Sivak, "Optical coherence tomography and microscopy in gastrointestinal tissues," Trends in Optics & Photonics 2, 203 (1996).

G. Gelikonov V. Gelikonov, F. Feldchtein, J. Stepanov, A. Sergeev, I. Antoniou, J. Ioannovich, D. Reitze, and W. Dawson, "Two-color-in-one-interferometer OCT system for bioimaging," in Digest of Conference on Lasers and Electro-Optics (Optical Society of America, Washington, D.C., 1997) p.210.

G. Tearney, S. A. Boppart, B. E. Bouma, C. Pitris, M. E. Brezinski, J. F. Southern, E. A. Swanson, and J. G. Fujimoto, "High-speed catheter/endoscopy optical coherence tomography for the optical biopsy of in vivo tissues," in Digest of Conference on Lasers and Electro-Optics (Optical Society of America, Washington, D.C., 1997) p.211.

F. I. Feldchtein, G. V. Gelikonov, V. M. Gelikonov, N. D. Gladkova, V. I. Leonov, A. M. Sergeev, "Optical fiber interferometer and piezoelectric modulator," International application PCT/RU96/00045 (1995).

American Joint Committee on Cancer: Manual for Staging of Cancer, 3rd edition (JB Lippincott Company, Philadelphia, USA 1988).

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