Abstract

We demonstrate ultra-broadband Fourier-transform coherent anti-Stokes Raman scattering (FT-CARS) spectroscopy spanning over 3,000 cm−1 with a rapid-scan Michelson interferometer at a scan rate of 24,000 spectra/s. Using sub-10-fs optical pulses from a mode-locked laser, we measure broad CARS spectrum covering both the fingerprint region (500-1,800 cm−1) and the C-H, N-H, O-H stretching region (2,700-3,600 cm−1). To the best of our knowledge, this is the first demonstration of coherent Raman scattering spectroscopy covering over 3,000 cm−1 at a scan rate of more than 10,000 spectra/s. Our system holds the potential for high-speed or high-throughput label-free chemical analysis, such as investigating non-repetitive chemical dynamics, taking large area images of materials or biological specimens, or counting and sorting a large number of heterogeneous cells.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Full Article  |  PDF Article
OSA Recommended Articles
Broadband Fourier-transform coherent Raman spectroscopy with an ytterbium fiber laser

Nicola Coluccelli, Edoardo Vicentini, Alessio Gambetta, Christopher R Howle, Kenneth Mcewan, Paolo Laporta, and Gianluca Galzerano
Opt. Express 26(15) 18855-18862 (2018)

Broadband stimulated Raman scattering spectroscopy by a photonic time stretcher

Francesco Saltarelli, Vikas Kumar, Daniele Viola, Francesco Crisafi, Fabrizio Preda, Giulio Cerullo, and Dario Polli
Opt. Express 24(19) 21264-21275 (2016)

References

  • View by:
  • |
  • |
  • |

  1. W. Min, C. W. Freudiger, S. Lu, and X. S. Xie, “Coherent nonlinear optical imaging: beyond fluorescence microscopy,” Annu. Rev. Phys. Chem. 62(1), 507–530 (2011).
    [Crossref] [PubMed]
  2. J. X. Cheng and X. S. Xie, Coherent Raman Scattering Microscopy (CRC, 2012).
  3. C. Y. Chung and E. O. Potma, “Biomolecular imaging with coherent nonlinear vibrational microscopy,” Annu. Rev. Phys. Chem. 64(1), 77–99 (2013).
    [Crossref] [PubMed]
  4. C. H. Camp and M. T. Cicerone, “Chemically sensitive bioimaging with coherent Raman scattering,” Nat. Photonics 9(5), 295–305 (2015).
    [Crossref]
  5. C. Krafft, I. W. Schie, T. Meyer, M. Schmitt, and J. Popp, “Developments in spontaneous and coherent Raman scattering microscopic imaging for biomedical applications,” Chem. Soc. Rev. 45(7), 1819–1849 (2016).
    [Crossref] [PubMed]
  6. D. W. Shipp, F. Sinjab, and L. Notingher, “Raman spectroscopy: Techniques and applications in the life sciences,” Adv. Opt. Photonics 9(2), 315–428 (2017).
    [Crossref]
  7. C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005).
    [Crossref] [PubMed]
  8. B. G. Saar, C. W. Freudiger, J. Reichman, C. M. Stanley, G. R. Holtom, and X. S. Xie, “Video-rate molecular imaging in vivo with stimulated Raman scattering,” Science 330(6009), 1368–1370 (2010).
    [Crossref] [PubMed]
  9. C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
    [Crossref] [PubMed]
  10. R. Beams, L. Gustavo Cançado, and L. Novotny, “Raman characterization of defects and dopants in graphene,” J. Phys. Condens. Matter 27(8), 083002 (2015).
    [Crossref] [PubMed]
  11. H. Kano and H. Hamaguchi, “Ultrabroadband (>2500cm−1) multiplex coherent anti-Stokes Raman scattering microspectroscopy using a supercontinuum generated from a photonic crystal fiber,” Appl. Phys. Lett. 86(12), 121113 (2005).
    [Crossref]
  12. R. Arora, G. I. Petrov, V. V. Yakovlev, and M. O. Scully, “Detecting anthrax in the mail by coherent Raman microspectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 109(4), 1151–1153 (2012).
    [Crossref] [PubMed]
  13. W. Rock, M. Bonn, and S. H. Parekh, “Near shot-noise limited hyperspectral stimulated Raman scattering spectroscopy using low energy lasers and a fast CMOS array,” Opt. Express 21(13), 15113–15120 (2013).
    [Crossref] [PubMed]
  14. C. S. Liao, M. N. Slipchenko, P. Wang, J. Li, S. Y. Lee, R. A. Oglesbee, and J. X. Cheng, “Microsecond scale vibrational spectroscopic imaging by multiplex stimulated Raman scattering microscopy,” Light Sci. Appl. 4(3), e265 (2015).
    [Crossref] [PubMed]
  15. Y. Ozeki, W. Umemura, Y. Otsuka, S. Satoh, H. Hashimoto, K. Sumimura, N. Nishizawa, K. Fukui, and K. Itoh, “High-speed molecular spectral imaging of tissue with stimulated Raman scattering,” Nat. Photonics 6(12), 845–851 (2012).
    [Crossref]
  16. S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy,” Nat. Commun. 6(1), 6784 (2015).
    [Crossref] [PubMed]
  17. T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
    [Crossref] [PubMed]
  18. P. L. Luo, M. Yan, T. W. Hänsch, and N. Picqué, “Ultra-broadband dual comb coherent anti-Stokes Raman spectroscopy,” in Fourier Transform Spectroscopy 2016, OSA Technical Digest (online) (Optical Society of America, 2016), paper FW2E.2.
  19. J. P. Ogilvie, E. Beaurepaire, A. Alexandrou, and M. Joffre, “Fourier-transform coherent anti-Stokes Raman scattering microscopy,” Opt. Lett. 31(4), 480–482 (2006).
    [Crossref] [PubMed]
  20. M. Cui, M. Joffre, J. Skodack, and J. P. Ogilvie, “Interferometric Fourier transform coherent anti-stokes Raman scattering,” Opt. Express 14(18), 8448–8458 (2006).
    [Crossref] [PubMed]
  21. K. Isobe, A. Suda, M. Tanaka, H. Hashimoto, F. Kannari, H. Kawano, H. Mizuno, A. Miyawaki, and K. Midorikawa, “Single-pulse coherent anti-Stokes Raman scattering microscopy employing an octave spanning pulse,” Opt. Express 17(14), 11259–11266 (2009).
    [Crossref] [PubMed]
  22. K. Hashimoto, M. Takahashi, T. Ideguchi, and K. Goda, “Broadband coherent Raman spectroscopy running at 24,000 spectra per second,” Sci. Rep. 6, 21036 (2016).
  23. C. S. Liao, K. C. Huang, W. Hong, A. J. Chen, C. Karanja, P. Wang, G. Eakins, and J. X. Cheng, “Stimulated Raman spectroscopic imaging by microsecond delay-line tuning,” Optica 3(12), 1377–1380 (2016).
    [Crossref]
  24. M. Tamamitsu, Y. Sakaki, T. Nakamura, G. K. Podagatlapalli, T. Ideguchi, and K. Goda, “Ultrafast broadband Fourier-transform CARS spectroscopy at 50,000 spectra/s enabled by a scanning Fourier-domain delay line,” Vib. Spectrosc. 91(1), 163–169 (2017).
    [Crossref]
  25. M. S. Alshaykh, C. S. Liao, O. E. Sandoval, G. Gitzinger, N. Forget, D. E. Leaird, J. X. Cheng, and A. M. Weiner, “High-speed stimulated hyperspectral Raman imaging using rapid acousto-optic delay lines,” Opt. Lett. 42(8), 1548–1551 (2017).
    [Crossref] [PubMed]
  26. X. Liu, M. J. Cobb, and X. Li, “Rapid scanning all-reflective optical delay line for real-time optical coherence tomography,” Opt. Lett. 29(1), 80–82 (2004).
    [Crossref] [PubMed]
  27. K. Moutzouris, M. Papamichael, S. C. Betsis, I. Stavrakas, G. Hloupis, and D. Triantis, “Refractive, dispersive and thermo-optic properties of twelve organic solvents in the visible and near-infrared,” Appl. Phys. B 116(3), 617–622 (2014).
    [Crossref]
  28. H. Yamakoshi, K. Dodo, A. Palonpon, J. Ando, K. Fujita, S. Kawata, and M. Sodeoka, “Alkyne-Tag Raman imaging for visualization of mobile small molecules in live cells,” J. Am. Chem. Soc. 134(51), 20681–20689 (2012).
    [Crossref] [PubMed]
  29. L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C. C. Lin, M. C. Wang, and W. Min, “Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering,” Nat. Methods 11(4), 410–412 (2014).
    [Crossref] [PubMed]
  30. K. Hiramatsu, Y. Luo, T. Ideguchi, and K. Goda, “Rapid-scan Fourier-transform coherent anti-Stokes Raman scattering spectroscopy with heterodyne detection,” Opt. Lett. 42(21), 4335–4338 (2017).
    [Crossref] [PubMed]

2017 (4)

D. W. Shipp, F. Sinjab, and L. Notingher, “Raman spectroscopy: Techniques and applications in the life sciences,” Adv. Opt. Photonics 9(2), 315–428 (2017).
[Crossref]

M. Tamamitsu, Y. Sakaki, T. Nakamura, G. K. Podagatlapalli, T. Ideguchi, and K. Goda, “Ultrafast broadband Fourier-transform CARS spectroscopy at 50,000 spectra/s enabled by a scanning Fourier-domain delay line,” Vib. Spectrosc. 91(1), 163–169 (2017).
[Crossref]

M. S. Alshaykh, C. S. Liao, O. E. Sandoval, G. Gitzinger, N. Forget, D. E. Leaird, J. X. Cheng, and A. M. Weiner, “High-speed stimulated hyperspectral Raman imaging using rapid acousto-optic delay lines,” Opt. Lett. 42(8), 1548–1551 (2017).
[Crossref] [PubMed]

K. Hiramatsu, Y. Luo, T. Ideguchi, and K. Goda, “Rapid-scan Fourier-transform coherent anti-Stokes Raman scattering spectroscopy with heterodyne detection,” Opt. Lett. 42(21), 4335–4338 (2017).
[Crossref] [PubMed]

2016 (3)

K. Hashimoto, M. Takahashi, T. Ideguchi, and K. Goda, “Broadband coherent Raman spectroscopy running at 24,000 spectra per second,” Sci. Rep. 6, 21036 (2016).

C. S. Liao, K. C. Huang, W. Hong, A. J. Chen, C. Karanja, P. Wang, G. Eakins, and J. X. Cheng, “Stimulated Raman spectroscopic imaging by microsecond delay-line tuning,” Optica 3(12), 1377–1380 (2016).
[Crossref]

C. Krafft, I. W. Schie, T. Meyer, M. Schmitt, and J. Popp, “Developments in spontaneous and coherent Raman scattering microscopic imaging for biomedical applications,” Chem. Soc. Rev. 45(7), 1819–1849 (2016).
[Crossref] [PubMed]

2015 (4)

C. H. Camp and M. T. Cicerone, “Chemically sensitive bioimaging with coherent Raman scattering,” Nat. Photonics 9(5), 295–305 (2015).
[Crossref]

R. Beams, L. Gustavo Cançado, and L. Novotny, “Raman characterization of defects and dopants in graphene,” J. Phys. Condens. Matter 27(8), 083002 (2015).
[Crossref] [PubMed]

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy,” Nat. Commun. 6(1), 6784 (2015).
[Crossref] [PubMed]

C. S. Liao, M. N. Slipchenko, P. Wang, J. Li, S. Y. Lee, R. A. Oglesbee, and J. X. Cheng, “Microsecond scale vibrational spectroscopic imaging by multiplex stimulated Raman scattering microscopy,” Light Sci. Appl. 4(3), e265 (2015).
[Crossref] [PubMed]

2014 (3)

K. Moutzouris, M. Papamichael, S. C. Betsis, I. Stavrakas, G. Hloupis, and D. Triantis, “Refractive, dispersive and thermo-optic properties of twelve organic solvents in the visible and near-infrared,” Appl. Phys. B 116(3), 617–622 (2014).
[Crossref]

L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C. C. Lin, M. C. Wang, and W. Min, “Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering,” Nat. Methods 11(4), 410–412 (2014).
[Crossref] [PubMed]

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

2013 (3)

C. Y. Chung and E. O. Potma, “Biomolecular imaging with coherent nonlinear vibrational microscopy,” Annu. Rev. Phys. Chem. 64(1), 77–99 (2013).
[Crossref] [PubMed]

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

W. Rock, M. Bonn, and S. H. Parekh, “Near shot-noise limited hyperspectral stimulated Raman scattering spectroscopy using low energy lasers and a fast CMOS array,” Opt. Express 21(13), 15113–15120 (2013).
[Crossref] [PubMed]

2012 (3)

R. Arora, G. I. Petrov, V. V. Yakovlev, and M. O. Scully, “Detecting anthrax in the mail by coherent Raman microspectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 109(4), 1151–1153 (2012).
[Crossref] [PubMed]

H. Yamakoshi, K. Dodo, A. Palonpon, J. Ando, K. Fujita, S. Kawata, and M. Sodeoka, “Alkyne-Tag Raman imaging for visualization of mobile small molecules in live cells,” J. Am. Chem. Soc. 134(51), 20681–20689 (2012).
[Crossref] [PubMed]

Y. Ozeki, W. Umemura, Y. Otsuka, S. Satoh, H. Hashimoto, K. Sumimura, N. Nishizawa, K. Fukui, and K. Itoh, “High-speed molecular spectral imaging of tissue with stimulated Raman scattering,” Nat. Photonics 6(12), 845–851 (2012).
[Crossref]

2011 (1)

W. Min, C. W. Freudiger, S. Lu, and X. S. Xie, “Coherent nonlinear optical imaging: beyond fluorescence microscopy,” Annu. Rev. Phys. Chem. 62(1), 507–530 (2011).
[Crossref] [PubMed]

2010 (1)

B. G. Saar, C. W. Freudiger, J. Reichman, C. M. Stanley, G. R. Holtom, and X. S. Xie, “Video-rate molecular imaging in vivo with stimulated Raman scattering,” Science 330(6009), 1368–1370 (2010).
[Crossref] [PubMed]

2009 (1)

2006 (2)

2005 (2)

H. Kano and H. Hamaguchi, “Ultrabroadband (>2500cm−1) multiplex coherent anti-Stokes Raman scattering microspectroscopy using a supercontinuum generated from a photonic crystal fiber,” Appl. Phys. Lett. 86(12), 121113 (2005).
[Crossref]

C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005).
[Crossref] [PubMed]

2004 (1)

Alexandrou, A.

Alshaykh, M. S.

Ando, J.

H. Yamakoshi, K. Dodo, A. Palonpon, J. Ando, K. Fujita, S. Kawata, and M. Sodeoka, “Alkyne-Tag Raman imaging for visualization of mobile small molecules in live cells,” J. Am. Chem. Soc. 134(51), 20681–20689 (2012).
[Crossref] [PubMed]

Arora, R.

R. Arora, G. I. Petrov, V. V. Yakovlev, and M. O. Scully, “Detecting anthrax in the mail by coherent Raman microspectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 109(4), 1151–1153 (2012).
[Crossref] [PubMed]

Beams, R.

R. Beams, L. Gustavo Cançado, and L. Novotny, “Raman characterization of defects and dopants in graphene,” J. Phys. Condens. Matter 27(8), 083002 (2015).
[Crossref] [PubMed]

Beaurepaire, E.

Bernhardt, B.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Betsis, S. C.

K. Moutzouris, M. Papamichael, S. C. Betsis, I. Stavrakas, G. Hloupis, and D. Triantis, “Refractive, dispersive and thermo-optic properties of twelve organic solvents in the visible and near-infrared,” Appl. Phys. B 116(3), 617–622 (2014).
[Crossref]

Bonn, M.

Camp, C. H.

C. H. Camp and M. T. Cicerone, “Chemically sensitive bioimaging with coherent Raman scattering,” Nat. Photonics 9(5), 295–305 (2015).
[Crossref]

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Chen, A. J.

Chen, Z.

L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C. C. Lin, M. C. Wang, and W. Min, “Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering,” Nat. Methods 11(4), 410–412 (2014).
[Crossref] [PubMed]

Cheng, J. X.

Chung, C. Y.

C. Y. Chung and E. O. Potma, “Biomolecular imaging with coherent nonlinear vibrational microscopy,” Annu. Rev. Phys. Chem. 64(1), 77–99 (2013).
[Crossref] [PubMed]

Cicerone, M. T.

C. H. Camp and M. T. Cicerone, “Chemically sensitive bioimaging with coherent Raman scattering,” Nat. Photonics 9(5), 295–305 (2015).
[Crossref]

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Cobb, M. J.

Côté, D.

C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005).
[Crossref] [PubMed]

Cui, M.

Dodo, K.

H. Yamakoshi, K. Dodo, A. Palonpon, J. Ando, K. Fujita, S. Kawata, and M. Sodeoka, “Alkyne-Tag Raman imaging for visualization of mobile small molecules in live cells,” J. Am. Chem. Soc. 134(51), 20681–20689 (2012).
[Crossref] [PubMed]

Eakins, G.

Eibl, M.

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy,” Nat. Commun. 6(1), 6784 (2015).
[Crossref] [PubMed]

Evans, C. L.

C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005).
[Crossref] [PubMed]

Forget, N.

Freudiger, C. W.

W. Min, C. W. Freudiger, S. Lu, and X. S. Xie, “Coherent nonlinear optical imaging: beyond fluorescence microscopy,” Annu. Rev. Phys. Chem. 62(1), 507–530 (2011).
[Crossref] [PubMed]

B. G. Saar, C. W. Freudiger, J. Reichman, C. M. Stanley, G. R. Holtom, and X. S. Xie, “Video-rate molecular imaging in vivo with stimulated Raman scattering,” Science 330(6009), 1368–1370 (2010).
[Crossref] [PubMed]

Fujita, K.

H. Yamakoshi, K. Dodo, A. Palonpon, J. Ando, K. Fujita, S. Kawata, and M. Sodeoka, “Alkyne-Tag Raman imaging for visualization of mobile small molecules in live cells,” J. Am. Chem. Soc. 134(51), 20681–20689 (2012).
[Crossref] [PubMed]

Fukui, K.

Y. Ozeki, W. Umemura, Y. Otsuka, S. Satoh, H. Hashimoto, K. Sumimura, N. Nishizawa, K. Fukui, and K. Itoh, “High-speed molecular spectral imaging of tissue with stimulated Raman scattering,” Nat. Photonics 6(12), 845–851 (2012).
[Crossref]

Gitzinger, G.

Goda, K.

K. Hiramatsu, Y. Luo, T. Ideguchi, and K. Goda, “Rapid-scan Fourier-transform coherent anti-Stokes Raman scattering spectroscopy with heterodyne detection,” Opt. Lett. 42(21), 4335–4338 (2017).
[Crossref] [PubMed]

M. Tamamitsu, Y. Sakaki, T. Nakamura, G. K. Podagatlapalli, T. Ideguchi, and K. Goda, “Ultrafast broadband Fourier-transform CARS spectroscopy at 50,000 spectra/s enabled by a scanning Fourier-domain delay line,” Vib. Spectrosc. 91(1), 163–169 (2017).
[Crossref]

K. Hashimoto, M. Takahashi, T. Ideguchi, and K. Goda, “Broadband coherent Raman spectroscopy running at 24,000 spectra per second,” Sci. Rep. 6, 21036 (2016).

Guelachvili, G.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Gustavo Cançado, L.

R. Beams, L. Gustavo Cançado, and L. Novotny, “Raman characterization of defects and dopants in graphene,” J. Phys. Condens. Matter 27(8), 083002 (2015).
[Crossref] [PubMed]

Hamaguchi, H.

H. Kano and H. Hamaguchi, “Ultrabroadband (>2500cm−1) multiplex coherent anti-Stokes Raman scattering microspectroscopy using a supercontinuum generated from a photonic crystal fiber,” Appl. Phys. Lett. 86(12), 121113 (2005).
[Crossref]

Hänsch, T. W.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Hartshorn, C. M.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Hashimoto, H.

Y. Ozeki, W. Umemura, Y. Otsuka, S. Satoh, H. Hashimoto, K. Sumimura, N. Nishizawa, K. Fukui, and K. Itoh, “High-speed molecular spectral imaging of tissue with stimulated Raman scattering,” Nat. Photonics 6(12), 845–851 (2012).
[Crossref]

K. Isobe, A. Suda, M. Tanaka, H. Hashimoto, F. Kannari, H. Kawano, H. Mizuno, A. Miyawaki, and K. Midorikawa, “Single-pulse coherent anti-Stokes Raman scattering microscopy employing an octave spanning pulse,” Opt. Express 17(14), 11259–11266 (2009).
[Crossref] [PubMed]

Hashimoto, K.

K. Hashimoto, M. Takahashi, T. Ideguchi, and K. Goda, “Broadband coherent Raman spectroscopy running at 24,000 spectra per second,” Sci. Rep. 6, 21036 (2016).

Heddleston, J. M.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Hight Walker, A. R.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Hiramatsu, K.

Hloupis, G.

K. Moutzouris, M. Papamichael, S. C. Betsis, I. Stavrakas, G. Hloupis, and D. Triantis, “Refractive, dispersive and thermo-optic properties of twelve organic solvents in the visible and near-infrared,” Appl. Phys. B 116(3), 617–622 (2014).
[Crossref]

Holtom, G. R.

B. G. Saar, C. W. Freudiger, J. Reichman, C. M. Stanley, G. R. Holtom, and X. S. Xie, “Video-rate molecular imaging in vivo with stimulated Raman scattering,” Science 330(6009), 1368–1370 (2010).
[Crossref] [PubMed]

Holzner, S.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Hong, W.

Hu, F.

L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C. C. Lin, M. C. Wang, and W. Min, “Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering,” Nat. Methods 11(4), 410–412 (2014).
[Crossref] [PubMed]

Huang, K. C.

Huber, R.

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy,” Nat. Commun. 6(1), 6784 (2015).
[Crossref] [PubMed]

Ideguchi, T.

K. Hiramatsu, Y. Luo, T. Ideguchi, and K. Goda, “Rapid-scan Fourier-transform coherent anti-Stokes Raman scattering spectroscopy with heterodyne detection,” Opt. Lett. 42(21), 4335–4338 (2017).
[Crossref] [PubMed]

M. Tamamitsu, Y. Sakaki, T. Nakamura, G. K. Podagatlapalli, T. Ideguchi, and K. Goda, “Ultrafast broadband Fourier-transform CARS spectroscopy at 50,000 spectra/s enabled by a scanning Fourier-domain delay line,” Vib. Spectrosc. 91(1), 163–169 (2017).
[Crossref]

K. Hashimoto, M. Takahashi, T. Ideguchi, and K. Goda, “Broadband coherent Raman spectroscopy running at 24,000 spectra per second,” Sci. Rep. 6, 21036 (2016).

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Isobe, K.

Itoh, K.

Y. Ozeki, W. Umemura, Y. Otsuka, S. Satoh, H. Hashimoto, K. Sumimura, N. Nishizawa, K. Fukui, and K. Itoh, “High-speed molecular spectral imaging of tissue with stimulated Raman scattering,” Nat. Photonics 6(12), 845–851 (2012).
[Crossref]

Joffre, M.

Kannari, F.

Kano, H.

H. Kano and H. Hamaguchi, “Ultrabroadband (>2500cm−1) multiplex coherent anti-Stokes Raman scattering microspectroscopy using a supercontinuum generated from a photonic crystal fiber,” Appl. Phys. Lett. 86(12), 121113 (2005).
[Crossref]

Karanja, C.

Karpf, S.

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy,” Nat. Commun. 6(1), 6784 (2015).
[Crossref] [PubMed]

Kawano, H.

Kawata, S.

H. Yamakoshi, K. Dodo, A. Palonpon, J. Ando, K. Fujita, S. Kawata, and M. Sodeoka, “Alkyne-Tag Raman imaging for visualization of mobile small molecules in live cells,” J. Am. Chem. Soc. 134(51), 20681–20689 (2012).
[Crossref] [PubMed]

Klein, T.

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy,” Nat. Commun. 6(1), 6784 (2015).
[Crossref] [PubMed]

Krafft, C.

C. Krafft, I. W. Schie, T. Meyer, M. Schmitt, and J. Popp, “Developments in spontaneous and coherent Raman scattering microscopic imaging for biomedical applications,” Chem. Soc. Rev. 45(7), 1819–1849 (2016).
[Crossref] [PubMed]

Lathia, J. D.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Leaird, D. E.

Lee, S. Y.

C. S. Liao, M. N. Slipchenko, P. Wang, J. Li, S. Y. Lee, R. A. Oglesbee, and J. X. Cheng, “Microsecond scale vibrational spectroscopic imaging by multiplex stimulated Raman scattering microscopy,” Light Sci. Appl. 4(3), e265 (2015).
[Crossref] [PubMed]

Lee, Y. J.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Li, J.

C. S. Liao, M. N. Slipchenko, P. Wang, J. Li, S. Y. Lee, R. A. Oglesbee, and J. X. Cheng, “Microsecond scale vibrational spectroscopic imaging by multiplex stimulated Raman scattering microscopy,” Light Sci. Appl. 4(3), e265 (2015).
[Crossref] [PubMed]

Li, X.

Liao, C. S.

Lin, C. C.

L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C. C. Lin, M. C. Wang, and W. Min, “Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering,” Nat. Methods 11(4), 410–412 (2014).
[Crossref] [PubMed]

Lin, C. P.

C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005).
[Crossref] [PubMed]

Liu, X.

Lu, S.

W. Min, C. W. Freudiger, S. Lu, and X. S. Xie, “Coherent nonlinear optical imaging: beyond fluorescence microscopy,” Annu. Rev. Phys. Chem. 62(1), 507–530 (2011).
[Crossref] [PubMed]

Luo, Y.

Meyer, T.

C. Krafft, I. W. Schie, T. Meyer, M. Schmitt, and J. Popp, “Developments in spontaneous and coherent Raman scattering microscopic imaging for biomedical applications,” Chem. Soc. Rev. 45(7), 1819–1849 (2016).
[Crossref] [PubMed]

Midorikawa, K.

Min, W.

L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C. C. Lin, M. C. Wang, and W. Min, “Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering,” Nat. Methods 11(4), 410–412 (2014).
[Crossref] [PubMed]

W. Min, C. W. Freudiger, S. Lu, and X. S. Xie, “Coherent nonlinear optical imaging: beyond fluorescence microscopy,” Annu. Rev. Phys. Chem. 62(1), 507–530 (2011).
[Crossref] [PubMed]

Miyawaki, A.

Mizuno, H.

Moutzouris, K.

K. Moutzouris, M. Papamichael, S. C. Betsis, I. Stavrakas, G. Hloupis, and D. Triantis, “Refractive, dispersive and thermo-optic properties of twelve organic solvents in the visible and near-infrared,” Appl. Phys. B 116(3), 617–622 (2014).
[Crossref]

Nakamura, T.

M. Tamamitsu, Y. Sakaki, T. Nakamura, G. K. Podagatlapalli, T. Ideguchi, and K. Goda, “Ultrafast broadband Fourier-transform CARS spectroscopy at 50,000 spectra/s enabled by a scanning Fourier-domain delay line,” Vib. Spectrosc. 91(1), 163–169 (2017).
[Crossref]

Nishizawa, N.

Y. Ozeki, W. Umemura, Y. Otsuka, S. Satoh, H. Hashimoto, K. Sumimura, N. Nishizawa, K. Fukui, and K. Itoh, “High-speed molecular spectral imaging of tissue with stimulated Raman scattering,” Nat. Photonics 6(12), 845–851 (2012).
[Crossref]

Notingher, L.

D. W. Shipp, F. Sinjab, and L. Notingher, “Raman spectroscopy: Techniques and applications in the life sciences,” Adv. Opt. Photonics 9(2), 315–428 (2017).
[Crossref]

Novotny, L.

R. Beams, L. Gustavo Cançado, and L. Novotny, “Raman characterization of defects and dopants in graphene,” J. Phys. Condens. Matter 27(8), 083002 (2015).
[Crossref] [PubMed]

Ogilvie, J. P.

Oglesbee, R. A.

C. S. Liao, M. N. Slipchenko, P. Wang, J. Li, S. Y. Lee, R. A. Oglesbee, and J. X. Cheng, “Microsecond scale vibrational spectroscopic imaging by multiplex stimulated Raman scattering microscopy,” Light Sci. Appl. 4(3), e265 (2015).
[Crossref] [PubMed]

Otsuka, Y.

Y. Ozeki, W. Umemura, Y. Otsuka, S. Satoh, H. Hashimoto, K. Sumimura, N. Nishizawa, K. Fukui, and K. Itoh, “High-speed molecular spectral imaging of tissue with stimulated Raman scattering,” Nat. Photonics 6(12), 845–851 (2012).
[Crossref]

Ozeki, Y.

Y. Ozeki, W. Umemura, Y. Otsuka, S. Satoh, H. Hashimoto, K. Sumimura, N. Nishizawa, K. Fukui, and K. Itoh, “High-speed molecular spectral imaging of tissue with stimulated Raman scattering,” Nat. Photonics 6(12), 845–851 (2012).
[Crossref]

Palonpon, A.

H. Yamakoshi, K. Dodo, A. Palonpon, J. Ando, K. Fujita, S. Kawata, and M. Sodeoka, “Alkyne-Tag Raman imaging for visualization of mobile small molecules in live cells,” J. Am. Chem. Soc. 134(51), 20681–20689 (2012).
[Crossref] [PubMed]

Papamichael, M.

K. Moutzouris, M. Papamichael, S. C. Betsis, I. Stavrakas, G. Hloupis, and D. Triantis, “Refractive, dispersive and thermo-optic properties of twelve organic solvents in the visible and near-infrared,” Appl. Phys. B 116(3), 617–622 (2014).
[Crossref]

Parekh, S. H.

Petrov, G. I.

R. Arora, G. I. Petrov, V. V. Yakovlev, and M. O. Scully, “Detecting anthrax in the mail by coherent Raman microspectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 109(4), 1151–1153 (2012).
[Crossref] [PubMed]

Picqué, N.

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Podagatlapalli, G. K.

M. Tamamitsu, Y. Sakaki, T. Nakamura, G. K. Podagatlapalli, T. Ideguchi, and K. Goda, “Ultrafast broadband Fourier-transform CARS spectroscopy at 50,000 spectra/s enabled by a scanning Fourier-domain delay line,” Vib. Spectrosc. 91(1), 163–169 (2017).
[Crossref]

Popp, J.

C. Krafft, I. W. Schie, T. Meyer, M. Schmitt, and J. Popp, “Developments in spontaneous and coherent Raman scattering microscopic imaging for biomedical applications,” Chem. Soc. Rev. 45(7), 1819–1849 (2016).
[Crossref] [PubMed]

Potma, E. O.

C. Y. Chung and E. O. Potma, “Biomolecular imaging with coherent nonlinear vibrational microscopy,” Annu. Rev. Phys. Chem. 64(1), 77–99 (2013).
[Crossref] [PubMed]

C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005).
[Crossref] [PubMed]

Puoris’haag, M.

C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005).
[Crossref] [PubMed]

Reichman, J.

B. G. Saar, C. W. Freudiger, J. Reichman, C. M. Stanley, G. R. Holtom, and X. S. Xie, “Video-rate molecular imaging in vivo with stimulated Raman scattering,” Science 330(6009), 1368–1370 (2010).
[Crossref] [PubMed]

Rich, J. N.

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

Rock, W.

Saar, B. G.

B. G. Saar, C. W. Freudiger, J. Reichman, C. M. Stanley, G. R. Holtom, and X. S. Xie, “Video-rate molecular imaging in vivo with stimulated Raman scattering,” Science 330(6009), 1368–1370 (2010).
[Crossref] [PubMed]

Sakaki, Y.

M. Tamamitsu, Y. Sakaki, T. Nakamura, G. K. Podagatlapalli, T. Ideguchi, and K. Goda, “Ultrafast broadband Fourier-transform CARS spectroscopy at 50,000 spectra/s enabled by a scanning Fourier-domain delay line,” Vib. Spectrosc. 91(1), 163–169 (2017).
[Crossref]

Sandoval, O. E.

Satoh, S.

Y. Ozeki, W. Umemura, Y. Otsuka, S. Satoh, H. Hashimoto, K. Sumimura, N. Nishizawa, K. Fukui, and K. Itoh, “High-speed molecular spectral imaging of tissue with stimulated Raman scattering,” Nat. Photonics 6(12), 845–851 (2012).
[Crossref]

Schie, I. W.

C. Krafft, I. W. Schie, T. Meyer, M. Schmitt, and J. Popp, “Developments in spontaneous and coherent Raman scattering microscopic imaging for biomedical applications,” Chem. Soc. Rev. 45(7), 1819–1849 (2016).
[Crossref] [PubMed]

Schmitt, M.

C. Krafft, I. W. Schie, T. Meyer, M. Schmitt, and J. Popp, “Developments in spontaneous and coherent Raman scattering microscopic imaging for biomedical applications,” Chem. Soc. Rev. 45(7), 1819–1849 (2016).
[Crossref] [PubMed]

Scully, M. O.

R. Arora, G. I. Petrov, V. V. Yakovlev, and M. O. Scully, “Detecting anthrax in the mail by coherent Raman microspectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 109(4), 1151–1153 (2012).
[Crossref] [PubMed]

Shen, Y.

L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C. C. Lin, M. C. Wang, and W. Min, “Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering,” Nat. Methods 11(4), 410–412 (2014).
[Crossref] [PubMed]

Shipp, D. W.

D. W. Shipp, F. Sinjab, and L. Notingher, “Raman spectroscopy: Techniques and applications in the life sciences,” Adv. Opt. Photonics 9(2), 315–428 (2017).
[Crossref]

Sinjab, F.

D. W. Shipp, F. Sinjab, and L. Notingher, “Raman spectroscopy: Techniques and applications in the life sciences,” Adv. Opt. Photonics 9(2), 315–428 (2017).
[Crossref]

Skodack, J.

Slipchenko, M. N.

C. S. Liao, M. N. Slipchenko, P. Wang, J. Li, S. Y. Lee, R. A. Oglesbee, and J. X. Cheng, “Microsecond scale vibrational spectroscopic imaging by multiplex stimulated Raman scattering microscopy,” Light Sci. Appl. 4(3), e265 (2015).
[Crossref] [PubMed]

Sodeoka, M.

H. Yamakoshi, K. Dodo, A. Palonpon, J. Ando, K. Fujita, S. Kawata, and M. Sodeoka, “Alkyne-Tag Raman imaging for visualization of mobile small molecules in live cells,” J. Am. Chem. Soc. 134(51), 20681–20689 (2012).
[Crossref] [PubMed]

Stanley, C. M.

B. G. Saar, C. W. Freudiger, J. Reichman, C. M. Stanley, G. R. Holtom, and X. S. Xie, “Video-rate molecular imaging in vivo with stimulated Raman scattering,” Science 330(6009), 1368–1370 (2010).
[Crossref] [PubMed]

Stavrakas, I.

K. Moutzouris, M. Papamichael, S. C. Betsis, I. Stavrakas, G. Hloupis, and D. Triantis, “Refractive, dispersive and thermo-optic properties of twelve organic solvents in the visible and near-infrared,” Appl. Phys. B 116(3), 617–622 (2014).
[Crossref]

Suda, A.

Sumimura, K.

Y. Ozeki, W. Umemura, Y. Otsuka, S. Satoh, H. Hashimoto, K. Sumimura, N. Nishizawa, K. Fukui, and K. Itoh, “High-speed molecular spectral imaging of tissue with stimulated Raman scattering,” Nat. Photonics 6(12), 845–851 (2012).
[Crossref]

Takahashi, M.

K. Hashimoto, M. Takahashi, T. Ideguchi, and K. Goda, “Broadband coherent Raman spectroscopy running at 24,000 spectra per second,” Sci. Rep. 6, 21036 (2016).

Tamamitsu, M.

M. Tamamitsu, Y. Sakaki, T. Nakamura, G. K. Podagatlapalli, T. Ideguchi, and K. Goda, “Ultrafast broadband Fourier-transform CARS spectroscopy at 50,000 spectra/s enabled by a scanning Fourier-domain delay line,” Vib. Spectrosc. 91(1), 163–169 (2017).
[Crossref]

Tanaka, M.

Triantis, D.

K. Moutzouris, M. Papamichael, S. C. Betsis, I. Stavrakas, G. Hloupis, and D. Triantis, “Refractive, dispersive and thermo-optic properties of twelve organic solvents in the visible and near-infrared,” Appl. Phys. B 116(3), 617–622 (2014).
[Crossref]

Umemura, W.

Y. Ozeki, W. Umemura, Y. Otsuka, S. Satoh, H. Hashimoto, K. Sumimura, N. Nishizawa, K. Fukui, and K. Itoh, “High-speed molecular spectral imaging of tissue with stimulated Raman scattering,” Nat. Photonics 6(12), 845–851 (2012).
[Crossref]

Wang, M. C.

L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C. C. Lin, M. C. Wang, and W. Min, “Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering,” Nat. Methods 11(4), 410–412 (2014).
[Crossref] [PubMed]

Wang, P.

C. S. Liao, K. C. Huang, W. Hong, A. J. Chen, C. Karanja, P. Wang, G. Eakins, and J. X. Cheng, “Stimulated Raman spectroscopic imaging by microsecond delay-line tuning,” Optica 3(12), 1377–1380 (2016).
[Crossref]

C. S. Liao, M. N. Slipchenko, P. Wang, J. Li, S. Y. Lee, R. A. Oglesbee, and J. X. Cheng, “Microsecond scale vibrational spectroscopic imaging by multiplex stimulated Raman scattering microscopy,” Light Sci. Appl. 4(3), e265 (2015).
[Crossref] [PubMed]

Wei, L.

L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C. C. Lin, M. C. Wang, and W. Min, “Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering,” Nat. Methods 11(4), 410–412 (2014).
[Crossref] [PubMed]

Weiner, A. M.

Wieser, W.

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy,” Nat. Commun. 6(1), 6784 (2015).
[Crossref] [PubMed]

Xie, X. S.

W. Min, C. W. Freudiger, S. Lu, and X. S. Xie, “Coherent nonlinear optical imaging: beyond fluorescence microscopy,” Annu. Rev. Phys. Chem. 62(1), 507–530 (2011).
[Crossref] [PubMed]

B. G. Saar, C. W. Freudiger, J. Reichman, C. M. Stanley, G. R. Holtom, and X. S. Xie, “Video-rate molecular imaging in vivo with stimulated Raman scattering,” Science 330(6009), 1368–1370 (2010).
[Crossref] [PubMed]

C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005).
[Crossref] [PubMed]

Yakovlev, V. V.

R. Arora, G. I. Petrov, V. V. Yakovlev, and M. O. Scully, “Detecting anthrax in the mail by coherent Raman microspectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 109(4), 1151–1153 (2012).
[Crossref] [PubMed]

Yamakoshi, H.

H. Yamakoshi, K. Dodo, A. Palonpon, J. Ando, K. Fujita, S. Kawata, and M. Sodeoka, “Alkyne-Tag Raman imaging for visualization of mobile small molecules in live cells,” J. Am. Chem. Soc. 134(51), 20681–20689 (2012).
[Crossref] [PubMed]

Yu, Y.

L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C. C. Lin, M. C. Wang, and W. Min, “Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering,” Nat. Methods 11(4), 410–412 (2014).
[Crossref] [PubMed]

Adv. Opt. Photonics (1)

D. W. Shipp, F. Sinjab, and L. Notingher, “Raman spectroscopy: Techniques and applications in the life sciences,” Adv. Opt. Photonics 9(2), 315–428 (2017).
[Crossref]

Annu. Rev. Phys. Chem. (2)

W. Min, C. W. Freudiger, S. Lu, and X. S. Xie, “Coherent nonlinear optical imaging: beyond fluorescence microscopy,” Annu. Rev. Phys. Chem. 62(1), 507–530 (2011).
[Crossref] [PubMed]

C. Y. Chung and E. O. Potma, “Biomolecular imaging with coherent nonlinear vibrational microscopy,” Annu. Rev. Phys. Chem. 64(1), 77–99 (2013).
[Crossref] [PubMed]

Appl. Phys. B (1)

K. Moutzouris, M. Papamichael, S. C. Betsis, I. Stavrakas, G. Hloupis, and D. Triantis, “Refractive, dispersive and thermo-optic properties of twelve organic solvents in the visible and near-infrared,” Appl. Phys. B 116(3), 617–622 (2014).
[Crossref]

Appl. Phys. Lett. (1)

H. Kano and H. Hamaguchi, “Ultrabroadband (>2500cm−1) multiplex coherent anti-Stokes Raman scattering microspectroscopy using a supercontinuum generated from a photonic crystal fiber,” Appl. Phys. Lett. 86(12), 121113 (2005).
[Crossref]

Chem. Soc. Rev. (1)

C. Krafft, I. W. Schie, T. Meyer, M. Schmitt, and J. Popp, “Developments in spontaneous and coherent Raman scattering microscopic imaging for biomedical applications,” Chem. Soc. Rev. 45(7), 1819–1849 (2016).
[Crossref] [PubMed]

J. Am. Chem. Soc. (1)

H. Yamakoshi, K. Dodo, A. Palonpon, J. Ando, K. Fujita, S. Kawata, and M. Sodeoka, “Alkyne-Tag Raman imaging for visualization of mobile small molecules in live cells,” J. Am. Chem. Soc. 134(51), 20681–20689 (2012).
[Crossref] [PubMed]

J. Phys. Condens. Matter (1)

R. Beams, L. Gustavo Cançado, and L. Novotny, “Raman characterization of defects and dopants in graphene,” J. Phys. Condens. Matter 27(8), 083002 (2015).
[Crossref] [PubMed]

Light Sci. Appl. (1)

C. S. Liao, M. N. Slipchenko, P. Wang, J. Li, S. Y. Lee, R. A. Oglesbee, and J. X. Cheng, “Microsecond scale vibrational spectroscopic imaging by multiplex stimulated Raman scattering microscopy,” Light Sci. Appl. 4(3), e265 (2015).
[Crossref] [PubMed]

Nat. Commun. (1)

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy,” Nat. Commun. 6(1), 6784 (2015).
[Crossref] [PubMed]

Nat. Methods (1)

L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C. C. Lin, M. C. Wang, and W. Min, “Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering,” Nat. Methods 11(4), 410–412 (2014).
[Crossref] [PubMed]

Nat. Photonics (3)

Y. Ozeki, W. Umemura, Y. Otsuka, S. Satoh, H. Hashimoto, K. Sumimura, N. Nishizawa, K. Fukui, and K. Itoh, “High-speed molecular spectral imaging of tissue with stimulated Raman scattering,” Nat. Photonics 6(12), 845–851 (2012).
[Crossref]

C. H. Camp, Y. J. Lee, J. M. Heddleston, C. M. Hartshorn, A. R. Hight Walker, J. N. Rich, J. D. Lathia, and M. T. Cicerone, “High-speed coherent Raman fingerprint imaging of biological tissues,” Nat. Photonics 8(8), 627–634 (2014).
[Crossref] [PubMed]

C. H. Camp and M. T. Cicerone, “Chemically sensitive bioimaging with coherent Raman scattering,” Nat. Photonics 9(5), 295–305 (2015).
[Crossref]

Nature (1)

T. Ideguchi, S. Holzner, B. Bernhardt, G. Guelachvili, N. Picqué, and T. W. Hänsch, “Coherent Raman spectro-imaging with laser frequency combs,” Nature 502(7471), 355–358 (2013).
[Crossref] [PubMed]

Opt. Express (3)

Opt. Lett. (4)

Optica (1)

Proc. Natl. Acad. Sci. U.S.A. (2)

R. Arora, G. I. Petrov, V. V. Yakovlev, and M. O. Scully, “Detecting anthrax in the mail by coherent Raman microspectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 109(4), 1151–1153 (2012).
[Crossref] [PubMed]

C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005).
[Crossref] [PubMed]

Sci. Rep. (1)

K. Hashimoto, M. Takahashi, T. Ideguchi, and K. Goda, “Broadband coherent Raman spectroscopy running at 24,000 spectra per second,” Sci. Rep. 6, 21036 (2016).

Science (1)

B. G. Saar, C. W. Freudiger, J. Reichman, C. M. Stanley, G. R. Holtom, and X. S. Xie, “Video-rate molecular imaging in vivo with stimulated Raman scattering,” Science 330(6009), 1368–1370 (2010).
[Crossref] [PubMed]

Vib. Spectrosc. (1)

M. Tamamitsu, Y. Sakaki, T. Nakamura, G. K. Podagatlapalli, T. Ideguchi, and K. Goda, “Ultrafast broadband Fourier-transform CARS spectroscopy at 50,000 spectra/s enabled by a scanning Fourier-domain delay line,” Vib. Spectrosc. 91(1), 163–169 (2017).
[Crossref]

Other (2)

J. X. Cheng and X. S. Xie, Coherent Raman Scattering Microscopy (CRC, 2012).

P. L. Luo, M. Yan, T. W. Hänsch, and N. Picqué, “Ultra-broadband dual comb coherent anti-Stokes Raman spectroscopy,” in Fourier Transform Spectroscopy 2016, OSA Technical Digest (online) (Optical Society of America, 2016), paper FW2E.2.

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (4)

Fig. 1
Fig. 1 Schematic of the ultra-broadband rapid-scan FT-CARS system. The top and middle inset panels show the autocorrelation trace and spectrum of the laser output, respectively. The bottom panel shows the autocorrelation trace at the sample position. BS: beamsplitter, CG: Compensation glass, LPF: long-pass filter, SPF: short-pass filter, APD: avalanche photodetector, PD: photodetector.
Fig. 2
Fig. 2 Sequential CARS (a) interferograms and (b) spectra of benzene measured at the rate of 24,000 Hz. The red-colored spectrum on the bottom shows the 500-averaged spectrum. Several CARS lines of benzene are observed in the fingerprint region (595, 992, 1,586 cm−1) and in the higher C-H stretching region (3,062 cm−1).
Fig. 3
Fig. 3 CARS signal intensity dependence on relative sample position to the laser’s focal position. The Raman line at 992 cm−1 of benzene is used for the analysis. The solid line is a spline interpolation of the data points and its FWHM is 400 μm.
Fig. 4
Fig. 4 500-averaged CARS spectra of chloroform, dimethyl sulfoxide (DMSO), toluene, and benzene. The vibrational modes both at the fingerprint region and the C-H stretching higher wavenumber region around 3,000 cm−1 are clearly observed.

Metrics