Abstract

The spectro-angular light scattering measurements of individual microscopic objects are presented. Using spectroscopic quantitative phase microscopy and Fourier transform light scattering, the 2D angle-resolved light scattering intensity and phase patterns are measured in a spectral range of 450-750 nm and an angular range of –70-70°. The spectro-angular light scattering measurements of individual polystyrene beads are demonstrated with high sensitivity and precision.

© 2014 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. H. C. d. Hulst, Light Scattering by Small Particles, Structure of Matter Series (Wiley, 1957).
  2. N. N. Boustany, S. A. Boppart, V. Backman, “Microscopic imaging and spectroscopy with scattered light,” Annu. Rev. Biomed. Eng. 12(1), 285–314 (2010).
    [CrossRef] [PubMed]
  3. A. Wax, M. G. Giacomelli, T. E. Matthews, M. T. Rinehart, F. E. Robles, Y. Zhu, “Optical spectroscopy of biological cells,” Adv. Opt. Photonics 4(3), 322–378 (2012).
    [CrossRef]
  4. H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
    [CrossRef] [PubMed]
  5. G. Popescu, Quantitative Phase Imaging of Cells and Tissues (McGraw-Hill, 2011).
  6. K. Lee, K. Kim, J. Jung, J. H. Heo, S. Cho, S. Lee, G. Chang, Y. J. Jo, H. Park, Y. K. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13(4), 4170–4191 (2013).
    [CrossRef] [PubMed]
  7. H. Ding, F. Nguyen, S. A. Boppart, G. Popescu, “Optical properties of tissues quantified by Fourier-transform light scattering,” Opt. Lett. 34(9), 1372–1374 (2009).
    [CrossRef] [PubMed]
  8. H. Ding, E. Berl, Z. Wang, L. J. Millet, M. U. Gillette, J. Liu, M. Boppart, G. Popescu, “Fourier transform light scattering of biological structure and dynamics,” IEEE J. Sel. Top. Quantum Electron. 16(4), 909–918 (2010).
    [CrossRef]
  9. Y. Park, C. A. Best-Popescu, R. R. Dasari, G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
    [CrossRef] [PubMed]
  10. H. Ding, L. J. Millet, M. U. Gillette, G. Popescu, “Actin-driven cell dynamics probed by Fourier transform light scattering,” Biomed. Opt. Express 1(1), 260–267 (2010).
    [CrossRef] [PubMed]
  11. H. Yu, H. Park, Y. Kim, M. W. Kim, Y. Park, “Fourier-transform light scattering of individual colloidal clusters,” Opt. Lett. 37(13), 2577–2579 (2012).
    [CrossRef] [PubMed]
  12. C. Cho, H. Kim, S. Jeong, S.-W. Baek, J.-W. Seo, D. Han, K. Kim, Y. Park, S. Yoo, J.-Y. Lee, “Random and V-groove texturing for efficient light trapping in organic photovoltaic cells,” Sol. Energy Mater. Sol. Cells 115, 36–41 (2013).
    [CrossRef]
  13. Y. Liu, X. Li, Y. L. Kim, V. Backman, “Elastic backscattering spectroscopic microscopy,” Opt. Lett. 30(18), 2445–2447 (2005).
    [CrossRef] [PubMed]
  14. W. J. Cottrell, J. D. Wilson, T. H. Foster, “Microscope enabling multimodality imaging, angle-resolved scattering, and scattering spectroscopy,” Opt. Lett. 32(16), 2348–2350 (2007).
    [CrossRef] [PubMed]
  15. Z. J. Smith, A. J. Berger, “Validation of an integrated Raman- and angular-scattering microscopy system on heterogeneous bead mixtures and single human immune cells,” Appl. Opt. 48(10), D109–D120 (2009).
    [CrossRef] [PubMed]
  16. T. Rothe, M. Schmitz, A. Kienle, “Angular and spectrally resolved investigation of single particles by darkfield scattering microscopy,” J. Biomed. Opt. 17(11), 117006 (2012).
    [CrossRef] [PubMed]
  17. W. Choi, C.-C. Yu, C. Fang-Yen, K. Badizadegan, R. R. Dasari, M. S. Feld, “Field-based angle-resolved light-scattering study of single live cells,” Opt. Lett. 33(14), 1596–1598 (2008).
    [CrossRef] [PubMed]
  18. T. R. Hillman, S. A. Alexandrov, T. Gutzler, D. D. Sampson, “Microscopic particle discrimination using spatially-resolved Fourier-holographic light scattering angular spectroscopy,” Opt. Express 14(23), 11088–11102 (2006).
    [CrossRef] [PubMed]
  19. I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
    [CrossRef] [PubMed]
  20. D. Fu, W. Choi, Y. Sung, S. Oh, Z. Yaqoob, Y. Park, R. R. Dasari, M. S. Feld, “Ultraviolet refractometry using field-based light scattering spectroscopy,” Opt. Express 17(21), 18878–18886 (2009).
    [CrossRef] [PubMed]
  21. J.-H. Jung, J. Jang, Y. Park, “Spectro-refractometry of individual microscopic objects using swept-source quantitative phase imaging,” Anal. Chem. 85(21), 10519–10525 (2013).
    [CrossRef] [PubMed]
  22. Y. Jang, J. Jang, Y. Park, “Dynamic spectroscopic phase microscopy for quantifying hemoglobin concentration and dynamic membrane fluctuation in red blood cells,” Opt. Express 20(9), 9673–9681 (2012).
    [CrossRef] [PubMed]
  23. Y. Park, T. Yamauchi, W. Choi, R. Dasari, M. S. Feld, “Spectroscopic phase microscopy for quantifying hemoglobin concentrations in intact red blood cells,” Opt. Lett. 34(23), 3668–3670 (2009).
    [CrossRef] [PubMed]
  24. H. Pham, B. Bhaduri, H. Ding, G. Popescu, “Spectroscopic diffraction phase microscopy,” Opt. Lett. 37(16), 3438–3440 (2012).
    [CrossRef] [PubMed]
  25. F. E. Robles, C. Wilson, G. Grant, A. Wax, “Molecular imaging true-colour spectroscopic optical coherence tomography,” Nat. Photonics 5(12), 744–747 (2011).
    [CrossRef] [PubMed]
  26. S. K. Debnath, Y. Park, “Real-time quantitative phase imaging with a spatial phase-shifting algorithm,” Opt. Lett. 36(23), 4677–4679 (2011).
    [CrossRef] [PubMed]
  27. J.-P. Schäfer, “Implementierung und Anwendung analytischer und numerischer Verfahren zur Lösung der Maxwellgleichungen für die Untersuchung der Lichtausbreitung in biologischem Gewebe,” (Ulm, Universität Ulm, Diss., 2011).
  28. Y. Park, G. Popescu, K. Badizadegan, R. R. Dasari, M. S. Feld, “Fresnel particle tracing in three dimensions using diffraction phase microscopy,” Opt. Lett. 32(7), 811–813 (2007).
    [CrossRef] [PubMed]
  29. W. W. Tscharnuter, “Mobility measurements by phase analysis,” Appl. Opt. 40(24), 3995–4003 (2001).
    [CrossRef] [PubMed]
  30. K. Lee, H.-D. Kim, K. Kim, Y. Kim, T. R. Hillman, B. Min, Y. Park, “Synthetic Fourier transform light scattering,” Opt. Express 21(19), 22453–22463 (2013).
    [CrossRef] [PubMed]
  31. S. Cho, S. Kim, Y. Kim, Y. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
    [CrossRef] [PubMed]
  32. M. Kinnunen, A. Kauppila, A. Karmenyan, R. Myllylä, “Effect of the size and shape of a red blood cell on elastic light scattering properties at the single-cell level,” Biomed. Opt. Express 2(7), 1803–1814 (2011).
    [CrossRef] [PubMed]
  33. H. Byun, T. R. Hillman, J. M. Higgins, M. Diez-Silva, Z. Peng, M. Dao, R. R. Dasari, S. Suresh, Y. Park, “Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient,” Acta Biomater. 8(11), 4130–4138 (2012).
    [CrossRef] [PubMed]
  34. S. Lee, W. Lu, “Using elastic light scattering of red blood cells to detect infection of malaria parasite,” IEEE Trans. Biomed. Eng. 59(1), 150–155 (2012).
    [CrossRef] [PubMed]
  35. A. Anand, V. Chhaniwal, N. Patel, B. Javidi, “Automatic identification of malaria-infected RBC with digital holographic microscopy using correlation algorithms,” IEEE Photonics J. 4(5), 1456–1464 (2012).
    [CrossRef]
  36. K. Kim, Y. Park, “Fourier transform light scattering angular spectroscopy using digital inline holography,” Opt. Lett. 37(19), 4161–4163 (2012).
    [CrossRef] [PubMed]
  37. Y. Kim, J. Jeong, J. Jang, M. W. Kim, Y. Park, “Polarization holographic microscopy for extracting spatio-temporally resolved Jones matrix,” Opt. Express 20(9), 9948–9955 (2012).
    [CrossRef] [PubMed]

2013 (4)

K. Lee, K. Kim, J. Jung, J. H. Heo, S. Cho, S. Lee, G. Chang, Y. J. Jo, H. Park, Y. K. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13(4), 4170–4191 (2013).
[CrossRef] [PubMed]

C. Cho, H. Kim, S. Jeong, S.-W. Baek, J.-W. Seo, D. Han, K. Kim, Y. Park, S. Yoo, J.-Y. Lee, “Random and V-groove texturing for efficient light trapping in organic photovoltaic cells,” Sol. Energy Mater. Sol. Cells 115, 36–41 (2013).
[CrossRef]

J.-H. Jung, J. Jang, Y. Park, “Spectro-refractometry of individual microscopic objects using swept-source quantitative phase imaging,” Anal. Chem. 85(21), 10519–10525 (2013).
[CrossRef] [PubMed]

K. Lee, H.-D. Kim, K. Kim, Y. Kim, T. R. Hillman, B. Min, Y. Park, “Synthetic Fourier transform light scattering,” Opt. Express 21(19), 22453–22463 (2013).
[CrossRef] [PubMed]

2012 (11)

Y. Jang, J. Jang, Y. Park, “Dynamic spectroscopic phase microscopy for quantifying hemoglobin concentration and dynamic membrane fluctuation in red blood cells,” Opt. Express 20(9), 9673–9681 (2012).
[CrossRef] [PubMed]

Y. Kim, J. Jeong, J. Jang, M. W. Kim, Y. Park, “Polarization holographic microscopy for extracting spatio-temporally resolved Jones matrix,” Opt. Express 20(9), 9948–9955 (2012).
[CrossRef] [PubMed]

H. Yu, H. Park, Y. Kim, M. W. Kim, Y. Park, “Fourier-transform light scattering of individual colloidal clusters,” Opt. Lett. 37(13), 2577–2579 (2012).
[CrossRef] [PubMed]

H. Pham, B. Bhaduri, H. Ding, G. Popescu, “Spectroscopic diffraction phase microscopy,” Opt. Lett. 37(16), 3438–3440 (2012).
[CrossRef] [PubMed]

K. Kim, Y. Park, “Fourier transform light scattering angular spectroscopy using digital inline holography,” Opt. Lett. 37(19), 4161–4163 (2012).
[CrossRef] [PubMed]

S. Cho, S. Kim, Y. Kim, Y. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
[CrossRef] [PubMed]

H. Byun, T. R. Hillman, J. M. Higgins, M. Diez-Silva, Z. Peng, M. Dao, R. R. Dasari, S. Suresh, Y. Park, “Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient,” Acta Biomater. 8(11), 4130–4138 (2012).
[CrossRef] [PubMed]

S. Lee, W. Lu, “Using elastic light scattering of red blood cells to detect infection of malaria parasite,” IEEE Trans. Biomed. Eng. 59(1), 150–155 (2012).
[CrossRef] [PubMed]

A. Anand, V. Chhaniwal, N. Patel, B. Javidi, “Automatic identification of malaria-infected RBC with digital holographic microscopy using correlation algorithms,” IEEE Photonics J. 4(5), 1456–1464 (2012).
[CrossRef]

T. Rothe, M. Schmitz, A. Kienle, “Angular and spectrally resolved investigation of single particles by darkfield scattering microscopy,” J. Biomed. Opt. 17(11), 117006 (2012).
[CrossRef] [PubMed]

A. Wax, M. G. Giacomelli, T. E. Matthews, M. T. Rinehart, F. E. Robles, Y. Zhu, “Optical spectroscopy of biological cells,” Adv. Opt. Photonics 4(3), 322–378 (2012).
[CrossRef]

2011 (4)

Y. Park, C. A. Best-Popescu, R. R. Dasari, G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[CrossRef] [PubMed]

F. E. Robles, C. Wilson, G. Grant, A. Wax, “Molecular imaging true-colour spectroscopic optical coherence tomography,” Nat. Photonics 5(12), 744–747 (2011).
[CrossRef] [PubMed]

M. Kinnunen, A. Kauppila, A. Karmenyan, R. Myllylä, “Effect of the size and shape of a red blood cell on elastic light scattering properties at the single-cell level,” Biomed. Opt. Express 2(7), 1803–1814 (2011).
[CrossRef] [PubMed]

S. K. Debnath, Y. Park, “Real-time quantitative phase imaging with a spatial phase-shifting algorithm,” Opt. Lett. 36(23), 4677–4679 (2011).
[CrossRef] [PubMed]

2010 (3)

H. Ding, L. J. Millet, M. U. Gillette, G. Popescu, “Actin-driven cell dynamics probed by Fourier transform light scattering,” Biomed. Opt. Express 1(1), 260–267 (2010).
[CrossRef] [PubMed]

N. N. Boustany, S. A. Boppart, V. Backman, “Microscopic imaging and spectroscopy with scattered light,” Annu. Rev. Biomed. Eng. 12(1), 285–314 (2010).
[CrossRef] [PubMed]

H. Ding, E. Berl, Z. Wang, L. J. Millet, M. U. Gillette, J. Liu, M. Boppart, G. Popescu, “Fourier transform light scattering of biological structure and dynamics,” IEEE J. Sel. Top. Quantum Electron. 16(4), 909–918 (2010).
[CrossRef]

2009 (4)

2008 (2)

W. Choi, C.-C. Yu, C. Fang-Yen, K. Badizadegan, R. R. Dasari, M. S. Feld, “Field-based angle-resolved light-scattering study of single live cells,” Opt. Lett. 33(14), 1596–1598 (2008).
[CrossRef] [PubMed]

H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[CrossRef] [PubMed]

2007 (3)

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Y. Park, G. Popescu, K. Badizadegan, R. R. Dasari, M. S. Feld, “Fresnel particle tracing in three dimensions using diffraction phase microscopy,” Opt. Lett. 32(7), 811–813 (2007).
[CrossRef] [PubMed]

W. J. Cottrell, J. D. Wilson, T. H. Foster, “Microscope enabling multimodality imaging, angle-resolved scattering, and scattering spectroscopy,” Opt. Lett. 32(16), 2348–2350 (2007).
[CrossRef] [PubMed]

2006 (1)

2005 (1)

2001 (1)

Alexandrov, S. A.

Anand, A.

A. Anand, V. Chhaniwal, N. Patel, B. Javidi, “Automatic identification of malaria-infected RBC with digital holographic microscopy using correlation algorithms,” IEEE Photonics J. 4(5), 1456–1464 (2012).
[CrossRef]

Andersson, C.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Backman, V.

N. N. Boustany, S. A. Boppart, V. Backman, “Microscopic imaging and spectroscopy with scattered light,” Annu. Rev. Biomed. Eng. 12(1), 285–314 (2010).
[CrossRef] [PubMed]

Y. Liu, X. Li, Y. L. Kim, V. Backman, “Elastic backscattering spectroscopic microscopy,” Opt. Lett. 30(18), 2445–2447 (2005).
[CrossRef] [PubMed]

Badizadegan, K.

Baek, S.-W.

C. Cho, H. Kim, S. Jeong, S.-W. Baek, J.-W. Seo, D. Han, K. Kim, Y. Park, S. Yoo, J.-Y. Lee, “Random and V-groove texturing for efficient light trapping in organic photovoltaic cells,” Sol. Energy Mater. Sol. Cells 115, 36–41 (2013).
[CrossRef]

Berger, A. J.

Berl, E.

H. Ding, E. Berl, Z. Wang, L. J. Millet, M. U. Gillette, J. Liu, M. Boppart, G. Popescu, “Fourier transform light scattering of biological structure and dynamics,” IEEE J. Sel. Top. Quantum Electron. 16(4), 909–918 (2010).
[CrossRef]

Best-Popescu, C. A.

Y. Park, C. A. Best-Popescu, R. R. Dasari, G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[CrossRef] [PubMed]

Bhaduri, B.

Bigio, I.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Boppart, M.

H. Ding, E. Berl, Z. Wang, L. J. Millet, M. U. Gillette, J. Liu, M. Boppart, G. Popescu, “Fourier transform light scattering of biological structure and dynamics,” IEEE J. Sel. Top. Quantum Electron. 16(4), 909–918 (2010).
[CrossRef]

Boppart, S. A.

N. N. Boustany, S. A. Boppart, V. Backman, “Microscopic imaging and spectroscopy with scattered light,” Annu. Rev. Biomed. Eng. 12(1), 285–314 (2010).
[CrossRef] [PubMed]

H. Ding, F. Nguyen, S. A. Boppart, G. Popescu, “Optical properties of tissues quantified by Fourier-transform light scattering,” Opt. Lett. 34(9), 1372–1374 (2009).
[CrossRef] [PubMed]

H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[CrossRef] [PubMed]

Boustany, N. N.

N. N. Boustany, S. A. Boppart, V. Backman, “Microscopic imaging and spectroscopy with scattered light,” Annu. Rev. Biomed. Eng. 12(1), 285–314 (2010).
[CrossRef] [PubMed]

Byun, H.

H. Byun, T. R. Hillman, J. M. Higgins, M. Diez-Silva, Z. Peng, M. Dao, R. R. Dasari, S. Suresh, Y. Park, “Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient,” Acta Biomater. 8(11), 4130–4138 (2012).
[CrossRef] [PubMed]

Chang, G.

K. Lee, K. Kim, J. Jung, J. H. Heo, S. Cho, S. Lee, G. Chang, Y. J. Jo, H. Park, Y. K. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13(4), 4170–4191 (2013).
[CrossRef] [PubMed]

Chhaniwal, V.

A. Anand, V. Chhaniwal, N. Patel, B. Javidi, “Automatic identification of malaria-infected RBC with digital holographic microscopy using correlation algorithms,” IEEE Photonics J. 4(5), 1456–1464 (2012).
[CrossRef]

Cho, C.

C. Cho, H. Kim, S. Jeong, S.-W. Baek, J.-W. Seo, D. Han, K. Kim, Y. Park, S. Yoo, J.-Y. Lee, “Random and V-groove texturing for efficient light trapping in organic photovoltaic cells,” Sol. Energy Mater. Sol. Cells 115, 36–41 (2013).
[CrossRef]

Cho, S.

K. Lee, K. Kim, J. Jung, J. H. Heo, S. Cho, S. Lee, G. Chang, Y. J. Jo, H. Park, Y. K. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13(4), 4170–4191 (2013).
[CrossRef] [PubMed]

S. Cho, S. Kim, Y. Kim, Y. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
[CrossRef] [PubMed]

Choi, W.

Cipolloni, P. B.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Cottrell, W. J.

Dao, M.

H. Byun, T. R. Hillman, J. M. Higgins, M. Diez-Silva, Z. Peng, M. Dao, R. R. Dasari, S. Suresh, Y. Park, “Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient,” Acta Biomater. 8(11), 4130–4138 (2012).
[CrossRef] [PubMed]

Dasari, R.

Dasari, R. R.

Debnath, S. K.

Diez-Silva, M.

H. Byun, T. R. Hillman, J. M. Higgins, M. Diez-Silva, Z. Peng, M. Dao, R. R. Dasari, S. Suresh, Y. Park, “Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient,” Acta Biomater. 8(11), 4130–4138 (2012).
[CrossRef] [PubMed]

Ding, H.

H. Pham, B. Bhaduri, H. Ding, G. Popescu, “Spectroscopic diffraction phase microscopy,” Opt. Lett. 37(16), 3438–3440 (2012).
[CrossRef] [PubMed]

H. Ding, E. Berl, Z. Wang, L. J. Millet, M. U. Gillette, J. Liu, M. Boppart, G. Popescu, “Fourier transform light scattering of biological structure and dynamics,” IEEE J. Sel. Top. Quantum Electron. 16(4), 909–918 (2010).
[CrossRef]

H. Ding, L. J. Millet, M. U. Gillette, G. Popescu, “Actin-driven cell dynamics probed by Fourier transform light scattering,” Biomed. Opt. Express 1(1), 260–267 (2010).
[CrossRef] [PubMed]

H. Ding, F. Nguyen, S. A. Boppart, G. Popescu, “Optical properties of tissues quantified by Fourier-transform light scattering,” Opt. Lett. 34(9), 1372–1374 (2009).
[CrossRef] [PubMed]

H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[CrossRef] [PubMed]

Fang, H.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Fang-Yen, C.

Feld, M. S.

Foster, T. H.

Freedman, S. D.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Fu, D.

Ghiran, I. C.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Giacomelli, M. G.

A. Wax, M. G. Giacomelli, T. E. Matthews, M. T. Rinehart, F. E. Robles, Y. Zhu, “Optical spectroscopy of biological cells,” Adv. Opt. Photonics 4(3), 322–378 (2012).
[CrossRef]

Gillette, M. U.

H. Ding, L. J. Millet, M. U. Gillette, G. Popescu, “Actin-driven cell dynamics probed by Fourier transform light scattering,” Biomed. Opt. Express 1(1), 260–267 (2010).
[CrossRef] [PubMed]

H. Ding, E. Berl, Z. Wang, L. J. Millet, M. U. Gillette, J. Liu, M. Boppart, G. Popescu, “Fourier transform light scattering of biological structure and dynamics,” IEEE J. Sel. Top. Quantum Electron. 16(4), 909–918 (2010).
[CrossRef]

Grant, G.

F. E. Robles, C. Wilson, G. Grant, A. Wax, “Molecular imaging true-colour spectroscopic optical coherence tomography,” Nat. Photonics 5(12), 744–747 (2011).
[CrossRef] [PubMed]

Gutzler, T.

Han, D.

C. Cho, H. Kim, S. Jeong, S.-W. Baek, J.-W. Seo, D. Han, K. Kim, Y. Park, S. Yoo, J.-Y. Lee, “Random and V-groove texturing for efficient light trapping in organic photovoltaic cells,” Sol. Energy Mater. Sol. Cells 115, 36–41 (2013).
[CrossRef]

Hanlon, E. B.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Heo, J. H.

K. Lee, K. Kim, J. Jung, J. H. Heo, S. Cho, S. Lee, G. Chang, Y. J. Jo, H. Park, Y. K. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13(4), 4170–4191 (2013).
[CrossRef] [PubMed]

Higgins, J. M.

H. Byun, T. R. Hillman, J. M. Higgins, M. Diez-Silva, Z. Peng, M. Dao, R. R. Dasari, S. Suresh, Y. Park, “Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient,” Acta Biomater. 8(11), 4130–4138 (2012).
[CrossRef] [PubMed]

Hillman, T. R.

Itzkan, I.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Jang, J.

Jang, Y.

Javidi, B.

A. Anand, V. Chhaniwal, N. Patel, B. Javidi, “Automatic identification of malaria-infected RBC with digital holographic microscopy using correlation algorithms,” IEEE Photonics J. 4(5), 1456–1464 (2012).
[CrossRef]

Jeong, J.

Jeong, S.

C. Cho, H. Kim, S. Jeong, S.-W. Baek, J.-W. Seo, D. Han, K. Kim, Y. Park, S. Yoo, J.-Y. Lee, “Random and V-groove texturing for efficient light trapping in organic photovoltaic cells,” Sol. Energy Mater. Sol. Cells 115, 36–41 (2013).
[CrossRef]

Jo, Y. J.

K. Lee, K. Kim, J. Jung, J. H. Heo, S. Cho, S. Lee, G. Chang, Y. J. Jo, H. Park, Y. K. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13(4), 4170–4191 (2013).
[CrossRef] [PubMed]

Jung, J.

K. Lee, K. Kim, J. Jung, J. H. Heo, S. Cho, S. Lee, G. Chang, Y. J. Jo, H. Park, Y. K. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13(4), 4170–4191 (2013).
[CrossRef] [PubMed]

Jung, J.-H.

J.-H. Jung, J. Jang, Y. Park, “Spectro-refractometry of individual microscopic objects using swept-source quantitative phase imaging,” Anal. Chem. 85(21), 10519–10525 (2013).
[CrossRef] [PubMed]

Karmenyan, A.

Kauppila, A.

Kienle, A.

T. Rothe, M. Schmitz, A. Kienle, “Angular and spectrally resolved investigation of single particles by darkfield scattering microscopy,” J. Biomed. Opt. 17(11), 117006 (2012).
[CrossRef] [PubMed]

Kim, H.

C. Cho, H. Kim, S. Jeong, S.-W. Baek, J.-W. Seo, D. Han, K. Kim, Y. Park, S. Yoo, J.-Y. Lee, “Random and V-groove texturing for efficient light trapping in organic photovoltaic cells,” Sol. Energy Mater. Sol. Cells 115, 36–41 (2013).
[CrossRef]

Kim, H.-D.

Kim, K.

K. Lee, H.-D. Kim, K. Kim, Y. Kim, T. R. Hillman, B. Min, Y. Park, “Synthetic Fourier transform light scattering,” Opt. Express 21(19), 22453–22463 (2013).
[CrossRef] [PubMed]

K. Lee, K. Kim, J. Jung, J. H. Heo, S. Cho, S. Lee, G. Chang, Y. J. Jo, H. Park, Y. K. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13(4), 4170–4191 (2013).
[CrossRef] [PubMed]

C. Cho, H. Kim, S. Jeong, S.-W. Baek, J.-W. Seo, D. Han, K. Kim, Y. Park, S. Yoo, J.-Y. Lee, “Random and V-groove texturing for efficient light trapping in organic photovoltaic cells,” Sol. Energy Mater. Sol. Cells 115, 36–41 (2013).
[CrossRef]

K. Kim, Y. Park, “Fourier transform light scattering angular spectroscopy using digital inline holography,” Opt. Lett. 37(19), 4161–4163 (2012).
[CrossRef] [PubMed]

Kim, M. W.

Kim, S.

S. Cho, S. Kim, Y. Kim, Y. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
[CrossRef] [PubMed]

Kim, Y.

Kim, Y. L.

Kimerer, L. M.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Kinnunen, M.

Lee, J.-Y.

C. Cho, H. Kim, S. Jeong, S.-W. Baek, J.-W. Seo, D. Han, K. Kim, Y. Park, S. Yoo, J.-Y. Lee, “Random and V-groove texturing for efficient light trapping in organic photovoltaic cells,” Sol. Energy Mater. Sol. Cells 115, 36–41 (2013).
[CrossRef]

Lee, K.

K. Lee, K. Kim, J. Jung, J. H. Heo, S. Cho, S. Lee, G. Chang, Y. J. Jo, H. Park, Y. K. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13(4), 4170–4191 (2013).
[CrossRef] [PubMed]

K. Lee, H.-D. Kim, K. Kim, Y. Kim, T. R. Hillman, B. Min, Y. Park, “Synthetic Fourier transform light scattering,” Opt. Express 21(19), 22453–22463 (2013).
[CrossRef] [PubMed]

Lee, S.

K. Lee, K. Kim, J. Jung, J. H. Heo, S. Cho, S. Lee, G. Chang, Y. J. Jo, H. Park, Y. K. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13(4), 4170–4191 (2013).
[CrossRef] [PubMed]

S. Lee, W. Lu, “Using elastic light scattering of red blood cells to detect infection of malaria parasite,” IEEE Trans. Biomed. Eng. 59(1), 150–155 (2012).
[CrossRef] [PubMed]

Li, X.

Lim, K. H.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Liu, J.

H. Ding, E. Berl, Z. Wang, L. J. Millet, M. U. Gillette, J. Liu, M. Boppart, G. Popescu, “Fourier transform light scattering of biological structure and dynamics,” IEEE J. Sel. Top. Quantum Electron. 16(4), 909–918 (2010).
[CrossRef]

Liu, Y.

Lu, W.

S. Lee, W. Lu, “Using elastic light scattering of red blood cells to detect infection of malaria parasite,” IEEE Trans. Biomed. Eng. 59(1), 150–155 (2012).
[CrossRef] [PubMed]

Matthews, T. E.

A. Wax, M. G. Giacomelli, T. E. Matthews, M. T. Rinehart, F. E. Robles, Y. Zhu, “Optical spectroscopy of biological cells,” Adv. Opt. Photonics 4(3), 322–378 (2012).
[CrossRef]

Millet, L. J.

H. Ding, L. J. Millet, M. U. Gillette, G. Popescu, “Actin-driven cell dynamics probed by Fourier transform light scattering,” Biomed. Opt. Express 1(1), 260–267 (2010).
[CrossRef] [PubMed]

H. Ding, E. Berl, Z. Wang, L. J. Millet, M. U. Gillette, J. Liu, M. Boppart, G. Popescu, “Fourier transform light scattering of biological structure and dynamics,” IEEE J. Sel. Top. Quantum Electron. 16(4), 909–918 (2010).
[CrossRef]

Min, B.

Modell, M.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Myllylä, R.

Nguyen, F.

H. Ding, F. Nguyen, S. A. Boppart, G. Popescu, “Optical properties of tissues quantified by Fourier-transform light scattering,” Opt. Lett. 34(9), 1372–1374 (2009).
[CrossRef] [PubMed]

H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[CrossRef] [PubMed]

Oh, S.

Park, H.

K. Lee, K. Kim, J. Jung, J. H. Heo, S. Cho, S. Lee, G. Chang, Y. J. Jo, H. Park, Y. K. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13(4), 4170–4191 (2013).
[CrossRef] [PubMed]

H. Yu, H. Park, Y. Kim, M. W. Kim, Y. Park, “Fourier-transform light scattering of individual colloidal clusters,” Opt. Lett. 37(13), 2577–2579 (2012).
[CrossRef] [PubMed]

Park, Y.

J.-H. Jung, J. Jang, Y. Park, “Spectro-refractometry of individual microscopic objects using swept-source quantitative phase imaging,” Anal. Chem. 85(21), 10519–10525 (2013).
[CrossRef] [PubMed]

C. Cho, H. Kim, S. Jeong, S.-W. Baek, J.-W. Seo, D. Han, K. Kim, Y. Park, S. Yoo, J.-Y. Lee, “Random and V-groove texturing for efficient light trapping in organic photovoltaic cells,” Sol. Energy Mater. Sol. Cells 115, 36–41 (2013).
[CrossRef]

K. Lee, H.-D. Kim, K. Kim, Y. Kim, T. R. Hillman, B. Min, Y. Park, “Synthetic Fourier transform light scattering,” Opt. Express 21(19), 22453–22463 (2013).
[CrossRef] [PubMed]

S. Cho, S. Kim, Y. Kim, Y. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
[CrossRef] [PubMed]

Y. Jang, J. Jang, Y. Park, “Dynamic spectroscopic phase microscopy for quantifying hemoglobin concentration and dynamic membrane fluctuation in red blood cells,” Opt. Express 20(9), 9673–9681 (2012).
[CrossRef] [PubMed]

H. Byun, T. R. Hillman, J. M. Higgins, M. Diez-Silva, Z. Peng, M. Dao, R. R. Dasari, S. Suresh, Y. Park, “Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient,” Acta Biomater. 8(11), 4130–4138 (2012).
[CrossRef] [PubMed]

Y. Kim, J. Jeong, J. Jang, M. W. Kim, Y. Park, “Polarization holographic microscopy for extracting spatio-temporally resolved Jones matrix,” Opt. Express 20(9), 9948–9955 (2012).
[CrossRef] [PubMed]

H. Yu, H. Park, Y. Kim, M. W. Kim, Y. Park, “Fourier-transform light scattering of individual colloidal clusters,” Opt. Lett. 37(13), 2577–2579 (2012).
[CrossRef] [PubMed]

K. Kim, Y. Park, “Fourier transform light scattering angular spectroscopy using digital inline holography,” Opt. Lett. 37(19), 4161–4163 (2012).
[CrossRef] [PubMed]

Y. Park, C. A. Best-Popescu, R. R. Dasari, G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[CrossRef] [PubMed]

S. K. Debnath, Y. Park, “Real-time quantitative phase imaging with a spatial phase-shifting algorithm,” Opt. Lett. 36(23), 4677–4679 (2011).
[CrossRef] [PubMed]

D. Fu, W. Choi, Y. Sung, S. Oh, Z. Yaqoob, Y. Park, R. R. Dasari, M. S. Feld, “Ultraviolet refractometry using field-based light scattering spectroscopy,” Opt. Express 17(21), 18878–18886 (2009).
[CrossRef] [PubMed]

Y. Park, T. Yamauchi, W. Choi, R. Dasari, M. S. Feld, “Spectroscopic phase microscopy for quantifying hemoglobin concentrations in intact red blood cells,” Opt. Lett. 34(23), 3668–3670 (2009).
[CrossRef] [PubMed]

Y. Park, G. Popescu, K. Badizadegan, R. R. Dasari, M. S. Feld, “Fresnel particle tracing in three dimensions using diffraction phase microscopy,” Opt. Lett. 32(7), 811–813 (2007).
[CrossRef] [PubMed]

Park, Y. K.

K. Lee, K. Kim, J. Jung, J. H. Heo, S. Cho, S. Lee, G. Chang, Y. J. Jo, H. Park, Y. K. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13(4), 4170–4191 (2013).
[CrossRef] [PubMed]

Patel, N.

A. Anand, V. Chhaniwal, N. Patel, B. Javidi, “Automatic identification of malaria-infected RBC with digital holographic microscopy using correlation algorithms,” IEEE Photonics J. 4(5), 1456–1464 (2012).
[CrossRef]

Peng, Z.

H. Byun, T. R. Hillman, J. M. Higgins, M. Diez-Silva, Z. Peng, M. Dao, R. R. Dasari, S. Suresh, Y. Park, “Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient,” Acta Biomater. 8(11), 4130–4138 (2012).
[CrossRef] [PubMed]

Perelman, L. T.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Pham, H.

Popescu, G.

H. Pham, B. Bhaduri, H. Ding, G. Popescu, “Spectroscopic diffraction phase microscopy,” Opt. Lett. 37(16), 3438–3440 (2012).
[CrossRef] [PubMed]

Y. Park, C. A. Best-Popescu, R. R. Dasari, G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[CrossRef] [PubMed]

H. Ding, E. Berl, Z. Wang, L. J. Millet, M. U. Gillette, J. Liu, M. Boppart, G. Popescu, “Fourier transform light scattering of biological structure and dynamics,” IEEE J. Sel. Top. Quantum Electron. 16(4), 909–918 (2010).
[CrossRef]

H. Ding, L. J. Millet, M. U. Gillette, G. Popescu, “Actin-driven cell dynamics probed by Fourier transform light scattering,” Biomed. Opt. Express 1(1), 260–267 (2010).
[CrossRef] [PubMed]

H. Ding, F. Nguyen, S. A. Boppart, G. Popescu, “Optical properties of tissues quantified by Fourier-transform light scattering,” Opt. Lett. 34(9), 1372–1374 (2009).
[CrossRef] [PubMed]

H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[CrossRef] [PubMed]

Y. Park, G. Popescu, K. Badizadegan, R. R. Dasari, M. S. Feld, “Fresnel particle tracing in three dimensions using diffraction phase microscopy,” Opt. Lett. 32(7), 811–813 (2007).
[CrossRef] [PubMed]

Qiu, L.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Rinehart, M. T.

A. Wax, M. G. Giacomelli, T. E. Matthews, M. T. Rinehart, F. E. Robles, Y. Zhu, “Optical spectroscopy of biological cells,” Adv. Opt. Photonics 4(3), 322–378 (2012).
[CrossRef]

Robles, F. E.

A. Wax, M. G. Giacomelli, T. E. Matthews, M. T. Rinehart, F. E. Robles, Y. Zhu, “Optical spectroscopy of biological cells,” Adv. Opt. Photonics 4(3), 322–378 (2012).
[CrossRef]

F. E. Robles, C. Wilson, G. Grant, A. Wax, “Molecular imaging true-colour spectroscopic optical coherence tomography,” Nat. Photonics 5(12), 744–747 (2011).
[CrossRef] [PubMed]

Rothe, T.

T. Rothe, M. Schmitz, A. Kienle, “Angular and spectrally resolved investigation of single particles by darkfield scattering microscopy,” J. Biomed. Opt. 17(11), 117006 (2012).
[CrossRef] [PubMed]

Sachs, B. P.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Salahuddin, S.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Sampson, D. D.

Schmitz, M.

T. Rothe, M. Schmitz, A. Kienle, “Angular and spectrally resolved investigation of single particles by darkfield scattering microscopy,” J. Biomed. Opt. 17(11), 117006 (2012).
[CrossRef] [PubMed]

Seo, J.-W.

C. Cho, H. Kim, S. Jeong, S.-W. Baek, J.-W. Seo, D. Han, K. Kim, Y. Park, S. Yoo, J.-Y. Lee, “Random and V-groove texturing for efficient light trapping in organic photovoltaic cells,” Sol. Energy Mater. Sol. Cells 115, 36–41 (2013).
[CrossRef]

Smith, Z. J.

Sung, Y.

Suresh, S.

H. Byun, T. R. Hillman, J. M. Higgins, M. Diez-Silva, Z. Peng, M. Dao, R. R. Dasari, S. Suresh, Y. Park, “Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient,” Acta Biomater. 8(11), 4130–4138 (2012).
[CrossRef] [PubMed]

Tscharnuter, W. W.

Vitkin, E.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Wang, Z.

H. Ding, E. Berl, Z. Wang, L. J. Millet, M. U. Gillette, J. Liu, M. Boppart, G. Popescu, “Fourier transform light scattering of biological structure and dynamics,” IEEE J. Sel. Top. Quantum Electron. 16(4), 909–918 (2010).
[CrossRef]

H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[CrossRef] [PubMed]

Wax, A.

A. Wax, M. G. Giacomelli, T. E. Matthews, M. T. Rinehart, F. E. Robles, Y. Zhu, “Optical spectroscopy of biological cells,” Adv. Opt. Photonics 4(3), 322–378 (2012).
[CrossRef]

F. E. Robles, C. Wilson, G. Grant, A. Wax, “Molecular imaging true-colour spectroscopic optical coherence tomography,” Nat. Photonics 5(12), 744–747 (2011).
[CrossRef] [PubMed]

Wilson, C.

F. E. Robles, C. Wilson, G. Grant, A. Wax, “Molecular imaging true-colour spectroscopic optical coherence tomography,” Nat. Photonics 5(12), 744–747 (2011).
[CrossRef] [PubMed]

Wilson, J. D.

Yamauchi, T.

Yaqoob, Z.

Yoo, S.

C. Cho, H. Kim, S. Jeong, S.-W. Baek, J.-W. Seo, D. Han, K. Kim, Y. Park, S. Yoo, J.-Y. Lee, “Random and V-groove texturing for efficient light trapping in organic photovoltaic cells,” Sol. Energy Mater. Sol. Cells 115, 36–41 (2013).
[CrossRef]

Yu, C.-C.

Yu, H.

Zaman, M. M.

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Zhu, Y.

A. Wax, M. G. Giacomelli, T. E. Matthews, M. T. Rinehart, F. E. Robles, Y. Zhu, “Optical spectroscopy of biological cells,” Adv. Opt. Photonics 4(3), 322–378 (2012).
[CrossRef]

Acta Biomater. (1)

H. Byun, T. R. Hillman, J. M. Higgins, M. Diez-Silva, Z. Peng, M. Dao, R. R. Dasari, S. Suresh, Y. Park, “Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient,” Acta Biomater. 8(11), 4130–4138 (2012).
[CrossRef] [PubMed]

Adv. Opt. Photonics (1)

A. Wax, M. G. Giacomelli, T. E. Matthews, M. T. Rinehart, F. E. Robles, Y. Zhu, “Optical spectroscopy of biological cells,” Adv. Opt. Photonics 4(3), 322–378 (2012).
[CrossRef]

Anal. Chem. (1)

J.-H. Jung, J. Jang, Y. Park, “Spectro-refractometry of individual microscopic objects using swept-source quantitative phase imaging,” Anal. Chem. 85(21), 10519–10525 (2013).
[CrossRef] [PubMed]

Annu. Rev. Biomed. Eng. (1)

N. N. Boustany, S. A. Boppart, V. Backman, “Microscopic imaging and spectroscopy with scattered light,” Annu. Rev. Biomed. Eng. 12(1), 285–314 (2010).
[CrossRef] [PubMed]

Appl. Opt. (2)

Biomed. Opt. Express (2)

IEEE J. Sel. Top. Quantum Electron. (1)

H. Ding, E. Berl, Z. Wang, L. J. Millet, M. U. Gillette, J. Liu, M. Boppart, G. Popescu, “Fourier transform light scattering of biological structure and dynamics,” IEEE J. Sel. Top. Quantum Electron. 16(4), 909–918 (2010).
[CrossRef]

IEEE Photonics J. (1)

A. Anand, V. Chhaniwal, N. Patel, B. Javidi, “Automatic identification of malaria-infected RBC with digital holographic microscopy using correlation algorithms,” IEEE Photonics J. 4(5), 1456–1464 (2012).
[CrossRef]

IEEE Trans. Biomed. Eng. (1)

S. Lee, W. Lu, “Using elastic light scattering of red blood cells to detect infection of malaria parasite,” IEEE Trans. Biomed. Eng. 59(1), 150–155 (2012).
[CrossRef] [PubMed]

J. Biomed. Opt. (2)

Y. Park, C. A. Best-Popescu, R. R. Dasari, G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[CrossRef] [PubMed]

T. Rothe, M. Schmitz, A. Kienle, “Angular and spectrally resolved investigation of single particles by darkfield scattering microscopy,” J. Biomed. Opt. 17(11), 117006 (2012).
[CrossRef] [PubMed]

Nat. Photonics (1)

F. E. Robles, C. Wilson, G. Grant, A. Wax, “Molecular imaging true-colour spectroscopic optical coherence tomography,” Nat. Photonics 5(12), 744–747 (2011).
[CrossRef] [PubMed]

Opt. Express (5)

Opt. Lett. (10)

Y. Park, G. Popescu, K. Badizadegan, R. R. Dasari, M. S. Feld, “Fresnel particle tracing in three dimensions using diffraction phase microscopy,” Opt. Lett. 32(7), 811–813 (2007).
[CrossRef] [PubMed]

W. J. Cottrell, J. D. Wilson, T. H. Foster, “Microscope enabling multimodality imaging, angle-resolved scattering, and scattering spectroscopy,” Opt. Lett. 32(16), 2348–2350 (2007).
[CrossRef] [PubMed]

W. Choi, C.-C. Yu, C. Fang-Yen, K. Badizadegan, R. R. Dasari, M. S. Feld, “Field-based angle-resolved light-scattering study of single live cells,” Opt. Lett. 33(14), 1596–1598 (2008).
[CrossRef] [PubMed]

Y. Park, T. Yamauchi, W. Choi, R. Dasari, M. S. Feld, “Spectroscopic phase microscopy for quantifying hemoglobin concentrations in intact red blood cells,” Opt. Lett. 34(23), 3668–3670 (2009).
[CrossRef] [PubMed]

H. Ding, F. Nguyen, S. A. Boppart, G. Popescu, “Optical properties of tissues quantified by Fourier-transform light scattering,” Opt. Lett. 34(9), 1372–1374 (2009).
[CrossRef] [PubMed]

H. Yu, H. Park, Y. Kim, M. W. Kim, Y. Park, “Fourier-transform light scattering of individual colloidal clusters,” Opt. Lett. 37(13), 2577–2579 (2012).
[CrossRef] [PubMed]

H. Pham, B. Bhaduri, H. Ding, G. Popescu, “Spectroscopic diffraction phase microscopy,” Opt. Lett. 37(16), 3438–3440 (2012).
[CrossRef] [PubMed]

K. Kim, Y. Park, “Fourier transform light scattering angular spectroscopy using digital inline holography,” Opt. Lett. 37(19), 4161–4163 (2012).
[CrossRef] [PubMed]

S. K. Debnath, Y. Park, “Real-time quantitative phase imaging with a spatial phase-shifting algorithm,” Opt. Lett. 36(23), 4677–4679 (2011).
[CrossRef] [PubMed]

Y. Liu, X. Li, Y. L. Kim, V. Backman, “Elastic backscattering spectroscopic microscopy,” Opt. Lett. 30(18), 2445–2447 (2005).
[CrossRef] [PubMed]

Phys. Rev. Lett. (1)

H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[CrossRef] [PubMed]

Proc. Natl. Acad. Sci. U. S. A. (1)

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U. S. A. 104(44), 17255–17260 (2007).
[CrossRef] [PubMed]

Sensors (1)

K. Lee, K. Kim, J. Jung, J. H. Heo, S. Cho, S. Lee, G. Chang, Y. J. Jo, H. Park, Y. K. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors 13(4), 4170–4191 (2013).
[CrossRef] [PubMed]

Sol. Energy Mater. Sol. Cells (1)

C. Cho, H. Kim, S. Jeong, S.-W. Baek, J.-W. Seo, D. Han, K. Kim, Y. Park, S. Yoo, J.-Y. Lee, “Random and V-groove texturing for efficient light trapping in organic photovoltaic cells,” Sol. Energy Mater. Sol. Cells 115, 36–41 (2013).
[CrossRef]

Trends Biotechnol. (1)

S. Cho, S. Kim, Y. Kim, Y. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
[CrossRef] [PubMed]

Other (3)

J.-P. Schäfer, “Implementierung und Anwendung analytischer und numerischer Verfahren zur Lösung der Maxwellgleichungen für die Untersuchung der Lichtausbreitung in biologischem Gewebe,” (Ulm, Universität Ulm, Diss., 2011).

G. Popescu, Quantitative Phase Imaging of Cells and Tissues (McGraw-Hill, 2011).

H. C. d. Hulst, Light Scattering by Small Particles, Structure of Matter Series (Wiley, 1957).

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (4)

Fig. 1
Fig. 1

ssFTLS procedure for measuring the spectro-angular light scattering. (a) The holograms of a sample are recorded at various wavelengths; (b) the corresponding optical fields are obtained using an appropriate retrieval algorithm; (c) the angle-resolved scattering signals at each wavelength are calculated using FTLS; and the scattering signals are presented as a function of the (d) scattering angle and (e) wavelength after averaging in the azimuthal direction.

Fig. 2
Fig. 2

Spectro-angular light scattering measurements of a polystyrene bead submersed in a PBS solution. (a) The average scattering intensity of nine samples measured using ssFTLS; (b) the theoretical scattering intensity calculated using the Mie theory; and (c) for comparison, the experimental results from (a) and the theory from (b) are plotted together at five representative wavelengths [i.e. the black dashed lines in (a) and (b)]. The color-shaded areas represent the standard deviations for the nine measurements.

Fig. 3
Fig. 3

Spectro-angular light scattering measurement of a polystyrene bead submersed in the BSA solution. (a) The average scattering intensity of the nine samples measured using ssFTLS; (b) the theoretical scattering intensity calculated using the Mie theory; and (c) for comparison, the experimental results from (a) and the theory from (b) are plotted together at five representative wavelengths [i.e. the black dashed lines in (a) and (b)]. The color-shaded areas represent the standard deviations for the nine measurements.

Fig. 4
Fig. 4

The optical phases of the spectro-angular light scattering. (a) and (b) The optical phase of the spectro-angular light scattering from a polystyrene bead submersed in a PBS solution (a) measured using ssFTLS and (b) calculated from the Mie theory. (c) and (d) The optical phase of the spectro-angular light scattering from a polystyrene bead submersed in a 30% BSA solution (c) measured using ssFTLS and (d) calculated from the Mie theory.

Equations (2)

Equations on this page are rendered with MathJax. Learn more.

U s ( k x , k y ;λ )= 1 2π U( x,y;λ )exp[ j( k x x+ k y y ) ]dxdy ,
U s ( k x , k y ;λ )=| U s ( k x , k y ;λ ) |exp[ jϕ( k x , k y ;λ) ] ,

Metrics