Abstract

We present a way to generate acousto-optical signals in timovssue-like media with nanosecond laser pulses. Our method is based on recording and analyzing speckle patterns formed by interaction of nanosecond laser pulses with tissue, without and with simultaneous application of ultrasound. Stroboscopic application allows visualizing the temporal behavior of speckles while the ultrasound is propagating through the medium. We investigate two ways of quantifying the acousto-optic effect, viz. adding and subtracting speckle patterns obtained at various ultrasound phases. Both methods are compared with the existing speckle contrast method using a 2D scan and are found to perform similarly. Our method gives outlook on overcoming the speckle decorrelation problem in acousto-optics, and therefore brings in-vivo acousto-optic measurements one step closer. Furthermore it enables combining acousto-optics and photoacoustics in one setup with a single laser.

© 2014 Optical Society of America

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2012

S. G. Resink, A. C. Boccara, W. Steenbergen, “State-of-the art of acousto-optic sensing and imaging of turbid media,” J. Biomed. Opt. 17(4), 040901 (2012).
[CrossRef] [PubMed]

K. Daoudi, A. Hussain, E. Hondebrink, W. Steenbergen, “Correcting photoacoustic signals for fluence variations using acousto-optic modulation,” Opt. Express 20(13), 14117–14129 (2012).
[CrossRef] [PubMed]

2011

D. S. Elson, R. Li, C. Dunsby, R. Eckersley, M. X. Tang, “Ultrasound-mediated optical tomography: a review of current methods,” Interface Focus 1(4), 632–648 (2011).
[CrossRef] [PubMed]

2007

2002

2001

L. H. V. Wang, “Mechanisms of ultrasonic modulation of multiply scattered coherent light: An analytic model,” Phys Rev Lett. 87(4), 043903 (2001).

2000

1995

Boccara, A. C.

Daoudi, K.

Delaye, P.

Dunsby, C.

D. S. Elson, R. Li, C. Dunsby, R. Eckersley, M. X. Tang, “Ultrasound-mediated optical tomography: a review of current methods,” Interface Focus 1(4), 632–648 (2011).
[CrossRef] [PubMed]

Eckersley, R.

D. S. Elson, R. Li, C. Dunsby, R. Eckersley, M. X. Tang, “Ultrasound-mediated optical tomography: a review of current methods,” Interface Focus 1(4), 632–648 (2011).
[CrossRef] [PubMed]

Elson, D. S.

D. S. Elson, R. Li, C. Dunsby, R. Eckersley, M. X. Tang, “Ultrasound-mediated optical tomography: a review of current methods,” Interface Focus 1(4), 632–648 (2011).
[CrossRef] [PubMed]

Gross, M.

Hondebrink, E.

Hussain, A.

Jacques, S. L.

Jean, F.

Ku, G.

Lesaffre, M.

Leutz, W.

W. Leutz, G. Maret, “Ultrasonic modulation of multiply scattered-light,” Physica B 204(1-4), 14–19 (1995).
[CrossRef]

Lévêque-Fort, S.

Li, J.

Li, R.

D. S. Elson, R. Li, C. Dunsby, R. Eckersley, M. X. Tang, “Ultrasound-mediated optical tomography: a review of current methods,” Interface Focus 1(4), 632–648 (2011).
[CrossRef] [PubMed]

Maret, G.

W. Leutz, G. Maret, “Ultrasonic modulation of multiply scattered-light,” Physica B 204(1-4), 14–19 (1995).
[CrossRef]

Ramaz, F.

Resink, S. G.

S. G. Resink, A. C. Boccara, W. Steenbergen, “State-of-the art of acousto-optic sensing and imaging of turbid media,” J. Biomed. Opt. 17(4), 040901 (2012).
[CrossRef] [PubMed]

Roosen, G.

Steenbergen, W.

S. G. Resink, A. C. Boccara, W. Steenbergen, “State-of-the art of acousto-optic sensing and imaging of turbid media,” J. Biomed. Opt. 17(4), 040901 (2012).
[CrossRef] [PubMed]

K. Daoudi, A. Hussain, E. Hondebrink, W. Steenbergen, “Correcting photoacoustic signals for fluence variations using acousto-optic modulation,” Opt. Express 20(13), 14117–14129 (2012).
[CrossRef] [PubMed]

Tang, M. X.

D. S. Elson, R. Li, C. Dunsby, R. Eckersley, M. X. Tang, “Ultrasound-mediated optical tomography: a review of current methods,” Interface Focus 1(4), 632–648 (2011).
[CrossRef] [PubMed]

Wang, L. H.

Wang, L. H. V.

L. H. V. Wang, “Mechanisms of ultrasonic modulation of multiply scattered coherent light: An analytic model,” Phys Rev Lett. 87(4), 043903 (2001).

Wang, L. V.

Zhao, X. M.

Appl. Opt.

Interface Focus

D. S. Elson, R. Li, C. Dunsby, R. Eckersley, M. X. Tang, “Ultrasound-mediated optical tomography: a review of current methods,” Interface Focus 1(4), 632–648 (2011).
[CrossRef] [PubMed]

J. Biomed. Opt.

S. G. Resink, A. C. Boccara, W. Steenbergen, “State-of-the art of acousto-optic sensing and imaging of turbid media,” J. Biomed. Opt. 17(4), 040901 (2012).
[CrossRef] [PubMed]

Opt. Express

Opt. Lett.

Phys Rev Lett.

L. H. V. Wang, “Mechanisms of ultrasonic modulation of multiply scattered coherent light: An analytic model,” Phys Rev Lett. 87(4), 043903 (2001).

Physica B

W. Leutz, G. Maret, “Ultrasonic modulation of multiply scattered-light,” Physica B 204(1-4), 14–19 (1995).
[CrossRef]

Other

A. Hussain, K. Daoudi, E. Hondebrink, and W. Steenbergen, “Quantitative Photoacoustic Imaging by Acousto-Optically Measured Light Fluence,” in OSA Technical Digest (Optical Society of America, 2012), BM2B.5.

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