Abstract

We report emission spectrum measurements on single YxEu1-xVO4 nanoparticles. The inhomogeneous widths of the emission peaks are identical for single nanoparticles and for ensembles of nanoparticles, while being broader than those of the bulk material. This indicates that individual nanoparticles are identical in terms of the distribution of different local Eu3+ sites due to crystalline defects and confirms their usability as identical, single-particle oxidant biosensors. Moreover, we report a 465 nm solid-state laser based on sum-frequency mixing that provides a compact, efficient solution for direct Eu3+ excitation of these nanoparticles. Both these two aspects should broaden the scope of Eu-doped nanoparticle applications.

© 2014 Optical Society of America

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  1. C. Bouzigues, T. Gacoin, and A. Alexandrou, “Biological applications of rare-earth based nanoparticles,” ACS Nano 5(11), 8488–8505 (2011).
    [CrossRef] [PubMed]
  2. K. Riwotzki and M. Haase, “Wet-chemical synthesis of doped colloidal nanoparticles: YVO4:Ln (Ln = Eu, Sm, Dy),” J. Phys. Chem. B 102(50), 10129–10135 (1998).
    [CrossRef]
  3. A. Huignard, T. Gacoin, and J.-P. Boilot, “Synthesis and luminescence properties of colloidal YVO4:Eu phosphors,” Chem. Mater. 12(4), 1090–1094 (2000).
    [CrossRef]
  4. A. Son, A. Dhirapong, D. K. Dosev, I. M. Kennedy, R. H. Weiss, and K. R. Hristova, “Rapid and quantitative DNA analysis of genetic mutations for polycystic kidney disease (PKD) using magnetic/luminescent nanoparticles,” Anal. Bioanal. Chem. 390(7), 1829–1835 (2008).
    [CrossRef] [PubMed]
  5. D. Dosev, M. Nichkova, M. Liu, B. Guo, G. Y. Liu, B. D. Hammock, and I. M. Kennedy, “Application of luminescent Eu:Gd2O3 nanoparticles to the visualization of protein micropatterns,” J. Biomed. Opt. 10(6), 064006 (2005).
    [CrossRef] [PubMed]
  6. E. Beaurepaire, V. Buissette, M.-P. Sauviat, D. Giaume, K. Lahlil, A. Mercuri, D. Casanova, A. Huignard, J.-L. Martin, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Functionalized fluorescent oxide nanoparticles: artificial toxins for sodium channel targeting and imaging at the single-molecule level,” Nano Lett. 4(11), 2079–2083 (2004).
    [CrossRef]
  7. J.-B. Masson, D. Casanova, S. Türkcan, G. Voisinne, M. R. Popoff, M. Vergassola, and A. Alexandrou, “Inferring maps of forces inside cell membrane microdomains,” Phys. Rev. Lett. 102(4), 048103 (2009).
    [CrossRef] [PubMed]
  8. S. Türkcan, J.-B. Masson, D. Casanova, G. Mialon, T. Gacoin, J.-P. Boilot, M. R. Popoff, and A. Alexandrou, “Observing the confinement potential of bacterial pore-forming toxin receptors inside rafts with nonblinking Eu3+-doped oxide nanoparticles,” Biophys. J. 102(10), 2299–2308 (2012).
    [CrossRef] [PubMed]
  9. S. Türkcan, M. U. Richly, A. Alexandrou, and J.-B. Masson, “Probing membrane protein interactions with their lipid raft environment using single-molecule tracking and Bayesian inference analysis,” PLoS ONE 8(1), e53073 (2013).
    [CrossRef] [PubMed]
  10. S. Türkcan, M. U. Richly, C. I. Bouzigues, J.-M. Allain, and A. Alexandrou, “Receptor displacement in the cell membrane by hydrodynamic force amplification through nanoparticles,” Biophys. J. 105(1), 116–126 (2013).
    [CrossRef] [PubMed]
  11. D. Casanova, C. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, L. Bouzhir-Sima, T. Gacoin, J.-P. Boilot, P.-L. Tharaux, and A. Alexandrou, “Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells,” Nat. Nanotechnol. 4(9), 581–585 (2009).
    [CrossRef] [PubMed]
  12. C. I. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, A. Claeson, P.-L. Tharaux, and A. Alexandrou, “Regulation of the ROS response dynamics and organization to PDGF motile stimuli revealed by single nanoparticle imaging,” Chem. Biol. 21(5), 647–656 (2014).
    [CrossRef] [PubMed]
  13. M. Schoeffel, M. Abdesselem, I. Maurin, G. Autret, O. Clément, J.-P. Boilot, T. Gacoin, C.I. Bouzigues, and A. Alexandrou, Submitted.
  14. D. Casanova, D. Giaume, E. Beaurepaire, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Optical in situ size determination of single lanthanide-ion doped oxide nanoparticles,” Appl. Phys. Lett. 89(25), 253103 (2006).
    [CrossRef]
  15. K. Riwotzki and M. Haase, “Colloidal YVO4:Eu and YP0.95V0.05O4:Eu nanoparticles: luminescence and energy transfer processes,” J. Phys. Chem. B 105(51), 12709–12713 (2001).
    [CrossRef]
  16. A. Huignard, V. Buissette, A.-C. Franville, T. Gacoin, and J.-P. Boilot, “Emission processes in YVO4:Eu nanoparticles,” J. Phys. Chem. B 107(28), 6754–6759 (2003).
    [CrossRef]
  17. G. Mialon, M. Gohin, T. Gacoin, and J.-P. Boilot, “High temperature strategy for oxide nanoparticle synthesis,” ACS Nano 2(12), 2505–2512 (2008).
    [CrossRef] [PubMed]
  18. G. Mialon, S. Türkcan, A. Alexandrou, T. Gacoin, and J.-P. Boilot, “New insights into size effects in luminescent oxide nanocrystals,” J. Phys. Chem. C 113(43), 18699–18706 (2009).
    [CrossRef]
  19. To our knowledge, only the company Modulight proposes custom-made diode lasers at 465 nm, www.modulight.com .
  20. D. Woll, B. Beier, K. J. Boller, R. Wallenstein, M. Hagberg, and S. O’Brien, “1 W of blue 465-nm radiation generated by frequency doubling of the output of a high-power diode laser in critically phase-matched LiB3O5.,” Opt. Lett. 24(10), 691–693 (1999).
    [CrossRef] [PubMed]
  21. K. Li, H. Wang, N. J. Copner, C. B. E. Gawith, I. G. Knight, H.-U. Pfeiffer, B. Musk, and G. Moss, “465 nm laser sources by intracavity frequency doubling using a 49-edge-emitters laser bar,” Opt. Lett. 36(3), 361–363 (2011).
    [CrossRef] [PubMed]
  22. Y. L. Li, H. L. Jiang, W. Liang, T. Y. Ni, T. Y. Zhang, Z. H. Tao, and Y. H. Zeng, “Quasi-three level laser based on diode-pumped Nd3+:YAlO3 crystal,” Laser Phys. 21(5), 897–900 (2011).
    [CrossRef]
  23. T. Baer, “Large-amplitude fluctuations due to longitudinal mode-coupling in diode-pumped intracavity-doubled Nd-YAG lasers,” J. Opt. Soc. Am. B 3(9), 1175–1180 (1986).
    [CrossRef]
  24. P. J. Cutler, M. D. Malik, S. Liu, J. M. Byars, D. S. Lidke, and K. A. Lidke, “Multi-color quantum dot tracking using a high-speed hyperspectral line-scanning microscope,” PLoS ONE 8(5), e64320 (2013).
    [CrossRef] [PubMed]
  25. C. Brecher, H. Samelson, A. Lempicki, R. Riley, and T. Peters, “Polarized spectra and crystal-field parameters of Eu+3 in YVO4,” Phys. Rev. 155(2), 178–187 (1967).
    [CrossRef]
  26. B. R. Judd, “Optical absorption intensities of rare-earth ions,” Phys. Rev. 127(3), 750–761 (1962).
    [CrossRef]
  27. G. S. Ofelt, “Intensities of crystal spectra of rare-earth ions,” J. Chem. Phys. 37(3), 511 (1962).
    [CrossRef]
  28. O. Lehmann, K. Kömpe, and M. Haase, “Synthesis of Eu3+-doped core and core/shell nanoparticles and direct spectroscopic identification of dopant sites at the surface and in the interior of the particles,” J. Am. Chem. Soc. 126(45), 14935–14942 (2004).
    [CrossRef] [PubMed]
  29. B. Fleury, M. A. Neouze, J. M. Guigner, N. Menguy, O. Spalla, T. Gacoin, and D. Carriere, “Amorphous to crystal conversion as a mechanism governing the structure of luminescent YVO4:Eu nanoparticles,” ACS Nano 8(3), 2602–2608 (2014).
    [CrossRef] [PubMed]

2014

C. I. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, A. Claeson, P.-L. Tharaux, and A. Alexandrou, “Regulation of the ROS response dynamics and organization to PDGF motile stimuli revealed by single nanoparticle imaging,” Chem. Biol. 21(5), 647–656 (2014).
[CrossRef] [PubMed]

B. Fleury, M. A. Neouze, J. M. Guigner, N. Menguy, O. Spalla, T. Gacoin, and D. Carriere, “Amorphous to crystal conversion as a mechanism governing the structure of luminescent YVO4:Eu nanoparticles,” ACS Nano 8(3), 2602–2608 (2014).
[CrossRef] [PubMed]

2013

P. J. Cutler, M. D. Malik, S. Liu, J. M. Byars, D. S. Lidke, and K. A. Lidke, “Multi-color quantum dot tracking using a high-speed hyperspectral line-scanning microscope,” PLoS ONE 8(5), e64320 (2013).
[CrossRef] [PubMed]

S. Türkcan, M. U. Richly, A. Alexandrou, and J.-B. Masson, “Probing membrane protein interactions with their lipid raft environment using single-molecule tracking and Bayesian inference analysis,” PLoS ONE 8(1), e53073 (2013).
[CrossRef] [PubMed]

S. Türkcan, M. U. Richly, C. I. Bouzigues, J.-M. Allain, and A. Alexandrou, “Receptor displacement in the cell membrane by hydrodynamic force amplification through nanoparticles,” Biophys. J. 105(1), 116–126 (2013).
[CrossRef] [PubMed]

2012

S. Türkcan, J.-B. Masson, D. Casanova, G. Mialon, T. Gacoin, J.-P. Boilot, M. R. Popoff, and A. Alexandrou, “Observing the confinement potential of bacterial pore-forming toxin receptors inside rafts with nonblinking Eu3+-doped oxide nanoparticles,” Biophys. J. 102(10), 2299–2308 (2012).
[CrossRef] [PubMed]

2011

C. Bouzigues, T. Gacoin, and A. Alexandrou, “Biological applications of rare-earth based nanoparticles,” ACS Nano 5(11), 8488–8505 (2011).
[CrossRef] [PubMed]

Y. L. Li, H. L. Jiang, W. Liang, T. Y. Ni, T. Y. Zhang, Z. H. Tao, and Y. H. Zeng, “Quasi-three level laser based on diode-pumped Nd3+:YAlO3 crystal,” Laser Phys. 21(5), 897–900 (2011).
[CrossRef]

K. Li, H. Wang, N. J. Copner, C. B. E. Gawith, I. G. Knight, H.-U. Pfeiffer, B. Musk, and G. Moss, “465 nm laser sources by intracavity frequency doubling using a 49-edge-emitters laser bar,” Opt. Lett. 36(3), 361–363 (2011).
[CrossRef] [PubMed]

2009

G. Mialon, S. Türkcan, A. Alexandrou, T. Gacoin, and J.-P. Boilot, “New insights into size effects in luminescent oxide nanocrystals,” J. Phys. Chem. C 113(43), 18699–18706 (2009).
[CrossRef]

D. Casanova, C. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, L. Bouzhir-Sima, T. Gacoin, J.-P. Boilot, P.-L. Tharaux, and A. Alexandrou, “Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells,” Nat. Nanotechnol. 4(9), 581–585 (2009).
[CrossRef] [PubMed]

J.-B. Masson, D. Casanova, S. Türkcan, G. Voisinne, M. R. Popoff, M. Vergassola, and A. Alexandrou, “Inferring maps of forces inside cell membrane microdomains,” Phys. Rev. Lett. 102(4), 048103 (2009).
[CrossRef] [PubMed]

2008

A. Son, A. Dhirapong, D. K. Dosev, I. M. Kennedy, R. H. Weiss, and K. R. Hristova, “Rapid and quantitative DNA analysis of genetic mutations for polycystic kidney disease (PKD) using magnetic/luminescent nanoparticles,” Anal. Bioanal. Chem. 390(7), 1829–1835 (2008).
[CrossRef] [PubMed]

G. Mialon, M. Gohin, T. Gacoin, and J.-P. Boilot, “High temperature strategy for oxide nanoparticle synthesis,” ACS Nano 2(12), 2505–2512 (2008).
[CrossRef] [PubMed]

2006

D. Casanova, D. Giaume, E. Beaurepaire, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Optical in situ size determination of single lanthanide-ion doped oxide nanoparticles,” Appl. Phys. Lett. 89(25), 253103 (2006).
[CrossRef]

2005

D. Dosev, M. Nichkova, M. Liu, B. Guo, G. Y. Liu, B. D. Hammock, and I. M. Kennedy, “Application of luminescent Eu:Gd2O3 nanoparticles to the visualization of protein micropatterns,” J. Biomed. Opt. 10(6), 064006 (2005).
[CrossRef] [PubMed]

2004

E. Beaurepaire, V. Buissette, M.-P. Sauviat, D. Giaume, K. Lahlil, A. Mercuri, D. Casanova, A. Huignard, J.-L. Martin, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Functionalized fluorescent oxide nanoparticles: artificial toxins for sodium channel targeting and imaging at the single-molecule level,” Nano Lett. 4(11), 2079–2083 (2004).
[CrossRef]

O. Lehmann, K. Kömpe, and M. Haase, “Synthesis of Eu3+-doped core and core/shell nanoparticles and direct spectroscopic identification of dopant sites at the surface and in the interior of the particles,” J. Am. Chem. Soc. 126(45), 14935–14942 (2004).
[CrossRef] [PubMed]

2003

A. Huignard, V. Buissette, A.-C. Franville, T. Gacoin, and J.-P. Boilot, “Emission processes in YVO4:Eu nanoparticles,” J. Phys. Chem. B 107(28), 6754–6759 (2003).
[CrossRef]

2001

K. Riwotzki and M. Haase, “Colloidal YVO4:Eu and YP0.95V0.05O4:Eu nanoparticles: luminescence and energy transfer processes,” J. Phys. Chem. B 105(51), 12709–12713 (2001).
[CrossRef]

2000

A. Huignard, T. Gacoin, and J.-P. Boilot, “Synthesis and luminescence properties of colloidal YVO4:Eu phosphors,” Chem. Mater. 12(4), 1090–1094 (2000).
[CrossRef]

1999

1998

K. Riwotzki and M. Haase, “Wet-chemical synthesis of doped colloidal nanoparticles: YVO4:Ln (Ln = Eu, Sm, Dy),” J. Phys. Chem. B 102(50), 10129–10135 (1998).
[CrossRef]

1986

1967

C. Brecher, H. Samelson, A. Lempicki, R. Riley, and T. Peters, “Polarized spectra and crystal-field parameters of Eu+3 in YVO4,” Phys. Rev. 155(2), 178–187 (1967).
[CrossRef]

1962

B. R. Judd, “Optical absorption intensities of rare-earth ions,” Phys. Rev. 127(3), 750–761 (1962).
[CrossRef]

G. S. Ofelt, “Intensities of crystal spectra of rare-earth ions,” J. Chem. Phys. 37(3), 511 (1962).
[CrossRef]

Abdesselem, M.

M. Schoeffel, M. Abdesselem, I. Maurin, G. Autret, O. Clément, J.-P. Boilot, T. Gacoin, C.I. Bouzigues, and A. Alexandrou, Submitted.

Alexandrou, A.

C. I. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, A. Claeson, P.-L. Tharaux, and A. Alexandrou, “Regulation of the ROS response dynamics and organization to PDGF motile stimuli revealed by single nanoparticle imaging,” Chem. Biol. 21(5), 647–656 (2014).
[CrossRef] [PubMed]

S. Türkcan, M. U. Richly, C. I. Bouzigues, J.-M. Allain, and A. Alexandrou, “Receptor displacement in the cell membrane by hydrodynamic force amplification through nanoparticles,” Biophys. J. 105(1), 116–126 (2013).
[CrossRef] [PubMed]

S. Türkcan, M. U. Richly, A. Alexandrou, and J.-B. Masson, “Probing membrane protein interactions with their lipid raft environment using single-molecule tracking and Bayesian inference analysis,” PLoS ONE 8(1), e53073 (2013).
[CrossRef] [PubMed]

S. Türkcan, J.-B. Masson, D. Casanova, G. Mialon, T. Gacoin, J.-P. Boilot, M. R. Popoff, and A. Alexandrou, “Observing the confinement potential of bacterial pore-forming toxin receptors inside rafts with nonblinking Eu3+-doped oxide nanoparticles,” Biophys. J. 102(10), 2299–2308 (2012).
[CrossRef] [PubMed]

C. Bouzigues, T. Gacoin, and A. Alexandrou, “Biological applications of rare-earth based nanoparticles,” ACS Nano 5(11), 8488–8505 (2011).
[CrossRef] [PubMed]

D. Casanova, C. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, L. Bouzhir-Sima, T. Gacoin, J.-P. Boilot, P.-L. Tharaux, and A. Alexandrou, “Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells,” Nat. Nanotechnol. 4(9), 581–585 (2009).
[CrossRef] [PubMed]

G. Mialon, S. Türkcan, A. Alexandrou, T. Gacoin, and J.-P. Boilot, “New insights into size effects in luminescent oxide nanocrystals,” J. Phys. Chem. C 113(43), 18699–18706 (2009).
[CrossRef]

J.-B. Masson, D. Casanova, S. Türkcan, G. Voisinne, M. R. Popoff, M. Vergassola, and A. Alexandrou, “Inferring maps of forces inside cell membrane microdomains,” Phys. Rev. Lett. 102(4), 048103 (2009).
[CrossRef] [PubMed]

D. Casanova, D. Giaume, E. Beaurepaire, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Optical in situ size determination of single lanthanide-ion doped oxide nanoparticles,” Appl. Phys. Lett. 89(25), 253103 (2006).
[CrossRef]

E. Beaurepaire, V. Buissette, M.-P. Sauviat, D. Giaume, K. Lahlil, A. Mercuri, D. Casanova, A. Huignard, J.-L. Martin, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Functionalized fluorescent oxide nanoparticles: artificial toxins for sodium channel targeting and imaging at the single-molecule level,” Nano Lett. 4(11), 2079–2083 (2004).
[CrossRef]

M. Schoeffel, M. Abdesselem, I. Maurin, G. Autret, O. Clément, J.-P. Boilot, T. Gacoin, C.I. Bouzigues, and A. Alexandrou, Submitted.

Allain, J.-M.

S. Türkcan, M. U. Richly, C. I. Bouzigues, J.-M. Allain, and A. Alexandrou, “Receptor displacement in the cell membrane by hydrodynamic force amplification through nanoparticles,” Biophys. J. 105(1), 116–126 (2013).
[CrossRef] [PubMed]

Autret, G.

M. Schoeffel, M. Abdesselem, I. Maurin, G. Autret, O. Clément, J.-P. Boilot, T. Gacoin, C.I. Bouzigues, and A. Alexandrou, Submitted.

Baer, T.

Beaurepaire, E.

D. Casanova, D. Giaume, E. Beaurepaire, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Optical in situ size determination of single lanthanide-ion doped oxide nanoparticles,” Appl. Phys. Lett. 89(25), 253103 (2006).
[CrossRef]

E. Beaurepaire, V. Buissette, M.-P. Sauviat, D. Giaume, K. Lahlil, A. Mercuri, D. Casanova, A. Huignard, J.-L. Martin, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Functionalized fluorescent oxide nanoparticles: artificial toxins for sodium channel targeting and imaging at the single-molecule level,” Nano Lett. 4(11), 2079–2083 (2004).
[CrossRef]

Beier, B.

Boilot, J.-P.

S. Türkcan, J.-B. Masson, D. Casanova, G. Mialon, T. Gacoin, J.-P. Boilot, M. R. Popoff, and A. Alexandrou, “Observing the confinement potential of bacterial pore-forming toxin receptors inside rafts with nonblinking Eu3+-doped oxide nanoparticles,” Biophys. J. 102(10), 2299–2308 (2012).
[CrossRef] [PubMed]

D. Casanova, C. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, L. Bouzhir-Sima, T. Gacoin, J.-P. Boilot, P.-L. Tharaux, and A. Alexandrou, “Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells,” Nat. Nanotechnol. 4(9), 581–585 (2009).
[CrossRef] [PubMed]

G. Mialon, S. Türkcan, A. Alexandrou, T. Gacoin, and J.-P. Boilot, “New insights into size effects in luminescent oxide nanocrystals,” J. Phys. Chem. C 113(43), 18699–18706 (2009).
[CrossRef]

G. Mialon, M. Gohin, T. Gacoin, and J.-P. Boilot, “High temperature strategy for oxide nanoparticle synthesis,” ACS Nano 2(12), 2505–2512 (2008).
[CrossRef] [PubMed]

D. Casanova, D. Giaume, E. Beaurepaire, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Optical in situ size determination of single lanthanide-ion doped oxide nanoparticles,” Appl. Phys. Lett. 89(25), 253103 (2006).
[CrossRef]

E. Beaurepaire, V. Buissette, M.-P. Sauviat, D. Giaume, K. Lahlil, A. Mercuri, D. Casanova, A. Huignard, J.-L. Martin, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Functionalized fluorescent oxide nanoparticles: artificial toxins for sodium channel targeting and imaging at the single-molecule level,” Nano Lett. 4(11), 2079–2083 (2004).
[CrossRef]

A. Huignard, V. Buissette, A.-C. Franville, T. Gacoin, and J.-P. Boilot, “Emission processes in YVO4:Eu nanoparticles,” J. Phys. Chem. B 107(28), 6754–6759 (2003).
[CrossRef]

A. Huignard, T. Gacoin, and J.-P. Boilot, “Synthesis and luminescence properties of colloidal YVO4:Eu phosphors,” Chem. Mater. 12(4), 1090–1094 (2000).
[CrossRef]

M. Schoeffel, M. Abdesselem, I. Maurin, G. Autret, O. Clément, J.-P. Boilot, T. Gacoin, C.I. Bouzigues, and A. Alexandrou, Submitted.

Boller, K. J.

Bouzhir-Sima, L.

D. Casanova, C. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, L. Bouzhir-Sima, T. Gacoin, J.-P. Boilot, P.-L. Tharaux, and A. Alexandrou, “Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells,” Nat. Nanotechnol. 4(9), 581–585 (2009).
[CrossRef] [PubMed]

Bouzigues, C.

C. Bouzigues, T. Gacoin, and A. Alexandrou, “Biological applications of rare-earth based nanoparticles,” ACS Nano 5(11), 8488–8505 (2011).
[CrossRef] [PubMed]

D. Casanova, C. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, L. Bouzhir-Sima, T. Gacoin, J.-P. Boilot, P.-L. Tharaux, and A. Alexandrou, “Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells,” Nat. Nanotechnol. 4(9), 581–585 (2009).
[CrossRef] [PubMed]

Bouzigues, C. I.

C. I. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, A. Claeson, P.-L. Tharaux, and A. Alexandrou, “Regulation of the ROS response dynamics and organization to PDGF motile stimuli revealed by single nanoparticle imaging,” Chem. Biol. 21(5), 647–656 (2014).
[CrossRef] [PubMed]

S. Türkcan, M. U. Richly, C. I. Bouzigues, J.-M. Allain, and A. Alexandrou, “Receptor displacement in the cell membrane by hydrodynamic force amplification through nanoparticles,” Biophys. J. 105(1), 116–126 (2013).
[CrossRef] [PubMed]

Bouzigues, C.I.

M. Schoeffel, M. Abdesselem, I. Maurin, G. Autret, O. Clément, J.-P. Boilot, T. Gacoin, C.I. Bouzigues, and A. Alexandrou, Submitted.

Brecher, C.

C. Brecher, H. Samelson, A. Lempicki, R. Riley, and T. Peters, “Polarized spectra and crystal-field parameters of Eu+3 in YVO4,” Phys. Rev. 155(2), 178–187 (1967).
[CrossRef]

Buissette, V.

E. Beaurepaire, V. Buissette, M.-P. Sauviat, D. Giaume, K. Lahlil, A. Mercuri, D. Casanova, A. Huignard, J.-L. Martin, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Functionalized fluorescent oxide nanoparticles: artificial toxins for sodium channel targeting and imaging at the single-molecule level,” Nano Lett. 4(11), 2079–2083 (2004).
[CrossRef]

A. Huignard, V. Buissette, A.-C. Franville, T. Gacoin, and J.-P. Boilot, “Emission processes in YVO4:Eu nanoparticles,” J. Phys. Chem. B 107(28), 6754–6759 (2003).
[CrossRef]

Byars, J. M.

P. J. Cutler, M. D. Malik, S. Liu, J. M. Byars, D. S. Lidke, and K. A. Lidke, “Multi-color quantum dot tracking using a high-speed hyperspectral line-scanning microscope,” PLoS ONE 8(5), e64320 (2013).
[CrossRef] [PubMed]

Carriere, D.

B. Fleury, M. A. Neouze, J. M. Guigner, N. Menguy, O. Spalla, T. Gacoin, and D. Carriere, “Amorphous to crystal conversion as a mechanism governing the structure of luminescent YVO4:Eu nanoparticles,” ACS Nano 8(3), 2602–2608 (2014).
[CrossRef] [PubMed]

Casanova, D.

S. Türkcan, J.-B. Masson, D. Casanova, G. Mialon, T. Gacoin, J.-P. Boilot, M. R. Popoff, and A. Alexandrou, “Observing the confinement potential of bacterial pore-forming toxin receptors inside rafts with nonblinking Eu3+-doped oxide nanoparticles,” Biophys. J. 102(10), 2299–2308 (2012).
[CrossRef] [PubMed]

D. Casanova, C. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, L. Bouzhir-Sima, T. Gacoin, J.-P. Boilot, P.-L. Tharaux, and A. Alexandrou, “Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells,” Nat. Nanotechnol. 4(9), 581–585 (2009).
[CrossRef] [PubMed]

J.-B. Masson, D. Casanova, S. Türkcan, G. Voisinne, M. R. Popoff, M. Vergassola, and A. Alexandrou, “Inferring maps of forces inside cell membrane microdomains,” Phys. Rev. Lett. 102(4), 048103 (2009).
[CrossRef] [PubMed]

D. Casanova, D. Giaume, E. Beaurepaire, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Optical in situ size determination of single lanthanide-ion doped oxide nanoparticles,” Appl. Phys. Lett. 89(25), 253103 (2006).
[CrossRef]

E. Beaurepaire, V. Buissette, M.-P. Sauviat, D. Giaume, K. Lahlil, A. Mercuri, D. Casanova, A. Huignard, J.-L. Martin, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Functionalized fluorescent oxide nanoparticles: artificial toxins for sodium channel targeting and imaging at the single-molecule level,” Nano Lett. 4(11), 2079–2083 (2004).
[CrossRef]

Claeson, A.

C. I. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, A. Claeson, P.-L. Tharaux, and A. Alexandrou, “Regulation of the ROS response dynamics and organization to PDGF motile stimuli revealed by single nanoparticle imaging,” Chem. Biol. 21(5), 647–656 (2014).
[CrossRef] [PubMed]

Clément, O.

M. Schoeffel, M. Abdesselem, I. Maurin, G. Autret, O. Clément, J.-P. Boilot, T. Gacoin, C.I. Bouzigues, and A. Alexandrou, Submitted.

Copner, N. J.

Cutler, P. J.

P. J. Cutler, M. D. Malik, S. Liu, J. M. Byars, D. S. Lidke, and K. A. Lidke, “Multi-color quantum dot tracking using a high-speed hyperspectral line-scanning microscope,” PLoS ONE 8(5), e64320 (2013).
[CrossRef] [PubMed]

Dhirapong, A.

A. Son, A. Dhirapong, D. K. Dosev, I. M. Kennedy, R. H. Weiss, and K. R. Hristova, “Rapid and quantitative DNA analysis of genetic mutations for polycystic kidney disease (PKD) using magnetic/luminescent nanoparticles,” Anal. Bioanal. Chem. 390(7), 1829–1835 (2008).
[CrossRef] [PubMed]

Dosev, D.

D. Dosev, M. Nichkova, M. Liu, B. Guo, G. Y. Liu, B. D. Hammock, and I. M. Kennedy, “Application of luminescent Eu:Gd2O3 nanoparticles to the visualization of protein micropatterns,” J. Biomed. Opt. 10(6), 064006 (2005).
[CrossRef] [PubMed]

Dosev, D. K.

A. Son, A. Dhirapong, D. K. Dosev, I. M. Kennedy, R. H. Weiss, and K. R. Hristova, “Rapid and quantitative DNA analysis of genetic mutations for polycystic kidney disease (PKD) using magnetic/luminescent nanoparticles,” Anal. Bioanal. Chem. 390(7), 1829–1835 (2008).
[CrossRef] [PubMed]

Fleury, B.

B. Fleury, M. A. Neouze, J. M. Guigner, N. Menguy, O. Spalla, T. Gacoin, and D. Carriere, “Amorphous to crystal conversion as a mechanism governing the structure of luminescent YVO4:Eu nanoparticles,” ACS Nano 8(3), 2602–2608 (2014).
[CrossRef] [PubMed]

Franville, A.-C.

A. Huignard, V. Buissette, A.-C. Franville, T. Gacoin, and J.-P. Boilot, “Emission processes in YVO4:Eu nanoparticles,” J. Phys. Chem. B 107(28), 6754–6759 (2003).
[CrossRef]

Gacoin, T.

B. Fleury, M. A. Neouze, J. M. Guigner, N. Menguy, O. Spalla, T. Gacoin, and D. Carriere, “Amorphous to crystal conversion as a mechanism governing the structure of luminescent YVO4:Eu nanoparticles,” ACS Nano 8(3), 2602–2608 (2014).
[CrossRef] [PubMed]

S. Türkcan, J.-B. Masson, D. Casanova, G. Mialon, T. Gacoin, J.-P. Boilot, M. R. Popoff, and A. Alexandrou, “Observing the confinement potential of bacterial pore-forming toxin receptors inside rafts with nonblinking Eu3+-doped oxide nanoparticles,” Biophys. J. 102(10), 2299–2308 (2012).
[CrossRef] [PubMed]

C. Bouzigues, T. Gacoin, and A. Alexandrou, “Biological applications of rare-earth based nanoparticles,” ACS Nano 5(11), 8488–8505 (2011).
[CrossRef] [PubMed]

D. Casanova, C. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, L. Bouzhir-Sima, T. Gacoin, J.-P. Boilot, P.-L. Tharaux, and A. Alexandrou, “Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells,” Nat. Nanotechnol. 4(9), 581–585 (2009).
[CrossRef] [PubMed]

G. Mialon, S. Türkcan, A. Alexandrou, T. Gacoin, and J.-P. Boilot, “New insights into size effects in luminescent oxide nanocrystals,” J. Phys. Chem. C 113(43), 18699–18706 (2009).
[CrossRef]

G. Mialon, M. Gohin, T. Gacoin, and J.-P. Boilot, “High temperature strategy for oxide nanoparticle synthesis,” ACS Nano 2(12), 2505–2512 (2008).
[CrossRef] [PubMed]

D. Casanova, D. Giaume, E. Beaurepaire, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Optical in situ size determination of single lanthanide-ion doped oxide nanoparticles,” Appl. Phys. Lett. 89(25), 253103 (2006).
[CrossRef]

E. Beaurepaire, V. Buissette, M.-P. Sauviat, D. Giaume, K. Lahlil, A. Mercuri, D. Casanova, A. Huignard, J.-L. Martin, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Functionalized fluorescent oxide nanoparticles: artificial toxins for sodium channel targeting and imaging at the single-molecule level,” Nano Lett. 4(11), 2079–2083 (2004).
[CrossRef]

A. Huignard, V. Buissette, A.-C. Franville, T. Gacoin, and J.-P. Boilot, “Emission processes in YVO4:Eu nanoparticles,” J. Phys. Chem. B 107(28), 6754–6759 (2003).
[CrossRef]

A. Huignard, T. Gacoin, and J.-P. Boilot, “Synthesis and luminescence properties of colloidal YVO4:Eu phosphors,” Chem. Mater. 12(4), 1090–1094 (2000).
[CrossRef]

M. Schoeffel, M. Abdesselem, I. Maurin, G. Autret, O. Clément, J.-P. Boilot, T. Gacoin, C.I. Bouzigues, and A. Alexandrou, Submitted.

Gawith, C. B. E.

Giaume, D.

D. Casanova, D. Giaume, E. Beaurepaire, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Optical in situ size determination of single lanthanide-ion doped oxide nanoparticles,” Appl. Phys. Lett. 89(25), 253103 (2006).
[CrossRef]

E. Beaurepaire, V. Buissette, M.-P. Sauviat, D. Giaume, K. Lahlil, A. Mercuri, D. Casanova, A. Huignard, J.-L. Martin, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Functionalized fluorescent oxide nanoparticles: artificial toxins for sodium channel targeting and imaging at the single-molecule level,” Nano Lett. 4(11), 2079–2083 (2004).
[CrossRef]

Gohin, M.

G. Mialon, M. Gohin, T. Gacoin, and J.-P. Boilot, “High temperature strategy for oxide nanoparticle synthesis,” ACS Nano 2(12), 2505–2512 (2008).
[CrossRef] [PubMed]

Guigner, J. M.

B. Fleury, M. A. Neouze, J. M. Guigner, N. Menguy, O. Spalla, T. Gacoin, and D. Carriere, “Amorphous to crystal conversion as a mechanism governing the structure of luminescent YVO4:Eu nanoparticles,” ACS Nano 8(3), 2602–2608 (2014).
[CrossRef] [PubMed]

Guo, B.

D. Dosev, M. Nichkova, M. Liu, B. Guo, G. Y. Liu, B. D. Hammock, and I. M. Kennedy, “Application of luminescent Eu:Gd2O3 nanoparticles to the visualization of protein micropatterns,” J. Biomed. Opt. 10(6), 064006 (2005).
[CrossRef] [PubMed]

Haase, M.

O. Lehmann, K. Kömpe, and M. Haase, “Synthesis of Eu3+-doped core and core/shell nanoparticles and direct spectroscopic identification of dopant sites at the surface and in the interior of the particles,” J. Am. Chem. Soc. 126(45), 14935–14942 (2004).
[CrossRef] [PubMed]

K. Riwotzki and M. Haase, “Colloidal YVO4:Eu and YP0.95V0.05O4:Eu nanoparticles: luminescence and energy transfer processes,” J. Phys. Chem. B 105(51), 12709–12713 (2001).
[CrossRef]

K. Riwotzki and M. Haase, “Wet-chemical synthesis of doped colloidal nanoparticles: YVO4:Ln (Ln = Eu, Sm, Dy),” J. Phys. Chem. B 102(50), 10129–10135 (1998).
[CrossRef]

Hagberg, M.

Hammock, B. D.

D. Dosev, M. Nichkova, M. Liu, B. Guo, G. Y. Liu, B. D. Hammock, and I. M. Kennedy, “Application of luminescent Eu:Gd2O3 nanoparticles to the visualization of protein micropatterns,” J. Biomed. Opt. 10(6), 064006 (2005).
[CrossRef] [PubMed]

Hristova, K. R.

A. Son, A. Dhirapong, D. K. Dosev, I. M. Kennedy, R. H. Weiss, and K. R. Hristova, “Rapid and quantitative DNA analysis of genetic mutations for polycystic kidney disease (PKD) using magnetic/luminescent nanoparticles,” Anal. Bioanal. Chem. 390(7), 1829–1835 (2008).
[CrossRef] [PubMed]

Huignard, A.

E. Beaurepaire, V. Buissette, M.-P. Sauviat, D. Giaume, K. Lahlil, A. Mercuri, D. Casanova, A. Huignard, J.-L. Martin, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Functionalized fluorescent oxide nanoparticles: artificial toxins for sodium channel targeting and imaging at the single-molecule level,” Nano Lett. 4(11), 2079–2083 (2004).
[CrossRef]

A. Huignard, V. Buissette, A.-C. Franville, T. Gacoin, and J.-P. Boilot, “Emission processes in YVO4:Eu nanoparticles,” J. Phys. Chem. B 107(28), 6754–6759 (2003).
[CrossRef]

A. Huignard, T. Gacoin, and J.-P. Boilot, “Synthesis and luminescence properties of colloidal YVO4:Eu phosphors,” Chem. Mater. 12(4), 1090–1094 (2000).
[CrossRef]

Jiang, H. L.

Y. L. Li, H. L. Jiang, W. Liang, T. Y. Ni, T. Y. Zhang, Z. H. Tao, and Y. H. Zeng, “Quasi-three level laser based on diode-pumped Nd3+:YAlO3 crystal,” Laser Phys. 21(5), 897–900 (2011).
[CrossRef]

Judd, B. R.

B. R. Judd, “Optical absorption intensities of rare-earth ions,” Phys. Rev. 127(3), 750–761 (1962).
[CrossRef]

Kennedy, I. M.

A. Son, A. Dhirapong, D. K. Dosev, I. M. Kennedy, R. H. Weiss, and K. R. Hristova, “Rapid and quantitative DNA analysis of genetic mutations for polycystic kidney disease (PKD) using magnetic/luminescent nanoparticles,” Anal. Bioanal. Chem. 390(7), 1829–1835 (2008).
[CrossRef] [PubMed]

D. Dosev, M. Nichkova, M. Liu, B. Guo, G. Y. Liu, B. D. Hammock, and I. M. Kennedy, “Application of luminescent Eu:Gd2O3 nanoparticles to the visualization of protein micropatterns,” J. Biomed. Opt. 10(6), 064006 (2005).
[CrossRef] [PubMed]

Knight, I. G.

Kömpe, K.

O. Lehmann, K. Kömpe, and M. Haase, “Synthesis of Eu3+-doped core and core/shell nanoparticles and direct spectroscopic identification of dopant sites at the surface and in the interior of the particles,” J. Am. Chem. Soc. 126(45), 14935–14942 (2004).
[CrossRef] [PubMed]

Lahlil, K.

E. Beaurepaire, V. Buissette, M.-P. Sauviat, D. Giaume, K. Lahlil, A. Mercuri, D. Casanova, A. Huignard, J.-L. Martin, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Functionalized fluorescent oxide nanoparticles: artificial toxins for sodium channel targeting and imaging at the single-molecule level,” Nano Lett. 4(11), 2079–2083 (2004).
[CrossRef]

Lehmann, O.

O. Lehmann, K. Kömpe, and M. Haase, “Synthesis of Eu3+-doped core and core/shell nanoparticles and direct spectroscopic identification of dopant sites at the surface and in the interior of the particles,” J. Am. Chem. Soc. 126(45), 14935–14942 (2004).
[CrossRef] [PubMed]

Lempicki, A.

C. Brecher, H. Samelson, A. Lempicki, R. Riley, and T. Peters, “Polarized spectra and crystal-field parameters of Eu+3 in YVO4,” Phys. Rev. 155(2), 178–187 (1967).
[CrossRef]

Li, K.

Li, Y. L.

Y. L. Li, H. L. Jiang, W. Liang, T. Y. Ni, T. Y. Zhang, Z. H. Tao, and Y. H. Zeng, “Quasi-three level laser based on diode-pumped Nd3+:YAlO3 crystal,” Laser Phys. 21(5), 897–900 (2011).
[CrossRef]

Liang, W.

Y. L. Li, H. L. Jiang, W. Liang, T. Y. Ni, T. Y. Zhang, Z. H. Tao, and Y. H. Zeng, “Quasi-three level laser based on diode-pumped Nd3+:YAlO3 crystal,” Laser Phys. 21(5), 897–900 (2011).
[CrossRef]

Lidke, D. S.

P. J. Cutler, M. D. Malik, S. Liu, J. M. Byars, D. S. Lidke, and K. A. Lidke, “Multi-color quantum dot tracking using a high-speed hyperspectral line-scanning microscope,” PLoS ONE 8(5), e64320 (2013).
[CrossRef] [PubMed]

Lidke, K. A.

P. J. Cutler, M. D. Malik, S. Liu, J. M. Byars, D. S. Lidke, and K. A. Lidke, “Multi-color quantum dot tracking using a high-speed hyperspectral line-scanning microscope,” PLoS ONE 8(5), e64320 (2013).
[CrossRef] [PubMed]

Liu, G. Y.

D. Dosev, M. Nichkova, M. Liu, B. Guo, G. Y. Liu, B. D. Hammock, and I. M. Kennedy, “Application of luminescent Eu:Gd2O3 nanoparticles to the visualization of protein micropatterns,” J. Biomed. Opt. 10(6), 064006 (2005).
[CrossRef] [PubMed]

Liu, M.

D. Dosev, M. Nichkova, M. Liu, B. Guo, G. Y. Liu, B. D. Hammock, and I. M. Kennedy, “Application of luminescent Eu:Gd2O3 nanoparticles to the visualization of protein micropatterns,” J. Biomed. Opt. 10(6), 064006 (2005).
[CrossRef] [PubMed]

Liu, S.

P. J. Cutler, M. D. Malik, S. Liu, J. M. Byars, D. S. Lidke, and K. A. Lidke, “Multi-color quantum dot tracking using a high-speed hyperspectral line-scanning microscope,” PLoS ONE 8(5), e64320 (2013).
[CrossRef] [PubMed]

Malik, M. D.

P. J. Cutler, M. D. Malik, S. Liu, J. M. Byars, D. S. Lidke, and K. A. Lidke, “Multi-color quantum dot tracking using a high-speed hyperspectral line-scanning microscope,” PLoS ONE 8(5), e64320 (2013).
[CrossRef] [PubMed]

Martin, J.-L.

E. Beaurepaire, V. Buissette, M.-P. Sauviat, D. Giaume, K. Lahlil, A. Mercuri, D. Casanova, A. Huignard, J.-L. Martin, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Functionalized fluorescent oxide nanoparticles: artificial toxins for sodium channel targeting and imaging at the single-molecule level,” Nano Lett. 4(11), 2079–2083 (2004).
[CrossRef]

Masson, J.-B.

S. Türkcan, M. U. Richly, A. Alexandrou, and J.-B. Masson, “Probing membrane protein interactions with their lipid raft environment using single-molecule tracking and Bayesian inference analysis,” PLoS ONE 8(1), e53073 (2013).
[CrossRef] [PubMed]

S. Türkcan, J.-B. Masson, D. Casanova, G. Mialon, T. Gacoin, J.-P. Boilot, M. R. Popoff, and A. Alexandrou, “Observing the confinement potential of bacterial pore-forming toxin receptors inside rafts with nonblinking Eu3+-doped oxide nanoparticles,” Biophys. J. 102(10), 2299–2308 (2012).
[CrossRef] [PubMed]

J.-B. Masson, D. Casanova, S. Türkcan, G. Voisinne, M. R. Popoff, M. Vergassola, and A. Alexandrou, “Inferring maps of forces inside cell membrane microdomains,” Phys. Rev. Lett. 102(4), 048103 (2009).
[CrossRef] [PubMed]

Maurin, I.

M. Schoeffel, M. Abdesselem, I. Maurin, G. Autret, O. Clément, J.-P. Boilot, T. Gacoin, C.I. Bouzigues, and A. Alexandrou, Submitted.

Menguy, N.

B. Fleury, M. A. Neouze, J. M. Guigner, N. Menguy, O. Spalla, T. Gacoin, and D. Carriere, “Amorphous to crystal conversion as a mechanism governing the structure of luminescent YVO4:Eu nanoparticles,” ACS Nano 8(3), 2602–2608 (2014).
[CrossRef] [PubMed]

Mercuri, A.

E. Beaurepaire, V. Buissette, M.-P. Sauviat, D. Giaume, K. Lahlil, A. Mercuri, D. Casanova, A. Huignard, J.-L. Martin, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Functionalized fluorescent oxide nanoparticles: artificial toxins for sodium channel targeting and imaging at the single-molecule level,” Nano Lett. 4(11), 2079–2083 (2004).
[CrossRef]

Mialon, G.

S. Türkcan, J.-B. Masson, D. Casanova, G. Mialon, T. Gacoin, J.-P. Boilot, M. R. Popoff, and A. Alexandrou, “Observing the confinement potential of bacterial pore-forming toxin receptors inside rafts with nonblinking Eu3+-doped oxide nanoparticles,” Biophys. J. 102(10), 2299–2308 (2012).
[CrossRef] [PubMed]

G. Mialon, S. Türkcan, A. Alexandrou, T. Gacoin, and J.-P. Boilot, “New insights into size effects in luminescent oxide nanocrystals,” J. Phys. Chem. C 113(43), 18699–18706 (2009).
[CrossRef]

G. Mialon, M. Gohin, T. Gacoin, and J.-P. Boilot, “High temperature strategy for oxide nanoparticle synthesis,” ACS Nano 2(12), 2505–2512 (2008).
[CrossRef] [PubMed]

Moss, G.

Musk, B.

Neouze, M. A.

B. Fleury, M. A. Neouze, J. M. Guigner, N. Menguy, O. Spalla, T. Gacoin, and D. Carriere, “Amorphous to crystal conversion as a mechanism governing the structure of luminescent YVO4:Eu nanoparticles,” ACS Nano 8(3), 2602–2608 (2014).
[CrossRef] [PubMed]

Nguyên, T.-L.

C. I. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, A. Claeson, P.-L. Tharaux, and A. Alexandrou, “Regulation of the ROS response dynamics and organization to PDGF motile stimuli revealed by single nanoparticle imaging,” Chem. Biol. 21(5), 647–656 (2014).
[CrossRef] [PubMed]

D. Casanova, C. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, L. Bouzhir-Sima, T. Gacoin, J.-P. Boilot, P.-L. Tharaux, and A. Alexandrou, “Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells,” Nat. Nanotechnol. 4(9), 581–585 (2009).
[CrossRef] [PubMed]

Ni, T. Y.

Y. L. Li, H. L. Jiang, W. Liang, T. Y. Ni, T. Y. Zhang, Z. H. Tao, and Y. H. Zeng, “Quasi-three level laser based on diode-pumped Nd3+:YAlO3 crystal,” Laser Phys. 21(5), 897–900 (2011).
[CrossRef]

Nichkova, M.

D. Dosev, M. Nichkova, M. Liu, B. Guo, G. Y. Liu, B. D. Hammock, and I. M. Kennedy, “Application of luminescent Eu:Gd2O3 nanoparticles to the visualization of protein micropatterns,” J. Biomed. Opt. 10(6), 064006 (2005).
[CrossRef] [PubMed]

O’Brien, S.

Ofelt, G. S.

G. S. Ofelt, “Intensities of crystal spectra of rare-earth ions,” J. Chem. Phys. 37(3), 511 (1962).
[CrossRef]

Peters, T.

C. Brecher, H. Samelson, A. Lempicki, R. Riley, and T. Peters, “Polarized spectra and crystal-field parameters of Eu+3 in YVO4,” Phys. Rev. 155(2), 178–187 (1967).
[CrossRef]

Pfeiffer, H.-U.

Popoff, M. R.

S. Türkcan, J.-B. Masson, D. Casanova, G. Mialon, T. Gacoin, J.-P. Boilot, M. R. Popoff, and A. Alexandrou, “Observing the confinement potential of bacterial pore-forming toxin receptors inside rafts with nonblinking Eu3+-doped oxide nanoparticles,” Biophys. J. 102(10), 2299–2308 (2012).
[CrossRef] [PubMed]

J.-B. Masson, D. Casanova, S. Türkcan, G. Voisinne, M. R. Popoff, M. Vergassola, and A. Alexandrou, “Inferring maps of forces inside cell membrane microdomains,” Phys. Rev. Lett. 102(4), 048103 (2009).
[CrossRef] [PubMed]

Ramodiharilafy, R. O.

C. I. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, A. Claeson, P.-L. Tharaux, and A. Alexandrou, “Regulation of the ROS response dynamics and organization to PDGF motile stimuli revealed by single nanoparticle imaging,” Chem. Biol. 21(5), 647–656 (2014).
[CrossRef] [PubMed]

D. Casanova, C. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, L. Bouzhir-Sima, T. Gacoin, J.-P. Boilot, P.-L. Tharaux, and A. Alexandrou, “Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells,” Nat. Nanotechnol. 4(9), 581–585 (2009).
[CrossRef] [PubMed]

Richly, M. U.

S. Türkcan, M. U. Richly, A. Alexandrou, and J.-B. Masson, “Probing membrane protein interactions with their lipid raft environment using single-molecule tracking and Bayesian inference analysis,” PLoS ONE 8(1), e53073 (2013).
[CrossRef] [PubMed]

S. Türkcan, M. U. Richly, C. I. Bouzigues, J.-M. Allain, and A. Alexandrou, “Receptor displacement in the cell membrane by hydrodynamic force amplification through nanoparticles,” Biophys. J. 105(1), 116–126 (2013).
[CrossRef] [PubMed]

Riley, R.

C. Brecher, H. Samelson, A. Lempicki, R. Riley, and T. Peters, “Polarized spectra and crystal-field parameters of Eu+3 in YVO4,” Phys. Rev. 155(2), 178–187 (1967).
[CrossRef]

Riwotzki, K.

K. Riwotzki and M. Haase, “Colloidal YVO4:Eu and YP0.95V0.05O4:Eu nanoparticles: luminescence and energy transfer processes,” J. Phys. Chem. B 105(51), 12709–12713 (2001).
[CrossRef]

K. Riwotzki and M. Haase, “Wet-chemical synthesis of doped colloidal nanoparticles: YVO4:Ln (Ln = Eu, Sm, Dy),” J. Phys. Chem. B 102(50), 10129–10135 (1998).
[CrossRef]

Samelson, H.

C. Brecher, H. Samelson, A. Lempicki, R. Riley, and T. Peters, “Polarized spectra and crystal-field parameters of Eu+3 in YVO4,” Phys. Rev. 155(2), 178–187 (1967).
[CrossRef]

Sauviat, M.-P.

E. Beaurepaire, V. Buissette, M.-P. Sauviat, D. Giaume, K. Lahlil, A. Mercuri, D. Casanova, A. Huignard, J.-L. Martin, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Functionalized fluorescent oxide nanoparticles: artificial toxins for sodium channel targeting and imaging at the single-molecule level,” Nano Lett. 4(11), 2079–2083 (2004).
[CrossRef]

Schoeffel, M.

M. Schoeffel, M. Abdesselem, I. Maurin, G. Autret, O. Clément, J.-P. Boilot, T. Gacoin, C.I. Bouzigues, and A. Alexandrou, Submitted.

Son, A.

A. Son, A. Dhirapong, D. K. Dosev, I. M. Kennedy, R. H. Weiss, and K. R. Hristova, “Rapid and quantitative DNA analysis of genetic mutations for polycystic kidney disease (PKD) using magnetic/luminescent nanoparticles,” Anal. Bioanal. Chem. 390(7), 1829–1835 (2008).
[CrossRef] [PubMed]

Spalla, O.

B. Fleury, M. A. Neouze, J. M. Guigner, N. Menguy, O. Spalla, T. Gacoin, and D. Carriere, “Amorphous to crystal conversion as a mechanism governing the structure of luminescent YVO4:Eu nanoparticles,” ACS Nano 8(3), 2602–2608 (2014).
[CrossRef] [PubMed]

Tao, Z. H.

Y. L. Li, H. L. Jiang, W. Liang, T. Y. Ni, T. Y. Zhang, Z. H. Tao, and Y. H. Zeng, “Quasi-three level laser based on diode-pumped Nd3+:YAlO3 crystal,” Laser Phys. 21(5), 897–900 (2011).
[CrossRef]

Tharaux, P.-L.

C. I. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, A. Claeson, P.-L. Tharaux, and A. Alexandrou, “Regulation of the ROS response dynamics and organization to PDGF motile stimuli revealed by single nanoparticle imaging,” Chem. Biol. 21(5), 647–656 (2014).
[CrossRef] [PubMed]

D. Casanova, C. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, L. Bouzhir-Sima, T. Gacoin, J.-P. Boilot, P.-L. Tharaux, and A. Alexandrou, “Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells,” Nat. Nanotechnol. 4(9), 581–585 (2009).
[CrossRef] [PubMed]

Türkcan, S.

S. Türkcan, M. U. Richly, A. Alexandrou, and J.-B. Masson, “Probing membrane protein interactions with their lipid raft environment using single-molecule tracking and Bayesian inference analysis,” PLoS ONE 8(1), e53073 (2013).
[CrossRef] [PubMed]

S. Türkcan, M. U. Richly, C. I. Bouzigues, J.-M. Allain, and A. Alexandrou, “Receptor displacement in the cell membrane by hydrodynamic force amplification through nanoparticles,” Biophys. J. 105(1), 116–126 (2013).
[CrossRef] [PubMed]

S. Türkcan, J.-B. Masson, D. Casanova, G. Mialon, T. Gacoin, J.-P. Boilot, M. R. Popoff, and A. Alexandrou, “Observing the confinement potential of bacterial pore-forming toxin receptors inside rafts with nonblinking Eu3+-doped oxide nanoparticles,” Biophys. J. 102(10), 2299–2308 (2012).
[CrossRef] [PubMed]

J.-B. Masson, D. Casanova, S. Türkcan, G. Voisinne, M. R. Popoff, M. Vergassola, and A. Alexandrou, “Inferring maps of forces inside cell membrane microdomains,” Phys. Rev. Lett. 102(4), 048103 (2009).
[CrossRef] [PubMed]

G. Mialon, S. Türkcan, A. Alexandrou, T. Gacoin, and J.-P. Boilot, “New insights into size effects in luminescent oxide nanocrystals,” J. Phys. Chem. C 113(43), 18699–18706 (2009).
[CrossRef]

Vergassola, M.

J.-B. Masson, D. Casanova, S. Türkcan, G. Voisinne, M. R. Popoff, M. Vergassola, and A. Alexandrou, “Inferring maps of forces inside cell membrane microdomains,” Phys. Rev. Lett. 102(4), 048103 (2009).
[CrossRef] [PubMed]

Voisinne, G.

J.-B. Masson, D. Casanova, S. Türkcan, G. Voisinne, M. R. Popoff, M. Vergassola, and A. Alexandrou, “Inferring maps of forces inside cell membrane microdomains,” Phys. Rev. Lett. 102(4), 048103 (2009).
[CrossRef] [PubMed]

Wallenstein, R.

Wang, H.

Weiss, R. H.

A. Son, A. Dhirapong, D. K. Dosev, I. M. Kennedy, R. H. Weiss, and K. R. Hristova, “Rapid and quantitative DNA analysis of genetic mutations for polycystic kidney disease (PKD) using magnetic/luminescent nanoparticles,” Anal. Bioanal. Chem. 390(7), 1829–1835 (2008).
[CrossRef] [PubMed]

Woll, D.

Zeng, Y. H.

Y. L. Li, H. L. Jiang, W. Liang, T. Y. Ni, T. Y. Zhang, Z. H. Tao, and Y. H. Zeng, “Quasi-three level laser based on diode-pumped Nd3+:YAlO3 crystal,” Laser Phys. 21(5), 897–900 (2011).
[CrossRef]

Zhang, T. Y.

Y. L. Li, H. L. Jiang, W. Liang, T. Y. Ni, T. Y. Zhang, Z. H. Tao, and Y. H. Zeng, “Quasi-three level laser based on diode-pumped Nd3+:YAlO3 crystal,” Laser Phys. 21(5), 897–900 (2011).
[CrossRef]

ACS Nano

C. Bouzigues, T. Gacoin, and A. Alexandrou, “Biological applications of rare-earth based nanoparticles,” ACS Nano 5(11), 8488–8505 (2011).
[CrossRef] [PubMed]

G. Mialon, M. Gohin, T. Gacoin, and J.-P. Boilot, “High temperature strategy for oxide nanoparticle synthesis,” ACS Nano 2(12), 2505–2512 (2008).
[CrossRef] [PubMed]

B. Fleury, M. A. Neouze, J. M. Guigner, N. Menguy, O. Spalla, T. Gacoin, and D. Carriere, “Amorphous to crystal conversion as a mechanism governing the structure of luminescent YVO4:Eu nanoparticles,” ACS Nano 8(3), 2602–2608 (2014).
[CrossRef] [PubMed]

Anal. Bioanal. Chem.

A. Son, A. Dhirapong, D. K. Dosev, I. M. Kennedy, R. H. Weiss, and K. R. Hristova, “Rapid and quantitative DNA analysis of genetic mutations for polycystic kidney disease (PKD) using magnetic/luminescent nanoparticles,” Anal. Bioanal. Chem. 390(7), 1829–1835 (2008).
[CrossRef] [PubMed]

Appl. Phys. Lett.

D. Casanova, D. Giaume, E. Beaurepaire, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Optical in situ size determination of single lanthanide-ion doped oxide nanoparticles,” Appl. Phys. Lett. 89(25), 253103 (2006).
[CrossRef]

Biophys. J.

S. Türkcan, M. U. Richly, C. I. Bouzigues, J.-M. Allain, and A. Alexandrou, “Receptor displacement in the cell membrane by hydrodynamic force amplification through nanoparticles,” Biophys. J. 105(1), 116–126 (2013).
[CrossRef] [PubMed]

S. Türkcan, J.-B. Masson, D. Casanova, G. Mialon, T. Gacoin, J.-P. Boilot, M. R. Popoff, and A. Alexandrou, “Observing the confinement potential of bacterial pore-forming toxin receptors inside rafts with nonblinking Eu3+-doped oxide nanoparticles,” Biophys. J. 102(10), 2299–2308 (2012).
[CrossRef] [PubMed]

Chem. Biol.

C. I. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, A. Claeson, P.-L. Tharaux, and A. Alexandrou, “Regulation of the ROS response dynamics and organization to PDGF motile stimuli revealed by single nanoparticle imaging,” Chem. Biol. 21(5), 647–656 (2014).
[CrossRef] [PubMed]

Chem. Mater.

A. Huignard, T. Gacoin, and J.-P. Boilot, “Synthesis and luminescence properties of colloidal YVO4:Eu phosphors,” Chem. Mater. 12(4), 1090–1094 (2000).
[CrossRef]

J. Am. Chem. Soc.

O. Lehmann, K. Kömpe, and M. Haase, “Synthesis of Eu3+-doped core and core/shell nanoparticles and direct spectroscopic identification of dopant sites at the surface and in the interior of the particles,” J. Am. Chem. Soc. 126(45), 14935–14942 (2004).
[CrossRef] [PubMed]

J. Biomed. Opt.

D. Dosev, M. Nichkova, M. Liu, B. Guo, G. Y. Liu, B. D. Hammock, and I. M. Kennedy, “Application of luminescent Eu:Gd2O3 nanoparticles to the visualization of protein micropatterns,” J. Biomed. Opt. 10(6), 064006 (2005).
[CrossRef] [PubMed]

J. Chem. Phys.

G. S. Ofelt, “Intensities of crystal spectra of rare-earth ions,” J. Chem. Phys. 37(3), 511 (1962).
[CrossRef]

J. Opt. Soc. Am. B

J. Phys. Chem. B

K. Riwotzki and M. Haase, “Wet-chemical synthesis of doped colloidal nanoparticles: YVO4:Ln (Ln = Eu, Sm, Dy),” J. Phys. Chem. B 102(50), 10129–10135 (1998).
[CrossRef]

K. Riwotzki and M. Haase, “Colloidal YVO4:Eu and YP0.95V0.05O4:Eu nanoparticles: luminescence and energy transfer processes,” J. Phys. Chem. B 105(51), 12709–12713 (2001).
[CrossRef]

A. Huignard, V. Buissette, A.-C. Franville, T. Gacoin, and J.-P. Boilot, “Emission processes in YVO4:Eu nanoparticles,” J. Phys. Chem. B 107(28), 6754–6759 (2003).
[CrossRef]

J. Phys. Chem. C

G. Mialon, S. Türkcan, A. Alexandrou, T. Gacoin, and J.-P. Boilot, “New insights into size effects in luminescent oxide nanocrystals,” J. Phys. Chem. C 113(43), 18699–18706 (2009).
[CrossRef]

Laser Phys.

Y. L. Li, H. L. Jiang, W. Liang, T. Y. Ni, T. Y. Zhang, Z. H. Tao, and Y. H. Zeng, “Quasi-three level laser based on diode-pumped Nd3+:YAlO3 crystal,” Laser Phys. 21(5), 897–900 (2011).
[CrossRef]

Nano Lett.

E. Beaurepaire, V. Buissette, M.-P. Sauviat, D. Giaume, K. Lahlil, A. Mercuri, D. Casanova, A. Huignard, J.-L. Martin, T. Gacoin, J.-P. Boilot, and A. Alexandrou, “Functionalized fluorescent oxide nanoparticles: artificial toxins for sodium channel targeting and imaging at the single-molecule level,” Nano Lett. 4(11), 2079–2083 (2004).
[CrossRef]

Nat. Nanotechnol.

D. Casanova, C. Bouzigues, T.-L. Nguyên, R. O. Ramodiharilafy, L. Bouzhir-Sima, T. Gacoin, J.-P. Boilot, P.-L. Tharaux, and A. Alexandrou, “Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells,” Nat. Nanotechnol. 4(9), 581–585 (2009).
[CrossRef] [PubMed]

Opt. Lett.

Phys. Rev.

C. Brecher, H. Samelson, A. Lempicki, R. Riley, and T. Peters, “Polarized spectra and crystal-field parameters of Eu+3 in YVO4,” Phys. Rev. 155(2), 178–187 (1967).
[CrossRef]

B. R. Judd, “Optical absorption intensities of rare-earth ions,” Phys. Rev. 127(3), 750–761 (1962).
[CrossRef]

Phys. Rev. Lett.

J.-B. Masson, D. Casanova, S. Türkcan, G. Voisinne, M. R. Popoff, M. Vergassola, and A. Alexandrou, “Inferring maps of forces inside cell membrane microdomains,” Phys. Rev. Lett. 102(4), 048103 (2009).
[CrossRef] [PubMed]

PLoS ONE

S. Türkcan, M. U. Richly, A. Alexandrou, and J.-B. Masson, “Probing membrane protein interactions with their lipid raft environment using single-molecule tracking and Bayesian inference analysis,” PLoS ONE 8(1), e53073 (2013).
[CrossRef] [PubMed]

P. J. Cutler, M. D. Malik, S. Liu, J. M. Byars, D. S. Lidke, and K. A. Lidke, “Multi-color quantum dot tracking using a high-speed hyperspectral line-scanning microscope,” PLoS ONE 8(5), e64320 (2013).
[CrossRef] [PubMed]

Other

M. Schoeffel, M. Abdesselem, I. Maurin, G. Autret, O. Clément, J.-P. Boilot, T. Gacoin, C.I. Bouzigues, and A. Alexandrou, Submitted.

To our knowledge, only the company Modulight proposes custom-made diode lasers at 465 nm, www.modulight.com .

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Figures (4)

Fig. 1
Fig. 1

Layout of the solid-state sum-frequency 465-nm laser. The inset shows the absorbance of a dense colloidal Y0.6Eu0.4VO4 nanoparticle solution in the spectral range of the 7F0,15D2 Eu3+ transition (the background slope due to diffusion has been subtracted) together with the emission spectrum of the sum-frequency 465-nm solid-state laser. The arrow shows the Argon-ion emission line.

Fig. 2
Fig. 2

Scheme of the experimental set-up. DM: dichroic mirror, TL: Tube lens, PH: diaphragm, BS: beam-splitter.

Fig. 3
Fig. 3

A) Spatial image of the sample area whose emission is recorded with the spectrometer and the CCD detector. A single diffraction-limited nanoparticle emission spot is observed. B) Emission spectrum of the Y0.6Eu0.4VO4 nanoparticle in A) (black; excitation power: 25 mW; acquisition time: 300 s) together with the five Lorentzian peaks used to fit the spectrum (green) and the resulting fit (red). C) Comparison between the single-nanoparticle emission spectrum in B) (magenta), the emission spectrum of an ensemble of Y0.6Eu0.4VO4 nanoparticles (blue; excitation power: 25 mW; acquisition time: 300 ms), and the emission spectrum of bulk Y0.5Eu0.5VO4 (black) together with the four Lorentzian peaks used to fit the spectrum (green) and the resulting fit (red). The single nanoparticle and the nanoparticle ensemble spectra have been displaced vertically for clarity.

Fig. 4
Fig. 4

A) Widths of the first, third and fifth Lorentzian peaks at 608.74, 614.84, and 618.70 nm (shown from left to right) used to reproduce the emission spectra of single YxEu1-xVO4 nanoparticles for x = 0.1 and 0.4. The error bars represent the standard deviation of the measurements for 15 and 14 single nanoparticles with 10% and 40% europium, respectively. B) Center wavelength of the first, third and fifth Lorentzian peaks used to reproduce the emission spectra of single YxEu1-xVO4 nanoparticles (black) and of an ensemble of YxEu1-xVO4 nanoparticles (red) for x = 0.1 and 0.4. The error bars represent the FWHM of the corresponding peaks. For single nanoparticles, the average FWHM is shown [see A)]. C) Emission peak area of the second and third Lorentzians used to reproduce the emission spectra for single YxEu1-xVO4 nanoparticles (black) and for an ensemble of particles (red) for x = 0.1 and 0.4 normalized to the peak area of the fifth Lorentzian. The error bars represent the standard deviation of the measurements for 15 and 14 single nanoparticles with 10% and 40% europium, respectively.

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