Abstract

Phase fluctuations in a two-transverse-dimensional scanning Fourier domain optical coherence tomography (FDOCT) seriously affect in vivo phase related applications. The phase difference between two A-scans sampled at the same scanning position or adjacent scanning position is acquired by matching of the phase distribution characteristics on the surface of two A-scans. Finger and palm scanning experiments are performed and defocused images of finger and palm are recovered based on Fresnel scalar diffraction algorithm by using phase compensated OCT complex signals. To further prove the performance of the proposed method, human eye scanning experiments are also performed and blood flow images of retina are extracted from the phase registration results. The accurate, fast and simple phase compensation method is critical for in vivo phase related applications.

© 2013 OSA

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, “Measurement of intraocular distances by backscattering spectral interferometry,” Opt. Commun.117(1–2), 43–48 (1995).
    [CrossRef]
  2. M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by Fourier domain optical coherence tomography,” J. Biomed. Opt.7(3), 457–463 (2002).
    [CrossRef] [PubMed]
  3. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
    [CrossRef] [PubMed]
  4. N. A. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, “In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve,” Opt. Express12(3), 367–376 (2004).
    [CrossRef] [PubMed]
  5. R. K. Wang and Z. Ma, “A practical approach to eliminate autocorrelation artefacts for volume-rate spectral domain optical coherence tomography,” Phys. Med. Biol.51(12), 3231–3239 (2006).
    [CrossRef] [PubMed]
  6. Y. Jia, P. O. Bagnaninchi, Y. Yang, A. E. Haj, M. T. Hinds, S. J. Kirkpatrick, and R. K. Wang, “Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds,” J. Biomed. Opt.14(3), 034014 (2009).
    [CrossRef] [PubMed]
  7. M. A. Choma, A. K. Ellerbee, C. Yang, T. L. Creazzo, and J. A. Izatt, “Spectral-domain phase microscopy,” Opt. Lett.30(10), 1162–1164 (2005).
    [CrossRef] [PubMed]
  8. C. Joo, T. Akkin, B. Cense, B. H. Park, and J. F. de Boer, “Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging,” Opt. Lett.30(16), 2131–2133 (2005).
    [CrossRef] [PubMed]
  9. J. F. de Boer, T. E. Milner, M. J. C. van Gemert, and J. S. Nelson, “Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography,” Opt. Lett.22(12), 934–936 (1997).
    [CrossRef] [PubMed]
  10. P. H. Tomlins and R. K. Wang, “Digital phase stabilization to improve detection sensitivity for optical coherence tomography,” Meas. Sci. Technol.18(11), 3365–3372 (2007).
    [CrossRef]
  11. D. Adler, T. Ko, P. Herz, and J. Fujimoto, “Optical coherence tomography contrast enhancement using spectroscopic analysis with spectral autocorrelation,” Opt. Express12(22), 5487–5501 (2004).
    [CrossRef] [PubMed]
  12. C. Xu, C. Vinegoni, T. S. Ralston, W. Luo, W. Tan, and S. A. Boppart, “Spectroscopic spectral-domain optical coherence microscopy,” Opt. Lett.31(8), 1079–1081 (2006).
    [CrossRef] [PubMed]
  13. T. S. Ralston, D. L. Marks, P. Scott Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys.3(2), 129–134 (2007).
    [CrossRef]
  14. L. Yu, B. Rao, J. Zhang, J. Su, Q. Wang, S. Guo, and Z. Chen, “Improved lateral resolution in optical coherence tomography by digital focusing using two-dimensional numerical diffraction method,” Opt. Express15(12), 7634–7641 (2007).
    [CrossRef] [PubMed]
  15. T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, “Deconvolution methods for mitigation of transverse blurring in optical coherence tomography,” IEEE Trans. Image Process.14(9), 1254–1264 (2005).
    [CrossRef] [PubMed]
  16. Y. Liu, Y. Liang, G. Mu, and X. Zhu, “Deconvolution methods for image deblurring in optical coherence tomography,” J. Opt. Soc. Am. A26(1), 72–77 (2009).
    [CrossRef] [PubMed]
  17. G. Liu, S. Yousefi, Z. Zhi, and R. K. Wang, “Automatic estimation of point-spread-function for deconvoluting out-of-focus optical coherence tomographic images using information entropy-based approach,” Opt. Express19(19), 18135–18148 (2011).
    [CrossRef] [PubMed]
  18. B. White, M. Pierce, N. Nassif, B. Cense, B. Park, G. Tearney, B. Bouma, T. Chen, and J. F. de Boer, “In vivo dynamic human retinal blood flow imaging using ultra-high-speed spectral domain optical coherence tomography,” Opt. Express11(25), 3490–3497 (2003).
    [CrossRef] [PubMed]
  19. J. Lee, V. Srinivasan, H. Radhakrishnan, and D. A. Boas, “Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex,” Opt. Express19(22), 21258–21270 (2011).
    [CrossRef] [PubMed]
  20. A. B. Vakhtin, D. J. Kane, W. R. Wood, and K. A. Peterson, “Common-path interferometer for frequency-domain optical coherence tomography,” Appl. Opt.42(34), 6953–6958 (2003).
    [CrossRef] [PubMed]
  21. D. Lin, X. Jiang, F. Xie, W. Zhang, L. Zhang, and I. Bennion, “High stability multiplexed fiber interferometer and its application on absolute displacement measurement and on-line surface metrology,” Opt. Express12(23), 5729–5734 (2004).
    [CrossRef] [PubMed]
  22. Z. Yaqoob, W. Choi, S. Oh, N. Lue, Y. Park, C. Fang-Yen, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing,” Opt. Express17(13), 10681–10687 (2009).
    [CrossRef] [PubMed]
  23. C. Yang, A. Wax, M. S. Hahn, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Phase-referenced interferometer with subwavelength and subhertz sensitivity applied to the study of cell membrane dynamics,” Opt. Lett.26(16), 1271–1273 (2001).
    [CrossRef] [PubMed]
  24. T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Phase stability technique for inverse scattering in optical coherence tomography,” 3rd IEEE International Symposium on Biomedical Imaging: Nano to Macro, 578–581 (2006).
    [CrossRef]
  25. L. An and R. K. Wang, “In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiography,” Opt. Express16(15), 11438–11452 (2008).
    [CrossRef] [PubMed]
  26. R. K. Wang and Z. H. Ma, “A practical approach to eliminate autocorrelation artefacts for volume-rate spectral domain optical coherence tomography,” Phys. Med. Biol.51(12), 3231–3239 (2006).
    [CrossRef] [PubMed]
  27. G. Liu, Z. Zhi, and R. K. Wang, “Digital focusing of OCT images based on scalar diffraction theory and information entropy,” Biomed. Opt. Express3(11), 2774–2783 (2012).
    [CrossRef] [PubMed]
  28. G. Liu and R. K. Wang, “Stripe motion artifact suppression in phase-resolved OCT blood flow images of the human eye based on the frequency rejection filter,” Chin. Opt. Lett.11(3), 031701–031705 (2013).
    [CrossRef]

2013 (1)

2012 (1)

2011 (2)

2009 (3)

2008 (1)

2007 (3)

L. Yu, B. Rao, J. Zhang, J. Su, Q. Wang, S. Guo, and Z. Chen, “Improved lateral resolution in optical coherence tomography by digital focusing using two-dimensional numerical diffraction method,” Opt. Express15(12), 7634–7641 (2007).
[CrossRef] [PubMed]

P. H. Tomlins and R. K. Wang, “Digital phase stabilization to improve detection sensitivity for optical coherence tomography,” Meas. Sci. Technol.18(11), 3365–3372 (2007).
[CrossRef]

T. S. Ralston, D. L. Marks, P. Scott Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys.3(2), 129–134 (2007).
[CrossRef]

2006 (3)

R. K. Wang and Z. Ma, “A practical approach to eliminate autocorrelation artefacts for volume-rate spectral domain optical coherence tomography,” Phys. Med. Biol.51(12), 3231–3239 (2006).
[CrossRef] [PubMed]

R. K. Wang and Z. H. Ma, “A practical approach to eliminate autocorrelation artefacts for volume-rate spectral domain optical coherence tomography,” Phys. Med. Biol.51(12), 3231–3239 (2006).
[CrossRef] [PubMed]

C. Xu, C. Vinegoni, T. S. Ralston, W. Luo, W. Tan, and S. A. Boppart, “Spectroscopic spectral-domain optical coherence microscopy,” Opt. Lett.31(8), 1079–1081 (2006).
[CrossRef] [PubMed]

2005 (3)

2004 (3)

2003 (2)

2002 (1)

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by Fourier domain optical coherence tomography,” J. Biomed. Opt.7(3), 457–463 (2002).
[CrossRef] [PubMed]

2001 (1)

1997 (1)

1995 (1)

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, “Measurement of intraocular distances by backscattering spectral interferometry,” Opt. Commun.117(1–2), 43–48 (1995).
[CrossRef]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Adler, D.

Akkin, T.

An, L.

Badizadegan, K.

Bagnaninchi, P. O.

Y. Jia, P. O. Bagnaninchi, Y. Yang, A. E. Haj, M. T. Hinds, S. J. Kirkpatrick, and R. K. Wang, “Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds,” J. Biomed. Opt.14(3), 034014 (2009).
[CrossRef] [PubMed]

Bajraszewski, T.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by Fourier domain optical coherence tomography,” J. Biomed. Opt.7(3), 457–463 (2002).
[CrossRef] [PubMed]

Bennion, I.

Boas, D. A.

Boppart, S. A.

T. S. Ralston, D. L. Marks, P. Scott Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys.3(2), 129–134 (2007).
[CrossRef]

C. Xu, C. Vinegoni, T. S. Ralston, W. Luo, W. Tan, and S. A. Boppart, “Spectroscopic spectral-domain optical coherence microscopy,” Opt. Lett.31(8), 1079–1081 (2006).
[CrossRef] [PubMed]

T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, “Deconvolution methods for mitigation of transverse blurring in optical coherence tomography,” IEEE Trans. Image Process.14(9), 1254–1264 (2005).
[CrossRef] [PubMed]

Bouma, B.

Bouma, B. E.

Cense, B.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Chen, T.

Chen, T. C.

Chen, Z.

Choi, W.

Choma, M. A.

Creazzo, T. L.

Dasari, R. R.

de Boer, J. F.

Ellerbee, A. K.

El-Zaiat, S. Y.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, “Measurement of intraocular distances by backscattering spectral interferometry,” Opt. Commun.117(1–2), 43–48 (1995).
[CrossRef]

Fang-Yen, C.

Feld, M. S.

Fercher, A. F.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by Fourier domain optical coherence tomography,” J. Biomed. Opt.7(3), 457–463 (2002).
[CrossRef] [PubMed]

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, “Measurement of intraocular distances by backscattering spectral interferometry,” Opt. Commun.117(1–2), 43–48 (1995).
[CrossRef]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Fujimoto, J.

Fujimoto, J. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Guo, S.

Hahn, M. S.

Haj, A. E.

Y. Jia, P. O. Bagnaninchi, Y. Yang, A. E. Haj, M. T. Hinds, S. J. Kirkpatrick, and R. K. Wang, “Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds,” J. Biomed. Opt.14(3), 034014 (2009).
[CrossRef] [PubMed]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Herz, P.

Hinds, M. T.

Y. Jia, P. O. Bagnaninchi, Y. Yang, A. E. Haj, M. T. Hinds, S. J. Kirkpatrick, and R. K. Wang, “Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds,” J. Biomed. Opt.14(3), 034014 (2009).
[CrossRef] [PubMed]

Hitzenberger, C. K.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, “Measurement of intraocular distances by backscattering spectral interferometry,” Opt. Commun.117(1–2), 43–48 (1995).
[CrossRef]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Izatt, J. A.

Jia, Y.

Y. Jia, P. O. Bagnaninchi, Y. Yang, A. E. Haj, M. T. Hinds, S. J. Kirkpatrick, and R. K. Wang, “Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds,” J. Biomed. Opt.14(3), 034014 (2009).
[CrossRef] [PubMed]

Jiang, X.

Joo, C.

Kamalabadi, F.

T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, “Deconvolution methods for mitigation of transverse blurring in optical coherence tomography,” IEEE Trans. Image Process.14(9), 1254–1264 (2005).
[CrossRef] [PubMed]

Kamp, G.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, “Measurement of intraocular distances by backscattering spectral interferometry,” Opt. Commun.117(1–2), 43–48 (1995).
[CrossRef]

Kane, D. J.

Kirkpatrick, S. J.

Y. Jia, P. O. Bagnaninchi, Y. Yang, A. E. Haj, M. T. Hinds, S. J. Kirkpatrick, and R. K. Wang, “Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds,” J. Biomed. Opt.14(3), 034014 (2009).
[CrossRef] [PubMed]

Ko, T.

Kowalczyk, A.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by Fourier domain optical coherence tomography,” J. Biomed. Opt.7(3), 457–463 (2002).
[CrossRef] [PubMed]

Lee, J.

Leitgeb, R.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by Fourier domain optical coherence tomography,” J. Biomed. Opt.7(3), 457–463 (2002).
[CrossRef] [PubMed]

Liang, Y.

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Lin, D.

Liu, G.

Liu, Y.

Lue, N.

Luo, W.

Ma, Z.

R. K. Wang and Z. Ma, “A practical approach to eliminate autocorrelation artefacts for volume-rate spectral domain optical coherence tomography,” Phys. Med. Biol.51(12), 3231–3239 (2006).
[CrossRef] [PubMed]

Ma, Z. H.

R. K. Wang and Z. H. Ma, “A practical approach to eliminate autocorrelation artefacts for volume-rate spectral domain optical coherence tomography,” Phys. Med. Biol.51(12), 3231–3239 (2006).
[CrossRef] [PubMed]

Marks, D. L.

T. S. Ralston, D. L. Marks, P. Scott Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys.3(2), 129–134 (2007).
[CrossRef]

T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, “Deconvolution methods for mitigation of transverse blurring in optical coherence tomography,” IEEE Trans. Image Process.14(9), 1254–1264 (2005).
[CrossRef] [PubMed]

Milner, T. E.

Mu, G.

Nassif, N.

Nassif, N. A.

Nelson, J. S.

Oh, S.

Park, B.

Park, B. H.

Park, Y.

Peterson, K. A.

Pierce, M.

Pierce, M. C.

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Radhakrishnan, H.

Ralston, T. S.

T. S. Ralston, D. L. Marks, P. Scott Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys.3(2), 129–134 (2007).
[CrossRef]

C. Xu, C. Vinegoni, T. S. Ralston, W. Luo, W. Tan, and S. A. Boppart, “Spectroscopic spectral-domain optical coherence microscopy,” Opt. Lett.31(8), 1079–1081 (2006).
[CrossRef] [PubMed]

T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, “Deconvolution methods for mitigation of transverse blurring in optical coherence tomography,” IEEE Trans. Image Process.14(9), 1254–1264 (2005).
[CrossRef] [PubMed]

Rao, B.

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Scott Carney, P.

T. S. Ralston, D. L. Marks, P. Scott Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys.3(2), 129–134 (2007).
[CrossRef]

Srinivasan, V.

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Su, J.

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Tan, W.

Tearney, G.

Tearney, G. J.

Tomlins, P. H.

P. H. Tomlins and R. K. Wang, “Digital phase stabilization to improve detection sensitivity for optical coherence tomography,” Meas. Sci. Technol.18(11), 3365–3372 (2007).
[CrossRef]

Vakhtin, A. B.

van Gemert, M. J. C.

Vinegoni, C.

Wang, Q.

Wang, R. K.

G. Liu and R. K. Wang, “Stripe motion artifact suppression in phase-resolved OCT blood flow images of the human eye based on the frequency rejection filter,” Chin. Opt. Lett.11(3), 031701–031705 (2013).
[CrossRef]

G. Liu, Z. Zhi, and R. K. Wang, “Digital focusing of OCT images based on scalar diffraction theory and information entropy,” Biomed. Opt. Express3(11), 2774–2783 (2012).
[CrossRef] [PubMed]

G. Liu, S. Yousefi, Z. Zhi, and R. K. Wang, “Automatic estimation of point-spread-function for deconvoluting out-of-focus optical coherence tomographic images using information entropy-based approach,” Opt. Express19(19), 18135–18148 (2011).
[CrossRef] [PubMed]

Y. Jia, P. O. Bagnaninchi, Y. Yang, A. E. Haj, M. T. Hinds, S. J. Kirkpatrick, and R. K. Wang, “Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds,” J. Biomed. Opt.14(3), 034014 (2009).
[CrossRef] [PubMed]

L. An and R. K. Wang, “In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiography,” Opt. Express16(15), 11438–11452 (2008).
[CrossRef] [PubMed]

P. H. Tomlins and R. K. Wang, “Digital phase stabilization to improve detection sensitivity for optical coherence tomography,” Meas. Sci. Technol.18(11), 3365–3372 (2007).
[CrossRef]

R. K. Wang and Z. Ma, “A practical approach to eliminate autocorrelation artefacts for volume-rate spectral domain optical coherence tomography,” Phys. Med. Biol.51(12), 3231–3239 (2006).
[CrossRef] [PubMed]

R. K. Wang and Z. H. Ma, “A practical approach to eliminate autocorrelation artefacts for volume-rate spectral domain optical coherence tomography,” Phys. Med. Biol.51(12), 3231–3239 (2006).
[CrossRef] [PubMed]

Wax, A.

White, B.

Wojtkowski, M.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by Fourier domain optical coherence tomography,” J. Biomed. Opt.7(3), 457–463 (2002).
[CrossRef] [PubMed]

Wood, W. R.

Xie, F.

Xu, C.

Yang, C.

Yang, Y.

Y. Jia, P. O. Bagnaninchi, Y. Yang, A. E. Haj, M. T. Hinds, S. J. Kirkpatrick, and R. K. Wang, “Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds,” J. Biomed. Opt.14(3), 034014 (2009).
[CrossRef] [PubMed]

Yaqoob, Z.

Yousefi, S.

Yu, L.

Yun, S. H.

Zhang, J.

Zhang, L.

Zhang, W.

Zhi, Z.

Zhu, X.

Appl. Opt. (1)

Biomed. Opt. Express (1)

Chin. Opt. Lett. (1)

IEEE Trans. Image Process. (1)

T. S. Ralston, D. L. Marks, F. Kamalabadi, and S. A. Boppart, “Deconvolution methods for mitigation of transverse blurring in optical coherence tomography,” IEEE Trans. Image Process.14(9), 1254–1264 (2005).
[CrossRef] [PubMed]

J. Biomed. Opt. (2)

Y. Jia, P. O. Bagnaninchi, Y. Yang, A. E. Haj, M. T. Hinds, S. J. Kirkpatrick, and R. K. Wang, “Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds,” J. Biomed. Opt.14(3), 034014 (2009).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by Fourier domain optical coherence tomography,” J. Biomed. Opt.7(3), 457–463 (2002).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (1)

Meas. Sci. Technol. (1)

P. H. Tomlins and R. K. Wang, “Digital phase stabilization to improve detection sensitivity for optical coherence tomography,” Meas. Sci. Technol.18(11), 3365–3372 (2007).
[CrossRef]

Nat. Phys. (1)

T. S. Ralston, D. L. Marks, P. Scott Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys.3(2), 129–134 (2007).
[CrossRef]

Opt. Commun. (1)

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, “Measurement of intraocular distances by backscattering spectral interferometry,” Opt. Commun.117(1–2), 43–48 (1995).
[CrossRef]

Opt. Express (9)

B. White, M. Pierce, N. Nassif, B. Cense, B. Park, G. Tearney, B. Bouma, T. Chen, and J. F. de Boer, “In vivo dynamic human retinal blood flow imaging using ultra-high-speed spectral domain optical coherence tomography,” Opt. Express11(25), 3490–3497 (2003).
[CrossRef] [PubMed]

N. A. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, “In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve,” Opt. Express12(3), 367–376 (2004).
[CrossRef] [PubMed]

D. Adler, T. Ko, P. Herz, and J. Fujimoto, “Optical coherence tomography contrast enhancement using spectroscopic analysis with spectral autocorrelation,” Opt. Express12(22), 5487–5501 (2004).
[CrossRef] [PubMed]

D. Lin, X. Jiang, F. Xie, W. Zhang, L. Zhang, and I. Bennion, “High stability multiplexed fiber interferometer and its application on absolute displacement measurement and on-line surface metrology,” Opt. Express12(23), 5729–5734 (2004).
[CrossRef] [PubMed]

Z. Yaqoob, W. Choi, S. Oh, N. Lue, Y. Park, C. Fang-Yen, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing,” Opt. Express17(13), 10681–10687 (2009).
[CrossRef] [PubMed]

G. Liu, S. Yousefi, Z. Zhi, and R. K. Wang, “Automatic estimation of point-spread-function for deconvoluting out-of-focus optical coherence tomographic images using information entropy-based approach,” Opt. Express19(19), 18135–18148 (2011).
[CrossRef] [PubMed]

J. Lee, V. Srinivasan, H. Radhakrishnan, and D. A. Boas, “Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex,” Opt. Express19(22), 21258–21270 (2011).
[CrossRef] [PubMed]

L. Yu, B. Rao, J. Zhang, J. Su, Q. Wang, S. Guo, and Z. Chen, “Improved lateral resolution in optical coherence tomography by digital focusing using two-dimensional numerical diffraction method,” Opt. Express15(12), 7634–7641 (2007).
[CrossRef] [PubMed]

L. An and R. K. Wang, “In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiography,” Opt. Express16(15), 11438–11452 (2008).
[CrossRef] [PubMed]

Opt. Lett. (5)

Phys. Med. Biol. (2)

R. K. Wang and Z. Ma, “A practical approach to eliminate autocorrelation artefacts for volume-rate spectral domain optical coherence tomography,” Phys. Med. Biol.51(12), 3231–3239 (2006).
[CrossRef] [PubMed]

R. K. Wang and Z. H. Ma, “A practical approach to eliminate autocorrelation artefacts for volume-rate spectral domain optical coherence tomography,” Phys. Med. Biol.51(12), 3231–3239 (2006).
[CrossRef] [PubMed]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Other (1)

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Phase stability technique for inverse scattering in optical coherence tomography,” 3rd IEEE International Symposium on Biomedical Imaging: Nano to Macro, 578–581 (2006).
[CrossRef]

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (14)

Fig. 1
Fig. 1

OCT 3D volume data consisting of sampling points, A-scans and B-scans.

Fig. 2
Fig. 2

Phase comparing of two adjacent A-scans. (a) B-scan image (512*512) of a tomato. (b) Partially magnified image of Fig. (a). (c) Phase curve of A-scan A 263 from z = 125 to z = 145. (d) Phase curve of A-scan A 264 from z = 125 to z = 145 and (e) Phase different between A-scan A 264 and A 263 .

Fig. 3
Fig. 3

Phase differences between adjacent A-scans of first B-scan image of (a) human finger and (b) human palm.

Fig. 4
Fig. 4

Phase differences between adjacent A-scans of adjacent B-scans of (a)-(d) human finger and (e)-(h) human palm.

Fig. 5
Fig. 5

The phase differences of all A-scans to the phase of the first A-scan of the first B-scan. (a) and (b) are phase differences expressed with positive angles (phase lead) of human finger and human palm, respectively. (c) is the enlargement of the selected part A in Fig. (a). (d) is the enlargement of the selected part B in Fig. (b). (e) and (f) are phase differences expressed with cyclic angle i.e. ±π of human finger and human palm, respectively. (g) and (h) are partially enlargement of Figs. (e) and (f), respectively.

Fig. 6
Fig. 6

Schematic illustration on the effect of numerical aperture on the desired lateral resolution and DOF of OCT images, in the case of (a) low NA and (b) high NA.

Fig. 7
Fig. 7

(a)The defocused finger image and (b) recovered image using phase compensated complex signal based on scalar diffraction algorithm.

Fig. 8
Fig. 8

(a)The defocused y-z plane image of palm and (b) recovered image without using phase compensated complex signal and (c) recovered image using phase compensated complex signal based on scalar diffraction algorithm.

Fig. 9
Fig. 9

Gray value along the line Z = Zi in (a) Fig. 8(a) (b) Fig. 8(b) and (c) Fig. 8(c), respectively.

Fig. 10
Fig. 10

Application of phase registration in retina blood flow imaging. (a) and (b) are two original B-scan cross section image of retina. (c) and (e) is extracted blood flow image before and after phase registration of A-scans, respectively. (d) is phase differences between A-scans of two original B-scans. (f) is the three dimensional display of the extracted blood flow image of retina.

Fig. 11
Fig. 11

Search results of strongly scattering points on the surface of two typical adjacent A-scans of human finger and calculated results of phase difference for different M and ε.

Fig. 12
Fig. 12

Digitally focused results of a y-z plane image of human palm for different M and ε.

Fig. 13
Fig. 13

Results of retina blood flow imaging before phase registration (on the top right corner) and after phase registration for different M and ε.

Fig. 14
Fig. 14

Better choices of M and ε for three different applications.

Equations (14)

Equations on this page are rendered with MathJax. Learn more.

I(k)= I S (k)+ I R (k)+2 I S (k) I R (k) cos( φ S (k) φ R (k))
I(k) | S(k) | 2 R(z) cos [2k( l 0 + l 0 z n( z ) d z )]dz = | S(k) | 2 R(z) cos [2k( l z )]dz
l z = l 0 + l 0 z n( z ) d z
F T 1 [I(k)]F T 1 [ | S(k) | 2 ] R(z) F T 1 {cos(2k l z )} dz =E(z) 1 2 R(z) [δ(z2 l z )+δ(z+2 l z )]dz = 1 2 R(z) [E(z2 l z )+E(z+2 l z )]dz
F(z)=A(z) e jφ(z)
F(z)=A(zΔz) e jφ(zΔz)
P D i,M (I) =[P D i,M (I) (1),,P D i,M (I) (j),,P D i,M (I) (M)] =[ φ i+1 (I) φ i (I) ,, φ i+j (I) φ i+j (I) ,, φ i+M (I) φ i+M1 (I) ],j=1,2,,M
P D error (I) = j=1 M | P D i,M (I) (j)P D i,M (I1) (j) | <ε
Δφ= k=1 N ( φ k (I) φ k (I1) ) N
U Compensated (x,y)= U Original (x,y) e jPhas e compensation (x,y)
U Focused (x,y)= 1 2π exp(jkz)F T 1 {FT[ U Defocused (x,y)]×exp[ jz 2k ( k x 2 + k y 2 )]}
F(x,z)=A(x,z)exp[iφ(x,z)]
F Compensated (x,z) t2 =F (x,z) t2 e jPhas e compensation (x)
F blow (x,z)=ΔF(x,z)= F Compensated (x,z) t2 F (x,z) t1

Metrics