Abstract

Occlusions of bilateral common carotid arteries (bi-CCA) in mice are popular models for the investigation of transient forebrain ischemia. Currently available technologies for assessing cerebral blood flow (CBF) and oxygenation in ischemic mice have limitations. This study tests a novel near-infrared diffuse correlation spectroscopy (DCS) flow-oximeter for monitoring both CBF and cerebral oxygenation in mice undergoing repeated transient forebrain ischemia. Concurrent flow measurements in a mouse brain were first conducted for validation purposes; DCS measurement was found highly correlated with laser Doppler measurement (R2 = 0.94) and less susceptible to motion artifacts. With unique designs in experimental protocols and fiber-optic probes, we have demonstrated high sensitivities of DCS flow-oximeter in detecting the regional heterogeneity of CBF responses in different hemispheres and global changes of both CBF and cerebral oxygenation across two hemispheres in mice undergoing repeated 2-minute bi-CCA occlusions over 5 days. More than 75% CBF reductions were found during bi-CCA occlusions in mice, which may be considered as a threshold to determine a successful bi-CCA occlusion. With the progress of repeated 2-minute bi-CCA occlusions over days, a longitudinal decline in the magnitudes of CBF reduction was observed, indicating the brain adaptation to cerebral ischemia through the repeated preconditioning.

© 2011 OSA

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2011

Y. Shang, R. Cheng, L. Dong, S. J. Ryan, S. P. Saha, and G. Yu, “Cerebral monitoring during carotid endarterectomy using near-infrared diffuse optical spectroscopies and electroencephalogram,” Phys. Med. Biol. 56(10), 3015–3032 (2011).
[CrossRef] [PubMed]

Y. L. Jia and R. K. K. Wang, “Optical micro-angiography images structural and functional cerebral blood perfusion in mice with cranium left intact,” J. Biophoton. 4(1-2), 57–63 (2011).
[CrossRef] [PubMed]

G. Yu, Y. Shang, Y. Zhao, R. Cheng, L. Dong, and S. P. Saha, “Intraoperative evaluation of revascularization effect on ischemic muscle hemodynamics using near-infrared diffuse optical spectroscopies,” J. Biomed. Opt. 16(2), 027004 (2011).
[CrossRef] [PubMed]

D. Irwin, L. Dong, Y. Shang, R. Cheng, M. Kudrimoti, S. D. Stevens, and G. Yu, “Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements,” Biomed. Opt. Express 2(7), 1969–1985 (2011).
[CrossRef] [PubMed]

2010

A. B. Parthasarathy, S. M. Kazmi, and A. K. Dunn, “Quantitative imaging of ischemic stroke through thinned skull in mice with Multi Exposure Speckle Imaging,” Biomed. Opt. Express 1(1), 246–259 (2010).
[CrossRef] [PubMed]

Y. Shang, T. B. Symons, T. Durduran, A. G. Yodh, and G. Yu, “Effects of muscle fiber motion on diffuse correlation spectroscopy blood flow measurements during exercise,” Biomed. Opt. Express 1(2), 500–511 (2010).
[CrossRef] [PubMed]

R. C. Mesquita, N. Skuli, M. N. Kim, J. Liang, S. Schenkel, A. J. Majmundar, M. C. Simon, and A. G. Yodh, “Hemodynamic and metabolic diffuse optical monitoring in a mouse model of hindlimb ischemia,” Biomed. Opt. Express 1(4), 1173–1187 (2010).
[CrossRef] [PubMed]

L. F. Yu, E. Nguyen, G. J. Liu, B. Choi, and Z. P. Chen, “Spectral Doppler optical coherence tomography imaging of localized ischemic stroke in a mouse model,” J. Biomed. Opt. 15(6), 066006 (2010).
[CrossRef] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

2009

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

F. H. Tian, B. Chance, and H. L. Liu, “Investigation of the prefrontal cortex in response to duration-variable anagram tasks using functional near-infrared spectroscopy,” J. Biomed. Opt. 14(5), 054016 (2009).
[CrossRef] [PubMed]

H. Piilgaard and M. Lauritzen, “Persistent increase in oxygen consumption and impaired neurovascular coupling after spreading depression in rat neocortex,” J. Cereb. Blood Flow Metab. 29(9), 1517–1527 (2009).
[CrossRef] [PubMed]

G. Pignataro, A. Scorziello, G. Di Renzo, and L. Annunziato, “Post-ischemic brain damage: effect of ischemic preconditioning and postconditioning and identification of potential candidates for stroke therapy,” FEBS J. 276(1), 46–57 (2009).
[CrossRef] [PubMed]

L. Chen, K. R. Swartz, and M. Toborek, “Vessel microport technique for applications in cerebrovascular research,” J. Neurosci. Res. 87(7), 1718–1727 (2009).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

Y. Shang, Y. Zhao, R. Cheng, L. Dong, D. Irwin, and G. Yu, “Portable optical tissue flow oximeter based on diffuse correlation spectroscopy,” Opt. Lett. 34(22), 3556–3558 (2009).
[CrossRef] [PubMed]

2008

L. Gagnon, M. Desjardins, J. Jehanne-Lacasse, L. Bherer, and F. Lesage, “Investigation of diffuse correlation spectroscopy in multi-layered media including the human head,” Opt. Express 16(20), 15514–15530 (2008).
[CrossRef] [PubMed]

J. Li, M. Ninck, L. Koban, T. Elbert, J. Kissler, and T. Gisler, “Transient functional blood flow change in the human brain measured noninvasively by diffusing-wave spectroscopy,” Opt. Lett. 33(19), 2233–2235 (2008).
[CrossRef] [PubMed]

L. F. Liu, C. K. Yeh, C. H. Chen, T. W. Wong, and J. J. J. Chen, “Measurement of Cerebral Blood Flow and Oxygen Saturation Using Laser Doppler Flowmetry and Near Infrared Spectroscopy in Ischemic Stroke Rats,” Med. Biol. Eng. 28, 101–105 (2008).

A. Durukan, D. Strbian, and T. Tatlisumak, “Rodent models of ischemic stroke: a useful tool for stroke drug development,” Curr. Pharm. Des. 14(4), 359–370 (2008).
[CrossRef] [PubMed]

2007

N. Khan, B. B. Williams, H. Hou, H. Li, and H. M. Swartz, “Repetitive tissue pO2 measurements by electron paramagnetic resonance oximetry: current status and future potential for experimental and clinical studies,” Antioxid. Redox Signal. 9(8), 1169–1182 (2007).
[CrossRef] [PubMed]

A. Van der Linden, N. Van Camp, P. Ramos-Cabrer, and M. Hoehn, “Current status of functional MRI on small animals: application to physiology, pathophysiology, and cognition,” NMR Biomed. 20(5), 522–545 (2007).
[CrossRef] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[CrossRef] [PubMed]

2006

J. M. Gidday, “Cerebral preconditioning and ischaemic tolerance,” Nat. Rev. Neurosci. 7(6), 437–448 (2006).
[CrossRef] [PubMed]

M. A. Franceschini, D. K. Joseph, T. J. Huppert, S. G. Diamond, and D. A. Boas, “Diffuse optical imaging of the whole head,” J. Biomed. Opt. 11(5), 054007 (2006).
[CrossRef] [PubMed]

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064021 (2006).
[CrossRef] [PubMed]

K. Kidoguchi, M. Tamaki, T. Mizobe, J. Koyama, T. Kondoh, E. Kohmura, T. Sakurai, K. Yokono, and K. Umetani, “In vivo X-ray angiography in the mouse brain using synchrotron radiation,” Stroke 37(7), 1856–1861 (2006).
[CrossRef] [PubMed]

2005

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
[CrossRef] [PubMed]

2004

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
[CrossRef] [PubMed]

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[CrossRef] [PubMed]

R. R. Ratan, A. Siddiq, L. Aminova, P. S. Lange, B. Langley, I. Ayoub, J. A. Gensert, and J. Chavez, “Translation of ischemic preconditioning to the patient - Prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy,” Stroke 35(11,Suppl. 1), 2687–2689 (2004).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[CrossRef] [PubMed]

2003

R. S. Marshall, T. Rundek, D. M. Sproule, B. F. M. Fitzsimmons, S. Schwartz, and R. M. Lazar, “Monitoring of cerebral vasodilatory capacity with transcranial Doppler carbon dioxide inhalation in patients with severe carotid artery disease,” Stroke 34(4), 945–949 (2003).
[CrossRef] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[CrossRef] [PubMed]

G. Strangman, M. A. Franceschini, and D. A. Boas, “Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters,” Neuroimage 18(4), 865–879 (2003).
[CrossRef] [PubMed]

2002

B. Schaller and R. Graf, “Cerebral ischemic preconditioning,” J. Neurol. 249(11), 1503–1511 (2002).
[CrossRef] [PubMed]

T. Kirino, “Ischemic tolerance,” J. Cereb. Blood Flow Metab. 22(11), 1283–1296 (2002).
[CrossRef] [PubMed]

P. Riyamongkol, W. Z. Zhao, Y. T. Liu, L. Belayev, R. Busto, and M. D. Ginsberg, “Automated registration of laser Doppler perfusion images by an adaptive correlation approach: application to focal cerebral ischemia in the rat,” J. Neurosci. Methods 122(1), 79–90 (2002).
[CrossRef] [PubMed]

2001

J. Hendrikse, M. J. Hartkamp, B. Hillen, W. P. T. M. Mali, and J. van der Grond, “Collateral ability of the circle of Willis in patients with unilateral internal carotid artery occlusion: Border zone infarcts and clinical symptoms,” Stroke 32(12), 2768–2773 (2001).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[CrossRef] [PubMed]

2000

Y. Kuge, H. Kawashima, T. Hashimoto, M. Imanishi, M. Shiomi, K. Minematsu, Y. Hasegawa, T. Yamaguchi, Y. Miyake, and N. Hashimoto, “Preliminary evaluation of [1-11C]octanoate as a PET tracer for studying cerebral ischemia: a PET study in rat and canine models of focal cerebral ischemia,” Ann. Nucl. Med. 14(1), 69–74 (2000).
[CrossRef] [PubMed]

1999

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol. 44(6), 1543–1563 (1999).
[CrossRef] [PubMed]

N. E. Stagliano, M. A. Pérez-Pinzón, M. A. Moskowitz, and P. L. Huang, “Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice,” J. Cereb. Blood Flow Metab. 19(7), 757–761 (1999).
[CrossRef] [PubMed]

M. J. Leahy, F. F. de Mul, G. E. Nilsson, and R. Maniewski, “Principles and practice of the laser-Doppler perfusion technique,” Technol. Health Care 7(2-3), 143–162 (1999).
[PubMed]

1998

K. Kitagawa, M. Matsumoto, G. M. Yang, T. Mabuchi, Y. Yagita, M. Hori, and T. Yanagihara, “Cerebral ischemia after bilateral carotid artery occlusion and intraluminal suture occlusion in mice: Evaluation of the patency of the posterior communicating artery,” J. Cereb. Blood Flow Metab. 18(5), 570–579 (1998).
[CrossRef] [PubMed]

P. T. Ulrich, S. Kroppenstedt, A. Heimann, O. Kempski, and B. G. Lyeth, “Laser-Doppler scanning of local cerebral blood flow and reserve capacity and testing of motor and memory functions in a chronic 2-vessel occlusion model in rats,” Stroke 29(11), 2412–2420 (1998).
[CrossRef] [PubMed]

1995

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, L. Tyszczuk, M. Cope, and D. T. Delpy, “Optical pathlength measurements on adult head, calf and forearm and the head of the newborn infant using phase resolved optical spectroscopy,” Phys. Med. Biol. 40(2), 295–304 (1995).
[CrossRef] [PubMed]

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and Imaging with Diffusing Temporal Field Correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
[CrossRef] [PubMed]

1992

B. Chance, M. T. Dait, C. D. Zhang, T. Hamaoka, and F. Hagerman, “Recovery from Exercise-Induced Desaturation in the Quadriceps Muscles of Elite Competitive Rowers,” Am. J. Physiol. 262(3 Pt 1), C766–C775 (1992).
[PubMed]

Aminova, L.

R. R. Ratan, A. Siddiq, L. Aminova, P. S. Lange, B. Langley, I. Ayoub, J. A. Gensert, and J. Chavez, “Translation of ischemic preconditioning to the patient - Prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy,” Stroke 35(11,Suppl. 1), 2687–2689 (2004).
[CrossRef] [PubMed]

Annunziato, L.

G. Pignataro, A. Scorziello, G. Di Renzo, and L. Annunziato, “Post-ischemic brain damage: effect of ischemic preconditioning and postconditioning and identification of potential candidates for stroke therapy,” FEBS J. 276(1), 46–57 (2009).
[CrossRef] [PubMed]

Arger, P. H.

Ayoub, I.

R. R. Ratan, A. Siddiq, L. Aminova, P. S. Lange, B. Langley, I. Ayoub, J. A. Gensert, and J. Chavez, “Translation of ischemic preconditioning to the patient - Prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy,” Stroke 35(11,Suppl. 1), 2687–2689 (2004).
[CrossRef] [PubMed]

Belayev, L.

P. Riyamongkol, W. Z. Zhao, Y. T. Liu, L. Belayev, R. Busto, and M. D. Ginsberg, “Automated registration of laser Doppler perfusion images by an adaptive correlation approach: application to focal cerebral ischemia in the rat,” J. Neurosci. Methods 122(1), 79–90 (2002).
[CrossRef] [PubMed]

Bherer, L.

Boas, D. A.

M. A. Franceschini, D. K. Joseph, T. J. Huppert, S. G. Diamond, and D. A. Boas, “Diffuse optical imaging of the whole head,” J. Biomed. Opt. 11(5), 054007 (2006).
[CrossRef] [PubMed]

G. Strangman, M. A. Franceschini, and D. A. Boas, “Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters,” Neuroimage 18(4), 865–879 (2003).
[CrossRef] [PubMed]

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and Imaging with Diffusing Temporal Field Correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
[CrossRef] [PubMed]

Buckley, E. M.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

Burnett, M. G.

Busch, T. M.

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
[CrossRef] [PubMed]

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[CrossRef] [PubMed]

Busto, R.

P. Riyamongkol, W. Z. Zhao, Y. T. Liu, L. Belayev, R. Busto, and M. D. Ginsberg, “Automated registration of laser Doppler perfusion images by an adaptive correlation approach: application to focal cerebral ischemia in the rat,” J. Neurosci. Methods 122(1), 79–90 (2002).
[CrossRef] [PubMed]

Campbell, L. E.

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and Imaging with Diffusing Temporal Field Correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
[CrossRef] [PubMed]

Chance, B.

F. H. Tian, B. Chance, and H. L. Liu, “Investigation of the prefrontal cortex in response to duration-variable anagram tasks using functional near-infrared spectroscopy,” J. Biomed. Opt. 14(5), 054016 (2009).
[CrossRef] [PubMed]

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064021 (2006).
[CrossRef] [PubMed]

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
[CrossRef] [PubMed]

B. Chance, M. T. Dait, C. D. Zhang, T. Hamaoka, and F. Hagerman, “Recovery from Exercise-Induced Desaturation in the Quadriceps Muscles of Elite Competitive Rowers,” Am. J. Physiol. 262(3 Pt 1), C766–C775 (1992).
[PubMed]

Chavez, J.

R. R. Ratan, A. Siddiq, L. Aminova, P. S. Lange, B. Langley, I. Ayoub, J. A. Gensert, and J. Chavez, “Translation of ischemic preconditioning to the patient - Prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy,” Stroke 35(11,Suppl. 1), 2687–2689 (2004).
[CrossRef] [PubMed]

Chen, C. H.

L. F. Liu, C. K. Yeh, C. H. Chen, T. W. Wong, and J. J. J. Chen, “Measurement of Cerebral Blood Flow and Oxygen Saturation Using Laser Doppler Flowmetry and Near Infrared Spectroscopy in Ischemic Stroke Rats,” Med. Biol. Eng. 28, 101–105 (2008).

Chen, J. J. J.

L. F. Liu, C. K. Yeh, C. H. Chen, T. W. Wong, and J. J. J. Chen, “Measurement of Cerebral Blood Flow and Oxygen Saturation Using Laser Doppler Flowmetry and Near Infrared Spectroscopy in Ischemic Stroke Rats,” Med. Biol. Eng. 28, 101–105 (2008).

Chen, L.

L. Chen, K. R. Swartz, and M. Toborek, “Vessel microport technique for applications in cerebrovascular research,” J. Neurosci. Res. 87(7), 1718–1727 (2009).
[CrossRef] [PubMed]

Chen, Z. P.

L. F. Yu, E. Nguyen, G. J. Liu, B. Choi, and Z. P. Chen, “Spectral Doppler optical coherence tomography imaging of localized ischemic stroke in a mouse model,” J. Biomed. Opt. 15(6), 066006 (2010).
[CrossRef] [PubMed]

Cheng, R.

Y. Shang, R. Cheng, L. Dong, S. J. Ryan, S. P. Saha, and G. Yu, “Cerebral monitoring during carotid endarterectomy using near-infrared diffuse optical spectroscopies and electroencephalogram,” Phys. Med. Biol. 56(10), 3015–3032 (2011).
[CrossRef] [PubMed]

G. Yu, Y. Shang, Y. Zhao, R. Cheng, L. Dong, and S. P. Saha, “Intraoperative evaluation of revascularization effect on ischemic muscle hemodynamics using near-infrared diffuse optical spectroscopies,” J. Biomed. Opt. 16(2), 027004 (2011).
[CrossRef] [PubMed]

D. Irwin, L. Dong, Y. Shang, R. Cheng, M. Kudrimoti, S. D. Stevens, and G. Yu, “Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements,” Biomed. Opt. Express 2(7), 1969–1985 (2011).
[CrossRef] [PubMed]

Y. Shang, Y. Zhao, R. Cheng, L. Dong, D. Irwin, and G. Yu, “Portable optical tissue flow oximeter based on diffuse correlation spectroscopy,” Opt. Lett. 34(22), 3556–3558 (2009).
[CrossRef] [PubMed]

Cheung, C.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[CrossRef] [PubMed]

Choe, R.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064021 (2006).
[CrossRef] [PubMed]

Choi, B.

L. F. Yu, E. Nguyen, G. J. Liu, B. Choi, and Z. P. Chen, “Spectral Doppler optical coherence tomography imaging of localized ischemic stroke in a mouse model,” J. Biomed. Opt. 15(6), 066006 (2010).
[CrossRef] [PubMed]

Clemence, M.

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, L. Tyszczuk, M. Cope, and D. T. Delpy, “Optical pathlength measurements on adult head, calf and forearm and the head of the newborn infant using phase resolved optical spectroscopy,” Phys. Med. Biol. 40(2), 295–304 (1995).
[CrossRef] [PubMed]

Cook, N. M.

Cope, M.

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, L. Tyszczuk, M. Cope, and D. T. Delpy, “Optical pathlength measurements on adult head, calf and forearm and the head of the newborn infant using phase resolved optical spectroscopy,” Phys. Med. Biol. 40(2), 295–304 (1995).
[CrossRef] [PubMed]

Culver, J. P.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[CrossRef] [PubMed]

Dait, M. T.

B. Chance, M. T. Dait, C. D. Zhang, T. Hamaoka, and F. Hagerman, “Recovery from Exercise-Induced Desaturation in the Quadriceps Muscles of Elite Competitive Rowers,” Am. J. Physiol. 262(3 Pt 1), C766–C775 (1992).
[PubMed]

de Mul, F. F.

M. J. Leahy, F. F. de Mul, G. E. Nilsson, and R. Maniewski, “Principles and practice of the laser-Doppler perfusion technique,” Technol. Health Care 7(2-3), 143–162 (1999).
[PubMed]

Delpy, D. T.

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, L. Tyszczuk, M. Cope, and D. T. Delpy, “Optical pathlength measurements on adult head, calf and forearm and the head of the newborn infant using phase resolved optical spectroscopy,” Phys. Med. Biol. 40(2), 295–304 (1995).
[CrossRef] [PubMed]

Desjardins, M.

Detre, J. A.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[CrossRef] [PubMed]

Di Renzo, G.

G. Pignataro, A. Scorziello, G. Di Renzo, and L. Annunziato, “Post-ischemic brain damage: effect of ischemic preconditioning and postconditioning and identification of potential candidates for stroke therapy,” FEBS J. 276(1), 46–57 (2009).
[CrossRef] [PubMed]

Diamond, S. G.

M. A. Franceschini, D. K. Joseph, T. J. Huppert, S. G. Diamond, and D. A. Boas, “Diffuse optical imaging of the whole head,” J. Biomed. Opt. 11(5), 054007 (2006).
[CrossRef] [PubMed]

Dong, L.

G. Yu, Y. Shang, Y. Zhao, R. Cheng, L. Dong, and S. P. Saha, “Intraoperative evaluation of revascularization effect on ischemic muscle hemodynamics using near-infrared diffuse optical spectroscopies,” J. Biomed. Opt. 16(2), 027004 (2011).
[CrossRef] [PubMed]

Y. Shang, R. Cheng, L. Dong, S. J. Ryan, S. P. Saha, and G. Yu, “Cerebral monitoring during carotid endarterectomy using near-infrared diffuse optical spectroscopies and electroencephalogram,” Phys. Med. Biol. 56(10), 3015–3032 (2011).
[CrossRef] [PubMed]

D. Irwin, L. Dong, Y. Shang, R. Cheng, M. Kudrimoti, S. D. Stevens, and G. Yu, “Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements,” Biomed. Opt. Express 2(7), 1969–1985 (2011).
[CrossRef] [PubMed]

Y. Shang, Y. Zhao, R. Cheng, L. Dong, D. Irwin, and G. Yu, “Portable optical tissue flow oximeter based on diffuse correlation spectroscopy,” Opt. Lett. 34(22), 3556–3558 (2009).
[CrossRef] [PubMed]

Du, J.

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064021 (2006).
[CrossRef] [PubMed]

Duncan, A.

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, L. Tyszczuk, M. Cope, and D. T. Delpy, “Optical pathlength measurements on adult head, calf and forearm and the head of the newborn infant using phase resolved optical spectroscopy,” Phys. Med. Biol. 40(2), 295–304 (1995).
[CrossRef] [PubMed]

Dunn, A. K.

Durduran, T.

Y. Shang, T. B. Symons, T. Durduran, A. G. Yodh, and G. Yu, “Effects of muscle fiber motion on diffuse correlation spectroscopy blood flow measurements during exercise,” Biomed. Opt. Express 1(2), 500–511 (2010).
[CrossRef] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[CrossRef] [PubMed]

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064021 (2006).
[CrossRef] [PubMed]

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[CrossRef] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[CrossRef] [PubMed]

Durukan, A.

A. Durukan, D. Strbian, and T. Tatlisumak, “Rodent models of ischemic stroke: a useful tool for stroke drug development,” Curr. Pharm. Des. 14(4), 359–370 (2008).
[CrossRef] [PubMed]

Edlow, B. L.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

Elbert, T.

Elwell, C. E.

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, L. Tyszczuk, M. Cope, and D. T. Delpy, “Optical pathlength measurements on adult head, calf and forearm and the head of the newborn infant using phase resolved optical spectroscopy,” Phys. Med. Biol. 40(2), 295–304 (1995).
[CrossRef] [PubMed]

Emanuele, M. J.

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[CrossRef] [PubMed]

Eucker, S. A.

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

Fantini, S.

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol. 44(6), 1543–1563 (1999).
[CrossRef] [PubMed]

Fitzsimmons, B. F. M.

R. S. Marshall, T. Rundek, D. M. Sproule, B. F. M. Fitzsimmons, S. Schwartz, and R. M. Lazar, “Monitoring of cerebral vasodilatory capacity with transcranial Doppler carbon dioxide inhalation in patients with severe carotid artery disease,” Stroke 34(4), 945–949 (2003).
[CrossRef] [PubMed]

Floyd, T. F.

Franceschini, M. A.

M. A. Franceschini, D. K. Joseph, T. J. Huppert, S. G. Diamond, and D. A. Boas, “Diffuse optical imaging of the whole head,” J. Biomed. Opt. 11(5), 054007 (2006).
[CrossRef] [PubMed]

G. Strangman, M. A. Franceschini, and D. A. Boas, “Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters,” Neuroimage 18(4), 865–879 (2003).
[CrossRef] [PubMed]

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol. 44(6), 1543–1563 (1999).
[CrossRef] [PubMed]

Frangos, S.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

Friess, S. H.

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

Furuya, D.

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[CrossRef] [PubMed]

Gagnon, L.

Gensert, J. A.

R. R. Ratan, A. Siddiq, L. Aminova, P. S. Lange, B. Langley, I. Ayoub, J. A. Gensert, and J. Chavez, “Translation of ischemic preconditioning to the patient - Prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy,” Stroke 35(11,Suppl. 1), 2687–2689 (2004).
[CrossRef] [PubMed]

Gidday, J. M.

J. M. Gidday, “Cerebral preconditioning and ischaemic tolerance,” Nat. Rev. Neurosci. 7(6), 437–448 (2006).
[CrossRef] [PubMed]

Ginsberg, M. D.

P. Riyamongkol, W. Z. Zhao, Y. T. Liu, L. Belayev, R. Busto, and M. D. Ginsberg, “Automated registration of laser Doppler perfusion images by an adaptive correlation approach: application to focal cerebral ischemia in the rat,” J. Neurosci. Methods 122(1), 79–90 (2002).
[CrossRef] [PubMed]

Gisler, T.

Glatstein, E.

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
[CrossRef] [PubMed]

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[CrossRef] [PubMed]

Grady, M. S.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

Graf, R.

B. Schaller and R. Graf, “Cerebral ischemic preconditioning,” J. Neurol. 249(11), 1503–1511 (2002).
[CrossRef] [PubMed]

Gratton, E.

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol. 44(6), 1543–1563 (1999).
[CrossRef] [PubMed]

Greenberg, J. H.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[CrossRef] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[CrossRef] [PubMed]

Guven, M.

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
[CrossRef] [PubMed]

Hagerman, F.

B. Chance, M. T. Dait, C. D. Zhang, T. Hamaoka, and F. Hagerman, “Recovery from Exercise-Induced Desaturation in the Quadriceps Muscles of Elite Competitive Rowers,” Am. J. Physiol. 262(3 Pt 1), C766–C775 (1992).
[PubMed]

Hamaoka, T.

B. Chance, M. T. Dait, C. D. Zhang, T. Hamaoka, and F. Hagerman, “Recovery from Exercise-Induced Desaturation in the Quadriceps Muscles of Elite Competitive Rowers,” Am. J. Physiol. 262(3 Pt 1), C766–C775 (1992).
[PubMed]

Hartkamp, M. J.

J. Hendrikse, M. J. Hartkamp, B. Hillen, W. P. T. M. Mali, and J. van der Grond, “Collateral ability of the circle of Willis in patients with unilateral internal carotid artery occlusion: Border zone infarcts and clinical symptoms,” Stroke 32(12), 2768–2773 (2001).
[CrossRef] [PubMed]

Hasegawa, Y.

Y. Kuge, H. Kawashima, T. Hashimoto, M. Imanishi, M. Shiomi, K. Minematsu, Y. Hasegawa, T. Yamaguchi, Y. Miyake, and N. Hashimoto, “Preliminary evaluation of [1-11C]octanoate as a PET tracer for studying cerebral ischemia: a PET study in rat and canine models of focal cerebral ischemia,” Ann. Nucl. Med. 14(1), 69–74 (2000).
[CrossRef] [PubMed]

Hashimoto, N.

Y. Kuge, H. Kawashima, T. Hashimoto, M. Imanishi, M. Shiomi, K. Minematsu, Y. Hasegawa, T. Yamaguchi, Y. Miyake, and N. Hashimoto, “Preliminary evaluation of [1-11C]octanoate as a PET tracer for studying cerebral ischemia: a PET study in rat and canine models of focal cerebral ischemia,” Ann. Nucl. Med. 14(1), 69–74 (2000).
[CrossRef] [PubMed]

Hashimoto, T.

Y. Kuge, H. Kawashima, T. Hashimoto, M. Imanishi, M. Shiomi, K. Minematsu, Y. Hasegawa, T. Yamaguchi, Y. Miyake, and N. Hashimoto, “Preliminary evaluation of [1-11C]octanoate as a PET tracer for studying cerebral ischemia: a PET study in rat and canine models of focal cerebral ischemia,” Ann. Nucl. Med. 14(1), 69–74 (2000).
[CrossRef] [PubMed]

Heimann, A.

P. T. Ulrich, S. Kroppenstedt, A. Heimann, O. Kempski, and B. G. Lyeth, “Laser-Doppler scanning of local cerebral blood flow and reserve capacity and testing of motor and memory functions in a chronic 2-vessel occlusion model in rats,” Stroke 29(11), 2412–2420 (1998).
[CrossRef] [PubMed]

Hendrikse, J.

J. Hendrikse, M. J. Hartkamp, B. Hillen, W. P. T. M. Mali, and J. van der Grond, “Collateral ability of the circle of Willis in patients with unilateral internal carotid artery occlusion: Border zone infarcts and clinical symptoms,” Stroke 32(12), 2768–2773 (2001).
[CrossRef] [PubMed]

Hillen, B.

J. Hendrikse, M. J. Hartkamp, B. Hillen, W. P. T. M. Mali, and J. van der Grond, “Collateral ability of the circle of Willis in patients with unilateral internal carotid artery occlusion: Border zone infarcts and clinical symptoms,” Stroke 32(12), 2768–2773 (2001).
[CrossRef] [PubMed]

Hoehn, M.

A. Van der Linden, N. Van Camp, P. Ramos-Cabrer, and M. Hoehn, “Current status of functional MRI on small animals: application to physiology, pathophysiology, and cognition,” NMR Biomed. 20(5), 522–545 (2007).
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Hori, M.

K. Kitagawa, M. Matsumoto, G. M. Yang, T. Mabuchi, Y. Yagita, M. Hori, and T. Yanagihara, “Cerebral ischemia after bilateral carotid artery occlusion and intraluminal suture occlusion in mice: Evaluation of the patency of the posterior communicating artery,” J. Cereb. Blood Flow Metab. 18(5), 570–579 (1998).
[CrossRef] [PubMed]

Hou, H.

N. Khan, B. B. Williams, H. Hou, H. Li, and H. M. Swartz, “Repetitive tissue pO2 measurements by electron paramagnetic resonance oximetry: current status and future potential for experimental and clinical studies,” Antioxid. Redox Signal. 9(8), 1169–1182 (2007).
[CrossRef] [PubMed]

Huang, P. L.

N. E. Stagliano, M. A. Pérez-Pinzón, M. A. Moskowitz, and P. L. Huang, “Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice,” J. Cereb. Blood Flow Metab. 19(7), 757–761 (1999).
[CrossRef] [PubMed]

Hueber, D.

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol. 44(6), 1543–1563 (1999).
[CrossRef] [PubMed]

Huppert, T. J.

M. A. Franceschini, D. K. Joseph, T. J. Huppert, S. G. Diamond, and D. A. Boas, “Diffuse optical imaging of the whole head,” J. Biomed. Opt. 11(5), 054007 (2006).
[CrossRef] [PubMed]

Hurt, H. H.

Ichord, R. N.

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

Imanishi, M.

Y. Kuge, H. Kawashima, T. Hashimoto, M. Imanishi, M. Shiomi, K. Minematsu, Y. Hasegawa, T. Yamaguchi, Y. Miyake, and N. Hashimoto, “Preliminary evaluation of [1-11C]octanoate as a PET tracer for studying cerebral ischemia: a PET study in rat and canine models of focal cerebral ischemia,” Ann. Nucl. Med. 14(1), 69–74 (2000).
[CrossRef] [PubMed]

Intes, X.

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
[CrossRef] [PubMed]

Irwin, D.

Jehanne-Lacasse, J.

Jia, Y. L.

Y. L. Jia and R. K. K. Wang, “Optical micro-angiography images structural and functional cerebral blood perfusion in mice with cranium left intact,” J. Biophoton. 4(1-2), 57–63 (2011).
[CrossRef] [PubMed]

Joseph, D. K.

M. A. Franceschini, D. K. Joseph, T. J. Huppert, S. G. Diamond, and D. A. Boas, “Diffuse optical imaging of the whole head,” J. Biomed. Opt. 11(5), 054007 (2006).
[CrossRef] [PubMed]

Kawashima, H.

Y. Kuge, H. Kawashima, T. Hashimoto, M. Imanishi, M. Shiomi, K. Minematsu, Y. Hasegawa, T. Yamaguchi, Y. Miyake, and N. Hashimoto, “Preliminary evaluation of [1-11C]octanoate as a PET tracer for studying cerebral ischemia: a PET study in rat and canine models of focal cerebral ischemia,” Ann. Nucl. Med. 14(1), 69–74 (2000).
[CrossRef] [PubMed]

Kazmi, S. M.

Kempski, O.

P. T. Ulrich, S. Kroppenstedt, A. Heimann, O. Kempski, and B. G. Lyeth, “Laser-Doppler scanning of local cerebral blood flow and reserve capacity and testing of motor and memory functions in a chronic 2-vessel occlusion model in rats,” Stroke 29(11), 2412–2420 (1998).
[CrossRef] [PubMed]

Khan, N.

N. Khan, B. B. Williams, H. Hou, H. Li, and H. M. Swartz, “Repetitive tissue pO2 measurements by electron paramagnetic resonance oximetry: current status and future potential for experimental and clinical studies,” Antioxid. Redox Signal. 9(8), 1169–1182 (2007).
[CrossRef] [PubMed]

Kidoguchi, K.

K. Kidoguchi, M. Tamaki, T. Mizobe, J. Koyama, T. Kondoh, E. Kohmura, T. Sakurai, K. Yokono, and K. Umetani, “In vivo X-ray angiography in the mouse brain using synchrotron radiation,” Stroke 37(7), 1856–1861 (2006).
[CrossRef] [PubMed]

Kilger, A.

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064021 (2006).
[CrossRef] [PubMed]

Kim, M. N.

Kirino, T.

T. Kirino, “Ischemic tolerance,” J. Cereb. Blood Flow Metab. 22(11), 1283–1296 (2002).
[CrossRef] [PubMed]

Kissler, J.

Kitagawa, K.

K. Kitagawa, M. Matsumoto, G. M. Yang, T. Mabuchi, Y. Yagita, M. Hori, and T. Yanagihara, “Cerebral ischemia after bilateral carotid artery occlusion and intraluminal suture occlusion in mice: Evaluation of the patency of the posterior communicating artery,” J. Cereb. Blood Flow Metab. 18(5), 570–579 (1998).
[CrossRef] [PubMed]

Koban, L.

Kofke, W. A.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

Kohmura, E.

K. Kidoguchi, M. Tamaki, T. Mizobe, J. Koyama, T. Kondoh, E. Kohmura, T. Sakurai, K. Yokono, and K. Umetani, “In vivo X-ray angiography in the mouse brain using synchrotron radiation,” Stroke 37(7), 1856–1861 (2006).
[CrossRef] [PubMed]

Kondoh, T.

K. Kidoguchi, M. Tamaki, T. Mizobe, J. Koyama, T. Kondoh, E. Kohmura, T. Sakurai, K. Yokono, and K. Umetani, “In vivo X-ray angiography in the mouse brain using synchrotron radiation,” Stroke 37(7), 1856–1861 (2006).
[CrossRef] [PubMed]

Koyama, J.

K. Kidoguchi, M. Tamaki, T. Mizobe, J. Koyama, T. Kondoh, E. Kohmura, T. Sakurai, K. Yokono, and K. Umetani, “In vivo X-ray angiography in the mouse brain using synchrotron radiation,” Stroke 37(7), 1856–1861 (2006).
[CrossRef] [PubMed]

Kroppenstedt, S.

P. T. Ulrich, S. Kroppenstedt, A. Heimann, O. Kempski, and B. G. Lyeth, “Laser-Doppler scanning of local cerebral blood flow and reserve capacity and testing of motor and memory functions in a chronic 2-vessel occlusion model in rats,” Stroke 29(11), 2412–2420 (1998).
[CrossRef] [PubMed]

Kudrimoti, M.

Kuge, Y.

Y. Kuge, H. Kawashima, T. Hashimoto, M. Imanishi, M. Shiomi, K. Minematsu, Y. Hasegawa, T. Yamaguchi, Y. Miyake, and N. Hashimoto, “Preliminary evaluation of [1-11C]octanoate as a PET tracer for studying cerebral ischemia: a PET study in rat and canine models of focal cerebral ischemia,” Ann. Nucl. Med. 14(1), 69–74 (2000).
[CrossRef] [PubMed]

Lange, P. S.

R. R. Ratan, A. Siddiq, L. Aminova, P. S. Lange, B. Langley, I. Ayoub, J. A. Gensert, and J. Chavez, “Translation of ischemic preconditioning to the patient - Prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy,” Stroke 35(11,Suppl. 1), 2687–2689 (2004).
[CrossRef] [PubMed]

Langley, B.

R. R. Ratan, A. Siddiq, L. Aminova, P. S. Lange, B. Langley, I. Ayoub, J. A. Gensert, and J. Chavez, “Translation of ischemic preconditioning to the patient - Prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy,” Stroke 35(11,Suppl. 1), 2687–2689 (2004).
[CrossRef] [PubMed]

Lauritzen, M.

H. Piilgaard and M. Lauritzen, “Persistent increase in oxygen consumption and impaired neurovascular coupling after spreading depression in rat neocortex,” J. Cereb. Blood Flow Metab. 29(9), 1517–1527 (2009).
[CrossRef] [PubMed]

Lazar, R. M.

R. S. Marshall, T. Rundek, D. M. Sproule, B. F. M. Fitzsimmons, S. Schwartz, and R. M. Lazar, “Monitoring of cerebral vasodilatory capacity with transcranial Doppler carbon dioxide inhalation in patients with severe carotid artery disease,” Stroke 34(4), 945–949 (2003).
[CrossRef] [PubMed]

Leahy, M. J.

M. J. Leahy, F. F. de Mul, G. E. Nilsson, and R. Maniewski, “Principles and practice of the laser-Doppler perfusion technique,” Technol. Health Care 7(2-3), 143–162 (1999).
[PubMed]

Lesage, F.

Levine, J. M.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

Li, H.

N. Khan, B. B. Williams, H. Hou, H. Li, and H. M. Swartz, “Repetitive tissue pO2 measurements by electron paramagnetic resonance oximetry: current status and future potential for experimental and clinical studies,” Antioxid. Redox Signal. 9(8), 1169–1182 (2007).
[CrossRef] [PubMed]

Li, J.

Liang, J.

Licht, D. J.

Liu, G. J.

L. F. Yu, E. Nguyen, G. J. Liu, B. Choi, and Z. P. Chen, “Spectral Doppler optical coherence tomography imaging of localized ischemic stroke in a mouse model,” J. Biomed. Opt. 15(6), 066006 (2010).
[CrossRef] [PubMed]

Liu, H. L.

F. H. Tian, B. Chance, and H. L. Liu, “Investigation of the prefrontal cortex in response to duration-variable anagram tasks using functional near-infrared spectroscopy,” J. Biomed. Opt. 14(5), 054016 (2009).
[CrossRef] [PubMed]

Liu, L. F.

L. F. Liu, C. K. Yeh, C. H. Chen, T. W. Wong, and J. J. J. Chen, “Measurement of Cerebral Blood Flow and Oxygen Saturation Using Laser Doppler Flowmetry and Near Infrared Spectroscopy in Ischemic Stroke Rats,” Med. Biol. Eng. 28, 101–105 (2008).

Liu, Y. T.

P. Riyamongkol, W. Z. Zhao, Y. T. Liu, L. Belayev, R. Busto, and M. D. Ginsberg, “Automated registration of laser Doppler perfusion images by an adaptive correlation approach: application to focal cerebral ischemia in the rat,” J. Neurosci. Methods 122(1), 79–90 (2002).
[CrossRef] [PubMed]

Loevner, L.

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064021 (2006).
[CrossRef] [PubMed]

Lustig, R.

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064021 (2006).
[CrossRef] [PubMed]

Lyeth, B. G.

P. T. Ulrich, S. Kroppenstedt, A. Heimann, O. Kempski, and B. G. Lyeth, “Laser-Doppler scanning of local cerebral blood flow and reserve capacity and testing of motor and memory functions in a chronic 2-vessel occlusion model in rats,” Stroke 29(11), 2412–2420 (1998).
[CrossRef] [PubMed]

Mabuchi, T.

K. Kitagawa, M. Matsumoto, G. M. Yang, T. Mabuchi, Y. Yagita, M. Hori, and T. Yanagihara, “Cerebral ischemia after bilateral carotid artery occlusion and intraluminal suture occlusion in mice: Evaluation of the patency of the posterior communicating artery,” J. Cereb. Blood Flow Metab. 18(5), 570–579 (1998).
[CrossRef] [PubMed]

Majmundar, A. J.

Mali, W. P. T. M.

J. Hendrikse, M. J. Hartkamp, B. Hillen, W. P. T. M. Mali, and J. van der Grond, “Collateral ability of the circle of Willis in patients with unilateral internal carotid artery occlusion: Border zone infarcts and clinical symptoms,” Stroke 32(12), 2768–2773 (2001).
[CrossRef] [PubMed]

Maloney-Wilensky, E.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

Maloux, C.

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
[CrossRef] [PubMed]

Maniewski, R.

M. J. Leahy, F. F. de Mul, G. E. Nilsson, and R. Maniewski, “Principles and practice of the laser-Doppler perfusion technique,” Technol. Health Care 7(2-3), 143–162 (1999).
[PubMed]

Margulies, S. S.

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

Marshall, R. S.

R. S. Marshall, T. Rundek, D. M. Sproule, B. F. M. Fitzsimmons, S. Schwartz, and R. M. Lazar, “Monitoring of cerebral vasodilatory capacity with transcranial Doppler carbon dioxide inhalation in patients with severe carotid artery disease,” Stroke 34(4), 945–949 (2003).
[CrossRef] [PubMed]

Matsumoto, M.

K. Kitagawa, M. Matsumoto, G. M. Yang, T. Mabuchi, Y. Yagita, M. Hori, and T. Yanagihara, “Cerebral ischemia after bilateral carotid artery occlusion and intraluminal suture occlusion in mice: Evaluation of the patency of the posterior communicating artery,” J. Cereb. Blood Flow Metab. 18(5), 570–579 (1998).
[CrossRef] [PubMed]

Maulik, D.

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A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, L. Tyszczuk, M. Cope, and D. T. Delpy, “Optical pathlength measurements on adult head, calf and forearm and the head of the newborn infant using phase resolved optical spectroscopy,” Phys. Med. Biol. 40(2), 295–304 (1995).
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Minematsu, K.

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Y. Kuge, H. Kawashima, T. Hashimoto, M. Imanishi, M. Shiomi, K. Minematsu, Y. Hasegawa, T. Yamaguchi, Y. Miyake, and N. Hashimoto, “Preliminary evaluation of [1-11C]octanoate as a PET tracer for studying cerebral ischemia: a PET study in rat and canine models of focal cerebral ischemia,” Ann. Nucl. Med. 14(1), 69–74 (2000).
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N. E. Stagliano, M. A. Pérez-Pinzón, M. A. Moskowitz, and P. L. Huang, “Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice,” J. Cereb. Blood Flow Metab. 19(7), 757–761 (1999).
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M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
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N. E. Stagliano, M. A. Pérez-Pinzón, M. A. Moskowitz, and P. L. Huang, “Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice,” J. Cereb. Blood Flow Metab. 19(7), 757–761 (1999).
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G. Pignataro, A. Scorziello, G. Di Renzo, and L. Annunziato, “Post-ischemic brain damage: effect of ischemic preconditioning and postconditioning and identification of potential candidates for stroke therapy,” FEBS J. 276(1), 46–57 (2009).
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H. Piilgaard and M. Lauritzen, “Persistent increase in oxygen consumption and impaired neurovascular coupling after spreading depression in rat neocortex,” J. Cereb. Blood Flow Metab. 29(9), 1517–1527 (2009).
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E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
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G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
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U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064021 (2006).
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A. Van der Linden, N. Van Camp, P. Ramos-Cabrer, and M. Hoehn, “Current status of functional MRI on small animals: application to physiology, pathophysiology, and cognition,” NMR Biomed. 20(5), 522–545 (2007).
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Y. Shang, R. Cheng, L. Dong, S. J. Ryan, S. P. Saha, and G. Yu, “Cerebral monitoring during carotid endarterectomy using near-infrared diffuse optical spectroscopies and electroencephalogram,” Phys. Med. Biol. 56(10), 3015–3032 (2011).
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G. Pignataro, A. Scorziello, G. Di Renzo, and L. Annunziato, “Post-ischemic brain damage: effect of ischemic preconditioning and postconditioning and identification of potential candidates for stroke therapy,” FEBS J. 276(1), 46–57 (2009).
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E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
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Skuli, N.

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R. S. Marshall, T. Rundek, D. M. Sproule, B. F. M. Fitzsimmons, S. Schwartz, and R. M. Lazar, “Monitoring of cerebral vasodilatory capacity with transcranial Doppler carbon dioxide inhalation in patients with severe carotid artery disease,” Stroke 34(4), 945–949 (2003).
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N. E. Stagliano, M. A. Pérez-Pinzón, M. A. Moskowitz, and P. L. Huang, “Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice,” J. Cereb. Blood Flow Metab. 19(7), 757–761 (1999).
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S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol. 44(6), 1543–1563 (1999).
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N. Khan, B. B. Williams, H. Hou, H. Li, and H. M. Swartz, “Repetitive tissue pO2 measurements by electron paramagnetic resonance oximetry: current status and future potential for experimental and clinical studies,” Antioxid. Redox Signal. 9(8), 1169–1182 (2007).
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L. Chen, K. R. Swartz, and M. Toborek, “Vessel microport technique for applications in cerebrovascular research,” J. Neurosci. Res. 87(7), 1718–1727 (2009).
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K. Kidoguchi, M. Tamaki, T. Mizobe, J. Koyama, T. Kondoh, E. Kohmura, T. Sakurai, K. Yokono, and K. Umetani, “In vivo X-ray angiography in the mouse brain using synchrotron radiation,” Stroke 37(7), 1856–1861 (2006).
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A. Durukan, D. Strbian, and T. Tatlisumak, “Rodent models of ischemic stroke: a useful tool for stroke drug development,” Curr. Pharm. Des. 14(4), 359–370 (2008).
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F. H. Tian, B. Chance, and H. L. Liu, “Investigation of the prefrontal cortex in response to duration-variable anagram tasks using functional near-infrared spectroscopy,” J. Biomed. Opt. 14(5), 054016 (2009).
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L. Chen, K. R. Swartz, and M. Toborek, “Vessel microport technique for applications in cerebrovascular research,” J. Neurosci. Res. 87(7), 1718–1727 (2009).
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A. Van der Linden, N. Van Camp, P. Ramos-Cabrer, and M. Hoehn, “Current status of functional MRI on small animals: application to physiology, pathophysiology, and cognition,” NMR Biomed. 20(5), 522–545 (2007).
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A. Van der Linden, N. Van Camp, P. Ramos-Cabrer, and M. Hoehn, “Current status of functional MRI on small animals: application to physiology, pathophysiology, and cognition,” NMR Biomed. 20(5), 522–545 (2007).
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G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
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M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
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M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
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C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
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G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
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U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064021 (2006).
[CrossRef] [PubMed]

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[CrossRef] [PubMed]

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[CrossRef] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[CrossRef] [PubMed]

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and Imaging with Diffusing Temporal Field Correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
[CrossRef] [PubMed]

Yokono, K.

K. Kidoguchi, M. Tamaki, T. Mizobe, J. Koyama, T. Kondoh, E. Kohmura, T. Sakurai, K. Yokono, and K. Umetani, “In vivo X-ray angiography in the mouse brain using synchrotron radiation,” Stroke 37(7), 1856–1861 (2006).
[CrossRef] [PubMed]

Yu, G.

D. Irwin, L. Dong, Y. Shang, R. Cheng, M. Kudrimoti, S. D. Stevens, and G. Yu, “Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements,” Biomed. Opt. Express 2(7), 1969–1985 (2011).
[CrossRef] [PubMed]

Y. Shang, R. Cheng, L. Dong, S. J. Ryan, S. P. Saha, and G. Yu, “Cerebral monitoring during carotid endarterectomy using near-infrared diffuse optical spectroscopies and electroencephalogram,” Phys. Med. Biol. 56(10), 3015–3032 (2011).
[CrossRef] [PubMed]

G. Yu, Y. Shang, Y. Zhao, R. Cheng, L. Dong, and S. P. Saha, “Intraoperative evaluation of revascularization effect on ischemic muscle hemodynamics using near-infrared diffuse optical spectroscopies,” J. Biomed. Opt. 16(2), 027004 (2011).
[CrossRef] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

Y. Shang, T. B. Symons, T. Durduran, A. G. Yodh, and G. Yu, “Effects of muscle fiber motion on diffuse correlation spectroscopy blood flow measurements during exercise,” Biomed. Opt. Express 1(2), 500–511 (2010).
[CrossRef] [PubMed]

Y. Shang, Y. Zhao, R. Cheng, L. Dong, D. Irwin, and G. Yu, “Portable optical tissue flow oximeter based on diffuse correlation spectroscopy,” Opt. Lett. 34(22), 3556–3558 (2009).
[CrossRef] [PubMed]

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[CrossRef] [PubMed]

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064021 (2006).
[CrossRef] [PubMed]

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[CrossRef] [PubMed]

Yu, L. F.

L. F. Yu, E. Nguyen, G. J. Liu, B. Choi, and Z. P. Chen, “Spectral Doppler optical coherence tomography imaging of localized ischemic stroke in a mouse model,” J. Biomed. Opt. 15(6), 066006 (2010).
[CrossRef] [PubMed]

Zhang, C. D.

B. Chance, M. T. Dait, C. D. Zhang, T. Hamaoka, and F. Hagerman, “Recovery from Exercise-Induced Desaturation in the Quadriceps Muscles of Elite Competitive Rowers,” Am. J. Physiol. 262(3 Pt 1), C766–C775 (1992).
[PubMed]

Zhang, J.

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064021 (2006).
[CrossRef] [PubMed]

Zhao, W. Z.

P. Riyamongkol, W. Z. Zhao, Y. T. Liu, L. Belayev, R. Busto, and M. D. Ginsberg, “Automated registration of laser Doppler perfusion images by an adaptive correlation approach: application to focal cerebral ischemia in the rat,” J. Neurosci. Methods 122(1), 79–90 (2002).
[CrossRef] [PubMed]

Zhao, Y.

G. Yu, Y. Shang, Y. Zhao, R. Cheng, L. Dong, and S. P. Saha, “Intraoperative evaluation of revascularization effect on ischemic muscle hemodynamics using near-infrared diffuse optical spectroscopies,” J. Biomed. Opt. 16(2), 027004 (2011).
[CrossRef] [PubMed]

Y. Shang, Y. Zhao, R. Cheng, L. Dong, D. Irwin, and G. Yu, “Portable optical tissue flow oximeter based on diffuse correlation spectroscopy,” Opt. Lett. 34(22), 3556–3558 (2009).
[CrossRef] [PubMed]

Zhou, C.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

E. M. Buckley, N. M. Cook, T. Durduran, M. N. Kim, C. Zhou, R. Choe, G. Yu, S. Schultz, C. M. Sehgal, D. J. Licht, P. H. Arger, M. E. Putt, H. H. Hurt, and A. G. Yodh, “Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound,” Opt. Express 17(15), 12571–12581 (2009).
[CrossRef] [PubMed]

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[CrossRef] [PubMed]

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064021 (2006).
[CrossRef] [PubMed]

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[CrossRef] [PubMed]

Am. J. Physiol.

B. Chance, M. T. Dait, C. D. Zhang, T. Hamaoka, and F. Hagerman, “Recovery from Exercise-Induced Desaturation in the Quadriceps Muscles of Elite Competitive Rowers,” Am. J. Physiol. 262(3 Pt 1), C766–C775 (1992).
[PubMed]

Ann. Nucl. Med.

Y. Kuge, H. Kawashima, T. Hashimoto, M. Imanishi, M. Shiomi, K. Minematsu, Y. Hasegawa, T. Yamaguchi, Y. Miyake, and N. Hashimoto, “Preliminary evaluation of [1-11C]octanoate as a PET tracer for studying cerebral ischemia: a PET study in rat and canine models of focal cerebral ischemia,” Ann. Nucl. Med. 14(1), 69–74 (2000).
[CrossRef] [PubMed]

Antioxid. Redox Signal.

N. Khan, B. B. Williams, H. Hou, H. Li, and H. M. Swartz, “Repetitive tissue pO2 measurements by electron paramagnetic resonance oximetry: current status and future potential for experimental and clinical studies,” Antioxid. Redox Signal. 9(8), 1169–1182 (2007).
[CrossRef] [PubMed]

Biomed. Opt. Express

Cancer Res.

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[CrossRef] [PubMed]

Clin. Cancer Res.

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
[CrossRef] [PubMed]

Curr. Pharm. Des.

A. Durukan, D. Strbian, and T. Tatlisumak, “Rodent models of ischemic stroke: a useful tool for stroke drug development,” Curr. Pharm. Des. 14(4), 359–370 (2008).
[CrossRef] [PubMed]

FEBS J.

G. Pignataro, A. Scorziello, G. Di Renzo, and L. Annunziato, “Post-ischemic brain damage: effect of ischemic preconditioning and postconditioning and identification of potential candidates for stroke therapy,” FEBS J. 276(1), 46–57 (2009).
[CrossRef] [PubMed]

J. Biomed. Opt.

L. F. Yu, E. Nguyen, G. J. Liu, B. Choi, and Z. P. Chen, “Spectral Doppler optical coherence tomography imaging of localized ischemic stroke in a mouse model,” J. Biomed. Opt. 15(6), 066006 (2010).
[CrossRef] [PubMed]

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[CrossRef] [PubMed]

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064021 (2006).
[CrossRef] [PubMed]

G. Yu, Y. Shang, Y. Zhao, R. Cheng, L. Dong, and S. P. Saha, “Intraoperative evaluation of revascularization effect on ischemic muscle hemodynamics using near-infrared diffuse optical spectroscopies,” J. Biomed. Opt. 16(2), 027004 (2011).
[CrossRef] [PubMed]

F. H. Tian, B. Chance, and H. L. Liu, “Investigation of the prefrontal cortex in response to duration-variable anagram tasks using functional near-infrared spectroscopy,” J. Biomed. Opt. 14(5), 054016 (2009).
[CrossRef] [PubMed]

M. A. Franceschini, D. K. Joseph, T. J. Huppert, S. G. Diamond, and D. A. Boas, “Diffuse optical imaging of the whole head,” J. Biomed. Opt. 11(5), 054007 (2006).
[CrossRef] [PubMed]

J. Biophoton.

Y. L. Jia and R. K. K. Wang, “Optical micro-angiography images structural and functional cerebral blood perfusion in mice with cranium left intact,” J. Biophoton. 4(1-2), 57–63 (2011).
[CrossRef] [PubMed]

J. Cereb. Blood Flow Metab.

H. Piilgaard and M. Lauritzen, “Persistent increase in oxygen consumption and impaired neurovascular coupling after spreading depression in rat neocortex,” J. Cereb. Blood Flow Metab. 29(9), 1517–1527 (2009).
[CrossRef] [PubMed]

T. Kirino, “Ischemic tolerance,” J. Cereb. Blood Flow Metab. 22(11), 1283–1296 (2002).
[CrossRef] [PubMed]

N. E. Stagliano, M. A. Pérez-Pinzón, M. A. Moskowitz, and P. L. Huang, “Focal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in mice,” J. Cereb. Blood Flow Metab. 19(7), 757–761 (1999).
[CrossRef] [PubMed]

K. Kitagawa, M. Matsumoto, G. M. Yang, T. Mabuchi, Y. Yagita, M. Hori, and T. Yanagihara, “Cerebral ischemia after bilateral carotid artery occlusion and intraluminal suture occlusion in mice: Evaluation of the patency of the posterior communicating artery,” J. Cereb. Blood Flow Metab. 18(5), 570–579 (1998).
[CrossRef] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23(8), 911–924 (2003).
[CrossRef] [PubMed]

J. Neurol.

B. Schaller and R. Graf, “Cerebral ischemic preconditioning,” J. Neurol. 249(11), 1503–1511 (2002).
[CrossRef] [PubMed]

J. Neurosci. Methods

P. Riyamongkol, W. Z. Zhao, Y. T. Liu, L. Belayev, R. Busto, and M. D. Ginsberg, “Automated registration of laser Doppler perfusion images by an adaptive correlation approach: application to focal cerebral ischemia in the rat,” J. Neurosci. Methods 122(1), 79–90 (2002).
[CrossRef] [PubMed]

J. Neurosci. Res.

L. Chen, K. R. Swartz, and M. Toborek, “Vessel microport technique for applications in cerebrovascular research,” J. Neurosci. Res. 87(7), 1718–1727 (2009).
[CrossRef] [PubMed]

Med. Biol. Eng.

L. F. Liu, C. K. Yeh, C. H. Chen, T. W. Wong, and J. J. J. Chen, “Measurement of Cerebral Blood Flow and Oxygen Saturation Using Laser Doppler Flowmetry and Near Infrared Spectroscopy in Ischemic Stroke Rats,” Med. Biol. Eng. 28, 101–105 (2008).

Nat. Rev. Neurosci.

J. M. Gidday, “Cerebral preconditioning and ischaemic tolerance,” Nat. Rev. Neurosci. 7(6), 437–448 (2006).
[CrossRef] [PubMed]

Neurocrit. Care

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[CrossRef] [PubMed]

Neuroimage

G. Strangman, M. A. Franceschini, and D. A. Boas, “Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters,” Neuroimage 18(4), 865–879 (2003).
[CrossRef] [PubMed]

NMR Biomed.

A. Van der Linden, N. Van Camp, P. Ramos-Cabrer, and M. Hoehn, “Current status of functional MRI on small animals: application to physiology, pathophysiology, and cognition,” NMR Biomed. 20(5), 522–545 (2007).
[CrossRef] [PubMed]

Opt. Express

Opt. Lett.

Phys. Med. Biol.

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, “Diffuse optical tomography with physiological and spatial a priori constraints,” Phys. Med. Biol. 49(12), N155–N163 (2004).
[CrossRef] [PubMed]

Y. Shang, R. Cheng, L. Dong, S. J. Ryan, S. P. Saha, and G. Yu, “Cerebral monitoring during carotid endarterectomy using near-infrared diffuse optical spectroscopies and electroencephalogram,” Phys. Med. Biol. 56(10), 3015–3032 (2011).
[CrossRef] [PubMed]

S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic, “Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy,” Phys. Med. Biol. 44(6), 1543–1563 (1999).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[CrossRef] [PubMed]

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, L. Tyszczuk, M. Cope, and D. T. Delpy, “Optical pathlength measurements on adult head, calf and forearm and the head of the newborn infant using phase resolved optical spectroscopy,” Phys. Med. Biol. 40(2), 295–304 (1995).
[CrossRef] [PubMed]

Phys. Rev. Lett.

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and Imaging with Diffusing Temporal Field Correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
[CrossRef] [PubMed]

Stroke

R. R. Ratan, A. Siddiq, L. Aminova, P. S. Lange, B. Langley, I. Ayoub, J. A. Gensert, and J. Chavez, “Translation of ischemic preconditioning to the patient - Prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy,” Stroke 35(11,Suppl. 1), 2687–2689 (2004).
[CrossRef] [PubMed]

R. S. Marshall, T. Rundek, D. M. Sproule, B. F. M. Fitzsimmons, S. Schwartz, and R. M. Lazar, “Monitoring of cerebral vasodilatory capacity with transcranial Doppler carbon dioxide inhalation in patients with severe carotid artery disease,” Stroke 34(4), 945–949 (2003).
[CrossRef] [PubMed]

P. T. Ulrich, S. Kroppenstedt, A. Heimann, O. Kempski, and B. G. Lyeth, “Laser-Doppler scanning of local cerebral blood flow and reserve capacity and testing of motor and memory functions in a chronic 2-vessel occlusion model in rats,” Stroke 29(11), 2412–2420 (1998).
[CrossRef] [PubMed]

K. Kidoguchi, M. Tamaki, T. Mizobe, J. Koyama, T. Kondoh, E. Kohmura, T. Sakurai, K. Yokono, and K. Umetani, “In vivo X-ray angiography in the mouse brain using synchrotron radiation,” Stroke 37(7), 1856–1861 (2006).
[CrossRef] [PubMed]

J. Hendrikse, M. J. Hartkamp, B. Hillen, W. P. T. M. Mali, and J. van der Grond, “Collateral ability of the circle of Willis in patients with unilateral internal carotid artery occlusion: Border zone infarcts and clinical symptoms,” Stroke 32(12), 2768–2773 (2001).
[CrossRef] [PubMed]

Technol. Health Care

M. J. Leahy, F. F. de Mul, G. E. Nilsson, and R. Maniewski, “Principles and practice of the laser-Doppler perfusion technique,” Technol. Health Care 7(2-3), 143–162 (1999).
[PubMed]

Other

T. Durduran, “Non-Invasive Measurements of Tissue Hemodynamics with Hybrid Diffuse Optical Methods,” Degree of Doctor of Philosophy (University of Pennsylvania, 2004).

P. J. Goadsby and L. Edvinsson, Neurovascular control of the cerebral circulation, (Lippincott Williams & Wilkins, 2002).

J. Luckl, W. Baker, Z. H. Sun, T. Durduran, A. G. Yodh, and J. H. Greenberg, “The biological effect of contralateral forepaw stimulation in rat focal cerebral ischemia: a multispectral optical imaging study,” Front. Neuroenergetics 2 (2010).

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Figures (7)

Fig. 1
Fig. 1

(a) Photography of DCS flow-oximeter. (b) Diagram of DCS flow-oximeter.

Fig. 2
Fig. 2

(a) Installation of a LDF probe and DCS detector fiber on mouse skull. S: LDF probe (integrating one pair of source and detector fibers); D: DCS detector fiber. (b) Installation of two DCS probes on two sides of mouse head. S1 and S2: DCS source fibers; D1 and D2: DCS detector fibers. (c) Installation of a single DCS probe on mouse skull. S: two DCS source fibers (tightly bundled and placed at the same location); D: DCS detector fiber.

Fig. 3
Fig. 3

(a) The CBF changes during unilateral clipping and bi-CCA clipping/unclipping (twice) measured by the laser Doppler (top panel) and DCS (bottom panel). (b) The linear regressions of CBF changes measured by the laser Doppler and DCS. The CBF changes measured by the two techniques are highly correlated (R2 = 0.94, p < 0.0001). The inset small plot shows a linear regression of the CBFs with sub-data sets during arterial clippings (CBF < 100%).

Fig. 4
Fig. 4

(a) The regional (left and right hemispheres) and global (across two hemispheres) CBF responses to unilateral and bi-CCA occlusions in a mouse brain measured by DCS flow-oximeter. (b)The average regional and global CBF changes over 9 mice during unilateral (RCCA ligated) and bilateral CCA (LCCA clipped) occlusions.

Fig. 5
Fig. 5

The CBF (a), Δ[HbO2] and Δ[Hb] (b) responses to unilateral and bi-CCA occlusions in a mouse brain measured by DCS flow-oximeter.

Fig. 6
Fig. 6

The average changes over 8 mice in CBF (a), Δ[HbO2] (b) and Δ[Hb] (c) during 5-day (D1 to D5) repeated transient I-R challenges.

Fig. 7
Fig. 7

The CBF changes during bi-CCA occlusions in 20 mice involved in Protocol #2 and Protocol #3 at Day 1. Mouse #1-10 and Mouse# 11-20 were measured in Protocol #2 and Protocol #3, respectively. Three mice were eventually excluded from statistical analysis due to the incomplete ischemic response (Mouse #1) or severe stroke symptoms (Mouse #17 and #18).

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