Abstract

2D images of label-free biochips exploiting resonant waveguide grating (RWG) are presented. They indicate sensitivities on the order of 1 pg/mm2 for proteins in air, and hence 10 pg/mm2 in water can be safely expected. A 320×256 pixels Aluminum-Gallium-Nitride-based sensor array is used, with an intrinsic narrow spectral window centered at 280 nm. The additional role of characteristic biological layer absorption at this wavelength is calculated, and regimes revealing its impact are discussed. Experimentally, the resonance of a chip coated with protein is revealed and the sensitivity evaluated through angular spectroscopy and imaging. In addition to a sensitivity similar to surface plasmon resonance (SPR), the RWGs resonance can be flexibly tailored to gain spatial, biochemical, or spectral sensitivity.

© 2010 OSA

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2009 (3)

2008 (2)

M. Nakkach, P. Lecaruyer, F. Bardin, J. Sakly, Z. Ben Lakhdar, and M. Canva, “Absorption and related optical dispersion effects on the spectral response of a surface plasmon resonance sensor,” Appl. Opt. 47(33), 6177–6182 (2008).
[CrossRef]

E. Özkumur, J. W. Needham, D. A. Bergstein, R. Gonzalez, M. Cabodi, J. M. Gershoni, B. B. Goldberg, and M. S. Unlü, “Label-free and dynamic detection of biomolecular interactions for high-throughput microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 105(23), 7988–7992 (2008).
[CrossRef]

2007 (1)

2006 (2)

A. David, “High efficiency GaN-based LEDs: light extraction by photonic crystals,” Ann. Phys. (Paris) 31(6), 1–235 (2006).
[CrossRef]

N. Ganesh, I. D. Block, and B. T. Cunningham, “Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface-to-bulk sensitivity ratio,” Appl. Phys. Lett. 89(2), 023901 (2006).
[CrossRef]

2004 (1)

P. Y. Li, B. Lin, J. Gerstenmaier, and B. T. Cunningham, “A new method for label-free imaging of biomolecular interactions,” Sens. Act. Chem. 99(1), 6–13 (2004).
[CrossRef]

2000 (1)

V. Brioude and O. Parriaux, “Normalised analysis for the design of evanescent-wave sensors and its use for tolerance evaluation,” Opt. Quant. Elec. 32(6/8), 899–908 (2000).
[CrossRef]

1996 (2)

E. M. Yeatman, “Resolution and sensitivity in surface plasmon microscopy and sensing,” Bios. Bioelec. 11(6-7), 635–649 (1996).
[CrossRef]

L. Li, “Formulation and comparison of two recursive matrix algorithms for modeling layered diffraction gratings,” J. Opt. Soc. Am. A 13(5), 1024–1035 (1996).
[CrossRef]

1965 (1)

1961 (1)

U. Fano, “Effects of Configuration Interaction on Intensities and Phase Shifts,” Phys. Rev. 124(6), 1866–1878 (1961).
[CrossRef]

Araci, I. E.

Bardin, F.

Bashir, R.

Ben Lakhdar, Z.

Benisty, H.

K. Robin, J. L. Reverchon, L. Mugherli, M. Fromant, P. Plateau, and H. Benisty, “Detection of biological macromolecules on a biochip dedicated to UV specific absorption,” Bios. Bioelec. 24(6), 1585–1591 (2009).
[CrossRef]

Bergstein, D. A.

E. Özkumur, J. W. Needham, D. A. Bergstein, R. Gonzalez, M. Cabodi, J. M. Gershoni, B. B. Goldberg, and M. S. Unlü, “Label-free and dynamic detection of biomolecular interactions for high-throughput microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 105(23), 7988–7992 (2008).
[CrossRef]

Block, I. D.

Brioude, V.

V. Brioude and O. Parriaux, “Normalised analysis for the design of evanescent-wave sensors and its use for tolerance evaluation,” Opt. Quant. Elec. 32(6/8), 899–908 (2000).
[CrossRef]

Cabodi, M.

E. Özkumur, J. W. Needham, D. A. Bergstein, R. Gonzalez, M. Cabodi, J. M. Gershoni, B. B. Goldberg, and M. S. Unlü, “Label-free and dynamic detection of biomolecular interactions for high-throughput microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 105(23), 7988–7992 (2008).
[CrossRef]

Canva, M.

Chaudhery, V.

Cunningham, B. T.

I. D. Block, P. C. Mathias, N. Ganesh, S. I. Jones, B. R. Dorvel, V. Chaudhery, L. O. Vodkin, R. Bashir, and B. T. Cunningham, “A detection instrument for enhanced-fluorescence and label-free imaging on photonic crystal surfaces,” Opt. Express 17(15), 13222–13235 (2009).
[CrossRef]

I. D. Block, P. C. Mathias, S. I. Jones, L. O. Vodkin, and B. T. Cunningham, “Optimizing the spatial resolution of photonic crystal label-free imaging,” Appl. Opt. 48(34), 6567–6574 (2009).
[CrossRef]

N. Ganesh, I. D. Block, and B. T. Cunningham, “Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface-to-bulk sensitivity ratio,” Appl. Phys. Lett. 89(2), 023901 (2006).
[CrossRef]

P. Y. Li, B. Lin, J. Gerstenmaier, and B. T. Cunningham, “A new method for label-free imaging of biomolecular interactions,” Sens. Act. Chem. 99(1), 6–13 (2004).
[CrossRef]

David, A.

A. David, “High efficiency GaN-based LEDs: light extraction by photonic crystals,” Ann. Phys. (Paris) 31(6), 1–235 (2006).
[CrossRef]

Dorvel, B. R.

Fano, U.

U. Fano, “Effects of Configuration Interaction on Intensities and Phase Shifts,” Phys. Rev. 124(6), 1866–1878 (1961).
[CrossRef]

Fromant, M.

K. Robin, J. L. Reverchon, L. Mugherli, M. Fromant, P. Plateau, and H. Benisty, “Detection of biological macromolecules on a biochip dedicated to UV specific absorption,” Bios. Bioelec. 24(6), 1585–1591 (2009).
[CrossRef]

Ganesh, N.

Gershoni, J. M.

E. Özkumur, J. W. Needham, D. A. Bergstein, R. Gonzalez, M. Cabodi, J. M. Gershoni, B. B. Goldberg, and M. S. Unlü, “Label-free and dynamic detection of biomolecular interactions for high-throughput microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 105(23), 7988–7992 (2008).
[CrossRef]

Gerstenmaier, J.

P. Y. Li, B. Lin, J. Gerstenmaier, and B. T. Cunningham, “A new method for label-free imaging of biomolecular interactions,” Sens. Act. Chem. 99(1), 6–13 (2004).
[CrossRef]

Goldberg, B. B.

E. Özkumur, J. W. Needham, D. A. Bergstein, R. Gonzalez, M. Cabodi, J. M. Gershoni, B. B. Goldberg, and M. S. Unlü, “Label-free and dynamic detection of biomolecular interactions for high-throughput microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 105(23), 7988–7992 (2008).
[CrossRef]

Gonzalez, R.

E. Özkumur, J. W. Needham, D. A. Bergstein, R. Gonzalez, M. Cabodi, J. M. Gershoni, B. B. Goldberg, and M. S. Unlü, “Label-free and dynamic detection of biomolecular interactions for high-throughput microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 105(23), 7988–7992 (2008).
[CrossRef]

Hessel, A.

Honkanen, S.

Jones, S. I.

Lecaruyer, P.

Li, L.

Li, P. Y.

P. Y. Li, B. Lin, J. Gerstenmaier, and B. T. Cunningham, “A new method for label-free imaging of biomolecular interactions,” Sens. Act. Chem. 99(1), 6–13 (2004).
[CrossRef]

Lin, B.

P. Y. Li, B. Lin, J. Gerstenmaier, and B. T. Cunningham, “A new method for label-free imaging of biomolecular interactions,” Sens. Act. Chem. 99(1), 6–13 (2004).
[CrossRef]

Mathias, P. C.

Mendes, S. B.

Mugherli, L.

K. Robin, J. L. Reverchon, L. Mugherli, M. Fromant, P. Plateau, and H. Benisty, “Detection of biological macromolecules on a biochip dedicated to UV specific absorption,” Bios. Bioelec. 24(6), 1585–1591 (2009).
[CrossRef]

Nakkach, M.

Needham, J. W.

E. Özkumur, J. W. Needham, D. A. Bergstein, R. Gonzalez, M. Cabodi, J. M. Gershoni, B. B. Goldberg, and M. S. Unlü, “Label-free and dynamic detection of biomolecular interactions for high-throughput microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 105(23), 7988–7992 (2008).
[CrossRef]

Oliner, A. A.

Özkumur, E.

E. Özkumur, J. W. Needham, D. A. Bergstein, R. Gonzalez, M. Cabodi, J. M. Gershoni, B. B. Goldberg, and M. S. Unlü, “Label-free and dynamic detection of biomolecular interactions for high-throughput microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 105(23), 7988–7992 (2008).
[CrossRef]

Parriaux, O.

V. Brioude and O. Parriaux, “Normalised analysis for the design of evanescent-wave sensors and its use for tolerance evaluation,” Opt. Quant. Elec. 32(6/8), 899–908 (2000).
[CrossRef]

Peyghambarian, N.

Plateau, P.

K. Robin, J. L. Reverchon, L. Mugherli, M. Fromant, P. Plateau, and H. Benisty, “Detection of biological macromolecules on a biochip dedicated to UV specific absorption,” Bios. Bioelec. 24(6), 1585–1591 (2009).
[CrossRef]

Reverchon, J. L.

K. Robin, J. L. Reverchon, L. Mugherli, M. Fromant, P. Plateau, and H. Benisty, “Detection of biological macromolecules on a biochip dedicated to UV specific absorption,” Bios. Bioelec. 24(6), 1585–1591 (2009).
[CrossRef]

Robin, K.

K. Robin, J. L. Reverchon, L. Mugherli, M. Fromant, P. Plateau, and H. Benisty, “Detection of biological macromolecules on a biochip dedicated to UV specific absorption,” Bios. Bioelec. 24(6), 1585–1591 (2009).
[CrossRef]

Sakly, J.

Unlü, M. S.

E. Özkumur, J. W. Needham, D. A. Bergstein, R. Gonzalez, M. Cabodi, J. M. Gershoni, B. B. Goldberg, and M. S. Unlü, “Label-free and dynamic detection of biomolecular interactions for high-throughput microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 105(23), 7988–7992 (2008).
[CrossRef]

Vodkin, L. O.

Yeatman, E. M.

E. M. Yeatman, “Resolution and sensitivity in surface plasmon microscopy and sensing,” Bios. Bioelec. 11(6-7), 635–649 (1996).
[CrossRef]

Yurt, N.

Ann. Phys. (Paris) (1)

A. David, “High efficiency GaN-based LEDs: light extraction by photonic crystals,” Ann. Phys. (Paris) 31(6), 1–235 (2006).
[CrossRef]

Appl. Opt. (3)

Appl. Phys. Lett. (1)

N. Ganesh, I. D. Block, and B. T. Cunningham, “Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface-to-bulk sensitivity ratio,” Appl. Phys. Lett. 89(2), 023901 (2006).
[CrossRef]

Bios. Bioelec. (2)

K. Robin, J. L. Reverchon, L. Mugherli, M. Fromant, P. Plateau, and H. Benisty, “Detection of biological macromolecules on a biochip dedicated to UV specific absorption,” Bios. Bioelec. 24(6), 1585–1591 (2009).
[CrossRef]

E. M. Yeatman, “Resolution and sensitivity in surface plasmon microscopy and sensing,” Bios. Bioelec. 11(6-7), 635–649 (1996).
[CrossRef]

J. Opt. Soc. Am. A (1)

Opt. Express (2)

Opt. Quant. Elec. (1)

V. Brioude and O. Parriaux, “Normalised analysis for the design of evanescent-wave sensors and its use for tolerance evaluation,” Opt. Quant. Elec. 32(6/8), 899–908 (2000).
[CrossRef]

Phys. Rev. (1)

U. Fano, “Effects of Configuration Interaction on Intensities and Phase Shifts,” Phys. Rev. 124(6), 1866–1878 (1961).
[CrossRef]

Proc. Natl. Acad. Sci. U.S.A. (1)

E. Özkumur, J. W. Needham, D. A. Bergstein, R. Gonzalez, M. Cabodi, J. M. Gershoni, B. B. Goldberg, and M. S. Unlü, “Label-free and dynamic detection of biomolecular interactions for high-throughput microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 105(23), 7988–7992 (2008).
[CrossRef]

Sens. Act. Chem. (1)

P. Y. Li, B. Lin, J. Gerstenmaier, and B. T. Cunningham, “A new method for label-free imaging of biomolecular interactions,” Sens. Act. Chem. 99(1), 6–13 (2004).
[CrossRef]

Other (5)

R. B. M. Schasfoort, and A. McWhirter, in Handbook of surface plasmon resonance (R.B.M Schasfoort and A. J. Tudos, RSC Publishing Enschede, Netherlands, 2007), Chap. 3.

J. L. Reverchon, J. A. Robo, J. P. Truffer, J. P. Caumes, I. Mourad, J. Brault, and J. Y. Duboz, “AlGaN-based focal plane arrays for selective UV imaging at 310nm and 280nm and route toward deep UV imaging”, Proc. SPIE 6744 (2007).

K. Robin, J. L. Reverchon, L. Mugherli, M. Fromant, and H. Benisty, “Biodetection of DNA and proteins using enhanced UV absorption by structuration of the chip surface”, Proc. SPIE 7188-04 (2009).

D. Bahatt, J. E. Cahill, K. Nishikida, E. G. Picozza, P. G. Saviano, D. H. Tracy, and Y. Wang, “Optical resonance analysis system”, US patent 7251085, (2007).

F. David, Edwards, “Silicon (Si)” in Handbook of optical constants of Solids, E. D. Palik ed.(Academic, Press, 1985).

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