Abstract

The purpose of this study was to investigate the effect of image quality on retinal nerve fiber layer (RNFL) and retinal thickness measurements obtained using three commercially available spectral domain-optical coherence tomographers (SD-OCT). Subjectively determined good, medium and poor quality images were obtained from four healthy and one glaucoma suspect eyes. RNFL and retinal thickness measurements were compared as a function of image quality. Results indicate that when image quality is within the range specified as acceptable by SD-OCT manufacturers, RNFL and retinal thickness measurements are comparable.

© 2009 Optical Society of America

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  1. T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
    [CrossRef] [PubMed]
  2. J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-tonoise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069 (2003).
    [CrossRef] [PubMed]
  3. J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838, 95-107 (1998).
    [CrossRef] [PubMed]
  4. N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29, 480-482 (2004).
    [CrossRef] [PubMed]
  5. M. E. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog. Retin. Eye Res. 26, 57-77 (2007).
    [CrossRef]
  6. M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
    [CrossRef] [PubMed]
  7. M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
    [CrossRef] [PubMed]
  8. A. O. Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol.in press.
    [PubMed]
  9. T. Mumcuoglu, G. Wollstein, M. Wojtkowski, L. Kagemann, H. Ishikawa, M. L. Gabriele, V. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Improved visualization of glaucomatous retinal damage using high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 115,. 782-789 e2 (2008).
    [CrossRef]
  10. V. J. Srinivasan, D. C. Adler, Y. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Invest. Ophthalmol. Vis. Sci. 49, 5103-5110 (2008).
    [CrossRef] [PubMed]
  11. G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F. A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol.in press.
    [PubMed]
  12. N. G. Strouthidis, E. T. White, V. M. Owen, T. A. Ho, C. J. Hammond, and D. F. Garway-Heath, "Factors affecting the test-retest variability of Heidelberg retina tomograph and Heidelberg retina tomograph II measurements," Br. J. Ophthalmol. 89, 1427-1432 (2005).
    [CrossRef] [PubMed]
  13. C. Bowd, F. A. Medeiros, R. N. Weinreb, and L. M. Zangwill, "The effect of atypical birefringence patterns on glaucoma detection using scanning laser polarimetry with variable corneal compensation," Invest. Ophthalmol. Vis. Sci. 48, 223-227 (2007).
    [CrossRef] [PubMed]
  14. F. A. Medeiros, C. Bowd, L. M. Zangwill, C. Patel, and R. N. Weinreb, "Detection of glaucoma using scanning laser polarimetry with enhanced corneal compensation," Invest. Ophthalmol. Vis. Sci. 48, 3146-3153 (2007).
    [CrossRef] [PubMed]
  15. Z. Wu, M. Vazeen, R. Varma, V. Chopra, A. C. Walsh, L. D. LaBree, and S. R. Sadda, "Factors associated with variability in retinal nerve fiber layer thickness measurements obtained by optical coherence tomography," Ophthalmology 114, 1505-1512 (2007).
    [CrossRef] [PubMed]
  16. D. M. Stein, G. Wollstein, H. Ishikawa, E. Hertzmark, R. J. Noecker, and J. S. Schuman, "Effect of corneal drying on optical coherence tomography," Ophthalmology 113, 985-991 (2006).
    [CrossRef] [PubMed]
  17. 17. C. Y. Cheung, C. K. Leung, D. Lin, C. P. Pang, and D. S. Lam, Relationship between retinal nerve fiber layer measurement and signal strength in optical coherence tomography. Ophthalmology 115, 1347-51, 1351 e1-2 (2008).
    [CrossRef] [PubMed]
  18. M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, K. A. Townsend, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability," Invest. Ophthalmol. Vis. Sci. 49, 2315-2321 (2008).
    [CrossRef] [PubMed]
  19. G. Vizzeri, C. Bowd, F. A. Medeiros, R. N. Weinreb, and L. M. Zangwill, "Effect of improper scan alignment on retinal nerve fiber layer thickness measurements using Stratus optical coherence tomograph," J. Glaucoma 17, 341-349 (2008).
    [CrossRef] [PubMed]
  20. B. Liu, and M. E. Brezinski, "Theoretical and practical considerations on detection performance of time domain, Fourier domain, and swept source optical coherence tomography," J. Biomed. Opt. 12, 044007 (2007).
    [CrossRef] [PubMed]

2008

V. J. Srinivasan, D. C. Adler, Y. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Invest. Ophthalmol. Vis. Sci. 49, 5103-5110 (2008).
[CrossRef] [PubMed]

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, K. A. Townsend, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability," Invest. Ophthalmol. Vis. Sci. 49, 2315-2321 (2008).
[CrossRef] [PubMed]

G. Vizzeri, C. Bowd, F. A. Medeiros, R. N. Weinreb, and L. M. Zangwill, "Effect of improper scan alignment on retinal nerve fiber layer thickness measurements using Stratus optical coherence tomograph," J. Glaucoma 17, 341-349 (2008).
[CrossRef] [PubMed]

2007

B. Liu, and M. E. Brezinski, "Theoretical and practical considerations on detection performance of time domain, Fourier domain, and swept source optical coherence tomography," J. Biomed. Opt. 12, 044007 (2007).
[CrossRef] [PubMed]

C. Bowd, F. A. Medeiros, R. N. Weinreb, and L. M. Zangwill, "The effect of atypical birefringence patterns on glaucoma detection using scanning laser polarimetry with variable corneal compensation," Invest. Ophthalmol. Vis. Sci. 48, 223-227 (2007).
[CrossRef] [PubMed]

F. A. Medeiros, C. Bowd, L. M. Zangwill, C. Patel, and R. N. Weinreb, "Detection of glaucoma using scanning laser polarimetry with enhanced corneal compensation," Invest. Ophthalmol. Vis. Sci. 48, 3146-3153 (2007).
[CrossRef] [PubMed]

Z. Wu, M. Vazeen, R. Varma, V. Chopra, A. C. Walsh, L. D. LaBree, and S. R. Sadda, "Factors associated with variability in retinal nerve fiber layer thickness measurements obtained by optical coherence tomography," Ophthalmology 114, 1505-1512 (2007).
[CrossRef] [PubMed]

M. E. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog. Retin. Eye Res. 26, 57-77 (2007).
[CrossRef]

2006

D. M. Stein, G. Wollstein, H. Ishikawa, E. Hertzmark, R. J. Noecker, and J. S. Schuman, "Effect of corneal drying on optical coherence tomography," Ophthalmology 113, 985-991 (2006).
[CrossRef] [PubMed]

2005

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

N. G. Strouthidis, E. T. White, V. M. Owen, T. A. Ho, C. J. Hammond, and D. F. Garway-Heath, "Factors affecting the test-retest variability of Heidelberg retina tomograph and Heidelberg retina tomograph II measurements," Br. J. Ophthalmol. 89, 1427-1432 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

2004

2003

2002

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

1998

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838, 95-107 (1998).
[CrossRef] [PubMed]

Adler, D. C.

V. J. Srinivasan, D. C. Adler, Y. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Invest. Ophthalmol. Vis. Sci. 49, 5103-5110 (2008).
[CrossRef] [PubMed]

Bajraszewski, T.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

Bilonick, R. A.

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, K. A. Townsend, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability," Invest. Ophthalmol. Vis. Sci. 49, 2315-2321 (2008).
[CrossRef] [PubMed]

Boppart, S. A.

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838, 95-107 (1998).
[CrossRef] [PubMed]

Bouma, B.

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838, 95-107 (1998).
[CrossRef] [PubMed]

Bouma, B. E.

Bowd, C.

G. Vizzeri, C. Bowd, F. A. Medeiros, R. N. Weinreb, and L. M. Zangwill, "Effect of improper scan alignment on retinal nerve fiber layer thickness measurements using Stratus optical coherence tomograph," J. Glaucoma 17, 341-349 (2008).
[CrossRef] [PubMed]

C. Bowd, F. A. Medeiros, R. N. Weinreb, and L. M. Zangwill, "The effect of atypical birefringence patterns on glaucoma detection using scanning laser polarimetry with variable corneal compensation," Invest. Ophthalmol. Vis. Sci. 48, 223-227 (2007).
[CrossRef] [PubMed]

F. A. Medeiros, C. Bowd, L. M. Zangwill, C. Patel, and R. N. Weinreb, "Detection of glaucoma using scanning laser polarimetry with enhanced corneal compensation," Invest. Ophthalmol. Vis. Sci. 48, 3146-3153 (2007).
[CrossRef] [PubMed]

A. O. Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol.in press.
[PubMed]

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F. A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol.in press.
[PubMed]

Brezinski, M. E.

B. Liu, and M. E. Brezinski, "Theoretical and practical considerations on detection performance of time domain, Fourier domain, and swept source optical coherence tomography," J. Biomed. Opt. 12, 044007 (2007).
[CrossRef] [PubMed]

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838, 95-107 (1998).
[CrossRef] [PubMed]

Cense, B.

Chen, T. C.

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29, 480-482 (2004).
[CrossRef] [PubMed]

Chen, Y.

V. J. Srinivasan, D. C. Adler, Y. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Invest. Ophthalmol. Vis. Sci. 49, 5103-5110 (2008).
[CrossRef] [PubMed]

Chopra, V.

Z. Wu, M. Vazeen, R. Varma, V. Chopra, A. C. Walsh, L. D. LaBree, and S. R. Sadda, "Factors associated with variability in retinal nerve fiber layer thickness measurements obtained by optical coherence tomography," Ophthalmology 114, 1505-1512 (2007).
[CrossRef] [PubMed]

de Boer, J. F.

de Smet, M. D.

M. E. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog. Retin. Eye Res. 26, 57-77 (2007).
[CrossRef]

Duker, J. S.

V. J. Srinivasan, D. C. Adler, Y. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Invest. Ophthalmol. Vis. Sci. 49, 5103-5110 (2008).
[CrossRef] [PubMed]

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, K. A. Townsend, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability," Invest. Ophthalmol. Vis. Sci. 49, 2315-2321 (2008).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Faber, D. J.

M. E. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog. Retin. Eye Res. 26, 57-77 (2007).
[CrossRef]

Fercher, A. F.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

Fujimoto, J. G.

V. J. Srinivasan, D. C. Adler, Y. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Invest. Ophthalmol. Vis. Sci. 49, 5103-5110 (2008).
[CrossRef] [PubMed]

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, K. A. Townsend, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability," Invest. Ophthalmol. Vis. Sci. 49, 2315-2321 (2008).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838, 95-107 (1998).
[CrossRef] [PubMed]

Gabriele, M. L.

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, K. A. Townsend, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability," Invest. Ophthalmol. Vis. Sci. 49, 2315-2321 (2008).
[CrossRef] [PubMed]

Garway-Heath, D. F.

N. G. Strouthidis, E. T. White, V. M. Owen, T. A. Ho, C. J. Hammond, and D. F. Garway-Heath, "Factors affecting the test-retest variability of Heidelberg retina tomograph and Heidelberg retina tomograph II measurements," Br. J. Ophthalmol. 89, 1427-1432 (2005).
[CrossRef] [PubMed]

Gonzalez-Garcia, A. O.

A. O. Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol.in press.
[PubMed]

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F. A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol.in press.
[PubMed]

Gorczynska, I.

V. J. Srinivasan, D. C. Adler, Y. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Invest. Ophthalmol. Vis. Sci. 49, 5103-5110 (2008).
[CrossRef] [PubMed]

Hammond, C. J.

N. G. Strouthidis, E. T. White, V. M. Owen, T. A. Ho, C. J. Hammond, and D. F. Garway-Heath, "Factors affecting the test-retest variability of Heidelberg retina tomograph and Heidelberg retina tomograph II measurements," Br. J. Ophthalmol. 89, 1427-1432 (2005).
[CrossRef] [PubMed]

Hertzmark, E.

D. M. Stein, G. Wollstein, H. Ishikawa, E. Hertzmark, R. J. Noecker, and J. S. Schuman, "Effect of corneal drying on optical coherence tomography," Ophthalmology 113, 985-991 (2006).
[CrossRef] [PubMed]

Ho, T. A.

N. G. Strouthidis, E. T. White, V. M. Owen, T. A. Ho, C. J. Hammond, and D. F. Garway-Heath, "Factors affecting the test-retest variability of Heidelberg retina tomograph and Heidelberg retina tomograph II measurements," Br. J. Ophthalmol. 89, 1427-1432 (2005).
[CrossRef] [PubMed]

Huber, R.

V. J. Srinivasan, D. C. Adler, Y. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Invest. Ophthalmol. Vis. Sci. 49, 5103-5110 (2008).
[CrossRef] [PubMed]

Ishikawa, H.

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, K. A. Townsend, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability," Invest. Ophthalmol. Vis. Sci. 49, 2315-2321 (2008).
[CrossRef] [PubMed]

D. M. Stein, G. Wollstein, H. Ishikawa, E. Hertzmark, R. J. Noecker, and J. S. Schuman, "Effect of corneal drying on optical coherence tomography," Ophthalmology 113, 985-991 (2006).
[CrossRef] [PubMed]

Kagemann, L.

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, K. A. Townsend, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability," Invest. Ophthalmol. Vis. Sci. 49, 2315-2321 (2008).
[CrossRef] [PubMed]

Ko, T.

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Kowalczyk, A.

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

LaBree, L. D.

Z. Wu, M. Vazeen, R. Varma, V. Chopra, A. C. Walsh, L. D. LaBree, and S. R. Sadda, "Factors associated with variability in retinal nerve fiber layer thickness measurements obtained by optical coherence tomography," Ophthalmology 114, 1505-1512 (2007).
[CrossRef] [PubMed]

Leitgeb, R.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

Liu, B.

B. Liu, and M. E. Brezinski, "Theoretical and practical considerations on detection performance of time domain, Fourier domain, and swept source optical coherence tomography," J. Biomed. Opt. 12, 044007 (2007).
[CrossRef] [PubMed]

Medeiros, F. A.

G. Vizzeri, C. Bowd, F. A. Medeiros, R. N. Weinreb, and L. M. Zangwill, "Effect of improper scan alignment on retinal nerve fiber layer thickness measurements using Stratus optical coherence tomograph," J. Glaucoma 17, 341-349 (2008).
[CrossRef] [PubMed]

F. A. Medeiros, C. Bowd, L. M. Zangwill, C. Patel, and R. N. Weinreb, "Detection of glaucoma using scanning laser polarimetry with enhanced corneal compensation," Invest. Ophthalmol. Vis. Sci. 48, 3146-3153 (2007).
[CrossRef] [PubMed]

C. Bowd, F. A. Medeiros, R. N. Weinreb, and L. M. Zangwill, "The effect of atypical birefringence patterns on glaucoma detection using scanning laser polarimetry with variable corneal compensation," Invest. Ophthalmol. Vis. Sci. 48, 223-227 (2007).
[CrossRef] [PubMed]

A. O. Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol.in press.
[PubMed]

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F. A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol.in press.
[PubMed]

Nassif, N.

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29, 480-482 (2004).
[CrossRef] [PubMed]

Noecker, R. J.

D. M. Stein, G. Wollstein, H. Ishikawa, E. Hertzmark, R. J. Noecker, and J. S. Schuman, "Effect of corneal drying on optical coherence tomography," Ophthalmology 113, 985-991 (2006).
[CrossRef] [PubMed]

Owen, V. M.

N. G. Strouthidis, E. T. White, V. M. Owen, T. A. Ho, C. J. Hammond, and D. F. Garway-Heath, "Factors affecting the test-retest variability of Heidelberg retina tomograph and Heidelberg retina tomograph II measurements," Br. J. Ophthalmol. 89, 1427-1432 (2005).
[CrossRef] [PubMed]

Park, B. H.

Patel, C.

F. A. Medeiros, C. Bowd, L. M. Zangwill, C. Patel, and R. N. Weinreb, "Detection of glaucoma using scanning laser polarimetry with enhanced corneal compensation," Invest. Ophthalmol. Vis. Sci. 48, 3146-3153 (2007).
[CrossRef] [PubMed]

Pierce, M. C.

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-tonoise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069 (2003).
[CrossRef] [PubMed]

Pitris, C.

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838, 95-107 (1998).
[CrossRef] [PubMed]

Sadda, S. R.

Z. Wu, M. Vazeen, R. Varma, V. Chopra, A. C. Walsh, L. D. LaBree, and S. R. Sadda, "Factors associated with variability in retinal nerve fiber layer thickness measurements obtained by optical coherence tomography," Ophthalmology 114, 1505-1512 (2007).
[CrossRef] [PubMed]

Sample, P. A.

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F. A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol.in press.
[PubMed]

Schuman, J. S.

V. J. Srinivasan, D. C. Adler, Y. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Invest. Ophthalmol. Vis. Sci. 49, 5103-5110 (2008).
[CrossRef] [PubMed]

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, K. A. Townsend, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability," Invest. Ophthalmol. Vis. Sci. 49, 2315-2321 (2008).
[CrossRef] [PubMed]

D. M. Stein, G. Wollstein, H. Ishikawa, E. Hertzmark, R. J. Noecker, and J. S. Schuman, "Effect of corneal drying on optical coherence tomography," Ophthalmology 113, 985-991 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Southern, J. F.

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838, 95-107 (1998).
[CrossRef] [PubMed]

Srinivasan, V.

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Srinivasan, V. J.

V. J. Srinivasan, D. C. Adler, Y. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Invest. Ophthalmol. Vis. Sci. 49, 5103-5110 (2008).
[CrossRef] [PubMed]

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, K. A. Townsend, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability," Invest. Ophthalmol. Vis. Sci. 49, 2315-2321 (2008).
[CrossRef] [PubMed]

Stein, D. M.

D. M. Stein, G. Wollstein, H. Ishikawa, E. Hertzmark, R. J. Noecker, and J. S. Schuman, "Effect of corneal drying on optical coherence tomography," Ophthalmology 113, 985-991 (2006).
[CrossRef] [PubMed]

Strouthidis, N. G.

N. G. Strouthidis, E. T. White, V. M. Owen, T. A. Ho, C. J. Hammond, and D. F. Garway-Heath, "Factors affecting the test-retest variability of Heidelberg retina tomograph and Heidelberg retina tomograph II measurements," Br. J. Ophthalmol. 89, 1427-1432 (2005).
[CrossRef] [PubMed]

Tearney, G. J.

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29, 480-482 (2004).
[CrossRef] [PubMed]

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-tonoise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069 (2003).
[CrossRef] [PubMed]

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838, 95-107 (1998).
[CrossRef] [PubMed]

Townsend, K. A.

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, K. A. Townsend, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability," Invest. Ophthalmol. Vis. Sci. 49, 2315-2321 (2008).
[CrossRef] [PubMed]

van Leeuwen, T. G.

M. E. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog. Retin. Eye Res. 26, 57-77 (2007).
[CrossRef]

van Velthoven, M. E.

M. E. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog. Retin. Eye Res. 26, 57-77 (2007).
[CrossRef]

Varma, R.

Z. Wu, M. Vazeen, R. Varma, V. Chopra, A. C. Walsh, L. D. LaBree, and S. R. Sadda, "Factors associated with variability in retinal nerve fiber layer thickness measurements obtained by optical coherence tomography," Ophthalmology 114, 1505-1512 (2007).
[CrossRef] [PubMed]

Vazeen, M.

Z. Wu, M. Vazeen, R. Varma, V. Chopra, A. C. Walsh, L. D. LaBree, and S. R. Sadda, "Factors associated with variability in retinal nerve fiber layer thickness measurements obtained by optical coherence tomography," Ophthalmology 114, 1505-1512 (2007).
[CrossRef] [PubMed]

Verbraak, F. D.

M. E. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog. Retin. Eye Res. 26, 57-77 (2007).
[CrossRef]

Vizzeri, G.

G. Vizzeri, C. Bowd, F. A. Medeiros, R. N. Weinreb, and L. M. Zangwill, "Effect of improper scan alignment on retinal nerve fiber layer thickness measurements using Stratus optical coherence tomograph," J. Glaucoma 17, 341-349 (2008).
[CrossRef] [PubMed]

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F. A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol.in press.
[PubMed]

A. O. Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol.in press.
[PubMed]

Walsh, A. C.

Z. Wu, M. Vazeen, R. Varma, V. Chopra, A. C. Walsh, L. D. LaBree, and S. R. Sadda, "Factors associated with variability in retinal nerve fiber layer thickness measurements obtained by optical coherence tomography," Ophthalmology 114, 1505-1512 (2007).
[CrossRef] [PubMed]

Weinreb, R. N.

G. Vizzeri, C. Bowd, F. A. Medeiros, R. N. Weinreb, and L. M. Zangwill, "Effect of improper scan alignment on retinal nerve fiber layer thickness measurements using Stratus optical coherence tomograph," J. Glaucoma 17, 341-349 (2008).
[CrossRef] [PubMed]

F. A. Medeiros, C. Bowd, L. M. Zangwill, C. Patel, and R. N. Weinreb, "Detection of glaucoma using scanning laser polarimetry with enhanced corneal compensation," Invest. Ophthalmol. Vis. Sci. 48, 3146-3153 (2007).
[CrossRef] [PubMed]

C. Bowd, F. A. Medeiros, R. N. Weinreb, and L. M. Zangwill, "The effect of atypical birefringence patterns on glaucoma detection using scanning laser polarimetry with variable corneal compensation," Invest. Ophthalmol. Vis. Sci. 48, 223-227 (2007).
[CrossRef] [PubMed]

A. O. Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol.in press.
[PubMed]

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F. A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol.in press.
[PubMed]

White, B. R.

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

White, E. T.

N. G. Strouthidis, E. T. White, V. M. Owen, T. A. Ho, C. J. Hammond, and D. F. Garway-Heath, "Factors affecting the test-retest variability of Heidelberg retina tomograph and Heidelberg retina tomograph II measurements," Br. J. Ophthalmol. 89, 1427-1432 (2005).
[CrossRef] [PubMed]

Wojtkowski, M.

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, K. A. Townsend, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability," Invest. Ophthalmol. Vis. Sci. 49, 2315-2321 (2008).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

Wollstein, G.

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, K. A. Townsend, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability," Invest. Ophthalmol. Vis. Sci. 49, 2315-2321 (2008).
[CrossRef] [PubMed]

D. M. Stein, G. Wollstein, H. Ishikawa, E. Hertzmark, R. J. Noecker, and J. S. Schuman, "Effect of corneal drying on optical coherence tomography," Ophthalmology 113, 985-991 (2006).
[CrossRef] [PubMed]

Wu, Z.

Z. Wu, M. Vazeen, R. Varma, V. Chopra, A. C. Walsh, L. D. LaBree, and S. R. Sadda, "Factors associated with variability in retinal nerve fiber layer thickness measurements obtained by optical coherence tomography," Ophthalmology 114, 1505-1512 (2007).
[CrossRef] [PubMed]

Yun, S. H.

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29, 480-482 (2004).
[CrossRef] [PubMed]

Zangwill, L. M.

G. Vizzeri, C. Bowd, F. A. Medeiros, R. N. Weinreb, and L. M. Zangwill, "Effect of improper scan alignment on retinal nerve fiber layer thickness measurements using Stratus optical coherence tomograph," J. Glaucoma 17, 341-349 (2008).
[CrossRef] [PubMed]

F. A. Medeiros, C. Bowd, L. M. Zangwill, C. Patel, and R. N. Weinreb, "Detection of glaucoma using scanning laser polarimetry with enhanced corneal compensation," Invest. Ophthalmol. Vis. Sci. 48, 3146-3153 (2007).
[CrossRef] [PubMed]

C. Bowd, F. A. Medeiros, R. N. Weinreb, and L. M. Zangwill, "The effect of atypical birefringence patterns on glaucoma detection using scanning laser polarimetry with variable corneal compensation," Invest. Ophthalmol. Vis. Sci. 48, 223-227 (2007).
[CrossRef] [PubMed]

A. O. Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol.in press.
[PubMed]

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F. A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol.in press.
[PubMed]

Am. J. Ophthalmol.

A. O. Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol.in press.
[PubMed]

Ann. N. Y. Acad. Sci.

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838, 95-107 (1998).
[CrossRef] [PubMed]

Arch. Ophthalmol.

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720 (2005).
[CrossRef] [PubMed]

Br. J. Ophthalmol.

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F. A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol.in press.
[PubMed]

N. G. Strouthidis, E. T. White, V. M. Owen, T. A. Ho, C. J. Hammond, and D. F. Garway-Heath, "Factors affecting the test-retest variability of Heidelberg retina tomograph and Heidelberg retina tomograph II measurements," Br. J. Ophthalmol. 89, 1427-1432 (2005).
[CrossRef] [PubMed]

Invest. Ophthalmol. Vis. Sci.

C. Bowd, F. A. Medeiros, R. N. Weinreb, and L. M. Zangwill, "The effect of atypical birefringence patterns on glaucoma detection using scanning laser polarimetry with variable corneal compensation," Invest. Ophthalmol. Vis. Sci. 48, 223-227 (2007).
[CrossRef] [PubMed]

F. A. Medeiros, C. Bowd, L. M. Zangwill, C. Patel, and R. N. Weinreb, "Detection of glaucoma using scanning laser polarimetry with enhanced corneal compensation," Invest. Ophthalmol. Vis. Sci. 48, 3146-3153 (2007).
[CrossRef] [PubMed]

M. L. Gabriele, H. Ishikawa, G. Wollstein, R. A. Bilonick, K. A. Townsend, L. Kagemann, M. Wojtkowski, V. J. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability," Invest. Ophthalmol. Vis. Sci. 49, 2315-2321 (2008).
[CrossRef] [PubMed]

V. J. Srinivasan, D. C. Adler, Y. Chen, I. Gorczynska, R. Huber, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Invest. Ophthalmol. Vis. Sci. 49, 5103-5110 (2008).
[CrossRef] [PubMed]

J. Biomed. Opt.

B. Liu, and M. E. Brezinski, "Theoretical and practical considerations on detection performance of time domain, Fourier domain, and swept source optical coherence tomography," J. Biomed. Opt. 12, 044007 (2007).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

J. Glaucoma

G. Vizzeri, C. Bowd, F. A. Medeiros, R. N. Weinreb, and L. M. Zangwill, "Effect of improper scan alignment on retinal nerve fiber layer thickness measurements using Stratus optical coherence tomograph," J. Glaucoma 17, 341-349 (2008).
[CrossRef] [PubMed]

Ophthalmology

Z. Wu, M. Vazeen, R. Varma, V. Chopra, A. C. Walsh, L. D. LaBree, and S. R. Sadda, "Factors associated with variability in retinal nerve fiber layer thickness measurements obtained by optical coherence tomography," Ophthalmology 114, 1505-1512 (2007).
[CrossRef] [PubMed]

D. M. Stein, G. Wollstein, H. Ishikawa, E. Hertzmark, R. J. Noecker, and J. S. Schuman, "Effect of corneal drying on optical coherence tomography," Ophthalmology 113, 985-991 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Opt. Lett.

Prog. Retin. Eye Res.

M. E. van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog. Retin. Eye Res. 26, 57-77 (2007).
[CrossRef]

Other

T. Mumcuoglu, G. Wollstein, M. Wojtkowski, L. Kagemann, H. Ishikawa, M. L. Gabriele, V. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Improved visualization of glaucomatous retinal damage using high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 115,. 782-789 e2 (2008).
[CrossRef]

17. C. Y. Cheung, C. K. Leung, D. Lin, C. P. Pang, and D. S. Lam, Relationship between retinal nerve fiber layer measurement and signal strength in optical coherence tomography. Ophthalmology 115, 1347-51, 1351 e1-2 (2008).
[CrossRef] [PubMed]

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Figures (9)

Fig. 1.
Fig. 1.

RTVue volume and cross-sectional scans (single B-scans) through the approximate center of the optic disc of the participant H1 at various subjective scan quality (SSQ) levels and at +2 diopters refractive error. Instrument quality scores (IQS) also are listed. (a) SSQ=“Best”; IQS=73.2 (View 1), (b) SSQ=“Medium”; IQS=47.2 (View 2), (c) SSQ=“Low”; IQS=36.1 (View 3), (d) At +2 dp refractive error; IQS=62.3 (View 4).

Fig. 2.
Fig. 2.

Spectralis volume and cross-sectional scans (single B-scans) through the approximate center of the optic disc of the participant H1 at various subjective scan quality (SSQ) levels and at +2 diopters refractive error. Instrument quality scores (IQS) also are listed. (a) SSQ=“Best”; IQS=30 dB (View 5), (b) SSQ=“Medium”; IQS=17 dB (View 6), (c) SSQ=“Low”; IQS=10 dB (View 7), (d) At +2 dp refractive error; IQS=27 dB (View 8).

Fig. 3.
Fig. 3.

Cirrus volume and cross-sectional scans (single B-scans) through the approximate center of the optic disc of the participant H1 at various subjective scan quality (SSQ) levels and at +2 diopters refractive error. Instrument quality scores (IQS) also are listed. (a) SSQ=“Best”; IQS=10 (View 9), (b) SSQ=“Medium”; IQS=6 (View 10), (c) SSQ=“Low”; IQS=3 (View 11), (d) At +2 dp refractive error; IQS=6 (View 12).

Fig. 4.
Fig. 4.

Spectralis cross-sectional scans (single B-scans) through the superior parapapillary region of participant H4 obtained at “best” (View 41) and “low” SSQ (View 43). Segmentation failure along Bruch’s membrane (shown in (b) is likely due to the reduced SNR at the low SSQ level. Fundus images to the left of each figure illustrate the respective B-scan placement.

Fig. 5.
Fig. 5.

TSNIT (temporal-superior-nasal-inferior-temporal) plots describing circumpapillary tissue thickness in participant H1 obtained using RTVue (top), Spectralis (middle), and Cirrus (bottom).

Fig. 6.
Fig. 6.

TSNIT (temporal-superior-nasal-inferior- temporal) plots describing circumpapillary tissue thickness in participant H2 obtained using RTVue (top), Spectralis (middle), and Cirrus (bottom).

Fig. 7.
Fig. 7.

TSNIT (temporal-superior-nasal-inferior- temporal) plots describing circumpapillary tissue thickness in participant H3 obtained using RTVue (top), Spectralis (middle), and Cirrus (bottom).

Fig. 8.
Fig. 8.

TSNIT (temporal-superior-nasal-inferior- temporal) plots describing circumpapillary tissue thickness in participant H4 obtained using RTVue (top), Spectralis (middle), and Cirrus (bottom).

Fig. 9.
Fig. 9.

TSNIT (temporal-superior-nasal-inferior- temporal) plots describing circumpapillary tissue thickness in participant GS obtained using RTVue (top), Spectralis (middle), and Cirrus (bottom). Exam with +2 diopters refractive error using Spectralis could not be completed due to time constraints.

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Tables (3)

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Table 1. Volumetric scan specifications of the commercial SD-OCT instruments

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Table 2. Scan quality scores of 3D volume scans acquired at various experimentally controlled subjective-scan-quality levels using RTVue, Spectralis, and Cirrus SD-OCT instruments. Healthy eyes are labeled H1–H4, and the glaucoma suspect eye is labeled GS. Navigable three-dimensional volume scans (Views 1–59) can be accessed by clicking on each SSQ cell.

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Table 3. Average RNFL thickness (microns) of scans acquired at various experimentally controlled subjective-scan-quality levels using RTVue, Spectralis (retinal thickness, not RNFL thickness), and Cirrus SD-OCT instruments. Healthy eyes are labeled H1–H4, and the glaucoma suspect eye is labeled GS. Navigable three-dimensional volume scans (Views 1–59) can be accessed by clicking on each thickness measurement cell.

Metrics