Abstract

This study examines the ability of RTVue, Cirrus and Spectralis OCT Spectral domain-optical coherence tomographs (SD-OCT) to detect localized retinal nerve fiber layer defects in glaucomatous eyes. In this observational case series, four glaucoma patients (8 eyes) were selected from the University of California, San Diego Shiley Eye Center and the Diagnostic Innovations in Glaucoma Study (DIGS) based on the presence of documented localized RNFL defects in at least one eye confirmed by masked stereophotograph assessment. One RTVue 3D Disc scan, one RTVue NHM4 scan, one Cirrus Optic Disk Cube 200×200 scan and one Spectralis scan centered on the optic disc (15×15 scan angle, 768 A-scans x 73 B-scans) were obtained on all undilated eyes within a single session. Results were compared with those obtained from stereophotographs. In 6 eyes the presence of localized RNFL defects was detected by stereophotography. In general, by qualitatively evaluating the retinal thickness maps generated, all SD-OCT instruments examined were able to confirm the presence of localized glaucomatous structural damage seen on stereophotographs. This study confirms SD-OCT is a promising technology for glaucoma detection as it may assist clinicians identify the presence of localized glaucomatous structural damage.

© 2009 Optical Society of America

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  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito. "Optical coherence tomography," Science 254,1178-81 (1991).
    [CrossRef] [PubMed]
  2. F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. SusannaJr, and R. N. Weinreb. "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139,44-55 (2005).
    [CrossRef] [PubMed]
  3. H. Bagga and D. S. Greenfield, "Quantitative assessment of structural damage in eyes with localized visual field abnormalities," Am. J. Ophthalmol. 137,797-805 (2004).
    [CrossRef] [PubMed]
  4. J. W. Jeoung, K. H. Park, T. W. Kim, S. I. Khwarg, and D. M. Kim. "Diagnostic ability of optical coherence tomography with a normative database to detect localized retinal nerve fiber layer defects," Ophthalmology 112,2157-63 (2005).
    [CrossRef] [PubMed]
  5. D. L. Budenz, A. Michael, R. T. Chang, J. McSoley, and J. Katz. "Sensitivity and specificity of the StratusOCT for perimetric glaucoma," Ophthalmology 112,3-9 (2005).
    [CrossRef] [PubMed]
  6. J. S. Schuman, M. R. Hee, C. A. Puliafito, C. Wong, T. Pedut-Kloizman, C. P. Lin, E. Hertzmark, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography," Arch. Ophthalmol. 113,586-96 (1995).
    [PubMed]
  7. V. Guedes, J. S. Schuman, E. Hertzmark, G. Wollstein, A. Correnti, R. Mancini, D. Lederer, S. Voskanian, L. Velazquez, H. M. Pakter, T. Pedut-Kloizman, J. G. Fujimoto, and C. Mattox, "Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes," Ophthalmology 110,177-89 (2003).
    [CrossRef] [PubMed]
  8. G. Wollstein, H. Ishikawa, J. Wang, S. A. Beaton, and J. S. Schuman, "Comparison of three optical coherence tomography scanning areas for detection of glaucomatous damage," Am. J. Ophthalmol. 139,39-43 (2005).
    [CrossRef] [PubMed]
  9. T. Mumcuoglu, G. Wollstein, M. Wojtkowski, L. Kagemann, H. Ishikawa, M. L. Gabriele, V. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Improved visualization of glaucomatous retinal damage using high-speed, ultra-high resolution optical coherence tomography," Ophthalmology 115, 782-89 (2008).
    [CrossRef]
  10. T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123,1715-20 (2005).
    [CrossRef] [PubMed]
  11. J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838,95-107 (1998).
    [CrossRef] [PubMed]
  12. R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of fourier domain vs. time domain optical coherence tomography," Opt. Express 11,889-94 (2003).
    [CrossRef] [PubMed]
  13. M. E. Van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog. Retin. Eye Res. 26,57-77 (2007).
    [CrossRef]
  14. M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewki, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biom. Opt. 7,457-63 (2002).
    [CrossRef]
  15. N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29,480-82 (2004).
    [CrossRef] [PubMed]
  16. J. F. De Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28,2067-69 (2003).
    [CrossRef] [PubMed]
  17. G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F.A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol., In press (2009).
    [CrossRef] [PubMed]
  18. A.O Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol., In press (2009).
    [CrossRef] [PubMed]
  19. U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005)
    [CrossRef] [PubMed]
  20. U. E. Wolf-Schnurrbusch, V. Enzmann, C. K. Brinkmann, and S. Wolf. "Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination," Invest. Ophthalmol. Vis. Sci. 49,3095-3099 (2008).
    [CrossRef] [PubMed]
  21. A. A. Khanifar, A. F. Koreishi, J. A. Izatt, and C. A. Toth. "Drusen Ultrastructure Imaging with Spectral Domain Optical Coherence Tomography in Age-related Macular Degeneration," Ophthalmology 115,1883-90 (2008).
    [CrossRef] [PubMed]
  22. K. Yi, M. Mujat, B. H. Park, W. Sun, J. W. Miller, J. M. Seddon, L. H. Young, J. F. de Boer, and T. C. Chen. "Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age Related Macular Degeneration," Br. J. Ophthalmol. published online 3 Dec 2008; doi:10.1136/bjo.2008.137356 (2008).
    [PubMed]
  23. F. A. Medeiros, R. N. Weinreb, P. A. Sample, C. F. Gomi, C. Bowd, J. G. Crowston, and L. M. Zangwill, "Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma," Am. J. Ophthalmol. 123,1351-60 (2005).
    [CrossRef]
  24. L. Pieroth, J. S. Schuman, E. Hertzmark, M. R. Hee, J. R. Wilkins, J. Coker, C. Mattox, R. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. Swanson, "Evaluation of focal defects of the nerve fiber layer using optical coherence tomography," Ophthalmology. 106,570-9 (1999).
    [CrossRef] [PubMed]

2009 (2)

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F.A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol., In press (2009).
[CrossRef] [PubMed]

A.O Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol., In press (2009).
[CrossRef] [PubMed]

2008 (4)

T. Mumcuoglu, G. Wollstein, M. Wojtkowski, L. Kagemann, H. Ishikawa, M. L. Gabriele, V. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Improved visualization of glaucomatous retinal damage using high-speed, ultra-high resolution optical coherence tomography," Ophthalmology 115, 782-89 (2008).
[CrossRef]

U. E. Wolf-Schnurrbusch, V. Enzmann, C. K. Brinkmann, and S. Wolf. "Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination," Invest. Ophthalmol. Vis. Sci. 49,3095-3099 (2008).
[CrossRef] [PubMed]

A. A. Khanifar, A. F. Koreishi, J. A. Izatt, and C. A. Toth. "Drusen Ultrastructure Imaging with Spectral Domain Optical Coherence Tomography in Age-related Macular Degeneration," Ophthalmology 115,1883-90 (2008).
[CrossRef] [PubMed]

K. Yi, M. Mujat, B. H. Park, W. Sun, J. W. Miller, J. M. Seddon, L. H. Young, J. F. de Boer, and T. C. Chen. "Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age Related Macular Degeneration," Br. J. Ophthalmol. published online 3 Dec 2008; doi:10.1136/bjo.2008.137356 (2008).
[PubMed]

2007 (1)

M. E. Van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog. Retin. Eye Res. 26,57-77 (2007).
[CrossRef]

2005 (7)

G. Wollstein, H. Ishikawa, J. Wang, S. A. Beaton, and J. S. Schuman, "Comparison of three optical coherence tomography scanning areas for detection of glaucomatous damage," Am. J. Ophthalmol. 139,39-43 (2005).
[CrossRef] [PubMed]

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005)
[CrossRef] [PubMed]

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123,1715-20 (2005).
[CrossRef] [PubMed]

F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. SusannaJr, and R. N. Weinreb. "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139,44-55 (2005).
[CrossRef] [PubMed]

J. W. Jeoung, K. H. Park, T. W. Kim, S. I. Khwarg, and D. M. Kim. "Diagnostic ability of optical coherence tomography with a normative database to detect localized retinal nerve fiber layer defects," Ophthalmology 112,2157-63 (2005).
[CrossRef] [PubMed]

D. L. Budenz, A. Michael, R. T. Chang, J. McSoley, and J. Katz. "Sensitivity and specificity of the StratusOCT for perimetric glaucoma," Ophthalmology 112,3-9 (2005).
[CrossRef] [PubMed]

F. A. Medeiros, R. N. Weinreb, P. A. Sample, C. F. Gomi, C. Bowd, J. G. Crowston, and L. M. Zangwill, "Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma," Am. J. Ophthalmol. 123,1351-60 (2005).
[CrossRef]

2004 (2)

2003 (3)

J. F. De Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28,2067-69 (2003).
[CrossRef] [PubMed]

R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of fourier domain vs. time domain optical coherence tomography," Opt. Express 11,889-94 (2003).
[CrossRef] [PubMed]

V. Guedes, J. S. Schuman, E. Hertzmark, G. Wollstein, A. Correnti, R. Mancini, D. Lederer, S. Voskanian, L. Velazquez, H. M. Pakter, T. Pedut-Kloizman, J. G. Fujimoto, and C. Mattox, "Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes," Ophthalmology 110,177-89 (2003).
[CrossRef] [PubMed]

2002 (1)

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewki, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biom. Opt. 7,457-63 (2002).
[CrossRef]

1999 (1)

L. Pieroth, J. S. Schuman, E. Hertzmark, M. R. Hee, J. R. Wilkins, J. Coker, C. Mattox, R. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. Swanson, "Evaluation of focal defects of the nerve fiber layer using optical coherence tomography," Ophthalmology. 106,570-9 (1999).
[CrossRef] [PubMed]

1998 (1)

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838,95-107 (1998).
[CrossRef] [PubMed]

1995 (1)

J. S. Schuman, M. R. Hee, C. A. Puliafito, C. Wong, T. Pedut-Kloizman, C. P. Lin, E. Hertzmark, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography," Arch. Ophthalmol. 113,586-96 (1995).
[PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito. "Optical coherence tomography," Science 254,1178-81 (1991).
[CrossRef] [PubMed]

Ahlers, C.

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005)
[CrossRef] [PubMed]

Bagga, H.

H. Bagga and D. S. Greenfield, "Quantitative assessment of structural damage in eyes with localized visual field abnormalities," Am. J. Ophthalmol. 137,797-805 (2004).
[CrossRef] [PubMed]

Bajraszewki, T.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewki, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biom. Opt. 7,457-63 (2002).
[CrossRef]

Beaton, S. A.

G. Wollstein, H. Ishikawa, J. Wang, S. A. Beaton, and J. S. Schuman, "Comparison of three optical coherence tomography scanning areas for detection of glaucomatous damage," Am. J. Ophthalmol. 139,39-43 (2005).
[CrossRef] [PubMed]

Boppart, S. A.

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838,95-107 (1998).
[CrossRef] [PubMed]

Bouma, B.

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838,95-107 (1998).
[CrossRef] [PubMed]

Bouma, B. E.

Bowd, C.

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F.A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol., In press (2009).
[CrossRef] [PubMed]

A.O Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol., In press (2009).
[CrossRef] [PubMed]

F. A. Medeiros, R. N. Weinreb, P. A. Sample, C. F. Gomi, C. Bowd, J. G. Crowston, and L. M. Zangwill, "Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma," Am. J. Ophthalmol. 123,1351-60 (2005).
[CrossRef]

F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. SusannaJr, and R. N. Weinreb. "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139,44-55 (2005).
[CrossRef] [PubMed]

Brezinski, M. E.

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838,95-107 (1998).
[CrossRef] [PubMed]

Brinkmann, C. K.

U. E. Wolf-Schnurrbusch, V. Enzmann, C. K. Brinkmann, and S. Wolf. "Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination," Invest. Ophthalmol. Vis. Sci. 49,3095-3099 (2008).
[CrossRef] [PubMed]

Budenz, D. L.

D. L. Budenz, A. Michael, R. T. Chang, J. McSoley, and J. Katz. "Sensitivity and specificity of the StratusOCT for perimetric glaucoma," Ophthalmology 112,3-9 (2005).
[CrossRef] [PubMed]

Cense, B.

Chang, R. T.

D. L. Budenz, A. Michael, R. T. Chang, J. McSoley, and J. Katz. "Sensitivity and specificity of the StratusOCT for perimetric glaucoma," Ophthalmology 112,3-9 (2005).
[CrossRef] [PubMed]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito. "Optical coherence tomography," Science 254,1178-81 (1991).
[CrossRef] [PubMed]

Chen, T. C.

K. Yi, M. Mujat, B. H. Park, W. Sun, J. W. Miller, J. M. Seddon, L. H. Young, J. F. de Boer, and T. C. Chen. "Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age Related Macular Degeneration," Br. J. Ophthalmol. published online 3 Dec 2008; doi:10.1136/bjo.2008.137356 (2008).
[PubMed]

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123,1715-20 (2005).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29,480-82 (2004).
[CrossRef] [PubMed]

Coker, J.

L. Pieroth, J. S. Schuman, E. Hertzmark, M. R. Hee, J. R. Wilkins, J. Coker, C. Mattox, R. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. Swanson, "Evaluation of focal defects of the nerve fiber layer using optical coherence tomography," Ophthalmology. 106,570-9 (1999).
[CrossRef] [PubMed]

Correnti, A.

V. Guedes, J. S. Schuman, E. Hertzmark, G. Wollstein, A. Correnti, R. Mancini, D. Lederer, S. Voskanian, L. Velazquez, H. M. Pakter, T. Pedut-Kloizman, J. G. Fujimoto, and C. Mattox, "Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes," Ophthalmology 110,177-89 (2003).
[CrossRef] [PubMed]

Crowston, J. G.

F. A. Medeiros, R. N. Weinreb, P. A. Sample, C. F. Gomi, C. Bowd, J. G. Crowston, and L. M. Zangwill, "Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma," Am. J. Ophthalmol. 123,1351-60 (2005).
[CrossRef]

de Boer, J. F.

K. Yi, M. Mujat, B. H. Park, W. Sun, J. W. Miller, J. M. Seddon, L. H. Young, J. F. de Boer, and T. C. Chen. "Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age Related Macular Degeneration," Br. J. Ophthalmol. published online 3 Dec 2008; doi:10.1136/bjo.2008.137356 (2008).
[PubMed]

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123,1715-20 (2005).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29,480-82 (2004).
[CrossRef] [PubMed]

J. F. De Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28,2067-69 (2003).
[CrossRef] [PubMed]

de Smet, M. D.

M. E. Van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog. Retin. Eye Res. 26,57-77 (2007).
[CrossRef]

Drexler, W.

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005)
[CrossRef] [PubMed]

Duker, J. S.

T. Mumcuoglu, G. Wollstein, M. Wojtkowski, L. Kagemann, H. Ishikawa, M. L. Gabriele, V. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Improved visualization of glaucomatous retinal damage using high-speed, ultra-high resolution optical coherence tomography," Ophthalmology 115, 782-89 (2008).
[CrossRef]

Enzmann, V.

U. E. Wolf-Schnurrbusch, V. Enzmann, C. K. Brinkmann, and S. Wolf. "Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination," Invest. Ophthalmol. Vis. Sci. 49,3095-3099 (2008).
[CrossRef] [PubMed]

Faber, D. J.

M. E. Van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog. Retin. Eye Res. 26,57-77 (2007).
[CrossRef]

Fercher, A. F.

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005)
[CrossRef] [PubMed]

R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of fourier domain vs. time domain optical coherence tomography," Opt. Express 11,889-94 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewki, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biom. Opt. 7,457-63 (2002).
[CrossRef]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito. "Optical coherence tomography," Science 254,1178-81 (1991).
[CrossRef] [PubMed]

Fujimoto, J. G.

T. Mumcuoglu, G. Wollstein, M. Wojtkowski, L. Kagemann, H. Ishikawa, M. L. Gabriele, V. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Improved visualization of glaucomatous retinal damage using high-speed, ultra-high resolution optical coherence tomography," Ophthalmology 115, 782-89 (2008).
[CrossRef]

V. Guedes, J. S. Schuman, E. Hertzmark, G. Wollstein, A. Correnti, R. Mancini, D. Lederer, S. Voskanian, L. Velazquez, H. M. Pakter, T. Pedut-Kloizman, J. G. Fujimoto, and C. Mattox, "Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes," Ophthalmology 110,177-89 (2003).
[CrossRef] [PubMed]

L. Pieroth, J. S. Schuman, E. Hertzmark, M. R. Hee, J. R. Wilkins, J. Coker, C. Mattox, R. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. Swanson, "Evaluation of focal defects of the nerve fiber layer using optical coherence tomography," Ophthalmology. 106,570-9 (1999).
[CrossRef] [PubMed]

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838,95-107 (1998).
[CrossRef] [PubMed]

J. S. Schuman, M. R. Hee, C. A. Puliafito, C. Wong, T. Pedut-Kloizman, C. P. Lin, E. Hertzmark, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography," Arch. Ophthalmol. 113,586-96 (1995).
[PubMed]

Gabriele, M. L.

T. Mumcuoglu, G. Wollstein, M. Wojtkowski, L. Kagemann, H. Ishikawa, M. L. Gabriele, V. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Improved visualization of glaucomatous retinal damage using high-speed, ultra-high resolution optical coherence tomography," Ophthalmology 115, 782-89 (2008).
[CrossRef]

Gomi, C. F.

F. A. Medeiros, R. N. Weinreb, P. A. Sample, C. F. Gomi, C. Bowd, J. G. Crowston, and L. M. Zangwill, "Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma," Am. J. Ophthalmol. 123,1351-60 (2005).
[CrossRef]

Gonzalez-Garcia, A. O.

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F.A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol., In press (2009).
[CrossRef] [PubMed]

Gonzalez-Garcia, A.O

A.O Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol., In press (2009).
[CrossRef] [PubMed]

Greenfield, D. S.

H. Bagga and D. S. Greenfield, "Quantitative assessment of structural damage in eyes with localized visual field abnormalities," Am. J. Ophthalmol. 137,797-805 (2004).
[CrossRef] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito. "Optical coherence tomography," Science 254,1178-81 (1991).
[CrossRef] [PubMed]

Guedes, V.

V. Guedes, J. S. Schuman, E. Hertzmark, G. Wollstein, A. Correnti, R. Mancini, D. Lederer, S. Voskanian, L. Velazquez, H. M. Pakter, T. Pedut-Kloizman, J. G. Fujimoto, and C. Mattox, "Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes," Ophthalmology 110,177-89 (2003).
[CrossRef] [PubMed]

Hee, M. R.

L. Pieroth, J. S. Schuman, E. Hertzmark, M. R. Hee, J. R. Wilkins, J. Coker, C. Mattox, R. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. Swanson, "Evaluation of focal defects of the nerve fiber layer using optical coherence tomography," Ophthalmology. 106,570-9 (1999).
[CrossRef] [PubMed]

J. S. Schuman, M. R. Hee, C. A. Puliafito, C. Wong, T. Pedut-Kloizman, C. P. Lin, E. Hertzmark, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography," Arch. Ophthalmol. 113,586-96 (1995).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito. "Optical coherence tomography," Science 254,1178-81 (1991).
[CrossRef] [PubMed]

Hermann, B.

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005)
[CrossRef] [PubMed]

Hertzmark, E.

V. Guedes, J. S. Schuman, E. Hertzmark, G. Wollstein, A. Correnti, R. Mancini, D. Lederer, S. Voskanian, L. Velazquez, H. M. Pakter, T. Pedut-Kloizman, J. G. Fujimoto, and C. Mattox, "Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes," Ophthalmology 110,177-89 (2003).
[CrossRef] [PubMed]

L. Pieroth, J. S. Schuman, E. Hertzmark, M. R. Hee, J. R. Wilkins, J. Coker, C. Mattox, R. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. Swanson, "Evaluation of focal defects of the nerve fiber layer using optical coherence tomography," Ophthalmology. 106,570-9 (1999).
[CrossRef] [PubMed]

J. S. Schuman, M. R. Hee, C. A. Puliafito, C. Wong, T. Pedut-Kloizman, C. P. Lin, E. Hertzmark, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography," Arch. Ophthalmol. 113,586-96 (1995).
[PubMed]

Hitzenberger, C. K.

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito. "Optical coherence tomography," Science 254,1178-81 (1991).
[CrossRef] [PubMed]

Ishikawa, H.

T. Mumcuoglu, G. Wollstein, M. Wojtkowski, L. Kagemann, H. Ishikawa, M. L. Gabriele, V. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Improved visualization of glaucomatous retinal damage using high-speed, ultra-high resolution optical coherence tomography," Ophthalmology 115, 782-89 (2008).
[CrossRef]

G. Wollstein, H. Ishikawa, J. Wang, S. A. Beaton, and J. S. Schuman, "Comparison of three optical coherence tomography scanning areas for detection of glaucomatous damage," Am. J. Ophthalmol. 139,39-43 (2005).
[CrossRef] [PubMed]

Izatt, J. A.

A. A. Khanifar, A. F. Koreishi, J. A. Izatt, and C. A. Toth. "Drusen Ultrastructure Imaging with Spectral Domain Optical Coherence Tomography in Age-related Macular Degeneration," Ophthalmology 115,1883-90 (2008).
[CrossRef] [PubMed]

J. S. Schuman, M. R. Hee, C. A. Puliafito, C. Wong, T. Pedut-Kloizman, C. P. Lin, E. Hertzmark, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography," Arch. Ophthalmol. 113,586-96 (1995).
[PubMed]

Jeoung, J. W.

J. W. Jeoung, K. H. Park, T. W. Kim, S. I. Khwarg, and D. M. Kim. "Diagnostic ability of optical coherence tomography with a normative database to detect localized retinal nerve fiber layer defects," Ophthalmology 112,2157-63 (2005).
[CrossRef] [PubMed]

Kagemann, L.

T. Mumcuoglu, G. Wollstein, M. Wojtkowski, L. Kagemann, H. Ishikawa, M. L. Gabriele, V. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Improved visualization of glaucomatous retinal damage using high-speed, ultra-high resolution optical coherence tomography," Ophthalmology 115, 782-89 (2008).
[CrossRef]

Katz, J.

D. L. Budenz, A. Michael, R. T. Chang, J. McSoley, and J. Katz. "Sensitivity and specificity of the StratusOCT for perimetric glaucoma," Ophthalmology 112,3-9 (2005).
[CrossRef] [PubMed]

Khanifar, A. A.

A. A. Khanifar, A. F. Koreishi, J. A. Izatt, and C. A. Toth. "Drusen Ultrastructure Imaging with Spectral Domain Optical Coherence Tomography in Age-related Macular Degeneration," Ophthalmology 115,1883-90 (2008).
[CrossRef] [PubMed]

Khwarg, S. I.

J. W. Jeoung, K. H. Park, T. W. Kim, S. I. Khwarg, and D. M. Kim. "Diagnostic ability of optical coherence tomography with a normative database to detect localized retinal nerve fiber layer defects," Ophthalmology 112,2157-63 (2005).
[CrossRef] [PubMed]

Kim, D. M.

J. W. Jeoung, K. H. Park, T. W. Kim, S. I. Khwarg, and D. M. Kim. "Diagnostic ability of optical coherence tomography with a normative database to detect localized retinal nerve fiber layer defects," Ophthalmology 112,2157-63 (2005).
[CrossRef] [PubMed]

Kim, T. W.

J. W. Jeoung, K. H. Park, T. W. Kim, S. I. Khwarg, and D. M. Kim. "Diagnostic ability of optical coherence tomography with a normative database to detect localized retinal nerve fiber layer defects," Ophthalmology 112,2157-63 (2005).
[CrossRef] [PubMed]

Koreishi, A. F.

A. A. Khanifar, A. F. Koreishi, J. A. Izatt, and C. A. Toth. "Drusen Ultrastructure Imaging with Spectral Domain Optical Coherence Tomography in Age-related Macular Degeneration," Ophthalmology 115,1883-90 (2008).
[CrossRef] [PubMed]

Kowalczyk, A.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewki, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biom. Opt. 7,457-63 (2002).
[CrossRef]

Lederer, D.

V. Guedes, J. S. Schuman, E. Hertzmark, G. Wollstein, A. Correnti, R. Mancini, D. Lederer, S. Voskanian, L. Velazquez, H. M. Pakter, T. Pedut-Kloizman, J. G. Fujimoto, and C. Mattox, "Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes," Ophthalmology 110,177-89 (2003).
[CrossRef] [PubMed]

Leitgeb, R.

R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of fourier domain vs. time domain optical coherence tomography," Opt. Express 11,889-94 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewki, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biom. Opt. 7,457-63 (2002).
[CrossRef]

Leitgeb, R.A.

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005)
[CrossRef] [PubMed]

Lin, C. P.

J. S. Schuman, M. R. Hee, C. A. Puliafito, C. Wong, T. Pedut-Kloizman, C. P. Lin, E. Hertzmark, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography," Arch. Ophthalmol. 113,586-96 (1995).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito. "Optical coherence tomography," Science 254,1178-81 (1991).
[CrossRef] [PubMed]

Mancini, R.

V. Guedes, J. S. Schuman, E. Hertzmark, G. Wollstein, A. Correnti, R. Mancini, D. Lederer, S. Voskanian, L. Velazquez, H. M. Pakter, T. Pedut-Kloizman, J. G. Fujimoto, and C. Mattox, "Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes," Ophthalmology 110,177-89 (2003).
[CrossRef] [PubMed]

Mattox, C.

V. Guedes, J. S. Schuman, E. Hertzmark, G. Wollstein, A. Correnti, R. Mancini, D. Lederer, S. Voskanian, L. Velazquez, H. M. Pakter, T. Pedut-Kloizman, J. G. Fujimoto, and C. Mattox, "Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes," Ophthalmology 110,177-89 (2003).
[CrossRef] [PubMed]

L. Pieroth, J. S. Schuman, E. Hertzmark, M. R. Hee, J. R. Wilkins, J. Coker, C. Mattox, R. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. Swanson, "Evaluation of focal defects of the nerve fiber layer using optical coherence tomography," Ophthalmology. 106,570-9 (1999).
[CrossRef] [PubMed]

McSoley, J.

D. L. Budenz, A. Michael, R. T. Chang, J. McSoley, and J. Katz. "Sensitivity and specificity of the StratusOCT for perimetric glaucoma," Ophthalmology 112,3-9 (2005).
[CrossRef] [PubMed]

Medeiros, F. A.

A.O Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol., In press (2009).
[CrossRef] [PubMed]

F. A. Medeiros, R. N. Weinreb, P. A. Sample, C. F. Gomi, C. Bowd, J. G. Crowston, and L. M. Zangwill, "Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma," Am. J. Ophthalmol. 123,1351-60 (2005).
[CrossRef]

F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. SusannaJr, and R. N. Weinreb. "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139,44-55 (2005).
[CrossRef] [PubMed]

Medeiros, F.A.

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F.A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol., In press (2009).
[CrossRef] [PubMed]

Michael, A.

D. L. Budenz, A. Michael, R. T. Chang, J. McSoley, and J. Katz. "Sensitivity and specificity of the StratusOCT for perimetric glaucoma," Ophthalmology 112,3-9 (2005).
[CrossRef] [PubMed]

Michels, S.

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005)
[CrossRef] [PubMed]

Miller, J. W.

K. Yi, M. Mujat, B. H. Park, W. Sun, J. W. Miller, J. M. Seddon, L. H. Young, J. F. de Boer, and T. C. Chen. "Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age Related Macular Degeneration," Br. J. Ophthalmol. published online 3 Dec 2008; doi:10.1136/bjo.2008.137356 (2008).
[PubMed]

Mujat, M.

K. Yi, M. Mujat, B. H. Park, W. Sun, J. W. Miller, J. M. Seddon, L. H. Young, J. F. de Boer, and T. C. Chen. "Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age Related Macular Degeneration," Br. J. Ophthalmol. published online 3 Dec 2008; doi:10.1136/bjo.2008.137356 (2008).
[PubMed]

Mumcuoglu, T.

T. Mumcuoglu, G. Wollstein, M. Wojtkowski, L. Kagemann, H. Ishikawa, M. L. Gabriele, V. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Improved visualization of glaucomatous retinal damage using high-speed, ultra-high resolution optical coherence tomography," Ophthalmology 115, 782-89 (2008).
[CrossRef]

Nassif, N.

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123,1715-20 (2005).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29,480-82 (2004).
[CrossRef] [PubMed]

Pakter, H. M.

V. Guedes, J. S. Schuman, E. Hertzmark, G. Wollstein, A. Correnti, R. Mancini, D. Lederer, S. Voskanian, L. Velazquez, H. M. Pakter, T. Pedut-Kloizman, J. G. Fujimoto, and C. Mattox, "Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes," Ophthalmology 110,177-89 (2003).
[CrossRef] [PubMed]

Park, B. H.

K. Yi, M. Mujat, B. H. Park, W. Sun, J. W. Miller, J. M. Seddon, L. H. Young, J. F. de Boer, and T. C. Chen. "Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age Related Macular Degeneration," Br. J. Ophthalmol. published online 3 Dec 2008; doi:10.1136/bjo.2008.137356 (2008).
[PubMed]

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123,1715-20 (2005).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29,480-82 (2004).
[CrossRef] [PubMed]

J. F. De Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28,2067-69 (2003).
[CrossRef] [PubMed]

Park, K. H.

J. W. Jeoung, K. H. Park, T. W. Kim, S. I. Khwarg, and D. M. Kim. "Diagnostic ability of optical coherence tomography with a normative database to detect localized retinal nerve fiber layer defects," Ophthalmology 112,2157-63 (2005).
[CrossRef] [PubMed]

Pedut-Kloizman, R.

L. Pieroth, J. S. Schuman, E. Hertzmark, M. R. Hee, J. R. Wilkins, J. Coker, C. Mattox, R. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. Swanson, "Evaluation of focal defects of the nerve fiber layer using optical coherence tomography," Ophthalmology. 106,570-9 (1999).
[CrossRef] [PubMed]

Pedut-Kloizman, T.

V. Guedes, J. S. Schuman, E. Hertzmark, G. Wollstein, A. Correnti, R. Mancini, D. Lederer, S. Voskanian, L. Velazquez, H. M. Pakter, T. Pedut-Kloizman, J. G. Fujimoto, and C. Mattox, "Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes," Ophthalmology 110,177-89 (2003).
[CrossRef] [PubMed]

J. S. Schuman, M. R. Hee, C. A. Puliafito, C. Wong, T. Pedut-Kloizman, C. P. Lin, E. Hertzmark, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography," Arch. Ophthalmol. 113,586-96 (1995).
[PubMed]

Pierce, M. C.

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123,1715-20 (2005).
[CrossRef] [PubMed]

J. F. De Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28,2067-69 (2003).
[CrossRef] [PubMed]

Pieroth, L.

L. Pieroth, J. S. Schuman, E. Hertzmark, M. R. Hee, J. R. Wilkins, J. Coker, C. Mattox, R. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. Swanson, "Evaluation of focal defects of the nerve fiber layer using optical coherence tomography," Ophthalmology. 106,570-9 (1999).
[CrossRef] [PubMed]

Pitris, C.

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838,95-107 (1998).
[CrossRef] [PubMed]

Povazay, B.

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005)
[CrossRef] [PubMed]

Puliafito, C. A.

L. Pieroth, J. S. Schuman, E. Hertzmark, M. R. Hee, J. R. Wilkins, J. Coker, C. Mattox, R. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. Swanson, "Evaluation of focal defects of the nerve fiber layer using optical coherence tomography," Ophthalmology. 106,570-9 (1999).
[CrossRef] [PubMed]

J. S. Schuman, M. R. Hee, C. A. Puliafito, C. Wong, T. Pedut-Kloizman, C. P. Lin, E. Hertzmark, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography," Arch. Ophthalmol. 113,586-96 (1995).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito. "Optical coherence tomography," Science 254,1178-81 (1991).
[CrossRef] [PubMed]

Sacu, S.

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005)
[CrossRef] [PubMed]

Sample, P. A.

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F.A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol., In press (2009).
[CrossRef] [PubMed]

F. A. Medeiros, R. N. Weinreb, P. A. Sample, C. F. Gomi, C. Bowd, J. G. Crowston, and L. M. Zangwill, "Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma," Am. J. Ophthalmol. 123,1351-60 (2005).
[CrossRef]

Sattmann, H.

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005)
[CrossRef] [PubMed]

Schmidt-Erfurth, U.

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005)
[CrossRef] [PubMed]

Scholda, C.

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A. F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Invest. Ophthalmol. Vis. Sci. 46,3393-3402 (2005)
[CrossRef] [PubMed]

Schuman, J. S.

T. Mumcuoglu, G. Wollstein, M. Wojtkowski, L. Kagemann, H. Ishikawa, M. L. Gabriele, V. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Improved visualization of glaucomatous retinal damage using high-speed, ultra-high resolution optical coherence tomography," Ophthalmology 115, 782-89 (2008).
[CrossRef]

G. Wollstein, H. Ishikawa, J. Wang, S. A. Beaton, and J. S. Schuman, "Comparison of three optical coherence tomography scanning areas for detection of glaucomatous damage," Am. J. Ophthalmol. 139,39-43 (2005).
[CrossRef] [PubMed]

V. Guedes, J. S. Schuman, E. Hertzmark, G. Wollstein, A. Correnti, R. Mancini, D. Lederer, S. Voskanian, L. Velazquez, H. M. Pakter, T. Pedut-Kloizman, J. G. Fujimoto, and C. Mattox, "Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes," Ophthalmology 110,177-89 (2003).
[CrossRef] [PubMed]

L. Pieroth, J. S. Schuman, E. Hertzmark, M. R. Hee, J. R. Wilkins, J. Coker, C. Mattox, R. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. Swanson, "Evaluation of focal defects of the nerve fiber layer using optical coherence tomography," Ophthalmology. 106,570-9 (1999).
[CrossRef] [PubMed]

J. S. Schuman, M. R. Hee, C. A. Puliafito, C. Wong, T. Pedut-Kloizman, C. P. Lin, E. Hertzmark, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography," Arch. Ophthalmol. 113,586-96 (1995).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito. "Optical coherence tomography," Science 254,1178-81 (1991).
[CrossRef] [PubMed]

Seddon, J. M.

K. Yi, M. Mujat, B. H. Park, W. Sun, J. W. Miller, J. M. Seddon, L. H. Young, J. F. de Boer, and T. C. Chen. "Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age Related Macular Degeneration," Br. J. Ophthalmol. published online 3 Dec 2008; doi:10.1136/bjo.2008.137356 (2008).
[PubMed]

Southern, J. F.

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838,95-107 (1998).
[CrossRef] [PubMed]

Srinivasan, V.

T. Mumcuoglu, G. Wollstein, M. Wojtkowski, L. Kagemann, H. Ishikawa, M. L. Gabriele, V. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Improved visualization of glaucomatous retinal damage using high-speed, ultra-high resolution optical coherence tomography," Ophthalmology 115, 782-89 (2008).
[CrossRef]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito. "Optical coherence tomography," Science 254,1178-81 (1991).
[CrossRef] [PubMed]

Sun, W.

K. Yi, M. Mujat, B. H. Park, W. Sun, J. W. Miller, J. M. Seddon, L. H. Young, J. F. de Boer, and T. C. Chen. "Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age Related Macular Degeneration," Br. J. Ophthalmol. published online 3 Dec 2008; doi:10.1136/bjo.2008.137356 (2008).
[PubMed]

Susanna, R.

F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. SusannaJr, and R. N. Weinreb. "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139,44-55 (2005).
[CrossRef] [PubMed]

Swanson, E.

L. Pieroth, J. S. Schuman, E. Hertzmark, M. R. Hee, J. R. Wilkins, J. Coker, C. Mattox, R. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. Swanson, "Evaluation of focal defects of the nerve fiber layer using optical coherence tomography," Ophthalmology. 106,570-9 (1999).
[CrossRef] [PubMed]

Swanson, E. A.

J. S. Schuman, M. R. Hee, C. A. Puliafito, C. Wong, T. Pedut-Kloizman, C. P. Lin, E. Hertzmark, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography," Arch. Ophthalmol. 113,586-96 (1995).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito. "Optical coherence tomography," Science 254,1178-81 (1991).
[CrossRef] [PubMed]

Tearney, G. J.

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123,1715-20 (2005).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29,480-82 (2004).
[CrossRef] [PubMed]

J. F. De Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28,2067-69 (2003).
[CrossRef] [PubMed]

J. G. Fujimoto, B. Bouma, G. J. Tearney, S. A. Boppart, C. Pitris, J. F. Southern, and M. E. Brezinski, "New technology for high-speed and high-resolution optical coherence tomography," Ann. N. Y. Acad. Sci. 838,95-107 (1998).
[CrossRef] [PubMed]

Toth, C. A.

A. A. Khanifar, A. F. Koreishi, J. A. Izatt, and C. A. Toth. "Drusen Ultrastructure Imaging with Spectral Domain Optical Coherence Tomography in Age-related Macular Degeneration," Ophthalmology 115,1883-90 (2008).
[CrossRef] [PubMed]

van Leeuwen, T. G.

M. E. Van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog. Retin. Eye Res. 26,57-77 (2007).
[CrossRef]

Van Velthoven, M. E.

M. E. Van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog. Retin. Eye Res. 26,57-77 (2007).
[CrossRef]

Velazquez, L.

V. Guedes, J. S. Schuman, E. Hertzmark, G. Wollstein, A. Correnti, R. Mancini, D. Lederer, S. Voskanian, L. Velazquez, H. M. Pakter, T. Pedut-Kloizman, J. G. Fujimoto, and C. Mattox, "Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes," Ophthalmology 110,177-89 (2003).
[CrossRef] [PubMed]

Verbraak, F. D.

M. E. Van Velthoven, D. J. Faber, F. D. Verbraak, T. G. van Leeuwen, and M. D. de Smet, "Recent developments in optical coherence tomography for imaging the retina," Prog. Retin. Eye Res. 26,57-77 (2007).
[CrossRef]

Vessani, R. M.

F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. SusannaJr, and R. N. Weinreb. "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139,44-55 (2005).
[CrossRef] [PubMed]

Vizzeri, G.

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F.A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol., In press (2009).
[CrossRef] [PubMed]

A.O Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol., In press (2009).
[CrossRef] [PubMed]

Voskanian, S.

V. Guedes, J. S. Schuman, E. Hertzmark, G. Wollstein, A. Correnti, R. Mancini, D. Lederer, S. Voskanian, L. Velazquez, H. M. Pakter, T. Pedut-Kloizman, J. G. Fujimoto, and C. Mattox, "Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes," Ophthalmology 110,177-89 (2003).
[CrossRef] [PubMed]

Wang, J.

G. Wollstein, H. Ishikawa, J. Wang, S. A. Beaton, and J. S. Schuman, "Comparison of three optical coherence tomography scanning areas for detection of glaucomatous damage," Am. J. Ophthalmol. 139,39-43 (2005).
[CrossRef] [PubMed]

Weinreb, R. N.

A.O Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol., In press (2009).
[CrossRef] [PubMed]

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F.A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol., In press (2009).
[CrossRef] [PubMed]

F. A. Medeiros, R. N. Weinreb, P. A. Sample, C. F. Gomi, C. Bowd, J. G. Crowston, and L. M. Zangwill, "Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma," Am. J. Ophthalmol. 123,1351-60 (2005).
[CrossRef]

F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. SusannaJr, and R. N. Weinreb. "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139,44-55 (2005).
[CrossRef] [PubMed]

White, B. R.

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123,1715-20 (2005).
[CrossRef] [PubMed]

Wilkins, J. R.

L. Pieroth, J. S. Schuman, E. Hertzmark, M. R. Hee, J. R. Wilkins, J. Coker, C. Mattox, R. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. Swanson, "Evaluation of focal defects of the nerve fiber layer using optical coherence tomography," Ophthalmology. 106,570-9 (1999).
[CrossRef] [PubMed]

Wojtkowski, M.

T. Mumcuoglu, G. Wollstein, M. Wojtkowski, L. Kagemann, H. Ishikawa, M. L. Gabriele, V. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Improved visualization of glaucomatous retinal damage using high-speed, ultra-high resolution optical coherence tomography," Ophthalmology 115, 782-89 (2008).
[CrossRef]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewki, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biom. Opt. 7,457-63 (2002).
[CrossRef]

Wolf, S.

U. E. Wolf-Schnurrbusch, V. Enzmann, C. K. Brinkmann, and S. Wolf. "Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination," Invest. Ophthalmol. Vis. Sci. 49,3095-3099 (2008).
[CrossRef] [PubMed]

Wolf-Schnurrbusch, U. E.

U. E. Wolf-Schnurrbusch, V. Enzmann, C. K. Brinkmann, and S. Wolf. "Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination," Invest. Ophthalmol. Vis. Sci. 49,3095-3099 (2008).
[CrossRef] [PubMed]

Wollstein, G.

T. Mumcuoglu, G. Wollstein, M. Wojtkowski, L. Kagemann, H. Ishikawa, M. L. Gabriele, V. Srinivasan, J. G. Fujimoto, J. S. Duker, and J. S. Schuman, "Improved visualization of glaucomatous retinal damage using high-speed, ultra-high resolution optical coherence tomography," Ophthalmology 115, 782-89 (2008).
[CrossRef]

G. Wollstein, H. Ishikawa, J. Wang, S. A. Beaton, and J. S. Schuman, "Comparison of three optical coherence tomography scanning areas for detection of glaucomatous damage," Am. J. Ophthalmol. 139,39-43 (2005).
[CrossRef] [PubMed]

V. Guedes, J. S. Schuman, E. Hertzmark, G. Wollstein, A. Correnti, R. Mancini, D. Lederer, S. Voskanian, L. Velazquez, H. M. Pakter, T. Pedut-Kloizman, J. G. Fujimoto, and C. Mattox, "Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes," Ophthalmology 110,177-89 (2003).
[CrossRef] [PubMed]

Wong, C.

J. S. Schuman, M. R. Hee, C. A. Puliafito, C. Wong, T. Pedut-Kloizman, C. P. Lin, E. Hertzmark, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, "Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography," Arch. Ophthalmol. 113,586-96 (1995).
[PubMed]

Yi, K.

K. Yi, M. Mujat, B. H. Park, W. Sun, J. W. Miller, J. M. Seddon, L. H. Young, J. F. de Boer, and T. C. Chen. "Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age Related Macular Degeneration," Br. J. Ophthalmol. published online 3 Dec 2008; doi:10.1136/bjo.2008.137356 (2008).
[PubMed]

Young, L. H.

K. Yi, M. Mujat, B. H. Park, W. Sun, J. W. Miller, J. M. Seddon, L. H. Young, J. F. de Boer, and T. C. Chen. "Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age Related Macular Degeneration," Br. J. Ophthalmol. published online 3 Dec 2008; doi:10.1136/bjo.2008.137356 (2008).
[PubMed]

Yun, S. H.

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123,1715-20 (2005).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29,480-82 (2004).
[CrossRef] [PubMed]

Zangwill, L. M.

A.O Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol., In press (2009).
[CrossRef] [PubMed]

G. Vizzeri, R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F.A. Medeiros, P. A. Sample, and L. M. Zangwill, "Agreement between Spectral-Domain and Time-Domain OCT for measuring RNFL thickness," Br. J. Ophthalmol., In press (2009).
[CrossRef] [PubMed]

F. A. Medeiros, R. N. Weinreb, P. A. Sample, C. F. Gomi, C. Bowd, J. G. Crowston, and L. M. Zangwill, "Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma," Am. J. Ophthalmol. 123,1351-60 (2005).
[CrossRef]

F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. SusannaJr, and R. N. Weinreb. "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139,44-55 (2005).
[CrossRef] [PubMed]

Am. J. Ophthalmol. (5)

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A.O Gonzalez-Garcia, G. Vizzeri, C. Bowd, F. A. Medeiros, L. M. Zangwill, and R. N. Weinreb, "Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus OCT Measurements," Am. J. Ophthalmol., In press (2009).
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Figures (4)

Fig. 1.
Fig. 1.

Results from photographs, visual fields (pattern standard deviation map) and SD-OCT devices for Case 1. A. The photographs show an inferior notch with a localized RNFL defect at 5-6 clock hours in OS (indicated by the white arrows) associated with a corresponding repeatable superior visual field defect. B. RTVue “Nerve Head/RNFL Analysis” map divided into 16 sectors. Values outside Normal limits based on the internal normative database are shown in red (to explore RTVue 3-D scans, see View 1 for OD and View 2 for OS). C. Cirrus “RNFL Thickness Map and “RNFL Thickness Deviation” map highlight in red clock hours and peripapillary RNFL Outside Normal Limits compared to on the internal normative database (to explore Cirrus 3-D scans, see View 3 for OD and View 4 for OS). D. Spectralis OCT retinal thickness map with retinal thickness measurements (microns, in black) and volume (mm3, in red) for the 2.2 and 3.45 mm diameters at the superior, inferior, temporal and nasal quadrants (to explore Spectralis 3-D scans, see View 5 for OD and View 6 for OS). All three instruments identify the wedge-shaped RNFL defect at 5 to 6 o’clock.

Fig. 2.
Fig. 2.

Results from photographs, visual fields (pattern standard deviation map) and SD-OCT devices for Case 2. A. The photographs show an enlarged cup with superior and inferior rim thinning with the presence of several localized RNFL defects (OD at 5, 7 and 11-12 o’clock,and OS at 1-2 and 5-6 o’clock), as indicated by the white arrows. B. RTVue “Nerve Head/RNFL Analysis” map identifies sectors Outside Normal in red based on the internal normative (to explore RTVue 3-D scans, see View 7 for OD and View 8 for OS). C. Cirrus “RNFL Thickness Map” and “RNFL Thickness Deviation” map highlight in red clock hours and peripapillary retina areas Outside Normal Limits based on the internal normative database (to explore Cirrus 3-D scans, View 9 for OD and View 10 for OS). D. Spectralis OCT retinal thickness map with retinal thickness measurements (microns, in black) and volume (mm3, in red) for the 2.2 and 3.45 mm diameters at the superior, inferior, temporal and nasal quadrants (to explore Spectralis 3-D scans, see View 11 for OD and View 12 for OS). All 3 instruments identify RNFL defects in the superior and inferior hemifields.

Fig. 3.
Fig. 3.

Results from photographs, visual fields (pattern standard deviation map) and SD-OCT devices for Case 3. A. The photographs show diffuse inferior RNFL loss in both eyes, as indicated by the white arrows, associated with a repeatable bilateral superior hemifield defect. B. RTVue “Nerve Head/RNFL Analysis” map identifies in red sectors Outside Normal based on the internal normative database (to explore RTVue 3-D scans, see View 13 for OD and View 14 for OS). C. Cirrus “RNFL Thickness Map” and “RNFL Thickness Deviation” map highlight in red clock hours and peripapillary retina areas Outside Normal Limits based on the internal normative database (to explore Cirrus 3-D scans, see View 15 for OD and View 16 for OS). D. Spectralis OCT retinal thickness map with retinal thickness measurements (microns, in black) and volume (mm3, in red) for the 2.2 and 3.45 mm diameters at the superior, inferior, temporal and nasal quadrants (to explore Spectralis 3-D scans, see View 17 for OD and View 18). All 3 instruments identify RNFL loss in the inferior region.

Fig. 4.
Fig. 4.

Results from photographs, visual fields (pattern standard deviation map) and SD-OCT devices for Case 4. A. The photographs show an enlarged cup in both eyes, with an inferior notch in OS with localized RNFL defect at 5-7 clock hours, indicated by the white arrows. B. . RTVue “Nerve Head/RNFL Analysis” map identifies in red sectors Outside Normal based on the internal normative database (to explore RTVue 3-D scans, see View 19 for OD and View 20 for OS). C. “RNFL Thickness Map” and “RNFL Thickness Deviation” map highlight in red clock hours and peripapillary retina areas Outside Normal Limits based on the internal normative database (to explore Cirrus 3-D scans, see View 21 for OD and View 22 for OS). D. Spectralis OCT retinal thickness map with retinal thickness measurements (microns, in black) and volume (mm3, in red) for the 2.2 and 3.45 mm diameters at the superior, inferior, temporal and nasal quadrants (to explore Spectralis 3-D scans, see View 23 for OD and View 24 for OS). All 3 instruments show RNFL loss in the left eye.

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Tables (1)

Tables Icon

Table 1. RTVue, Cirrus and Spectralis OCT average thickness measurements and RTVue and Cirrus sectoral results at RNFL defect locations (clock hours) identified based on masked stereophotographs evaluation. Measurements are derived from the internal standard analysis methods provided by each instrument.

Metrics