Abstract

We report a novel time-domain diffuse optical tomography to determine the optical properties in a faster speed than the conventional ones. Instead of using the ultrashort pulse laser, a 2.5 Gbps pseudorandom bit sequence is used to modulate the near-infrared light for tissue-like phantom illumination. The time-resolved signal can be retrieved very quickly by demodulation with the reference signal. The system impulse response has a full width at half maximum around 800 picoseconds and the 2-dimentional maps of optical properties can be obtained within a few seconds. The high signal-to-noise ratio and the environmental illumination insensitivity warrant a great potential for applications in clinical noninvasive breast cancer detection.

© 2008 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. D. R. Leff, O. Warren, L. C. Enfield, A. P. Gibson, T. Athanasiou, D. K. Pattern, J. C. Hebden, G. Z. Yang, and A. Darzi, "Diffuse optical imaging of the healthy and diseased breast - a systematic review," Breast Cancer Res. Treat. 108, 9-22 (2008).
    [CrossRef]
  2. L. C. Enfield, A. P. Gibson, N. L. Everdell, D. T. Delpy, M. Schweiger, S. R. Arridge, C. Richardson, M. Keshtgar, M. Douek, and J. C. Hebden, "Three-dimensional time-resolved optical mammography of the uncompressed breast," Appl. Opt. 46, 3628-3638 (2007).
    [CrossRef] [PubMed]
  3. A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
    [CrossRef] [PubMed]
  4. J. C. Hebden and T. Austin, "Optical tomography of the neonatal brain," Euro. Rad. 17, 2926-2933 (2007).
    [CrossRef]
  5. T. Austin, J. C. Hebden, A. P. Gibson, G. Branco, R. Yusof, S. R. Arridge, J. H. Meek, D. T. Delpy, and J. S. Wyatt, "Three-dimensional optical imaging of blood volume and oxygenation in the preterm brain," Neuroimage  31, 1426-1433 (2006).
    [CrossRef] [PubMed]
  6. M. A. Franceschini, D. K. Joseph, T. J. Huppert, S. G. Diamond, and D. A. Boas, "Diffuse optical imaging of the whole head," J. Biomed. Opt. 11, 054007 (2006).
    [CrossRef] [PubMed]
  7. G. Gulsen, O. Birgul, B. Xiong, and O. Nalcioglu, "Design and implementation of a multi-Frequency diffuse optical tomography (MF-DOT) System," J. Biomed. Opt. 11, 014020 (2006).
    [CrossRef] [PubMed]
  8. J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, and A. G. Yodh. "Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging," Med. Phys. 30, 235-247 (2003).
    [CrossRef] [PubMed]
  9. J. M. Yang, Y. H. Han, G. Yoon, B. S. Ahn, B. C. Lee, and K. S. Soh, "In vivo 783-channel diffuse reflectance imaging system and its application," Appl. Opt. 46, 5991-6003 (2007).
    [CrossRef] [PubMed]
  10. M. Schweiger, A. Gibson, and S. R. Arridge, "Computational aspectcts of diffuse optical tomography," Comput. Opt. 5, 33-41 (2001).
  11. F. Gao, H. J. Zhao, and Y. Yamada, "Improvement of image quality in diffuse optical tomography by use of full time-resolved data," Appl. Opt. 41, 778-791 (2002).
    [CrossRef] [PubMed]
  12. W. Becker, A. Bergmann, A. Gibson, N. Everdell, D. Jennions, M. Schweiger, A. R. Arridge, and J. C. Hebden, "Multi-dimensional time-correlated single photon counting applied to diffuse optical tomography," Proc. SPIE 5693, 34-42 (2005).
    [CrossRef]
  13. F. Schmidt, M. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, "A 32-channel time-resolved instrument for medical optical tomography," Rev. Sci. Instrum. 71, 256-265 (2000).
    [CrossRef]
  14. H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, "Multi-channel time-resolved optical tomographic imaging system," Rev. Sci. Instrum. 70, 3595-3602 (1999).
    [CrossRef]
  15. H. Zhao, F. Gao, Y. Tanikawa, K. Homma, and Y. Yamada, "Time-resolved diffuse optical tomographic imaging for the provision of both anatomical and functional information about biological tissue," Appl. Opt. 44, 1905-1916 (2005).
    [CrossRef] [PubMed]
  16. C. V. Zint,W. Uhring, M. Torregrossa, B. Cunin, and P. Poulet, "Streak camera: a multidetector for diffuse optical tomography," Appl. Opt. 42, 3313-3320 (2003).
    [CrossRef] [PubMed]
  17. J. C. Hebden, D. J. Hall, M. Firbank, and D. T. Delpy, "Time-resolved optical imaging of a solid tissue-equivalent phantom," Appl. Opt. 34, 8038-8047 (1995).
    [CrossRef] [PubMed]
  18. N. G. Chen and Q. Zhu, "Time-resolved optical measurements with spread spectrum excitations," Opt. Lett. 27, 1806-1808 (2002).
    [CrossRef]
  19. N. G. Chen and Q. Zhu, "Time-resolved diffusive optical imaging using pseudo-random bit sequences," Opt. Express 11, 3445-3454 (2003), http://www.opticsexpress.org/abstract.cfm?uri=OE-11-25-3445.
    [CrossRef] [PubMed]
  20. W. F. Cheong, S. A. Prohl, and A. J. Welch, "A review of the optical properties of biological tissues," IEEE J. Quantum Electron. 26, 2166-2185 (1990).
    [CrossRef]
  21. J. C. Hebden, B. D. Price, A. P. Gibson, and G. Royle, "A soft deformable tissue-equivalent phantom for diffuse optical tomography," Phys. Med. Biol. 51, 5581-5590 (2006).
    [CrossRef] [PubMed]
  22. M. Firbank, M. Oda, and D. T. Delpy, "An improved design for a stable and reproducible phantom material for use in near-infrared spectroscopy and imaging." Phys. Med. Biol. 40, 955-961 (1995).
    [CrossRef] [PubMed]
  23. M. S. Patterson, B. Chance, and B. C. Wilson, "Time resolved reflectance and transmittance for the noninvasive measurement of tissue optical properties," Appl. Opt. 28, 2331-2337 (1996).
    [CrossRef]
  24. D. A. Boas, T. Gaudette, and S. R. Arridge, "Simultaneous imaging and optode calibration with diffuse optical tomography," Opt. Express 8, 263-270 (2001), www.opticsexpress.org/abstract.cfm?URI=OPEX-8-5-263.
    [CrossRef] [PubMed]
  25. J. Wu, "Convolution picture of the boundary conditions in photon migration and its implications in time-resolved optical imaging of biological tissues," J. Opt. Soc. Am. A 14, 280-287 (1997).
    [CrossRef]

2008 (1)

D. R. Leff, O. Warren, L. C. Enfield, A. P. Gibson, T. Athanasiou, D. K. Pattern, J. C. Hebden, G. Z. Yang, and A. Darzi, "Diffuse optical imaging of the healthy and diseased breast - a systematic review," Breast Cancer Res. Treat. 108, 9-22 (2008).
[CrossRef]

2007 (3)

2006 (5)

T. Austin, J. C. Hebden, A. P. Gibson, G. Branco, R. Yusof, S. R. Arridge, J. H. Meek, D. T. Delpy, and J. S. Wyatt, "Three-dimensional optical imaging of blood volume and oxygenation in the preterm brain," Neuroimage  31, 1426-1433 (2006).
[CrossRef] [PubMed]

M. A. Franceschini, D. K. Joseph, T. J. Huppert, S. G. Diamond, and D. A. Boas, "Diffuse optical imaging of the whole head," J. Biomed. Opt. 11, 054007 (2006).
[CrossRef] [PubMed]

G. Gulsen, O. Birgul, B. Xiong, and O. Nalcioglu, "Design and implementation of a multi-Frequency diffuse optical tomography (MF-DOT) System," J. Biomed. Opt. 11, 014020 (2006).
[CrossRef] [PubMed]

J. C. Hebden, B. D. Price, A. P. Gibson, and G. Royle, "A soft deformable tissue-equivalent phantom for diffuse optical tomography," Phys. Med. Biol. 51, 5581-5590 (2006).
[CrossRef] [PubMed]

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef] [PubMed]

2005 (2)

W. Becker, A. Bergmann, A. Gibson, N. Everdell, D. Jennions, M. Schweiger, A. R. Arridge, and J. C. Hebden, "Multi-dimensional time-correlated single photon counting applied to diffuse optical tomography," Proc. SPIE 5693, 34-42 (2005).
[CrossRef]

H. Zhao, F. Gao, Y. Tanikawa, K. Homma, and Y. Yamada, "Time-resolved diffuse optical tomographic imaging for the provision of both anatomical and functional information about biological tissue," Appl. Opt. 44, 1905-1916 (2005).
[CrossRef] [PubMed]

2003 (3)

C. V. Zint,W. Uhring, M. Torregrossa, B. Cunin, and P. Poulet, "Streak camera: a multidetector for diffuse optical tomography," Appl. Opt. 42, 3313-3320 (2003).
[CrossRef] [PubMed]

N. G. Chen and Q. Zhu, "Time-resolved diffusive optical imaging using pseudo-random bit sequences," Opt. Express 11, 3445-3454 (2003), http://www.opticsexpress.org/abstract.cfm?uri=OE-11-25-3445.
[CrossRef] [PubMed]

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, and A. G. Yodh. "Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging," Med. Phys. 30, 235-247 (2003).
[CrossRef] [PubMed]

2002 (2)

2001 (2)

2000 (1)

F. Schmidt, M. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, "A 32-channel time-resolved instrument for medical optical tomography," Rev. Sci. Instrum. 71, 256-265 (2000).
[CrossRef]

1999 (1)

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, "Multi-channel time-resolved optical tomographic imaging system," Rev. Sci. Instrum. 70, 3595-3602 (1999).
[CrossRef]

1997 (1)

1996 (1)

1995 (2)

J. C. Hebden, D. J. Hall, M. Firbank, and D. T. Delpy, "Time-resolved optical imaging of a solid tissue-equivalent phantom," Appl. Opt. 34, 8038-8047 (1995).
[CrossRef] [PubMed]

M. Firbank, M. Oda, and D. T. Delpy, "An improved design for a stable and reproducible phantom material for use in near-infrared spectroscopy and imaging." Phys. Med. Biol. 40, 955-961 (1995).
[CrossRef] [PubMed]

1990 (1)

W. F. Cheong, S. A. Prohl, and A. J. Welch, "A review of the optical properties of biological tissues," IEEE J. Quantum Electron. 26, 2166-2185 (1990).
[CrossRef]

Ahn, B. S.

Arridge, A. R.

W. Becker, A. Bergmann, A. Gibson, N. Everdell, D. Jennions, M. Schweiger, A. R. Arridge, and J. C. Hebden, "Multi-dimensional time-correlated single photon counting applied to diffuse optical tomography," Proc. SPIE 5693, 34-42 (2005).
[CrossRef]

Arridge, S. R.

L. C. Enfield, A. P. Gibson, N. L. Everdell, D. T. Delpy, M. Schweiger, S. R. Arridge, C. Richardson, M. Keshtgar, M. Douek, and J. C. Hebden, "Three-dimensional time-resolved optical mammography of the uncompressed breast," Appl. Opt. 46, 3628-3638 (2007).
[CrossRef] [PubMed]

T. Austin, J. C. Hebden, A. P. Gibson, G. Branco, R. Yusof, S. R. Arridge, J. H. Meek, D. T. Delpy, and J. S. Wyatt, "Three-dimensional optical imaging of blood volume and oxygenation in the preterm brain," Neuroimage  31, 1426-1433 (2006).
[CrossRef] [PubMed]

M. Schweiger, A. Gibson, and S. R. Arridge, "Computational aspectcts of diffuse optical tomography," Comput. Opt. 5, 33-41 (2001).

D. A. Boas, T. Gaudette, and S. R. Arridge, "Simultaneous imaging and optode calibration with diffuse optical tomography," Opt. Express 8, 263-270 (2001), www.opticsexpress.org/abstract.cfm?URI=OPEX-8-5-263.
[CrossRef] [PubMed]

Athanasiou, T.

D. R. Leff, O. Warren, L. C. Enfield, A. P. Gibson, T. Athanasiou, D. K. Pattern, J. C. Hebden, G. Z. Yang, and A. Darzi, "Diffuse optical imaging of the healthy and diseased breast - a systematic review," Breast Cancer Res. Treat. 108, 9-22 (2008).
[CrossRef]

Austin, T.

J. C. Hebden and T. Austin, "Optical tomography of the neonatal brain," Euro. Rad. 17, 2926-2933 (2007).
[CrossRef]

T. Austin, J. C. Hebden, A. P. Gibson, G. Branco, R. Yusof, S. R. Arridge, J. H. Meek, D. T. Delpy, and J. S. Wyatt, "Three-dimensional optical imaging of blood volume and oxygenation in the preterm brain," Neuroimage  31, 1426-1433 (2006).
[CrossRef] [PubMed]

Becker, W.

W. Becker, A. Bergmann, A. Gibson, N. Everdell, D. Jennions, M. Schweiger, A. R. Arridge, and J. C. Hebden, "Multi-dimensional time-correlated single photon counting applied to diffuse optical tomography," Proc. SPIE 5693, 34-42 (2005).
[CrossRef]

Bergmann, A.

W. Becker, A. Bergmann, A. Gibson, N. Everdell, D. Jennions, M. Schweiger, A. R. Arridge, and J. C. Hebden, "Multi-dimensional time-correlated single photon counting applied to diffuse optical tomography," Proc. SPIE 5693, 34-42 (2005).
[CrossRef]

Birgul, O.

G. Gulsen, O. Birgul, B. Xiong, and O. Nalcioglu, "Design and implementation of a multi-Frequency diffuse optical tomography (MF-DOT) System," J. Biomed. Opt. 11, 014020 (2006).
[CrossRef] [PubMed]

Boas, D. A.

M. A. Franceschini, D. K. Joseph, T. J. Huppert, S. G. Diamond, and D. A. Boas, "Diffuse optical imaging of the whole head," J. Biomed. Opt. 11, 054007 (2006).
[CrossRef] [PubMed]

D. A. Boas, T. Gaudette, and S. R. Arridge, "Simultaneous imaging and optode calibration with diffuse optical tomography," Opt. Express 8, 263-270 (2001), www.opticsexpress.org/abstract.cfm?URI=OPEX-8-5-263.
[CrossRef] [PubMed]

Branco, G.

T. Austin, J. C. Hebden, A. P. Gibson, G. Branco, R. Yusof, S. R. Arridge, J. H. Meek, D. T. Delpy, and J. S. Wyatt, "Three-dimensional optical imaging of blood volume and oxygenation in the preterm brain," Neuroimage  31, 1426-1433 (2006).
[CrossRef] [PubMed]

Butler, J.

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef] [PubMed]

Cerussi, A.

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef] [PubMed]

Chance, B.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, and A. G. Yodh. "Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging," Med. Phys. 30, 235-247 (2003).
[CrossRef] [PubMed]

M. S. Patterson, B. Chance, and B. C. Wilson, "Time resolved reflectance and transmittance for the noninvasive measurement of tissue optical properties," Appl. Opt. 28, 2331-2337 (1996).
[CrossRef]

Chen, N. G.

Cheong, W. F.

W. F. Cheong, S. A. Prohl, and A. J. Welch, "A review of the optical properties of biological tissues," IEEE J. Quantum Electron. 26, 2166-2185 (1990).
[CrossRef]

Choe, R.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, and A. G. Yodh. "Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging," Med. Phys. 30, 235-247 (2003).
[CrossRef] [PubMed]

Culver, J. P.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, and A. G. Yodh. "Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging," Med. Phys. 30, 235-247 (2003).
[CrossRef] [PubMed]

Cunin, B.

Darzi, A.

D. R. Leff, O. Warren, L. C. Enfield, A. P. Gibson, T. Athanasiou, D. K. Pattern, J. C. Hebden, G. Z. Yang, and A. Darzi, "Diffuse optical imaging of the healthy and diseased breast - a systematic review," Breast Cancer Res. Treat. 108, 9-22 (2008).
[CrossRef]

Delpy, D. T.

L. C. Enfield, A. P. Gibson, N. L. Everdell, D. T. Delpy, M. Schweiger, S. R. Arridge, C. Richardson, M. Keshtgar, M. Douek, and J. C. Hebden, "Three-dimensional time-resolved optical mammography of the uncompressed breast," Appl. Opt. 46, 3628-3638 (2007).
[CrossRef] [PubMed]

T. Austin, J. C. Hebden, A. P. Gibson, G. Branco, R. Yusof, S. R. Arridge, J. H. Meek, D. T. Delpy, and J. S. Wyatt, "Three-dimensional optical imaging of blood volume and oxygenation in the preterm brain," Neuroimage  31, 1426-1433 (2006).
[CrossRef] [PubMed]

F. Schmidt, M. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, "A 32-channel time-resolved instrument for medical optical tomography," Rev. Sci. Instrum. 71, 256-265 (2000).
[CrossRef]

J. C. Hebden, D. J. Hall, M. Firbank, and D. T. Delpy, "Time-resolved optical imaging of a solid tissue-equivalent phantom," Appl. Opt. 34, 8038-8047 (1995).
[CrossRef] [PubMed]

M. Firbank, M. Oda, and D. T. Delpy, "An improved design for a stable and reproducible phantom material for use in near-infrared spectroscopy and imaging." Phys. Med. Biol. 40, 955-961 (1995).
[CrossRef] [PubMed]

Diamond, S. G.

M. A. Franceschini, D. K. Joseph, T. J. Huppert, S. G. Diamond, and D. A. Boas, "Diffuse optical imaging of the whole head," J. Biomed. Opt. 11, 054007 (2006).
[CrossRef] [PubMed]

Douek, M.

Durduran, T.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, and A. G. Yodh. "Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging," Med. Phys. 30, 235-247 (2003).
[CrossRef] [PubMed]

Durkin, A.

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef] [PubMed]

Eda, H.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, "Multi-channel time-resolved optical tomographic imaging system," Rev. Sci. Instrum. 70, 3595-3602 (1999).
[CrossRef]

Enfield, L. C.

D. R. Leff, O. Warren, L. C. Enfield, A. P. Gibson, T. Athanasiou, D. K. Pattern, J. C. Hebden, G. Z. Yang, and A. Darzi, "Diffuse optical imaging of the healthy and diseased breast - a systematic review," Breast Cancer Res. Treat. 108, 9-22 (2008).
[CrossRef]

L. C. Enfield, A. P. Gibson, N. L. Everdell, D. T. Delpy, M. Schweiger, S. R. Arridge, C. Richardson, M. Keshtgar, M. Douek, and J. C. Hebden, "Three-dimensional time-resolved optical mammography of the uncompressed breast," Appl. Opt. 46, 3628-3638 (2007).
[CrossRef] [PubMed]

Everdell, N.

W. Becker, A. Bergmann, A. Gibson, N. Everdell, D. Jennions, M. Schweiger, A. R. Arridge, and J. C. Hebden, "Multi-dimensional time-correlated single photon counting applied to diffuse optical tomography," Proc. SPIE 5693, 34-42 (2005).
[CrossRef]

Everdell, N. L.

Firbank, M.

J. C. Hebden, D. J. Hall, M. Firbank, and D. T. Delpy, "Time-resolved optical imaging of a solid tissue-equivalent phantom," Appl. Opt. 34, 8038-8047 (1995).
[CrossRef] [PubMed]

M. Firbank, M. Oda, and D. T. Delpy, "An improved design for a stable and reproducible phantom material for use in near-infrared spectroscopy and imaging." Phys. Med. Biol. 40, 955-961 (1995).
[CrossRef] [PubMed]

Franceschini, M. A.

M. A. Franceschini, D. K. Joseph, T. J. Huppert, S. G. Diamond, and D. A. Boas, "Diffuse optical imaging of the whole head," J. Biomed. Opt. 11, 054007 (2006).
[CrossRef] [PubMed]

Fry, M.

F. Schmidt, M. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, "A 32-channel time-resolved instrument for medical optical tomography," Rev. Sci. Instrum. 71, 256-265 (2000).
[CrossRef]

Gao, F.

Gaudette, T.

Gibson, A.

W. Becker, A. Bergmann, A. Gibson, N. Everdell, D. Jennions, M. Schweiger, A. R. Arridge, and J. C. Hebden, "Multi-dimensional time-correlated single photon counting applied to diffuse optical tomography," Proc. SPIE 5693, 34-42 (2005).
[CrossRef]

M. Schweiger, A. Gibson, and S. R. Arridge, "Computational aspectcts of diffuse optical tomography," Comput. Opt. 5, 33-41 (2001).

Gibson, A. P.

D. R. Leff, O. Warren, L. C. Enfield, A. P. Gibson, T. Athanasiou, D. K. Pattern, J. C. Hebden, G. Z. Yang, and A. Darzi, "Diffuse optical imaging of the healthy and diseased breast - a systematic review," Breast Cancer Res. Treat. 108, 9-22 (2008).
[CrossRef]

L. C. Enfield, A. P. Gibson, N. L. Everdell, D. T. Delpy, M. Schweiger, S. R. Arridge, C. Richardson, M. Keshtgar, M. Douek, and J. C. Hebden, "Three-dimensional time-resolved optical mammography of the uncompressed breast," Appl. Opt. 46, 3628-3638 (2007).
[CrossRef] [PubMed]

T. Austin, J. C. Hebden, A. P. Gibson, G. Branco, R. Yusof, S. R. Arridge, J. H. Meek, D. T. Delpy, and J. S. Wyatt, "Three-dimensional optical imaging of blood volume and oxygenation in the preterm brain," Neuroimage  31, 1426-1433 (2006).
[CrossRef] [PubMed]

J. C. Hebden, B. D. Price, A. P. Gibson, and G. Royle, "A soft deformable tissue-equivalent phantom for diffuse optical tomography," Phys. Med. Biol. 51, 5581-5590 (2006).
[CrossRef] [PubMed]

Gulsen, G.

G. Gulsen, O. Birgul, B. Xiong, and O. Nalcioglu, "Design and implementation of a multi-Frequency diffuse optical tomography (MF-DOT) System," J. Biomed. Opt. 11, 014020 (2006).
[CrossRef] [PubMed]

Hall, D. J.

Han, Y. H.

Hebden, J. C.

D. R. Leff, O. Warren, L. C. Enfield, A. P. Gibson, T. Athanasiou, D. K. Pattern, J. C. Hebden, G. Z. Yang, and A. Darzi, "Diffuse optical imaging of the healthy and diseased breast - a systematic review," Breast Cancer Res. Treat. 108, 9-22 (2008).
[CrossRef]

J. C. Hebden and T. Austin, "Optical tomography of the neonatal brain," Euro. Rad. 17, 2926-2933 (2007).
[CrossRef]

L. C. Enfield, A. P. Gibson, N. L. Everdell, D. T. Delpy, M. Schweiger, S. R. Arridge, C. Richardson, M. Keshtgar, M. Douek, and J. C. Hebden, "Three-dimensional time-resolved optical mammography of the uncompressed breast," Appl. Opt. 46, 3628-3638 (2007).
[CrossRef] [PubMed]

T. Austin, J. C. Hebden, A. P. Gibson, G. Branco, R. Yusof, S. R. Arridge, J. H. Meek, D. T. Delpy, and J. S. Wyatt, "Three-dimensional optical imaging of blood volume and oxygenation in the preterm brain," Neuroimage  31, 1426-1433 (2006).
[CrossRef] [PubMed]

J. C. Hebden, B. D. Price, A. P. Gibson, and G. Royle, "A soft deformable tissue-equivalent phantom for diffuse optical tomography," Phys. Med. Biol. 51, 5581-5590 (2006).
[CrossRef] [PubMed]

W. Becker, A. Bergmann, A. Gibson, N. Everdell, D. Jennions, M. Schweiger, A. R. Arridge, and J. C. Hebden, "Multi-dimensional time-correlated single photon counting applied to diffuse optical tomography," Proc. SPIE 5693, 34-42 (2005).
[CrossRef]

F. Schmidt, M. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, "A 32-channel time-resolved instrument for medical optical tomography," Rev. Sci. Instrum. 71, 256-265 (2000).
[CrossRef]

J. C. Hebden, D. J. Hall, M. Firbank, and D. T. Delpy, "Time-resolved optical imaging of a solid tissue-equivalent phantom," Appl. Opt. 34, 8038-8047 (1995).
[CrossRef] [PubMed]

Hillman, E. M. C.

F. Schmidt, M. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, "A 32-channel time-resolved instrument for medical optical tomography," Rev. Sci. Instrum. 71, 256-265 (2000).
[CrossRef]

Holboke, M. J.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, and A. G. Yodh. "Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging," Med. Phys. 30, 235-247 (2003).
[CrossRef] [PubMed]

Homma, K.

Hsiang, D.

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef] [PubMed]

Huppert, T. J.

M. A. Franceschini, D. K. Joseph, T. J. Huppert, S. G. Diamond, and D. A. Boas, "Diffuse optical imaging of the whole head," J. Biomed. Opt. 11, 054007 (2006).
[CrossRef] [PubMed]

Ito, Y.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, "Multi-channel time-resolved optical tomographic imaging system," Rev. Sci. Instrum. 70, 3595-3602 (1999).
[CrossRef]

Jennions, D.

W. Becker, A. Bergmann, A. Gibson, N. Everdell, D. Jennions, M. Schweiger, A. R. Arridge, and J. C. Hebden, "Multi-dimensional time-correlated single photon counting applied to diffuse optical tomography," Proc. SPIE 5693, 34-42 (2005).
[CrossRef]

Joseph, D. K.

M. A. Franceschini, D. K. Joseph, T. J. Huppert, S. G. Diamond, and D. A. Boas, "Diffuse optical imaging of the whole head," J. Biomed. Opt. 11, 054007 (2006).
[CrossRef] [PubMed]

Keshtgar, M.

Lee, B. C.

Leff, D. R.

D. R. Leff, O. Warren, L. C. Enfield, A. P. Gibson, T. Athanasiou, D. K. Pattern, J. C. Hebden, G. Z. Yang, and A. Darzi, "Diffuse optical imaging of the healthy and diseased breast - a systematic review," Breast Cancer Res. Treat. 108, 9-22 (2008).
[CrossRef]

Meek, J. H.

T. Austin, J. C. Hebden, A. P. Gibson, G. Branco, R. Yusof, S. R. Arridge, J. H. Meek, D. T. Delpy, and J. S. Wyatt, "Three-dimensional optical imaging of blood volume and oxygenation in the preterm brain," Neuroimage  31, 1426-1433 (2006).
[CrossRef] [PubMed]

Nalcioglu, O.

G. Gulsen, O. Birgul, B. Xiong, and O. Nalcioglu, "Design and implementation of a multi-Frequency diffuse optical tomography (MF-DOT) System," J. Biomed. Opt. 11, 014020 (2006).
[CrossRef] [PubMed]

Ntziachristos, V.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, and A. G. Yodh. "Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging," Med. Phys. 30, 235-247 (2003).
[CrossRef] [PubMed]

Oda, I.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, "Multi-channel time-resolved optical tomographic imaging system," Rev. Sci. Instrum. 70, 3595-3602 (1999).
[CrossRef]

Oda, M.

M. Firbank, M. Oda, and D. T. Delpy, "An improved design for a stable and reproducible phantom material for use in near-infrared spectroscopy and imaging." Phys. Med. Biol. 40, 955-961 (1995).
[CrossRef] [PubMed]

Oikawa, Y.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, "Multi-channel time-resolved optical tomographic imaging system," Rev. Sci. Instrum. 70, 3595-3602 (1999).
[CrossRef]

Pattern, D. K.

D. R. Leff, O. Warren, L. C. Enfield, A. P. Gibson, T. Athanasiou, D. K. Pattern, J. C. Hebden, G. Z. Yang, and A. Darzi, "Diffuse optical imaging of the healthy and diseased breast - a systematic review," Breast Cancer Res. Treat. 108, 9-22 (2008).
[CrossRef]

Patterson, M. S.

Poulet, P.

Price, B. D.

J. C. Hebden, B. D. Price, A. P. Gibson, and G. Royle, "A soft deformable tissue-equivalent phantom for diffuse optical tomography," Phys. Med. Biol. 51, 5581-5590 (2006).
[CrossRef] [PubMed]

Prohl, S. A.

W. F. Cheong, S. A. Prohl, and A. J. Welch, "A review of the optical properties of biological tissues," IEEE J. Quantum Electron. 26, 2166-2185 (1990).
[CrossRef]

Richardson, C.

Royle, G.

J. C. Hebden, B. D. Price, A. P. Gibson, and G. Royle, "A soft deformable tissue-equivalent phantom for diffuse optical tomography," Phys. Med. Biol. 51, 5581-5590 (2006).
[CrossRef] [PubMed]

Schmidt, F.

F. Schmidt, M. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, "A 32-channel time-resolved instrument for medical optical tomography," Rev. Sci. Instrum. 71, 256-265 (2000).
[CrossRef]

Schweiger, M.

L. C. Enfield, A. P. Gibson, N. L. Everdell, D. T. Delpy, M. Schweiger, S. R. Arridge, C. Richardson, M. Keshtgar, M. Douek, and J. C. Hebden, "Three-dimensional time-resolved optical mammography of the uncompressed breast," Appl. Opt. 46, 3628-3638 (2007).
[CrossRef] [PubMed]

W. Becker, A. Bergmann, A. Gibson, N. Everdell, D. Jennions, M. Schweiger, A. R. Arridge, and J. C. Hebden, "Multi-dimensional time-correlated single photon counting applied to diffuse optical tomography," Proc. SPIE 5693, 34-42 (2005).
[CrossRef]

M. Schweiger, A. Gibson, and S. R. Arridge, "Computational aspectcts of diffuse optical tomography," Comput. Opt. 5, 33-41 (2001).

Shah, N.

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef] [PubMed]

Slemp, A.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, and A. G. Yodh. "Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging," Med. Phys. 30, 235-247 (2003).
[CrossRef] [PubMed]

Soh, K. S.

Takada, M.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, "Multi-channel time-resolved optical tomographic imaging system," Rev. Sci. Instrum. 70, 3595-3602 (1999).
[CrossRef]

Tanikawa, Y.

Torregrossa, M.

Tromberg, B. J.

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef] [PubMed]

Tsunazawa, Y.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, "Multi-channel time-resolved optical tomographic imaging system," Rev. Sci. Instrum. 70, 3595-3602 (1999).
[CrossRef]

Uhring, W.

Wada, Y.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, "Multi-channel time-resolved optical tomographic imaging system," Rev. Sci. Instrum. 70, 3595-3602 (1999).
[CrossRef]

Warren, O.

D. R. Leff, O. Warren, L. C. Enfield, A. P. Gibson, T. Athanasiou, D. K. Pattern, J. C. Hebden, G. Z. Yang, and A. Darzi, "Diffuse optical imaging of the healthy and diseased breast - a systematic review," Breast Cancer Res. Treat. 108, 9-22 (2008).
[CrossRef]

Welch, A. J.

W. F. Cheong, S. A. Prohl, and A. J. Welch, "A review of the optical properties of biological tissues," IEEE J. Quantum Electron. 26, 2166-2185 (1990).
[CrossRef]

Wilson, B. C.

Wu, J.

Wyatt, J. S.

T. Austin, J. C. Hebden, A. P. Gibson, G. Branco, R. Yusof, S. R. Arridge, J. H. Meek, D. T. Delpy, and J. S. Wyatt, "Three-dimensional optical imaging of blood volume and oxygenation in the preterm brain," Neuroimage  31, 1426-1433 (2006).
[CrossRef] [PubMed]

Xiong, B.

G. Gulsen, O. Birgul, B. Xiong, and O. Nalcioglu, "Design and implementation of a multi-Frequency diffuse optical tomography (MF-DOT) System," J. Biomed. Opt. 11, 014020 (2006).
[CrossRef] [PubMed]

Yamada, Y.

Yang, G. Z.

D. R. Leff, O. Warren, L. C. Enfield, A. P. Gibson, T. Athanasiou, D. K. Pattern, J. C. Hebden, G. Z. Yang, and A. Darzi, "Diffuse optical imaging of the healthy and diseased breast - a systematic review," Breast Cancer Res. Treat. 108, 9-22 (2008).
[CrossRef]

Yang, J. M.

Yodh, A. G.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, and A. G. Yodh. "Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging," Med. Phys. 30, 235-247 (2003).
[CrossRef] [PubMed]

Yoon, G.

Yusof, R.

T. Austin, J. C. Hebden, A. P. Gibson, G. Branco, R. Yusof, S. R. Arridge, J. H. Meek, D. T. Delpy, and J. S. Wyatt, "Three-dimensional optical imaging of blood volume and oxygenation in the preterm brain," Neuroimage  31, 1426-1433 (2006).
[CrossRef] [PubMed]

Zhao, H.

Zhao, H. J.

Zhu, Q.

Zint, C. V.

Zubkov, L.

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, and A. G. Yodh. "Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging," Med. Phys. 30, 235-247 (2003).
[CrossRef] [PubMed]

Appl. Opt. (7)

M. S. Patterson, B. Chance, and B. C. Wilson, "Time resolved reflectance and transmittance for the noninvasive measurement of tissue optical properties," Appl. Opt. 28, 2331-2337 (1996).
[CrossRef]

J. C. Hebden, D. J. Hall, M. Firbank, and D. T. Delpy, "Time-resolved optical imaging of a solid tissue-equivalent phantom," Appl. Opt. 34, 8038-8047 (1995).
[CrossRef] [PubMed]

F. Gao, H. J. Zhao, and Y. Yamada, "Improvement of image quality in diffuse optical tomography by use of full time-resolved data," Appl. Opt. 41, 778-791 (2002).
[CrossRef] [PubMed]

C. V. Zint,W. Uhring, M. Torregrossa, B. Cunin, and P. Poulet, "Streak camera: a multidetector for diffuse optical tomography," Appl. Opt. 42, 3313-3320 (2003).
[CrossRef] [PubMed]

H. Zhao, F. Gao, Y. Tanikawa, K. Homma, and Y. Yamada, "Time-resolved diffuse optical tomographic imaging for the provision of both anatomical and functional information about biological tissue," Appl. Opt. 44, 1905-1916 (2005).
[CrossRef] [PubMed]

L. C. Enfield, A. P. Gibson, N. L. Everdell, D. T. Delpy, M. Schweiger, S. R. Arridge, C. Richardson, M. Keshtgar, M. Douek, and J. C. Hebden, "Three-dimensional time-resolved optical mammography of the uncompressed breast," Appl. Opt. 46, 3628-3638 (2007).
[CrossRef] [PubMed]

J. M. Yang, Y. H. Han, G. Yoon, B. S. Ahn, B. C. Lee, and K. S. Soh, "In vivo 783-channel diffuse reflectance imaging system and its application," Appl. Opt. 46, 5991-6003 (2007).
[CrossRef] [PubMed]

Breast Cancer Res. Treat. (1)

D. R. Leff, O. Warren, L. C. Enfield, A. P. Gibson, T. Athanasiou, D. K. Pattern, J. C. Hebden, G. Z. Yang, and A. Darzi, "Diffuse optical imaging of the healthy and diseased breast - a systematic review," Breast Cancer Res. Treat. 108, 9-22 (2008).
[CrossRef]

Comput. Opt. (1)

M. Schweiger, A. Gibson, and S. R. Arridge, "Computational aspectcts of diffuse optical tomography," Comput. Opt. 5, 33-41 (2001).

Euro. Rad. (1)

J. C. Hebden and T. Austin, "Optical tomography of the neonatal brain," Euro. Rad. 17, 2926-2933 (2007).
[CrossRef]

IEEE J. Quantum Electron. (1)

W. F. Cheong, S. A. Prohl, and A. J. Welch, "A review of the optical properties of biological tissues," IEEE J. Quantum Electron. 26, 2166-2185 (1990).
[CrossRef]

J. Biomed. Opt. (3)

A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler, and B. J. Tromberg, "In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy," J. Biomed. Opt. 11, 044005 (2006).
[CrossRef] [PubMed]

M. A. Franceschini, D. K. Joseph, T. J. Huppert, S. G. Diamond, and D. A. Boas, "Diffuse optical imaging of the whole head," J. Biomed. Opt. 11, 054007 (2006).
[CrossRef] [PubMed]

G. Gulsen, O. Birgul, B. Xiong, and O. Nalcioglu, "Design and implementation of a multi-Frequency diffuse optical tomography (MF-DOT) System," J. Biomed. Opt. 11, 014020 (2006).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (1)

Med. Phys. (1)

J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, and A. G. Yodh. "Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: Evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging," Med. Phys. 30, 235-247 (2003).
[CrossRef] [PubMed]

Neuroimage (1)

T. Austin, J. C. Hebden, A. P. Gibson, G. Branco, R. Yusof, S. R. Arridge, J. H. Meek, D. T. Delpy, and J. S. Wyatt, "Three-dimensional optical imaging of blood volume and oxygenation in the preterm brain," Neuroimage  31, 1426-1433 (2006).
[CrossRef] [PubMed]

Opt. Express (2)

Opt. Lett. (1)

Phys. Med. Biol. (2)

J. C. Hebden, B. D. Price, A. P. Gibson, and G. Royle, "A soft deformable tissue-equivalent phantom for diffuse optical tomography," Phys. Med. Biol. 51, 5581-5590 (2006).
[CrossRef] [PubMed]

M. Firbank, M. Oda, and D. T. Delpy, "An improved design for a stable and reproducible phantom material for use in near-infrared spectroscopy and imaging." Phys. Med. Biol. 40, 955-961 (1995).
[CrossRef] [PubMed]

Proc. SPIE (1)

W. Becker, A. Bergmann, A. Gibson, N. Everdell, D. Jennions, M. Schweiger, A. R. Arridge, and J. C. Hebden, "Multi-dimensional time-correlated single photon counting applied to diffuse optical tomography," Proc. SPIE 5693, 34-42 (2005).
[CrossRef]

Rev. Sci. Instrum. (2)

F. Schmidt, M. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, "A 32-channel time-resolved instrument for medical optical tomography," Rev. Sci. Instrum. 71, 256-265 (2000).
[CrossRef]

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, and M. Takada, "Multi-channel time-resolved optical tomographic imaging system," Rev. Sci. Instrum. 70, 3595-3602 (1999).
[CrossRef]

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (4)

Fig. 1.
Fig. 1.

Schematic of the fast time-domain DOT. The thick arrows represent the PRBS transmission path. The dashed arrows represent the optical signal path and the thin arrows represent the control signal.

Fig. 2.
Fig. 2.

(a) Configuration of the reflection-mode handheld probe. The 4 big circles represent the detection fiber-bundles and the 9 small circles represent the source fiber. (b) Illustration of the experimental setup with the absorbing targets included. P1 and P2 represent the target positions. The coordinates of P1[x, y, z] and P2[x, y, z] are [0, 0, 2]cm and [1.5, 0, 2]cm, respectively.

Fig. 3.
Fig. 3.

(a) The measured SIRs (blue solid line) vs. the theoretical prediction (red dashed line). The measured SIR is slightly wider than the predicted one. The error bars represent the standard deviation of the measured SIR. (b) The homogeneous TPSF (blue solid line) obtained from the homogeneous Lipofundin solution and the heterogeneous TPSF (red dashed line) obtained from the heterogeneous solution for a channel where the source-to-detection distance is 3.3 cm. (c) The comparison of the TPSFs with the room light on (red circles) and off (blue line). The source-to-detector distance is 3.3 cm.

Fig. 4.
Fig. 4.

The reconstructed image of the absorption coefficient based on the SIRT. (a–c) represent the cross sectional view where y equals to 0, 0.25 and 0.5 cm, respectively. The target (absorber) is located at position P1 [0.0, 0.0, 2.0]. (d–f) represent the cross sectional view where y equals to 0, 0.25 and 0.5 cm, respectively. The target is shifted 1.5 cm along x-axis from P1 to P2 [1.5, 0.0, 2.0].

Tables (1)

Tables Icon

Table 1. Analysis of the reconstructed absorption coefficient µa.

Metrics