Abstract

We present an endomicroscope apparatus that utilizes structured illumination to produce high resolution (~ 2.6μm) optically sectioned fluorescence images over a field of view of about 240μm. The endomicroscope is based on the use of a flexible imaging fiber bundle with a miniaturized objective. We also present a strategy to largely suppress structured illumination artifacts that arise when imaging in thick tissue that exhibits significant out-of-focus background. To establish the potential of our endomicroscope for preclinical or clinical applications, we provide images of BCECF-AM labeled rat colonic mucosa.

© 2008 Optical Society of America

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  1. B. Flusberg, E. Cocker, W. Piyawattanametha, J. Jung, E. Cheung, and M. Schnitzer, "Fiber-optic fluorescence imaging," Nat. Meth. 2, 941-950 (2005).
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    [CrossRef]
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    [CrossRef]
  11. P. Kim, M. Puoris??haag, D. Coté, C. P. Lin, and S. H. Yun, "In vivo confocal and multiphoton microendoscopy," J. Biomed. Opt. 13, 010501 (2008).
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    [CrossRef]
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    [CrossRef]
  24. L. H. Schaefer, D. Schuster, and J. Schaffer, "Structured illumination microscopy: artefact analysis and reduction utilizing a parameter optimization approach," J. Microsc. 216, 165-174 (2004).
    [CrossRef]
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    [CrossRef]

2008 (1)

P. Kim, M. Puoris??haag, D. Coté, C. P. Lin, and S. H. Yun, "In vivo confocal and multiphoton microendoscopy," J. Biomed. Opt. 13, 010501 (2008).
[CrossRef]

2007 (5)

2005 (3)

K. Carlson, M. Chidley, K.-B. Sung, M. Descour, A. Gillenwater, M. Follen, and R. Richards-Kortum, "In vivo fiber-optic confocal reflectance microscope with an injection-molded plastic miniature lens," Appl. Opt. 44, 1792-1797 (2005)
[CrossRef]

B. Flusberg, E. Cocker, W. Piyawattanametha, J. Jung, E. Cheung, and M. Schnitzer, "Fiber-optic fluorescence imaging," Nat. Meth. 2, 941-950 (2005).
[CrossRef]

T. Ota, H. Fukuyama, Y. Ishihara, H. Tanaka, and T. Takamatsu, "In situ fluorescence imaging of organs through compact scanning head for confocal laser microscopy," J. Biomed. Opt. 10, 1-4 (2005).
[CrossRef]

2004 (3)

E. Laemmela et al, "Fibered Confocal Fluorescence Microscopy (Cell-viZio?) Facilitates Extended Imaging in the Field of Microcirculation," J. Vasc. Res. 41, 400-411 (2004).
[CrossRef]

J. C. Jung, A. D. Mehta, E. Aksay, R. Stepnoski, and M. J. Schnitzer, "In vivo mammalian brain imaging using one- and two-photon fluorescence microendoscopy," J. Neurophys. 92, 3121-3133 (2004).
[CrossRef]

L. H. Schaefer, D. Schuster, and J. Schaffer, "Structured illumination microscopy: artefact analysis and reduction utilizing a parameter optimization approach," J. Microsc. 216, 165-174 (2004).
[CrossRef]

2003 (1)

L. D. Swindle, S. G. Thomas, M. Freeman, and P. M. Delaney, "View of normal human skin in vivo as observed using fluorescent fiber-optics confocal microscopic imaging," J. Invest. Dermatol. 121, 706-712 (2003).
[CrossRef]

2002 (2)

2001 (2)

J. Knittel, L. Schneider, L. Buess, G. Messerschmidt, and T. Possner, "Endoscope compatible confocal microscope using a gradient index lens system," Opt. Commun. 188, 267-273 (2001).
[CrossRef]

M. J. Cole, J. Siegel, S. E. D. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. W. French, M. J. Lever, L. O. D. Sucharov, M. A. A. Neil, R. Juškaitis, and T. Wilson, "Time-domain whole-field fluorescence lifetime imaging with optical sectioning," J. Microsc. 203, 246-257 (2001).
[CrossRef]

2000 (3)

M. A. A. Neil, A. Squire, R. Juškaitis, P. I. H. Bastiaens, and T. Wilson, "Wide field optically sectioning fluorescence microscopy with laser illumination," J. Microsc. 197 (Pt 1), 1-4 (2000).
[CrossRef]

M. G. L. Gustafsson, "Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy," J. Microsc. 198 (Pt 2), 82-87 (2000).
[CrossRef]

A. R. Rouse and A. F. Gmitro, "Multispectral imaging with a confocal microendoscope," Opt. Lett. 25, 1708-1710 (2000).
[CrossRef]

1998 (1)

M. A. A. Neil, R. Juškaitis, and T. Wilson, "Real time 3D fluorescence microscopy by two beam interference illumination," Opt. Commun. 153, 1-4 (1998).
[CrossRef]

1997 (1)

1996 (1)

1994 (1)

1993 (1)

1991 (1)

L. Giniunas, R. Juškaitis, and S. V. Shatalin, "Scanning fiber-optic microscope," Electron. Lett. 27, 724-726 (1991).
[CrossRef]

1980 (1)

K. Ouchi, "Statistics of image plane speckle," Opt. Quantum Electron. 12, 237-243 (1980).
[CrossRef]

1977 (1)

E. Jakeman and W. T. Welford, "Speckle statistics in imaging systems," Opt. Commun. 21, 72-79 (1977).
[CrossRef]

1976 (1)

Aksay, E.

J. C. Jung, A. D. Mehta, E. Aksay, R. Stepnoski, and M. J. Schnitzer, "In vivo mammalian brain imaging using one- and two-photon fluorescence microendoscopy," J. Neurophys. 92, 3121-3133 (2004).
[CrossRef]

Asakura, T.

Aziz, D.

Bastiaens, P. I. H.

M. A. A. Neil, A. Squire, R. Juškaitis, P. I. H. Bastiaens, and T. Wilson, "Wide field optically sectioning fluorescence microscopy with laser illumination," J. Microsc. 197 (Pt 1), 1-4 (2000).
[CrossRef]

Boccara, A. C.

Bourg-Heckly, G.

Buess, L.

J. Knittel, L. Schneider, L. Buess, G. Messerschmidt, and T. Possner, "Endoscope compatible confocal microscope using a gradient index lens system," Opt. Commun. 188, 267-273 (2001).
[CrossRef]

Carlson, K.

Chasles, F.

Cheung, E.

B. Flusberg, E. Cocker, W. Piyawattanametha, J. Jung, E. Cheung, and M. Schnitzer, "Fiber-optic fluorescence imaging," Nat. Meth. 2, 941-950 (2005).
[CrossRef]

Chidley, M.

Cocker, E.

B. Flusberg, E. Cocker, W. Piyawattanametha, J. Jung, E. Cheung, and M. Schnitzer, "Fiber-optic fluorescence imaging," Nat. Meth. 2, 941-950 (2005).
[CrossRef]

Cole, M. J.

M. J. Cole, J. Siegel, S. E. D. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. W. French, M. J. Lever, L. O. D. Sucharov, M. A. A. Neil, R. Juškaitis, and T. Wilson, "Time-domain whole-field fluorescence lifetime imaging with optical sectioning," J. Microsc. 203, 246-257 (2001).
[CrossRef]

Contag, C. H.

Coté, D.

P. Kim, M. Puoris??haag, D. Coté, C. P. Lin, and S. H. Yun, "In vivo confocal and multiphoton microendoscopy," J. Biomed. Opt. 13, 010501 (2008).
[CrossRef]

Dayel, M. J.

M. J. Cole, J. Siegel, S. E. D. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. W. French, M. J. Lever, L. O. D. Sucharov, M. A. A. Neil, R. Juškaitis, and T. Wilson, "Time-domain whole-field fluorescence lifetime imaging with optical sectioning," J. Microsc. 203, 246-257 (2001).
[CrossRef]

Delaney, P. M.

L. D. Swindle, S. G. Thomas, M. Freeman, and P. M. Delaney, "View of normal human skin in vivo as observed using fluorescent fiber-optics confocal microscopic imaging," J. Invest. Dermatol. 121, 706-712 (2003).
[CrossRef]

P. M. Delaney, M. R. Harris, and R. G. King, "Fiber-optic laser scanning confocal microscope suitable for fluorescence imaging," Appl. Opt. 33, 573-577 (1994).

Descour, M.

Descour, M. R.

Dickensheets, D. L.

Dowling, K.

M. J. Cole, J. Siegel, S. E. D. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. W. French, M. J. Lever, L. O. D. Sucharov, M. A. A. Neil, R. Juškaitis, and T. Wilson, "Time-domain whole-field fluorescence lifetime imaging with optical sectioning," J. Microsc. 203, 246-257 (2001).
[CrossRef]

Dubertret, B.

Flusberg, B.

B. Flusberg, E. Cocker, W. Piyawattanametha, J. Jung, E. Cheung, and M. Schnitzer, "Fiber-optic fluorescence imaging," Nat. Meth. 2, 941-950 (2005).
[CrossRef]

Follen, M.

Freeman, M.

L. D. Swindle, S. G. Thomas, M. Freeman, and P. M. Delaney, "View of normal human skin in vivo as observed using fluorescent fiber-optics confocal microscopic imaging," J. Invest. Dermatol. 121, 706-712 (2003).
[CrossRef]

French, P. M. W.

M. J. Cole, J. Siegel, S. E. D. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. W. French, M. J. Lever, L. O. D. Sucharov, M. A. A. Neil, R. Juškaitis, and T. Wilson, "Time-domain whole-field fluorescence lifetime imaging with optical sectioning," J. Microsc. 203, 246-257 (2001).
[CrossRef]

Fujii, H.

Fukuyama, H.

T. Ota, H. Fukuyama, Y. Ishihara, H. Tanaka, and T. Takamatsu, "In situ fluorescence imaging of organs through compact scanning head for confocal laser microscopy," J. Biomed. Opt. 10, 1-4 (2005).
[CrossRef]

Gillenwater, A.

Giniunas, L.

L. Giniunas, R. Juškaitis, and S. V. Shatalin, "Scanning fiber-optic microscope," Electron. Lett. 27, 724-726 (1991).
[CrossRef]

Gmitro, A. F.

Gustafsson, M. G. L.

M. G. L. Gustafsson, "Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy," J. Microsc. 198 (Pt 2), 82-87 (2000).
[CrossRef]

Harris, M. R.

Heintzmann, R.

Ishihara, Y.

T. Ota, H. Fukuyama, Y. Ishihara, H. Tanaka, and T. Takamatsu, "In situ fluorescence imaging of organs through compact scanning head for confocal laser microscopy," J. Biomed. Opt. 10, 1-4 (2005).
[CrossRef]

Jakeman, E.

E. Jakeman and W. T. Welford, "Speckle statistics in imaging systems," Opt. Commun. 21, 72-79 (1977).
[CrossRef]

Jean, F.

Jones, R.

M. J. Cole, J. Siegel, S. E. D. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. W. French, M. J. Lever, L. O. D. Sucharov, M. A. A. Neil, R. Juškaitis, and T. Wilson, "Time-domain whole-field fluorescence lifetime imaging with optical sectioning," J. Microsc. 203, 246-257 (2001).
[CrossRef]

Jung, J.

B. Flusberg, E. Cocker, W. Piyawattanametha, J. Jung, E. Cheung, and M. Schnitzer, "Fiber-optic fluorescence imaging," Nat. Meth. 2, 941-950 (2005).
[CrossRef]

Jung, J. C.

J. C. Jung, A. D. Mehta, E. Aksay, R. Stepnoski, and M. J. Schnitzer, "In vivo mammalian brain imaging using one- and two-photon fluorescence microendoscopy," J. Neurophys. 92, 3121-3133 (2004).
[CrossRef]

Juškaitis, R.

D. Karadaglic, R. Juškaitis, and T. Wilson, "Confocal Endoscopy via Structured Illumination," Scanning 24, 301-304 (2002).

M. J. Cole, J. Siegel, S. E. D. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. W. French, M. J. Lever, L. O. D. Sucharov, M. A. A. Neil, R. Juškaitis, and T. Wilson, "Time-domain whole-field fluorescence lifetime imaging with optical sectioning," J. Microsc. 203, 246-257 (2001).
[CrossRef]

M. A. A. Neil, A. Squire, R. Juškaitis, P. I. H. Bastiaens, and T. Wilson, "Wide field optically sectioning fluorescence microscopy with laser illumination," J. Microsc. 197 (Pt 1), 1-4 (2000).
[CrossRef]

M. A. A. Neil, R. Juškaitis, and T. Wilson, "Real time 3D fluorescence microscopy by two beam interference illumination," Opt. Commun. 153, 1-4 (1998).
[CrossRef]

M. A. A. Neil, R. Juškaitis, and T. Wilson, "Method of obtaining optical sectioning by using structured light in a conventional microscope," Opt. Lett. 22, 1905-1907 (1997).
[CrossRef]

L. Giniunas, R. Juškaitis, and S. V. Shatalin, "Scanning fiber-optic microscope," Electron. Lett. 27, 724-726 (1991).
[CrossRef]

Karadaglic, D.

D. Karadaglic, R. Juškaitis, and T. Wilson, "Confocal Endoscopy via Structured Illumination," Scanning 24, 301-304 (2002).

Kim, P.

P. Kim, M. Puoris??haag, D. Coté, C. P. Lin, and S. H. Yun, "In vivo confocal and multiphoton microendoscopy," J. Biomed. Opt. 13, 010501 (2008).
[CrossRef]

King, R. G.

Kino, G. S.

Knittel, J.

J. Knittel, L. Schneider, L. Buess, G. Messerschmidt, and T. Possner, "Endoscope compatible confocal microscope using a gradient index lens system," Opt. Commun. 188, 267-273 (2001).
[CrossRef]

Laemmela, E.

E. Laemmela et al, "Fibered Confocal Fluorescence Microscopy (Cell-viZio?) Facilitates Extended Imaging in the Field of Microcirculation," J. Vasc. Res. 41, 400-411 (2004).
[CrossRef]

Lee, D.

Lever, M. J.

M. J. Cole, J. Siegel, S. E. D. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. W. French, M. J. Lever, L. O. D. Sucharov, M. A. A. Neil, R. Juškaitis, and T. Wilson, "Time-domain whole-field fluorescence lifetime imaging with optical sectioning," J. Microsc. 203, 246-257 (2001).
[CrossRef]

Liang, C.

Lin, C. P.

P. Kim, M. Puoris??haag, D. Coté, C. P. Lin, and S. H. Yun, "In vivo confocal and multiphoton microendoscopy," J. Biomed. Opt. 13, 010501 (2008).
[CrossRef]

Liu, J. T. C.

Mandella, M. J.

Mehta, A. D.

J. C. Jung, A. D. Mehta, E. Aksay, R. Stepnoski, and M. J. Schnitzer, "In vivo mammalian brain imaging using one- and two-photon fluorescence microendoscopy," J. Neurophys. 92, 3121-3133 (2004).
[CrossRef]

Mertz, J.

Messerschmidt, G.

J. Knittel, L. Schneider, L. Buess, G. Messerschmidt, and T. Possner, "Endoscope compatible confocal microscope using a gradient index lens system," Opt. Commun. 188, 267-273 (2001).
[CrossRef]

Neil, M. A. A.

M. J. Cole, J. Siegel, S. E. D. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. W. French, M. J. Lever, L. O. D. Sucharov, M. A. A. Neil, R. Juškaitis, and T. Wilson, "Time-domain whole-field fluorescence lifetime imaging with optical sectioning," J. Microsc. 203, 246-257 (2001).
[CrossRef]

M. A. A. Neil, A. Squire, R. Juškaitis, P. I. H. Bastiaens, and T. Wilson, "Wide field optically sectioning fluorescence microscopy with laser illumination," J. Microsc. 197 (Pt 1), 1-4 (2000).
[CrossRef]

M. A. A. Neil, R. Juškaitis, and T. Wilson, "Real time 3D fluorescence microscopy by two beam interference illumination," Opt. Commun. 153, 1-4 (1998).
[CrossRef]

M. A. A. Neil, R. Juškaitis, and T. Wilson, "Method of obtaining optical sectioning by using structured light in a conventional microscope," Opt. Lett. 22, 1905-1907 (1997).
[CrossRef]

Ota, T.

T. Ota, H. Fukuyama, Y. Ishihara, H. Tanaka, and T. Takamatsu, "In situ fluorescence imaging of organs through compact scanning head for confocal laser microscopy," J. Biomed. Opt. 10, 1-4 (2005).
[CrossRef]

Ouchi, K.

K. Ouchi, "Statistics of image plane speckle," Opt. Quantum Electron. 12, 237-243 (1980).
[CrossRef]

Parsons-Karavassilis, D.

M. J. Cole, J. Siegel, S. E. D. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. W. French, M. J. Lever, L. O. D. Sucharov, M. A. A. Neil, R. Juškaitis, and T. Wilson, "Time-domain whole-field fluorescence lifetime imaging with optical sectioning," J. Microsc. 203, 246-257 (2001).
[CrossRef]

Pierce, M. C.

Piyawattanametha, W.

Possner, T.

J. Knittel, L. Schneider, L. Buess, G. Messerschmidt, and T. Possner, "Endoscope compatible confocal microscope using a gradient index lens system," Opt. Commun. 188, 267-273 (2001).
[CrossRef]

Puoris??haag, M.

P. Kim, M. Puoris??haag, D. Coté, C. P. Lin, and S. H. Yun, "In vivo confocal and multiphoton microendoscopy," J. Biomed. Opt. 13, 010501 (2008).
[CrossRef]

Ra, H.

Richards-Kortum, R.

Richards-Kortum, R. R.

Rouse, A. R.

Schaefer, L. H.

L. H. Schaefer, D. Schuster, and J. Schaffer, "Structured illumination microscopy: artefact analysis and reduction utilizing a parameter optimization approach," J. Microsc. 216, 165-174 (2004).
[CrossRef]

Schaffer, J.

L. H. Schaefer, D. Schuster, and J. Schaffer, "Structured illumination microscopy: artefact analysis and reduction utilizing a parameter optimization approach," J. Microsc. 216, 165-174 (2004).
[CrossRef]

Schneider, L.

J. Knittel, L. Schneider, L. Buess, G. Messerschmidt, and T. Possner, "Endoscope compatible confocal microscope using a gradient index lens system," Opt. Commun. 188, 267-273 (2001).
[CrossRef]

Schnitzer, M.

B. Flusberg, E. Cocker, W. Piyawattanametha, J. Jung, E. Cheung, and M. Schnitzer, "Fiber-optic fluorescence imaging," Nat. Meth. 2, 941-950 (2005).
[CrossRef]

Schnitzer, M. J.

J. C. Jung, A. D. Mehta, E. Aksay, R. Stepnoski, and M. J. Schnitzer, "In vivo mammalian brain imaging using one- and two-photon fluorescence microendoscopy," J. Neurophys. 92, 3121-3133 (2004).
[CrossRef]

Schuster, D.

L. H. Schaefer, D. Schuster, and J. Schaffer, "Structured illumination microscopy: artefact analysis and reduction utilizing a parameter optimization approach," J. Microsc. 216, 165-174 (2004).
[CrossRef]

Shatalin, S. V.

L. Giniunas, R. Juškaitis, and S. V. Shatalin, "Scanning fiber-optic microscope," Electron. Lett. 27, 724-726 (1991).
[CrossRef]

Shin, H.-J.

Shindo, Y.

Siegel, J.

M. J. Cole, J. Siegel, S. E. D. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. W. French, M. J. Lever, L. O. D. Sucharov, M. A. A. Neil, R. Juškaitis, and T. Wilson, "Time-domain whole-field fluorescence lifetime imaging with optical sectioning," J. Microsc. 203, 246-257 (2001).
[CrossRef]

Solgaard, O.

Squire, A.

M. A. A. Neil, A. Squire, R. Juškaitis, P. I. H. Bastiaens, and T. Wilson, "Wide field optically sectioning fluorescence microscopy with laser illumination," J. Microsc. 197 (Pt 1), 1-4 (2000).
[CrossRef]

Stepnoski, R.

J. C. Jung, A. D. Mehta, E. Aksay, R. Stepnoski, and M. J. Schnitzer, "In vivo mammalian brain imaging using one- and two-photon fluorescence microendoscopy," J. Neurophys. 92, 3121-3133 (2004).
[CrossRef]

Sucharov, L. O. D.

M. J. Cole, J. Siegel, S. E. D. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. W. French, M. J. Lever, L. O. D. Sucharov, M. A. A. Neil, R. Juškaitis, and T. Wilson, "Time-domain whole-field fluorescence lifetime imaging with optical sectioning," J. Microsc. 203, 246-257 (2001).
[CrossRef]

Sung, K.-B.

Swindle, L. D.

L. D. Swindle, S. G. Thomas, M. Freeman, and P. M. Delaney, "View of normal human skin in vivo as observed using fluorescent fiber-optics confocal microscopic imaging," J. Invest. Dermatol. 121, 706-712 (2003).
[CrossRef]

Takamatsu, T.

T. Ota, H. Fukuyama, Y. Ishihara, H. Tanaka, and T. Takamatsu, "In situ fluorescence imaging of organs through compact scanning head for confocal laser microscopy," J. Biomed. Opt. 10, 1-4 (2005).
[CrossRef]

Tanaka, H.

T. Ota, H. Fukuyama, Y. Ishihara, H. Tanaka, and T. Takamatsu, "In situ fluorescence imaging of organs through compact scanning head for confocal laser microscopy," J. Biomed. Opt. 10, 1-4 (2005).
[CrossRef]

Thomas, S. G.

L. D. Swindle, S. G. Thomas, M. Freeman, and P. M. Delaney, "View of normal human skin in vivo as observed using fluorescent fiber-optics confocal microscopic imaging," J. Invest. Dermatol. 121, 706-712 (2003).
[CrossRef]

Ventalon, C.

Viellerobe, B.

Wang, T. D.

Webb, S. E. D.

M. J. Cole, J. Siegel, S. E. D. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. W. French, M. J. Lever, L. O. D. Sucharov, M. A. A. Neil, R. Juškaitis, and T. Wilson, "Time-domain whole-field fluorescence lifetime imaging with optical sectioning," J. Microsc. 203, 246-257 (2001).
[CrossRef]

Welford, W. T.

E. Jakeman and W. T. Welford, "Speckle statistics in imaging systems," Opt. Commun. 21, 72-79 (1977).
[CrossRef]

Wilson, T.

D. Karadaglic, R. Juškaitis, and T. Wilson, "Confocal Endoscopy via Structured Illumination," Scanning 24, 301-304 (2002).

M. J. Cole, J. Siegel, S. E. D. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. W. French, M. J. Lever, L. O. D. Sucharov, M. A. A. Neil, R. Juškaitis, and T. Wilson, "Time-domain whole-field fluorescence lifetime imaging with optical sectioning," J. Microsc. 203, 246-257 (2001).
[CrossRef]

M. A. A. Neil, A. Squire, R. Juškaitis, P. I. H. Bastiaens, and T. Wilson, "Wide field optically sectioning fluorescence microscopy with laser illumination," J. Microsc. 197 (Pt 1), 1-4 (2000).
[CrossRef]

M. A. A. Neil, R. Juškaitis, and T. Wilson, "Real time 3D fluorescence microscopy by two beam interference illumination," Opt. Commun. 153, 1-4 (1998).
[CrossRef]

M. A. A. Neil, R. Juškaitis, and T. Wilson, "Method of obtaining optical sectioning by using structured light in a conventional microscope," Opt. Lett. 22, 1905-1907 (1997).
[CrossRef]

Wong, L. K.

Yun, S. H.

P. Kim, M. Puoris??haag, D. Coté, C. P. Lin, and S. H. Yun, "In vivo confocal and multiphoton microendoscopy," J. Biomed. Opt. 13, 010501 (2008).
[CrossRef]

Appl. Opt. (3)

Electron. Lett. (1)

L. Giniunas, R. Juškaitis, and S. V. Shatalin, "Scanning fiber-optic microscope," Electron. Lett. 27, 724-726 (1991).
[CrossRef]

J. Biomed. Opt. (2)

P. Kim, M. Puoris??haag, D. Coté, C. P. Lin, and S. H. Yun, "In vivo confocal and multiphoton microendoscopy," J. Biomed. Opt. 13, 010501 (2008).
[CrossRef]

T. Ota, H. Fukuyama, Y. Ishihara, H. Tanaka, and T. Takamatsu, "In situ fluorescence imaging of organs through compact scanning head for confocal laser microscopy," J. Biomed. Opt. 10, 1-4 (2005).
[CrossRef]

J. Invest. Dermatol. (1)

L. D. Swindle, S. G. Thomas, M. Freeman, and P. M. Delaney, "View of normal human skin in vivo as observed using fluorescent fiber-optics confocal microscopic imaging," J. Invest. Dermatol. 121, 706-712 (2003).
[CrossRef]

J. Microsc. (4)

M. G. L. Gustafsson, "Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy," J. Microsc. 198 (Pt 2), 82-87 (2000).
[CrossRef]

M. A. A. Neil, A. Squire, R. Juškaitis, P. I. H. Bastiaens, and T. Wilson, "Wide field optically sectioning fluorescence microscopy with laser illumination," J. Microsc. 197 (Pt 1), 1-4 (2000).
[CrossRef]

M. J. Cole, J. Siegel, S. E. D. Webb, R. Jones, K. Dowling, M. J. Dayel, D. Parsons-Karavassilis, P. M. W. French, M. J. Lever, L. O. D. Sucharov, M. A. A. Neil, R. Juškaitis, and T. Wilson, "Time-domain whole-field fluorescence lifetime imaging with optical sectioning," J. Microsc. 203, 246-257 (2001).
[CrossRef]

L. H. Schaefer, D. Schuster, and J. Schaffer, "Structured illumination microscopy: artefact analysis and reduction utilizing a parameter optimization approach," J. Microsc. 216, 165-174 (2004).
[CrossRef]

J. Neurophys. (1)

J. C. Jung, A. D. Mehta, E. Aksay, R. Stepnoski, and M. J. Schnitzer, "In vivo mammalian brain imaging using one- and two-photon fluorescence microendoscopy," J. Neurophys. 92, 3121-3133 (2004).
[CrossRef]

J. Opt. Soc. Am. (1)

J. Vasc. Res. (1)

E. Laemmela et al, "Fibered Confocal Fluorescence Microscopy (Cell-viZio?) Facilitates Extended Imaging in the Field of Microcirculation," J. Vasc. Res. 41, 400-411 (2004).
[CrossRef]

Nat. Meth. (1)

B. Flusberg, E. Cocker, W. Piyawattanametha, J. Jung, E. Cheung, and M. Schnitzer, "Fiber-optic fluorescence imaging," Nat. Meth. 2, 941-950 (2005).
[CrossRef]

Opt. Commun. (3)

J. Knittel, L. Schneider, L. Buess, G. Messerschmidt, and T. Possner, "Endoscope compatible confocal microscope using a gradient index lens system," Opt. Commun. 188, 267-273 (2001).
[CrossRef]

E. Jakeman and W. T. Welford, "Speckle statistics in imaging systems," Opt. Commun. 21, 72-79 (1977).
[CrossRef]

M. A. A. Neil, R. Juškaitis, and T. Wilson, "Real time 3D fluorescence microscopy by two beam interference illumination," Opt. Commun. 153, 1-4 (1998).
[CrossRef]

Opt. Express (3)

Opt. Lett. (6)

Opt. Quantum Electron. (1)

K. Ouchi, "Statistics of image plane speckle," Opt. Quantum Electron. 12, 237-243 (1980).
[CrossRef]

Scanning (1)

D. Karadaglic, R. Juškaitis, and T. Wilson, "Confocal Endoscopy via Structured Illumination," Scanning 24, 301-304 (2002).

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