Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Endoscopic applications of optical coherence tomography

Open Access Open Access

Abstract

Initial data, capabilities and limitations conclusions, and diagnostic usefulness recommendations derived from application of our endoscopic optical coherence tomography (EOCT) system to the imaging of the mucous membranes of human internal organs are presented herein based on in vivo study of more than 100 patients. These data suggest that EOCT can provide, non-invasively and innocuously, such significant clinical diagnostic information as the following: identification and localization of informative internal biopsy sites; structural characterization of normal and abnormal internal mucosal tissues; guidance in the rendering of surgical and non-surgical treatments; and monitoring of the functional states (both normal and abnormal) of internal orgarns and post-operative recovery processes in the same. This investigation demonstrated that OCT data is more informative for organs with epithelial tissues separated from their underlying stroma by a smooth basal membrane; therefore, this report focuses on the EOCT study of three such internal organs - the larynx, the bladder, and the uterine cervix. Additionally reported herein, for the first time, is the laparascopic OCT examination of the mucosal lining of the abdomen.

©1998 Optical Society of America

Full Article  |  PDF Article
More Like This
In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa

A. M. Sergeev, V. M. Gelikonov, G. V. Gelikonov, F. I. Feldchtein, R. V. Kuranov, N. D. Gladkova, N. M. Shakhova, L. B. Snopova, A. V. Shakhov, I. A. Kuznetzova, A. N. Denisenko, V. V. Pochinko, Yu. P. Chumakov, and O. S. Streltzova
Opt. Express 1(13) 432-440 (1997)

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Michalina J. Gora, Melissa J. Suter, Guillermo J. Tearney, and Xingde Li
Biomed. Opt. Express 8(5) 2405-2444 (2017)

Ultrahigh resolution optical biopsy with endoscopic optical coherence tomography

Paul R. Herz, Yu Chen, Aaron D. Aguirre, James G. Fujimoto, Hiroshi Mashimo, Joseph Schmitt, Amanda Koski, John Goodnow, and Chris Petersen
Opt. Express 12(15) 3532-3542 (2004)

Cited By

Optica participates in Crossref's Cited-By Linking service. Citing articles from Optica Publishing Group journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (19)

Fig. 1.
Fig. 1. Normal mucosa of the child’s urinary bladder.
Fig. 2.
Fig. 2. The active stage of chronic catarrhal fibrous cystitis.
Fig. 3.
Fig. 3. The active stage of chronic cystic cystitis. a,b) subepithelial cysts; c) fibrin deposits; d) submucosal cyst.
Fig. 4.
Fig. 4. Prolonged chronic cystitis in the remission stage. Arrow indicates sclerosed lamina propria.
Fig. 5
Fig. 5 The diversity of the normal mucosa of the larynx: a) anterior commissure; b) subglottic space; c) vocal fold; d) vestibular fold; e) posterior commissure; f) piriform sinus with mucous gland ducts; g) epiglottis; h) arytenoid cartilage.
Fig. 6.
Fig. 6. Transition from normal tissue (left) to carcinoma (right) of vocal fold.
Fig. 7.
Fig. 7. Vocal nodule with submucosal edema.
Fig. 8.
Fig. 8. Cyst of gland.
Fig. 9.
Fig. 9. Mucosa of the vocal fold after a course of distant γ - therapy.
Fig. 10.
Fig. 10. Normal transformation zone (cylindrical epithelium - left, metaplastic epithelium center, and normal stratified squamous epithelium - right).
Fig. 11.
Fig. 11. OCT tomografic (left) and microscopic (right) histologic view of high grade cervical intraepithelial neoplasia.
Fig. 12.
Fig. 12. Tomogram of invasive cervical cancer.
Fig. 13.
Fig. 13. Tomogram of transition from normal epithelium (left) to pathologic epithelium (right).
Fig. 14.
Fig. 14. Tomograms of the cervix under cryotherapy: a) before cryoapplication (normal epithelium - left, metaplastic epithelium - right); b) immediately after cryoapplication; c) two days later (zone of necrosis - right); d) six weeks later (normal epithelium seen as dark stripe).
Fig. 15.
Fig. 15. Tomograms of the cervix after electrosurgery: a) two weeks later (zone of necrosis - right); b) six weeks after (normal epithelium seen as an even stripe).
Fig. 16.
Fig. 16. Tomograms of the cervix after laser vaporization: a) two days after (zone of necrosis -right); b) three weeks after.
Fig. 17.
Fig. 17. Tomograms of the cervix in hypoestrogenia (a) and hyperestrogenia (b).
Fig. 18.
Fig. 18. Tomograms of the cervix of non-pregnant (a) and pregnant (b) female patients.
Fig. 19.
Fig. 19. Tomograms of the ovary (a), salpinx (b), and anterior abdominal wall (c).
Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved