Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
Journal Home About Issues in Progress Current Issue All Issues Feature Issues

Full-field laser Doppler perfusion imaging and monitoring with an intelligent CMOS camera

Alexandre Serov, Beda Steinacher, and Theo Lasser

Open Access Open Access

Abstract

A system for full-field laser Doppler blood flow imaging has been developed and tested on biomedical samples. The new imaging system allows 2D flow maps or monitoring flux signals to be obtained from a plurality of measured points simultaneously by using a 2D array of photodetectors. The detection part of the system is based on an intelligent CMOS camera with a built-in digital signal processor and memory. The imaging time of the system is as much as to 4 times faster than for the conventional scanning laser Doppler imager. The performance of the system was evaluated in vitro and in vivo. The first measurement results with this new system on human skin are reported.

©2005 Optical Society of America

Full Article  |  PDF Article
More Like This
High-speed laser Doppler perfusion imaging using an integrating CMOS image sensor

Alexandre Serov and Theo Lasser
Opt. Express 13(17) 6416-6428 (2005)

Laser Doppler perfusion imaging with a complimentary metal oxide semiconductor image sensor

Alexander Serov, Wiendelt Steenbergen, and Frits de Mul
Opt. Lett. 27(5) 300-302 (2002)

Twente Optical Perfusion Camera: system overview and performance for video rate laser Doppler perfusion imaging

Matthijs Draijer, Erwin Hondebrink, Ton van Leeuwen, and Wiendelt Steenbergen
Opt. Express 17(5) 3211-3225 (2009)

View More...

Cited By

Optica participates in Crossref's Cited-By Linking service. Citing articles from Optica Publishing Group journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (6)
Fig. 1.
Fig. 1. Experimental setup for full-field laser Doppler flow imaging.

Download Full Size | PDF

Fig. 2.
Fig. 2. Flux response of the CMOS imager in respect to velocity measured for different Intralipid™ concentrations.

Download Full Size | PDF

Fig. 3.
Fig. 3. Time traces of the perfusion signal obtained with the full-field laser Doppler imaging system. The decays in the perfusion signal are due to (left) the indicated occlusion of the upper arm and (right) the indicated deep breath, a so-called Valsava maneuver.

Download Full Size | PDF

Fig. 4.
Fig. 4. 128×256 pixel perfusion images of the finger obtained before, during, and after occlusion of the upper arm. The six-level color scale representing relative low-to-high tissue perfusion is displayed below the images.

Download Full Size | PDF

Fig. 5.
Fig. 5. 64×64 pixel perfusion images of the finger obtained before, during, and after occlusion of the upper arm. The arrow indicates a small wound on the finger where the perfusion is altered by healing. The six-level color scale representing relative low-to-high tissue perfusion is displayed below the images.

Download Full Size | PDF

Fig. 6.
Fig. 6. 256×256 pixel perfusion images directly after, 3 min after, and 10 min after the immersion of the index finger in the ice water. The six-level color scale representing relative low-to-high tissue perfusion is displayed below the images.

Download Full Size | PDF

Equations (4)

Equations on this page are rendered with MathJax. Learn more.

Perfusion = 〈 C 〉 V rms ∝ M 1 = ∫ 0 ∞ ν S ( ν ) d ν ,
Concentration = 〈 C 〉 ∝ M 0 = ∫ 0 ∞ S ( ν ) d ν ,
Speed ∝ M 1 M 0 ,
S ( ν ) = ∣ ∫ 0 ∞ I ( t ) exp ( − i 2 π ν t ) d t ∣ 2 .
Select as filters
Select Topics Cancel
Top
       
© Copyright 2024 | Optica Publishing Group. All rights reserved, including rights for text and data mining and training of artificial technologies or similar technologies.
Privacy | Terms of Use