Abstract

The optimization problem of the parameters of lightguides for fiber-optic probes used in fluorescent tumor diagnostics (of benign and malignant tumors) is considered. It has been shown that, to increase the sensitivity of a fluorimeter in the near-infrared region, it is promising to use fiber lightguides of the quartz–quartz type, with an increased numerical aperture of up to 0.30 and a biocompatible protective coating of P-12 polyamide or tetrafluoroethylene copolymer with Tefzel ethylene, as probe lightguides for detecting luminescence. Using such lightguides, a prototype version of a 19-core large-aperture fiber-optic probe for a laser oncofluorometer with increased sensitivity operating in the spectral range 900–1100 nm has been developed. The minimum dose of the injected drug was 10 μg/kg of bio-object weight, which corresponds to a world-class level of sensitivity of photosensitizer detection in biological tissues.

© 2019 Optical Society of America

PDF Article

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription