Abstract

The extension of fluorescence diagnosis into the near-IR region is promising, because this radiation penetrates more deeply into biological tissue, has higher contrast due to the absence of intrinsic fluorescence of the tissue, and can work in brightly lit operating rooms, as well as because new drugs have been developed that can specifically accumulate in pathological foci. The FLUM-808 multispectral system has been developed and makes it possible to visualize and simultaneously make quantitative estimates in IR fluorescence light and reflected white light or in as many as four spectrally separated fluorescences in the 410–950-nm range. Using the latter phenomena as an example, produced on experimental animals and during the performance of open, microsurgical, and endoscopic operations with indocyanine green as an IR fluorescence marker, it has been shown to be possible to employ the system to solve crucial medical problems: the detection of malignant tumors, metastases, and sentinel lymph nodes in the presence of cancer and the visualization of the circulatory and lymphatic systems and of bile ducts.

© 2017 Optical Society of America

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