Abstract

This paper proposes and discusses a fundamentally new approach to eliminating the poisonous action of carbon monoxide. A technology based on the phenomenon of laser-induced photodissociation of carboxyhemoglobin in the blood vessels and capillaries has been developed. The spectra of the action of carboxyhemoglobin and oxyhemoglobin in the cutaneous blood vessels are calculated by numerically modeling the interaction of laser radiation with biological tissue. Criteria are determined for the efficiency of the induced photodissociation of carboxyhemoglobin when the radiation acts directly on the pulmonary alveoli, through the epidermis, and intravenously.

© 2013 Optical Society of America

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  1. T.  Meredith, A.  Vale, “Carbon monoxide poisoning,” Braz. J. Med. Biol. Res. 296, 77 (1988).
    [CrossRef]
  2. J. E.  Peterson, R. D.  Stewart, “Absorption and elimination of carbon monoxide by inactive young men,” Arch. Environ. Health 21, 165 (1970).
    [CrossRef]
  3. W. J.  Egan, W. E.  Brewer, S. L.  Morgan, “Measurements of carboxyhemoglobin in forensic blood samples using UV–visible spectrometry and improved principal component regression,” Appl. Spectrosc. 53, 218 (1999).
    [CrossRef]
  4. M.  Goulon, A.  Barois, M.  Rapin, F.  Nouailat, S.  Grosbuis, J.  Labrousse, “Carbon monoxide poisoning and acute anoxia,” J. Hyperbaric Med. 1, 23 (1986).
  5. P.  Croker, “Carbon monoxide poisoning: the clinical entity and its treatment. A review,” Mil. Med. 149, 257 (1984).
  6. P. S.  Grim, L. J.  Gottlieb, A.  Boddie, E.  Batson, “Hyperbaric oxygen therapy,” J. Am. Med. Assoc. 263, 2216 (1990).
    [CrossRef]
  7. C.  Piantadosi, “The role of hyperbaric oxygen in carbon monoxide, cyanide and sulfide intoxications,” Probl. Respir. Care 4, 215 (1991).
  8. P. M.  Tibbles, J. S.  Edelsberg, “Hyperbaric-oxygen therapy,” N. Engl. J. Med. 334, 1642 (1996).
    [CrossRef]
  9. B. M.  Dzhagarov, V. S.  Chirvonyĭ, G. P.  Gurinovich, Laser Picosecond Spectroscopy and Photochemistry of Biomolecules, V. S.  Letokhova, ed., (Nauka, Moscow, 1987), pp. 203–212.
  10. W. A.  Saffran, Q. H.  Gibson, “Photodissociation of ligands from hem and hem proteins: effect of temperature and organic phosphate,” J. Biol. Chem. 252, 7955 (1977).
  11. V. F.  Kramerenko, Yu. A.  Sobchuk, T. N.  Gladyshevskaya, Methodological Indications of the Quantitative Determination of Carboxyhemoglobin and Carboxymyoglobin (Moscow, 1974).
  12. M. M.  Asimov, R. M.  Asimov, A. N.  Rubinov, “Laser-induced photodissociation of carboxyhemoglobin: an optical method for eliminating the toxic effect of carbon monoxide,” Opt. Spektrosk. 109, 1320 (2010) [Opt. Spectrosc. 109, 237 (2010)].
    [CrossRef]
  13. M. M.  Asimov, R. M.  Asimov, A. N.  Rubinov, “Method of deactivating the carboxyhemoglobin of blood,” Russian Patent No. 2,408,400 (2011).
  14. M. M.  Asimov, R. M.  Asimov, A. N.  Rubinov, “Method of increasing the local concentration of oxygen in biological tissue,” Eurasian Patent No. 015215 (2011).

2010 (1)

M. M.  Asimov, R. M.  Asimov, A. N.  Rubinov, “Laser-induced photodissociation of carboxyhemoglobin: an optical method for eliminating the toxic effect of carbon monoxide,” Opt. Spektrosk. 109, 1320 (2010) [Opt. Spectrosc. 109, 237 (2010)].
[CrossRef]

1999 (1)

1996 (1)

P. M.  Tibbles, J. S.  Edelsberg, “Hyperbaric-oxygen therapy,” N. Engl. J. Med. 334, 1642 (1996).
[CrossRef]

1991 (1)

C.  Piantadosi, “The role of hyperbaric oxygen in carbon monoxide, cyanide and sulfide intoxications,” Probl. Respir. Care 4, 215 (1991).

1990 (1)

P. S.  Grim, L. J.  Gottlieb, A.  Boddie, E.  Batson, “Hyperbaric oxygen therapy,” J. Am. Med. Assoc. 263, 2216 (1990).
[CrossRef]

1988 (1)

T.  Meredith, A.  Vale, “Carbon monoxide poisoning,” Braz. J. Med. Biol. Res. 296, 77 (1988).
[CrossRef]

1986 (1)

M.  Goulon, A.  Barois, M.  Rapin, F.  Nouailat, S.  Grosbuis, J.  Labrousse, “Carbon monoxide poisoning and acute anoxia,” J. Hyperbaric Med. 1, 23 (1986).

1984 (1)

P.  Croker, “Carbon monoxide poisoning: the clinical entity and its treatment. A review,” Mil. Med. 149, 257 (1984).

1977 (1)

W. A.  Saffran, Q. H.  Gibson, “Photodissociation of ligands from hem and hem proteins: effect of temperature and organic phosphate,” J. Biol. Chem. 252, 7955 (1977).

1970 (1)

J. E.  Peterson, R. D.  Stewart, “Absorption and elimination of carbon monoxide by inactive young men,” Arch. Environ. Health 21, 165 (1970).
[CrossRef]

Asimov, M. M.

M. M.  Asimov, R. M.  Asimov, A. N.  Rubinov, “Laser-induced photodissociation of carboxyhemoglobin: an optical method for eliminating the toxic effect of carbon monoxide,” Opt. Spektrosk. 109, 1320 (2010) [Opt. Spectrosc. 109, 237 (2010)].
[CrossRef]

M. M.  Asimov, R. M.  Asimov, A. N.  Rubinov, “Method of increasing the local concentration of oxygen in biological tissue,” Eurasian Patent No. 015215 (2011).

M. M.  Asimov, R. M.  Asimov, A. N.  Rubinov, “Method of deactivating the carboxyhemoglobin of blood,” Russian Patent No. 2,408,400 (2011).

Asimov, R. M.

M. M.  Asimov, R. M.  Asimov, A. N.  Rubinov, “Laser-induced photodissociation of carboxyhemoglobin: an optical method for eliminating the toxic effect of carbon monoxide,” Opt. Spektrosk. 109, 1320 (2010) [Opt. Spectrosc. 109, 237 (2010)].
[CrossRef]

M. M.  Asimov, R. M.  Asimov, A. N.  Rubinov, “Method of increasing the local concentration of oxygen in biological tissue,” Eurasian Patent No. 015215 (2011).

M. M.  Asimov, R. M.  Asimov, A. N.  Rubinov, “Method of deactivating the carboxyhemoglobin of blood,” Russian Patent No. 2,408,400 (2011).

Barois, A.

M.  Goulon, A.  Barois, M.  Rapin, F.  Nouailat, S.  Grosbuis, J.  Labrousse, “Carbon monoxide poisoning and acute anoxia,” J. Hyperbaric Med. 1, 23 (1986).

Batson, E.

P. S.  Grim, L. J.  Gottlieb, A.  Boddie, E.  Batson, “Hyperbaric oxygen therapy,” J. Am. Med. Assoc. 263, 2216 (1990).
[CrossRef]

Boddie, A.

P. S.  Grim, L. J.  Gottlieb, A.  Boddie, E.  Batson, “Hyperbaric oxygen therapy,” J. Am. Med. Assoc. 263, 2216 (1990).
[CrossRef]

Brewer, W. E.

Chirvonyi, V. S.

B. M.  Dzhagarov, V. S.  Chirvonyĭ, G. P.  Gurinovich, Laser Picosecond Spectroscopy and Photochemistry of Biomolecules, V. S.  Letokhova, ed., (Nauka, Moscow, 1987), pp. 203–212.

Croker, P.

P.  Croker, “Carbon monoxide poisoning: the clinical entity and its treatment. A review,” Mil. Med. 149, 257 (1984).

Dzhagarov, B. M.

B. M.  Dzhagarov, V. S.  Chirvonyĭ, G. P.  Gurinovich, Laser Picosecond Spectroscopy and Photochemistry of Biomolecules, V. S.  Letokhova, ed., (Nauka, Moscow, 1987), pp. 203–212.

Edelsberg, J. S.

P. M.  Tibbles, J. S.  Edelsberg, “Hyperbaric-oxygen therapy,” N. Engl. J. Med. 334, 1642 (1996).
[CrossRef]

Egan, W. J.

Gibson, Q. H.

W. A.  Saffran, Q. H.  Gibson, “Photodissociation of ligands from hem and hem proteins: effect of temperature and organic phosphate,” J. Biol. Chem. 252, 7955 (1977).

Gladyshevskaya, T. N.

V. F.  Kramerenko, Yu. A.  Sobchuk, T. N.  Gladyshevskaya, Methodological Indications of the Quantitative Determination of Carboxyhemoglobin and Carboxymyoglobin (Moscow, 1974).

Gottlieb, L. J.

P. S.  Grim, L. J.  Gottlieb, A.  Boddie, E.  Batson, “Hyperbaric oxygen therapy,” J. Am. Med. Assoc. 263, 2216 (1990).
[CrossRef]

Goulon, M.

M.  Goulon, A.  Barois, M.  Rapin, F.  Nouailat, S.  Grosbuis, J.  Labrousse, “Carbon monoxide poisoning and acute anoxia,” J. Hyperbaric Med. 1, 23 (1986).

Grim, P. S.

P. S.  Grim, L. J.  Gottlieb, A.  Boddie, E.  Batson, “Hyperbaric oxygen therapy,” J. Am. Med. Assoc. 263, 2216 (1990).
[CrossRef]

Grosbuis, S.

M.  Goulon, A.  Barois, M.  Rapin, F.  Nouailat, S.  Grosbuis, J.  Labrousse, “Carbon monoxide poisoning and acute anoxia,” J. Hyperbaric Med. 1, 23 (1986).

Gurinovich, G. P.

B. M.  Dzhagarov, V. S.  Chirvonyĭ, G. P.  Gurinovich, Laser Picosecond Spectroscopy and Photochemistry of Biomolecules, V. S.  Letokhova, ed., (Nauka, Moscow, 1987), pp. 203–212.

Kramerenko, V. F.

V. F.  Kramerenko, Yu. A.  Sobchuk, T. N.  Gladyshevskaya, Methodological Indications of the Quantitative Determination of Carboxyhemoglobin and Carboxymyoglobin (Moscow, 1974).

Labrousse, J.

M.  Goulon, A.  Barois, M.  Rapin, F.  Nouailat, S.  Grosbuis, J.  Labrousse, “Carbon monoxide poisoning and acute anoxia,” J. Hyperbaric Med. 1, 23 (1986).

Meredith, T.

T.  Meredith, A.  Vale, “Carbon monoxide poisoning,” Braz. J. Med. Biol. Res. 296, 77 (1988).
[CrossRef]

Morgan, S. L.

Nouailat, F.

M.  Goulon, A.  Barois, M.  Rapin, F.  Nouailat, S.  Grosbuis, J.  Labrousse, “Carbon monoxide poisoning and acute anoxia,” J. Hyperbaric Med. 1, 23 (1986).

Peterson, J. E.

J. E.  Peterson, R. D.  Stewart, “Absorption and elimination of carbon monoxide by inactive young men,” Arch. Environ. Health 21, 165 (1970).
[CrossRef]

Piantadosi, C.

C.  Piantadosi, “The role of hyperbaric oxygen in carbon monoxide, cyanide and sulfide intoxications,” Probl. Respir. Care 4, 215 (1991).

Rapin, M.

M.  Goulon, A.  Barois, M.  Rapin, F.  Nouailat, S.  Grosbuis, J.  Labrousse, “Carbon monoxide poisoning and acute anoxia,” J. Hyperbaric Med. 1, 23 (1986).

Rubinov, A. N.

M. M.  Asimov, R. M.  Asimov, A. N.  Rubinov, “Laser-induced photodissociation of carboxyhemoglobin: an optical method for eliminating the toxic effect of carbon monoxide,” Opt. Spektrosk. 109, 1320 (2010) [Opt. Spectrosc. 109, 237 (2010)].
[CrossRef]

M. M.  Asimov, R. M.  Asimov, A. N.  Rubinov, “Method of increasing the local concentration of oxygen in biological tissue,” Eurasian Patent No. 015215 (2011).

M. M.  Asimov, R. M.  Asimov, A. N.  Rubinov, “Method of deactivating the carboxyhemoglobin of blood,” Russian Patent No. 2,408,400 (2011).

Saffran, W. A.

W. A.  Saffran, Q. H.  Gibson, “Photodissociation of ligands from hem and hem proteins: effect of temperature and organic phosphate,” J. Biol. Chem. 252, 7955 (1977).

Sobchuk, Yu. A.

V. F.  Kramerenko, Yu. A.  Sobchuk, T. N.  Gladyshevskaya, Methodological Indications of the Quantitative Determination of Carboxyhemoglobin and Carboxymyoglobin (Moscow, 1974).

Stewart, R. D.

J. E.  Peterson, R. D.  Stewart, “Absorption and elimination of carbon monoxide by inactive young men,” Arch. Environ. Health 21, 165 (1970).
[CrossRef]

Tibbles, P. M.

P. M.  Tibbles, J. S.  Edelsberg, “Hyperbaric-oxygen therapy,” N. Engl. J. Med. 334, 1642 (1996).
[CrossRef]

Vale, A.

T.  Meredith, A.  Vale, “Carbon monoxide poisoning,” Braz. J. Med. Biol. Res. 296, 77 (1988).
[CrossRef]

Appl. Spectrosc. (1)

Arch. Environ. Health (1)

J. E.  Peterson, R. D.  Stewart, “Absorption and elimination of carbon monoxide by inactive young men,” Arch. Environ. Health 21, 165 (1970).
[CrossRef]

Braz. J. Med. Biol. Res. (1)

T.  Meredith, A.  Vale, “Carbon monoxide poisoning,” Braz. J. Med. Biol. Res. 296, 77 (1988).
[CrossRef]

J. Am. Med. Assoc. (1)

P. S.  Grim, L. J.  Gottlieb, A.  Boddie, E.  Batson, “Hyperbaric oxygen therapy,” J. Am. Med. Assoc. 263, 2216 (1990).
[CrossRef]

J. Biol. Chem. (1)

W. A.  Saffran, Q. H.  Gibson, “Photodissociation of ligands from hem and hem proteins: effect of temperature and organic phosphate,” J. Biol. Chem. 252, 7955 (1977).

J. Hyperbaric Med. (1)

M.  Goulon, A.  Barois, M.  Rapin, F.  Nouailat, S.  Grosbuis, J.  Labrousse, “Carbon monoxide poisoning and acute anoxia,” J. Hyperbaric Med. 1, 23 (1986).

Mil. Med. (1)

P.  Croker, “Carbon monoxide poisoning: the clinical entity and its treatment. A review,” Mil. Med. 149, 257 (1984).

N. Engl. J. Med. (1)

P. M.  Tibbles, J. S.  Edelsberg, “Hyperbaric-oxygen therapy,” N. Engl. J. Med. 334, 1642 (1996).
[CrossRef]

Opt. Spektrosk. (1)

M. M.  Asimov, R. M.  Asimov, A. N.  Rubinov, “Laser-induced photodissociation of carboxyhemoglobin: an optical method for eliminating the toxic effect of carbon monoxide,” Opt. Spektrosk. 109, 1320 (2010) [Opt. Spectrosc. 109, 237 (2010)].
[CrossRef]

Probl. Respir. Care (1)

C.  Piantadosi, “The role of hyperbaric oxygen in carbon monoxide, cyanide and sulfide intoxications,” Probl. Respir. Care 4, 215 (1991).

Other (4)

B. M.  Dzhagarov, V. S.  Chirvonyĭ, G. P.  Gurinovich, Laser Picosecond Spectroscopy and Photochemistry of Biomolecules, V. S.  Letokhova, ed., (Nauka, Moscow, 1987), pp. 203–212.

V. F.  Kramerenko, Yu. A.  Sobchuk, T. N.  Gladyshevskaya, Methodological Indications of the Quantitative Determination of Carboxyhemoglobin and Carboxymyoglobin (Moscow, 1974).

M. M.  Asimov, R. M.  Asimov, A. N.  Rubinov, “Method of deactivating the carboxyhemoglobin of blood,” Russian Patent No. 2,408,400 (2011).

M. M.  Asimov, R. M.  Asimov, A. N.  Rubinov, “Method of increasing the local concentration of oxygen in biological tissue,” Eurasian Patent No. 015215 (2011).

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