Abstract

A fluorescence–reflection multichannel fiber spectrometer has been developed that makes it possible to carry out a wide range of biomedical research, including estimating the concentration of glycation end-products in the skin and the oxidation–reduction state of various tissues. It has the feature of being able to simultaneously record diffuse reflection spectra and fluorescence emission. The fluorescence is excited by an LED that emits at 365 nm. The fluorescence spectra are recorded in the 400–750 nm region, while the reflection spectra are recorded in the 350–750 nm region. The convergence of the results of the measurements is 1.6%. A technique is proposed for correcting the autofluorescence index of the skin that makes it possible to sharply reduce its dependence on the degree of skin pigmentation. The possibilities of the device are illustrated by examples of biomedical research.

© 2013 Optical Society of America

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  1. V. V. Tuchin, ed., Optical Biomedical Diagnostics, vol. 2 (Fizmatlit, Moscow, 2007).
  2. R. Richards-Kortum and E. Sevick-Muraca, “Quantitative optical spectroscopy for tissue diagnosis,” Annu. Rev. Phys. Chem. 47, 555(1996).
    [CrossRef]
  3. G. V. Papayan and I. Ya. Barsky, “Contact luminescence spectrophotometry for biomedical studies,” Proc. SPIE 4515, 125 (2001).
    [CrossRef]
  4. A. Shahzad and G. Koehler, “Fluorescence spectroscopy: an emerging excellent diagnostic tool in medical sciences,” Internet J. Med. Technol. 5, No. 1 (2010).
  5. N. Ramanujam, M. F. Mitchell, A. Mahadevan, S. Thomsen, E. Silva, and R. Richards-Kortum, “Fluorescence spectroscopy: a diagnostic tool for cervical intraepithelial neoplasia,” Gynecol. Oncol. 52, 31 (1994).
    [CrossRef]
  6. M. Mitchell, S. B. Cantor, C. Brookner, U. Utzinger, and D. Schottenfeld, “Fluorescence spectroscopy for diagnosis of squamous intraepithelial lesions of the cervix,” Obstet. Gynecol. 93, 462 (1999).
    [CrossRef]
  7. S. K. Chang, Y. N. Mirabal, E. N. Atkinson, D. Cox, A. Malpica, M. Follen, and R. Richards-Kortum, “Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer,” J. Biomed. Opt. 10, 024031 (2005).
    [CrossRef]
  8. A. Zuluaga, U. Utzinger, A. Durkin, H. Fuchs, A. Gillenwater, R. Jacob, B. Kemp, J. Fan, and R. Richards-Kortum, “Fluorescence excitation-emission matrices of human tissue: a system for in vivo measurement and data analysis,” Appl. Spectrosc. 53, 302 (1999).
    [CrossRef]
  9. V. B. Loschenov, V. I. Konov, and A. M. Prokhorov, “Photodynamic therapy and fluorescence diagnostics,” Laser Phys. 10, 1188 (2000).
  10. N. N. Zharkova, D. N. Kozlov, Yu. N. Polivanov, R. L. Pykhov, and V. V. Smirnov, “Laser-excited fluorescence spectrometric system for tissue diagnostics,” Proc. SPIE 2328, 196 (1994).
    [CrossRef]
  11. K. A. Horvath, K. T. Schomacker, C. C. Lee, and L. H. Cohn, “Intraoperative myocardial ischemia detection with laser-induced fluorescence,” J. Thorac. Cardiovasc. Surg. 107, 220 (1994).
  12. A. Mayevsky and G. G. Rogatsky, “Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studies,” Am. J. Physiol. Lung Cell. Mol. Physiol. 292, 615 (2007).
  13. M. Beránek, D. Nováková, P. Rozsíval, J. Drsata, and V. Palicka, “Glycation and advanced glycation end-products in laboratory experiments in vivo and in vitro,” Acta Medica (Hradec Kralove) 49, No. 1, 35 (2006).
  14. R. Graaff, R. Meerwaldt, H. Lutgers, R. Baptist, E. de Jong, T. Andries, L. Smit, and G. Rakhorst, “Instrumentation for the measurement of autofluorescence in human skin,” Proc. SPIE 5692, 111 (2005).
    [CrossRef]
  15. H. L. Lutgers, R. Graaff, T. P. Links, L. J. Ubink-Veltmaat, H. J. Bilo, R. O. Gans, and A. J. Smit, “Skin autofluorescence as a noninvasive marker of vascular damage in patients with type-2 diabetes,” Diabetes Care 29, 2654 (2006).
    [CrossRef]
  16. R. Meervaldt, H. L. Lutgers, T. P. Links, R. Graaff, J. W. Baynes, R. Gans, and A. J. Smit, “Skin AF is a strong predictor of cardiac mortality in diabetes,” Diabetes Care 30, 107 (2007).
    [CrossRef]
  17. J. W. Hartog, S. Gross, L. H. Oterdoom, R. M. van Ree, A. P. de Vries, A. J. Smit, J. P. Schouten, P. P. Nawroth, R. O. Gans, W. J. van Son, A. Bierhaus, and S. J. Bakker, “Skin autofluorescence is an independent predictor of graft loss in renal transplant recipients,” Transplantation 87, 1069 (2009).
    [CrossRef]
  18. R. Meerwaldt, T. P. Links, R. Graaff, K. Hoogenberg, J. D. Lefrandt, J. W. Baynes, R. O. Gans, and A. J. Smit, “Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy,” Diabetologia 48, 1637 (2005).
    [CrossRef]
  19. A. Goldin, J. A. Beckman, A. M. Schmidt, and M. A. Creager, “Advanced glycation end-products sparking the development of diabetic vascular injury,” Circulation 114, 597 (2006).
    [CrossRef]
  20. R. Meerwaldt, J. W. Hartog, R. Graaff, R. J. Huisman, T. P. Links, N. C. den Hollander, S. R. Thorpe, J. W. Baynes, G. Navis, R. O. Gans, and A. J. Smit, “Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products mortality in hemodialysis patients,” J. Am. Soc. Nephrol. 16, 3687 (2005).
    [CrossRef]
  21. M. N. Ediger, R. D. Johnson, E. L. Hull, and C. D. Brown, “Determination of a measure of a glycation end-product or disease state using tissue fluorescence,” U.S. Patent No. 8078243 (2011).
  22. E. Hull, M. Ediger, A. Unione, E. Deemer, M. Stroman, and J. Baynes, “Noninvasive, optical detection of diabetes: model studies with porcine skin,” Opt. Express 12, 4496 (2004).
    [CrossRef]
  23. J. D. Maynard, M. Rohrscheib, J. F. Way, C. M. Nguyen, and M. N. Ediger, “Noninvasive type-2 diabetes screening, superior sensitivity to fasting plasma glucose and A1C,” Diabetes Care 30, 1120 (2007).
    [CrossRef]
  24. K. Uk, G. V. Papayan, S.-J. Bae, V. B. Berezin, and S. Kim, “Fluorescence video dermatoscope,” Opt. Zh. 75, No. 1, 32 (2008) [J. Opt. Technol.75, 24 (2008)].
    [CrossRef]
  25. K. Uk, G. V. Papayan, D. A. Makarov, S. Y. Lee, and S. J. Bae, “Illuminator for photodynamic therapy and fluorescence diagnosis with lightguide output of the radiation,” Opt. Zh. 75, No. 12, 16 (2008) [J. Opt. Technol.75, 772 (2008)].
    [CrossRef]
  26. O. Kim, J. McMurdy, C. Lines, S. Duffy, G. Crawford, and M. Alber, “Reflectance spectrometry of normal and bruised human skins: experiments and modeling,” Physiol. Meas. 33, 159 (2012).
    [CrossRef]
  27. R. S. Bradley and M. S. Thorniley, “A review of attenuation correction techniques for tissue fluorescence,” J. R. Soc., Interface 3, 1 (2006).
    [CrossRef]
  28. M. Koetsier, E. Nur, H. Chunmao, H. L. Lutgers, T. P. Links, A. J. Smit, G. Rakhorst, and R. Graaff, “Skin-color-independent assessment of aging using skin autofluorescence,” Opt. Express 18, 14416 (2010).
    [CrossRef]
  29. N. N. Petrishchev, G. V. Papayan, A. M. Esayan, E. N. Grineva, and K. Uk, “Study of glycation end-products by fluorescence spectroscopy of the skin. Photodynamic therapy and fluorescence diagnosis,” in Collection of Scientific Works, ed. N. N. Petrishcheva (Lan’, St. Petersburg, 2011), pp. 222–230.
  30. N. N. Petrishchev and G. V. Papayan, “Autofluorescence organoscopy. Photodynamic therapy and fluorescence diagnosis,” in Collection of Scientific Works, ed. N. N. Petrishcheva (Lan’, St. Petersburg, 2011), pp. 261–273.

2012

O. Kim, J. McMurdy, C. Lines, S. Duffy, G. Crawford, and M. Alber, “Reflectance spectrometry of normal and bruised human skins: experiments and modeling,” Physiol. Meas. 33, 159 (2012).
[CrossRef]

2010

M. Koetsier, E. Nur, H. Chunmao, H. L. Lutgers, T. P. Links, A. J. Smit, G. Rakhorst, and R. Graaff, “Skin-color-independent assessment of aging using skin autofluorescence,” Opt. Express 18, 14416 (2010).
[CrossRef]

A. Shahzad and G. Koehler, “Fluorescence spectroscopy: an emerging excellent diagnostic tool in medical sciences,” Internet J. Med. Technol. 5, No. 1 (2010).

2009

J. W. Hartog, S. Gross, L. H. Oterdoom, R. M. van Ree, A. P. de Vries, A. J. Smit, J. P. Schouten, P. P. Nawroth, R. O. Gans, W. J. van Son, A. Bierhaus, and S. J. Bakker, “Skin autofluorescence is an independent predictor of graft loss in renal transplant recipients,” Transplantation 87, 1069 (2009).
[CrossRef]

2007

A. Mayevsky and G. G. Rogatsky, “Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studies,” Am. J. Physiol. Lung Cell. Mol. Physiol. 292, 615 (2007).

R. Meervaldt, H. L. Lutgers, T. P. Links, R. Graaff, J. W. Baynes, R. Gans, and A. J. Smit, “Skin AF is a strong predictor of cardiac mortality in diabetes,” Diabetes Care 30, 107 (2007).
[CrossRef]

J. D. Maynard, M. Rohrscheib, J. F. Way, C. M. Nguyen, and M. N. Ediger, “Noninvasive type-2 diabetes screening, superior sensitivity to fasting plasma glucose and A1C,” Diabetes Care 30, 1120 (2007).
[CrossRef]

2006

R. S. Bradley and M. S. Thorniley, “A review of attenuation correction techniques for tissue fluorescence,” J. R. Soc., Interface 3, 1 (2006).
[CrossRef]

M. Beránek, D. Nováková, P. Rozsíval, J. Drsata, and V. Palicka, “Glycation and advanced glycation end-products in laboratory experiments in vivo and in vitro,” Acta Medica (Hradec Kralove) 49, No. 1, 35 (2006).

H. L. Lutgers, R. Graaff, T. P. Links, L. J. Ubink-Veltmaat, H. J. Bilo, R. O. Gans, and A. J. Smit, “Skin autofluorescence as a noninvasive marker of vascular damage in patients with type-2 diabetes,” Diabetes Care 29, 2654 (2006).
[CrossRef]

A. Goldin, J. A. Beckman, A. M. Schmidt, and M. A. Creager, “Advanced glycation end-products sparking the development of diabetic vascular injury,” Circulation 114, 597 (2006).
[CrossRef]

2005

R. Meerwaldt, J. W. Hartog, R. Graaff, R. J. Huisman, T. P. Links, N. C. den Hollander, S. R. Thorpe, J. W. Baynes, G. Navis, R. O. Gans, and A. J. Smit, “Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products mortality in hemodialysis patients,” J. Am. Soc. Nephrol. 16, 3687 (2005).
[CrossRef]

R. Meerwaldt, T. P. Links, R. Graaff, K. Hoogenberg, J. D. Lefrandt, J. W. Baynes, R. O. Gans, and A. J. Smit, “Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy,” Diabetologia 48, 1637 (2005).
[CrossRef]

R. Graaff, R. Meerwaldt, H. Lutgers, R. Baptist, E. de Jong, T. Andries, L. Smit, and G. Rakhorst, “Instrumentation for the measurement of autofluorescence in human skin,” Proc. SPIE 5692, 111 (2005).
[CrossRef]

S. K. Chang, Y. N. Mirabal, E. N. Atkinson, D. Cox, A. Malpica, M. Follen, and R. Richards-Kortum, “Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer,” J. Biomed. Opt. 10, 024031 (2005).
[CrossRef]

2004

2001

G. V. Papayan and I. Ya. Barsky, “Contact luminescence spectrophotometry for biomedical studies,” Proc. SPIE 4515, 125 (2001).
[CrossRef]

2000

V. B. Loschenov, V. I. Konov, and A. M. Prokhorov, “Photodynamic therapy and fluorescence diagnostics,” Laser Phys. 10, 1188 (2000).

1999

A. Zuluaga, U. Utzinger, A. Durkin, H. Fuchs, A. Gillenwater, R. Jacob, B. Kemp, J. Fan, and R. Richards-Kortum, “Fluorescence excitation-emission matrices of human tissue: a system for in vivo measurement and data analysis,” Appl. Spectrosc. 53, 302 (1999).
[CrossRef]

M. Mitchell, S. B. Cantor, C. Brookner, U. Utzinger, and D. Schottenfeld, “Fluorescence spectroscopy for diagnosis of squamous intraepithelial lesions of the cervix,” Obstet. Gynecol. 93, 462 (1999).
[CrossRef]

1996

R. Richards-Kortum and E. Sevick-Muraca, “Quantitative optical spectroscopy for tissue diagnosis,” Annu. Rev. Phys. Chem. 47, 555(1996).
[CrossRef]

1994

N. Ramanujam, M. F. Mitchell, A. Mahadevan, S. Thomsen, E. Silva, and R. Richards-Kortum, “Fluorescence spectroscopy: a diagnostic tool for cervical intraepithelial neoplasia,” Gynecol. Oncol. 52, 31 (1994).
[CrossRef]

N. N. Zharkova, D. N. Kozlov, Yu. N. Polivanov, R. L. Pykhov, and V. V. Smirnov, “Laser-excited fluorescence spectrometric system for tissue diagnostics,” Proc. SPIE 2328, 196 (1994).
[CrossRef]

K. A. Horvath, K. T. Schomacker, C. C. Lee, and L. H. Cohn, “Intraoperative myocardial ischemia detection with laser-induced fluorescence,” J. Thorac. Cardiovasc. Surg. 107, 220 (1994).

Alber, M.

O. Kim, J. McMurdy, C. Lines, S. Duffy, G. Crawford, and M. Alber, “Reflectance spectrometry of normal and bruised human skins: experiments and modeling,” Physiol. Meas. 33, 159 (2012).
[CrossRef]

Andries, T.

R. Graaff, R. Meerwaldt, H. Lutgers, R. Baptist, E. de Jong, T. Andries, L. Smit, and G. Rakhorst, “Instrumentation for the measurement of autofluorescence in human skin,” Proc. SPIE 5692, 111 (2005).
[CrossRef]

Atkinson, E. N.

S. K. Chang, Y. N. Mirabal, E. N. Atkinson, D. Cox, A. Malpica, M. Follen, and R. Richards-Kortum, “Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer,” J. Biomed. Opt. 10, 024031 (2005).
[CrossRef]

Bae, S. J.

K. Uk, G. V. Papayan, D. A. Makarov, S. Y. Lee, and S. J. Bae, “Illuminator for photodynamic therapy and fluorescence diagnosis with lightguide output of the radiation,” Opt. Zh. 75, No. 12, 16 (2008) [J. Opt. Technol.75, 772 (2008)].
[CrossRef]

Bae, S.-J.

K. Uk, G. V. Papayan, S.-J. Bae, V. B. Berezin, and S. Kim, “Fluorescence video dermatoscope,” Opt. Zh. 75, No. 1, 32 (2008) [J. Opt. Technol.75, 24 (2008)].
[CrossRef]

Bakker, S. J.

J. W. Hartog, S. Gross, L. H. Oterdoom, R. M. van Ree, A. P. de Vries, A. J. Smit, J. P. Schouten, P. P. Nawroth, R. O. Gans, W. J. van Son, A. Bierhaus, and S. J. Bakker, “Skin autofluorescence is an independent predictor of graft loss in renal transplant recipients,” Transplantation 87, 1069 (2009).
[CrossRef]

Baptist, R.

R. Graaff, R. Meerwaldt, H. Lutgers, R. Baptist, E. de Jong, T. Andries, L. Smit, and G. Rakhorst, “Instrumentation for the measurement of autofluorescence in human skin,” Proc. SPIE 5692, 111 (2005).
[CrossRef]

Barsky, I. Ya.

G. V. Papayan and I. Ya. Barsky, “Contact luminescence spectrophotometry for biomedical studies,” Proc. SPIE 4515, 125 (2001).
[CrossRef]

Baynes, J.

Baynes, J. W.

R. Meervaldt, H. L. Lutgers, T. P. Links, R. Graaff, J. W. Baynes, R. Gans, and A. J. Smit, “Skin AF is a strong predictor of cardiac mortality in diabetes,” Diabetes Care 30, 107 (2007).
[CrossRef]

R. Meerwaldt, T. P. Links, R. Graaff, K. Hoogenberg, J. D. Lefrandt, J. W. Baynes, R. O. Gans, and A. J. Smit, “Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy,” Diabetologia 48, 1637 (2005).
[CrossRef]

R. Meerwaldt, J. W. Hartog, R. Graaff, R. J. Huisman, T. P. Links, N. C. den Hollander, S. R. Thorpe, J. W. Baynes, G. Navis, R. O. Gans, and A. J. Smit, “Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products mortality in hemodialysis patients,” J. Am. Soc. Nephrol. 16, 3687 (2005).
[CrossRef]

Beckman, J. A.

A. Goldin, J. A. Beckman, A. M. Schmidt, and M. A. Creager, “Advanced glycation end-products sparking the development of diabetic vascular injury,” Circulation 114, 597 (2006).
[CrossRef]

Beránek, M.

M. Beránek, D. Nováková, P. Rozsíval, J. Drsata, and V. Palicka, “Glycation and advanced glycation end-products in laboratory experiments in vivo and in vitro,” Acta Medica (Hradec Kralove) 49, No. 1, 35 (2006).

Berezin, V. B.

K. Uk, G. V. Papayan, S.-J. Bae, V. B. Berezin, and S. Kim, “Fluorescence video dermatoscope,” Opt. Zh. 75, No. 1, 32 (2008) [J. Opt. Technol.75, 24 (2008)].
[CrossRef]

Bierhaus, A.

J. W. Hartog, S. Gross, L. H. Oterdoom, R. M. van Ree, A. P. de Vries, A. J. Smit, J. P. Schouten, P. P. Nawroth, R. O. Gans, W. J. van Son, A. Bierhaus, and S. J. Bakker, “Skin autofluorescence is an independent predictor of graft loss in renal transplant recipients,” Transplantation 87, 1069 (2009).
[CrossRef]

Bilo, H. J.

H. L. Lutgers, R. Graaff, T. P. Links, L. J. Ubink-Veltmaat, H. J. Bilo, R. O. Gans, and A. J. Smit, “Skin autofluorescence as a noninvasive marker of vascular damage in patients with type-2 diabetes,” Diabetes Care 29, 2654 (2006).
[CrossRef]

Bradley, R. S.

R. S. Bradley and M. S. Thorniley, “A review of attenuation correction techniques for tissue fluorescence,” J. R. Soc., Interface 3, 1 (2006).
[CrossRef]

Brookner, C.

M. Mitchell, S. B. Cantor, C. Brookner, U. Utzinger, and D. Schottenfeld, “Fluorescence spectroscopy for diagnosis of squamous intraepithelial lesions of the cervix,” Obstet. Gynecol. 93, 462 (1999).
[CrossRef]

Brown, C. D.

M. N. Ediger, R. D. Johnson, E. L. Hull, and C. D. Brown, “Determination of a measure of a glycation end-product or disease state using tissue fluorescence,” U.S. Patent No. 8078243 (2011).

Cantor, S. B.

M. Mitchell, S. B. Cantor, C. Brookner, U. Utzinger, and D. Schottenfeld, “Fluorescence spectroscopy for diagnosis of squamous intraepithelial lesions of the cervix,” Obstet. Gynecol. 93, 462 (1999).
[CrossRef]

Chang, S. K.

S. K. Chang, Y. N. Mirabal, E. N. Atkinson, D. Cox, A. Malpica, M. Follen, and R. Richards-Kortum, “Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer,” J. Biomed. Opt. 10, 024031 (2005).
[CrossRef]

Chunmao, H.

Cohn, L. H.

K. A. Horvath, K. T. Schomacker, C. C. Lee, and L. H. Cohn, “Intraoperative myocardial ischemia detection with laser-induced fluorescence,” J. Thorac. Cardiovasc. Surg. 107, 220 (1994).

Cox, D.

S. K. Chang, Y. N. Mirabal, E. N. Atkinson, D. Cox, A. Malpica, M. Follen, and R. Richards-Kortum, “Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer,” J. Biomed. Opt. 10, 024031 (2005).
[CrossRef]

Crawford, G.

O. Kim, J. McMurdy, C. Lines, S. Duffy, G. Crawford, and M. Alber, “Reflectance spectrometry of normal and bruised human skins: experiments and modeling,” Physiol. Meas. 33, 159 (2012).
[CrossRef]

Creager, M. A.

A. Goldin, J. A. Beckman, A. M. Schmidt, and M. A. Creager, “Advanced glycation end-products sparking the development of diabetic vascular injury,” Circulation 114, 597 (2006).
[CrossRef]

de Jong, E.

R. Graaff, R. Meerwaldt, H. Lutgers, R. Baptist, E. de Jong, T. Andries, L. Smit, and G. Rakhorst, “Instrumentation for the measurement of autofluorescence in human skin,” Proc. SPIE 5692, 111 (2005).
[CrossRef]

de Vries, A. P.

J. W. Hartog, S. Gross, L. H. Oterdoom, R. M. van Ree, A. P. de Vries, A. J. Smit, J. P. Schouten, P. P. Nawroth, R. O. Gans, W. J. van Son, A. Bierhaus, and S. J. Bakker, “Skin autofluorescence is an independent predictor of graft loss in renal transplant recipients,” Transplantation 87, 1069 (2009).
[CrossRef]

Deemer, E.

den Hollander, N. C.

R. Meerwaldt, J. W. Hartog, R. Graaff, R. J. Huisman, T. P. Links, N. C. den Hollander, S. R. Thorpe, J. W. Baynes, G. Navis, R. O. Gans, and A. J. Smit, “Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products mortality in hemodialysis patients,” J. Am. Soc. Nephrol. 16, 3687 (2005).
[CrossRef]

Drsata, J.

M. Beránek, D. Nováková, P. Rozsíval, J. Drsata, and V. Palicka, “Glycation and advanced glycation end-products in laboratory experiments in vivo and in vitro,” Acta Medica (Hradec Kralove) 49, No. 1, 35 (2006).

Duffy, S.

O. Kim, J. McMurdy, C. Lines, S. Duffy, G. Crawford, and M. Alber, “Reflectance spectrometry of normal and bruised human skins: experiments and modeling,” Physiol. Meas. 33, 159 (2012).
[CrossRef]

Durkin, A.

Ediger, M.

Ediger, M. N.

J. D. Maynard, M. Rohrscheib, J. F. Way, C. M. Nguyen, and M. N. Ediger, “Noninvasive type-2 diabetes screening, superior sensitivity to fasting plasma glucose and A1C,” Diabetes Care 30, 1120 (2007).
[CrossRef]

M. N. Ediger, R. D. Johnson, E. L. Hull, and C. D. Brown, “Determination of a measure of a glycation end-product or disease state using tissue fluorescence,” U.S. Patent No. 8078243 (2011).

Esayan, A. M.

N. N. Petrishchev, G. V. Papayan, A. M. Esayan, E. N. Grineva, and K. Uk, “Study of glycation end-products by fluorescence spectroscopy of the skin. Photodynamic therapy and fluorescence diagnosis,” in Collection of Scientific Works, ed. N. N. Petrishcheva (Lan’, St. Petersburg, 2011), pp. 222–230.

Fan, J.

Follen, M.

S. K. Chang, Y. N. Mirabal, E. N. Atkinson, D. Cox, A. Malpica, M. Follen, and R. Richards-Kortum, “Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer,” J. Biomed. Opt. 10, 024031 (2005).
[CrossRef]

Fuchs, H.

Gans, R.

R. Meervaldt, H. L. Lutgers, T. P. Links, R. Graaff, J. W. Baynes, R. Gans, and A. J. Smit, “Skin AF is a strong predictor of cardiac mortality in diabetes,” Diabetes Care 30, 107 (2007).
[CrossRef]

Gans, R. O.

J. W. Hartog, S. Gross, L. H. Oterdoom, R. M. van Ree, A. P. de Vries, A. J. Smit, J. P. Schouten, P. P. Nawroth, R. O. Gans, W. J. van Son, A. Bierhaus, and S. J. Bakker, “Skin autofluorescence is an independent predictor of graft loss in renal transplant recipients,” Transplantation 87, 1069 (2009).
[CrossRef]

H. L. Lutgers, R. Graaff, T. P. Links, L. J. Ubink-Veltmaat, H. J. Bilo, R. O. Gans, and A. J. Smit, “Skin autofluorescence as a noninvasive marker of vascular damage in patients with type-2 diabetes,” Diabetes Care 29, 2654 (2006).
[CrossRef]

R. Meerwaldt, J. W. Hartog, R. Graaff, R. J. Huisman, T. P. Links, N. C. den Hollander, S. R. Thorpe, J. W. Baynes, G. Navis, R. O. Gans, and A. J. Smit, “Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products mortality in hemodialysis patients,” J. Am. Soc. Nephrol. 16, 3687 (2005).
[CrossRef]

R. Meerwaldt, T. P. Links, R. Graaff, K. Hoogenberg, J. D. Lefrandt, J. W. Baynes, R. O. Gans, and A. J. Smit, “Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy,” Diabetologia 48, 1637 (2005).
[CrossRef]

Gillenwater, A.

Goldin, A.

A. Goldin, J. A. Beckman, A. M. Schmidt, and M. A. Creager, “Advanced glycation end-products sparking the development of diabetic vascular injury,” Circulation 114, 597 (2006).
[CrossRef]

Graaff, R.

M. Koetsier, E. Nur, H. Chunmao, H. L. Lutgers, T. P. Links, A. J. Smit, G. Rakhorst, and R. Graaff, “Skin-color-independent assessment of aging using skin autofluorescence,” Opt. Express 18, 14416 (2010).
[CrossRef]

R. Meervaldt, H. L. Lutgers, T. P. Links, R. Graaff, J. W. Baynes, R. Gans, and A. J. Smit, “Skin AF is a strong predictor of cardiac mortality in diabetes,” Diabetes Care 30, 107 (2007).
[CrossRef]

H. L. Lutgers, R. Graaff, T. P. Links, L. J. Ubink-Veltmaat, H. J. Bilo, R. O. Gans, and A. J. Smit, “Skin autofluorescence as a noninvasive marker of vascular damage in patients with type-2 diabetes,” Diabetes Care 29, 2654 (2006).
[CrossRef]

R. Graaff, R. Meerwaldt, H. Lutgers, R. Baptist, E. de Jong, T. Andries, L. Smit, and G. Rakhorst, “Instrumentation for the measurement of autofluorescence in human skin,” Proc. SPIE 5692, 111 (2005).
[CrossRef]

R. Meerwaldt, T. P. Links, R. Graaff, K. Hoogenberg, J. D. Lefrandt, J. W. Baynes, R. O. Gans, and A. J. Smit, “Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy,” Diabetologia 48, 1637 (2005).
[CrossRef]

R. Meerwaldt, J. W. Hartog, R. Graaff, R. J. Huisman, T. P. Links, N. C. den Hollander, S. R. Thorpe, J. W. Baynes, G. Navis, R. O. Gans, and A. J. Smit, “Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products mortality in hemodialysis patients,” J. Am. Soc. Nephrol. 16, 3687 (2005).
[CrossRef]

Grineva, E. N.

N. N. Petrishchev, G. V. Papayan, A. M. Esayan, E. N. Grineva, and K. Uk, “Study of glycation end-products by fluorescence spectroscopy of the skin. Photodynamic therapy and fluorescence diagnosis,” in Collection of Scientific Works, ed. N. N. Petrishcheva (Lan’, St. Petersburg, 2011), pp. 222–230.

Gross, S.

J. W. Hartog, S. Gross, L. H. Oterdoom, R. M. van Ree, A. P. de Vries, A. J. Smit, J. P. Schouten, P. P. Nawroth, R. O. Gans, W. J. van Son, A. Bierhaus, and S. J. Bakker, “Skin autofluorescence is an independent predictor of graft loss in renal transplant recipients,” Transplantation 87, 1069 (2009).
[CrossRef]

Hartog, J. W.

J. W. Hartog, S. Gross, L. H. Oterdoom, R. M. van Ree, A. P. de Vries, A. J. Smit, J. P. Schouten, P. P. Nawroth, R. O. Gans, W. J. van Son, A. Bierhaus, and S. J. Bakker, “Skin autofluorescence is an independent predictor of graft loss in renal transplant recipients,” Transplantation 87, 1069 (2009).
[CrossRef]

R. Meerwaldt, J. W. Hartog, R. Graaff, R. J. Huisman, T. P. Links, N. C. den Hollander, S. R. Thorpe, J. W. Baynes, G. Navis, R. O. Gans, and A. J. Smit, “Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products mortality in hemodialysis patients,” J. Am. Soc. Nephrol. 16, 3687 (2005).
[CrossRef]

Hoogenberg, K.

R. Meerwaldt, T. P. Links, R. Graaff, K. Hoogenberg, J. D. Lefrandt, J. W. Baynes, R. O. Gans, and A. J. Smit, “Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy,” Diabetologia 48, 1637 (2005).
[CrossRef]

Horvath, K. A.

K. A. Horvath, K. T. Schomacker, C. C. Lee, and L. H. Cohn, “Intraoperative myocardial ischemia detection with laser-induced fluorescence,” J. Thorac. Cardiovasc. Surg. 107, 220 (1994).

Huisman, R. J.

R. Meerwaldt, J. W. Hartog, R. Graaff, R. J. Huisman, T. P. Links, N. C. den Hollander, S. R. Thorpe, J. W. Baynes, G. Navis, R. O. Gans, and A. J. Smit, “Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products mortality in hemodialysis patients,” J. Am. Soc. Nephrol. 16, 3687 (2005).
[CrossRef]

Hull, E.

Hull, E. L.

M. N. Ediger, R. D. Johnson, E. L. Hull, and C. D. Brown, “Determination of a measure of a glycation end-product or disease state using tissue fluorescence,” U.S. Patent No. 8078243 (2011).

Jacob, R.

Johnson, R. D.

M. N. Ediger, R. D. Johnson, E. L. Hull, and C. D. Brown, “Determination of a measure of a glycation end-product or disease state using tissue fluorescence,” U.S. Patent No. 8078243 (2011).

Kemp, B.

Kim, O.

O. Kim, J. McMurdy, C. Lines, S. Duffy, G. Crawford, and M. Alber, “Reflectance spectrometry of normal and bruised human skins: experiments and modeling,” Physiol. Meas. 33, 159 (2012).
[CrossRef]

Kim, S.

K. Uk, G. V. Papayan, S.-J. Bae, V. B. Berezin, and S. Kim, “Fluorescence video dermatoscope,” Opt. Zh. 75, No. 1, 32 (2008) [J. Opt. Technol.75, 24 (2008)].
[CrossRef]

Koehler, G.

A. Shahzad and G. Koehler, “Fluorescence spectroscopy: an emerging excellent diagnostic tool in medical sciences,” Internet J. Med. Technol. 5, No. 1 (2010).

Koetsier, M.

Konov, V. I.

V. B. Loschenov, V. I. Konov, and A. M. Prokhorov, “Photodynamic therapy and fluorescence diagnostics,” Laser Phys. 10, 1188 (2000).

Kozlov, D. N.

N. N. Zharkova, D. N. Kozlov, Yu. N. Polivanov, R. L. Pykhov, and V. V. Smirnov, “Laser-excited fluorescence spectrometric system for tissue diagnostics,” Proc. SPIE 2328, 196 (1994).
[CrossRef]

Lee, C. C.

K. A. Horvath, K. T. Schomacker, C. C. Lee, and L. H. Cohn, “Intraoperative myocardial ischemia detection with laser-induced fluorescence,” J. Thorac. Cardiovasc. Surg. 107, 220 (1994).

Lee, S. Y.

K. Uk, G. V. Papayan, D. A. Makarov, S. Y. Lee, and S. J. Bae, “Illuminator for photodynamic therapy and fluorescence diagnosis with lightguide output of the radiation,” Opt. Zh. 75, No. 12, 16 (2008) [J. Opt. Technol.75, 772 (2008)].
[CrossRef]

Lefrandt, J. D.

R. Meerwaldt, T. P. Links, R. Graaff, K. Hoogenberg, J. D. Lefrandt, J. W. Baynes, R. O. Gans, and A. J. Smit, “Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy,” Diabetologia 48, 1637 (2005).
[CrossRef]

Lines, C.

O. Kim, J. McMurdy, C. Lines, S. Duffy, G. Crawford, and M. Alber, “Reflectance spectrometry of normal and bruised human skins: experiments and modeling,” Physiol. Meas. 33, 159 (2012).
[CrossRef]

Links, T. P.

M. Koetsier, E. Nur, H. Chunmao, H. L. Lutgers, T. P. Links, A. J. Smit, G. Rakhorst, and R. Graaff, “Skin-color-independent assessment of aging using skin autofluorescence,” Opt. Express 18, 14416 (2010).
[CrossRef]

R. Meervaldt, H. L. Lutgers, T. P. Links, R. Graaff, J. W. Baynes, R. Gans, and A. J. Smit, “Skin AF is a strong predictor of cardiac mortality in diabetes,” Diabetes Care 30, 107 (2007).
[CrossRef]

H. L. Lutgers, R. Graaff, T. P. Links, L. J. Ubink-Veltmaat, H. J. Bilo, R. O. Gans, and A. J. Smit, “Skin autofluorescence as a noninvasive marker of vascular damage in patients with type-2 diabetes,” Diabetes Care 29, 2654 (2006).
[CrossRef]

R. Meerwaldt, T. P. Links, R. Graaff, K. Hoogenberg, J. D. Lefrandt, J. W. Baynes, R. O. Gans, and A. J. Smit, “Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy,” Diabetologia 48, 1637 (2005).
[CrossRef]

R. Meerwaldt, J. W. Hartog, R. Graaff, R. J. Huisman, T. P. Links, N. C. den Hollander, S. R. Thorpe, J. W. Baynes, G. Navis, R. O. Gans, and A. J. Smit, “Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products mortality in hemodialysis patients,” J. Am. Soc. Nephrol. 16, 3687 (2005).
[CrossRef]

Loschenov, V. B.

V. B. Loschenov, V. I. Konov, and A. M. Prokhorov, “Photodynamic therapy and fluorescence diagnostics,” Laser Phys. 10, 1188 (2000).

Lutgers, H.

R. Graaff, R. Meerwaldt, H. Lutgers, R. Baptist, E. de Jong, T. Andries, L. Smit, and G. Rakhorst, “Instrumentation for the measurement of autofluorescence in human skin,” Proc. SPIE 5692, 111 (2005).
[CrossRef]

Lutgers, H. L.

M. Koetsier, E. Nur, H. Chunmao, H. L. Lutgers, T. P. Links, A. J. Smit, G. Rakhorst, and R. Graaff, “Skin-color-independent assessment of aging using skin autofluorescence,” Opt. Express 18, 14416 (2010).
[CrossRef]

R. Meervaldt, H. L. Lutgers, T. P. Links, R. Graaff, J. W. Baynes, R. Gans, and A. J. Smit, “Skin AF is a strong predictor of cardiac mortality in diabetes,” Diabetes Care 30, 107 (2007).
[CrossRef]

H. L. Lutgers, R. Graaff, T. P. Links, L. J. Ubink-Veltmaat, H. J. Bilo, R. O. Gans, and A. J. Smit, “Skin autofluorescence as a noninvasive marker of vascular damage in patients with type-2 diabetes,” Diabetes Care 29, 2654 (2006).
[CrossRef]

Mahadevan, A.

N. Ramanujam, M. F. Mitchell, A. Mahadevan, S. Thomsen, E. Silva, and R. Richards-Kortum, “Fluorescence spectroscopy: a diagnostic tool for cervical intraepithelial neoplasia,” Gynecol. Oncol. 52, 31 (1994).
[CrossRef]

Makarov, D. A.

K. Uk, G. V. Papayan, D. A. Makarov, S. Y. Lee, and S. J. Bae, “Illuminator for photodynamic therapy and fluorescence diagnosis with lightguide output of the radiation,” Opt. Zh. 75, No. 12, 16 (2008) [J. Opt. Technol.75, 772 (2008)].
[CrossRef]

Malpica, A.

S. K. Chang, Y. N. Mirabal, E. N. Atkinson, D. Cox, A. Malpica, M. Follen, and R. Richards-Kortum, “Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer,” J. Biomed. Opt. 10, 024031 (2005).
[CrossRef]

Mayevsky, A.

A. Mayevsky and G. G. Rogatsky, “Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studies,” Am. J. Physiol. Lung Cell. Mol. Physiol. 292, 615 (2007).

Maynard, J. D.

J. D. Maynard, M. Rohrscheib, J. F. Way, C. M. Nguyen, and M. N. Ediger, “Noninvasive type-2 diabetes screening, superior sensitivity to fasting plasma glucose and A1C,” Diabetes Care 30, 1120 (2007).
[CrossRef]

McMurdy, J.

O. Kim, J. McMurdy, C. Lines, S. Duffy, G. Crawford, and M. Alber, “Reflectance spectrometry of normal and bruised human skins: experiments and modeling,” Physiol. Meas. 33, 159 (2012).
[CrossRef]

Meervaldt, R.

R. Meervaldt, H. L. Lutgers, T. P. Links, R. Graaff, J. W. Baynes, R. Gans, and A. J. Smit, “Skin AF is a strong predictor of cardiac mortality in diabetes,” Diabetes Care 30, 107 (2007).
[CrossRef]

Meerwaldt, R.

R. Graaff, R. Meerwaldt, H. Lutgers, R. Baptist, E. de Jong, T. Andries, L. Smit, and G. Rakhorst, “Instrumentation for the measurement of autofluorescence in human skin,” Proc. SPIE 5692, 111 (2005).
[CrossRef]

R. Meerwaldt, J. W. Hartog, R. Graaff, R. J. Huisman, T. P. Links, N. C. den Hollander, S. R. Thorpe, J. W. Baynes, G. Navis, R. O. Gans, and A. J. Smit, “Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products mortality in hemodialysis patients,” J. Am. Soc. Nephrol. 16, 3687 (2005).
[CrossRef]

R. Meerwaldt, T. P. Links, R. Graaff, K. Hoogenberg, J. D. Lefrandt, J. W. Baynes, R. O. Gans, and A. J. Smit, “Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy,” Diabetologia 48, 1637 (2005).
[CrossRef]

Mirabal, Y. N.

S. K. Chang, Y. N. Mirabal, E. N. Atkinson, D. Cox, A. Malpica, M. Follen, and R. Richards-Kortum, “Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer,” J. Biomed. Opt. 10, 024031 (2005).
[CrossRef]

Mitchell, M.

M. Mitchell, S. B. Cantor, C. Brookner, U. Utzinger, and D. Schottenfeld, “Fluorescence spectroscopy for diagnosis of squamous intraepithelial lesions of the cervix,” Obstet. Gynecol. 93, 462 (1999).
[CrossRef]

Mitchell, M. F.

N. Ramanujam, M. F. Mitchell, A. Mahadevan, S. Thomsen, E. Silva, and R. Richards-Kortum, “Fluorescence spectroscopy: a diagnostic tool for cervical intraepithelial neoplasia,” Gynecol. Oncol. 52, 31 (1994).
[CrossRef]

Navis, G.

R. Meerwaldt, J. W. Hartog, R. Graaff, R. J. Huisman, T. P. Links, N. C. den Hollander, S. R. Thorpe, J. W. Baynes, G. Navis, R. O. Gans, and A. J. Smit, “Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products mortality in hemodialysis patients,” J. Am. Soc. Nephrol. 16, 3687 (2005).
[CrossRef]

Nawroth, P. P.

J. W. Hartog, S. Gross, L. H. Oterdoom, R. M. van Ree, A. P. de Vries, A. J. Smit, J. P. Schouten, P. P. Nawroth, R. O. Gans, W. J. van Son, A. Bierhaus, and S. J. Bakker, “Skin autofluorescence is an independent predictor of graft loss in renal transplant recipients,” Transplantation 87, 1069 (2009).
[CrossRef]

Nguyen, C. M.

J. D. Maynard, M. Rohrscheib, J. F. Way, C. M. Nguyen, and M. N. Ediger, “Noninvasive type-2 diabetes screening, superior sensitivity to fasting plasma glucose and A1C,” Diabetes Care 30, 1120 (2007).
[CrossRef]

Nováková, D.

M. Beránek, D. Nováková, P. Rozsíval, J. Drsata, and V. Palicka, “Glycation and advanced glycation end-products in laboratory experiments in vivo and in vitro,” Acta Medica (Hradec Kralove) 49, No. 1, 35 (2006).

Nur, E.

Oterdoom, L. H.

J. W. Hartog, S. Gross, L. H. Oterdoom, R. M. van Ree, A. P. de Vries, A. J. Smit, J. P. Schouten, P. P. Nawroth, R. O. Gans, W. J. van Son, A. Bierhaus, and S. J. Bakker, “Skin autofluorescence is an independent predictor of graft loss in renal transplant recipients,” Transplantation 87, 1069 (2009).
[CrossRef]

Palicka, V.

M. Beránek, D. Nováková, P. Rozsíval, J. Drsata, and V. Palicka, “Glycation and advanced glycation end-products in laboratory experiments in vivo and in vitro,” Acta Medica (Hradec Kralove) 49, No. 1, 35 (2006).

Papayan, G. V.

K. Uk, G. V. Papayan, S.-J. Bae, V. B. Berezin, and S. Kim, “Fluorescence video dermatoscope,” Opt. Zh. 75, No. 1, 32 (2008) [J. Opt. Technol.75, 24 (2008)].
[CrossRef]

K. Uk, G. V. Papayan, D. A. Makarov, S. Y. Lee, and S. J. Bae, “Illuminator for photodynamic therapy and fluorescence diagnosis with lightguide output of the radiation,” Opt. Zh. 75, No. 12, 16 (2008) [J. Opt. Technol.75, 772 (2008)].
[CrossRef]

G. V. Papayan and I. Ya. Barsky, “Contact luminescence spectrophotometry for biomedical studies,” Proc. SPIE 4515, 125 (2001).
[CrossRef]

N. N. Petrishchev, G. V. Papayan, A. M. Esayan, E. N. Grineva, and K. Uk, “Study of glycation end-products by fluorescence spectroscopy of the skin. Photodynamic therapy and fluorescence diagnosis,” in Collection of Scientific Works, ed. N. N. Petrishcheva (Lan’, St. Petersburg, 2011), pp. 222–230.

N. N. Petrishchev and G. V. Papayan, “Autofluorescence organoscopy. Photodynamic therapy and fluorescence diagnosis,” in Collection of Scientific Works, ed. N. N. Petrishcheva (Lan’, St. Petersburg, 2011), pp. 261–273.

Petrishchev, N. N.

N. N. Petrishchev and G. V. Papayan, “Autofluorescence organoscopy. Photodynamic therapy and fluorescence diagnosis,” in Collection of Scientific Works, ed. N. N. Petrishcheva (Lan’, St. Petersburg, 2011), pp. 261–273.

N. N. Petrishchev, G. V. Papayan, A. M. Esayan, E. N. Grineva, and K. Uk, “Study of glycation end-products by fluorescence spectroscopy of the skin. Photodynamic therapy and fluorescence diagnosis,” in Collection of Scientific Works, ed. N. N. Petrishcheva (Lan’, St. Petersburg, 2011), pp. 222–230.

Polivanov, Yu. N.

N. N. Zharkova, D. N. Kozlov, Yu. N. Polivanov, R. L. Pykhov, and V. V. Smirnov, “Laser-excited fluorescence spectrometric system for tissue diagnostics,” Proc. SPIE 2328, 196 (1994).
[CrossRef]

Prokhorov, A. M.

V. B. Loschenov, V. I. Konov, and A. M. Prokhorov, “Photodynamic therapy and fluorescence diagnostics,” Laser Phys. 10, 1188 (2000).

Pykhov, R. L.

N. N. Zharkova, D. N. Kozlov, Yu. N. Polivanov, R. L. Pykhov, and V. V. Smirnov, “Laser-excited fluorescence spectrometric system for tissue diagnostics,” Proc. SPIE 2328, 196 (1994).
[CrossRef]

Rakhorst, G.

M. Koetsier, E. Nur, H. Chunmao, H. L. Lutgers, T. P. Links, A. J. Smit, G. Rakhorst, and R. Graaff, “Skin-color-independent assessment of aging using skin autofluorescence,” Opt. Express 18, 14416 (2010).
[CrossRef]

R. Graaff, R. Meerwaldt, H. Lutgers, R. Baptist, E. de Jong, T. Andries, L. Smit, and G. Rakhorst, “Instrumentation for the measurement of autofluorescence in human skin,” Proc. SPIE 5692, 111 (2005).
[CrossRef]

Ramanujam, N.

N. Ramanujam, M. F. Mitchell, A. Mahadevan, S. Thomsen, E. Silva, and R. Richards-Kortum, “Fluorescence spectroscopy: a diagnostic tool for cervical intraepithelial neoplasia,” Gynecol. Oncol. 52, 31 (1994).
[CrossRef]

Richards-Kortum, R.

S. K. Chang, Y. N. Mirabal, E. N. Atkinson, D. Cox, A. Malpica, M. Follen, and R. Richards-Kortum, “Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer,” J. Biomed. Opt. 10, 024031 (2005).
[CrossRef]

A. Zuluaga, U. Utzinger, A. Durkin, H. Fuchs, A. Gillenwater, R. Jacob, B. Kemp, J. Fan, and R. Richards-Kortum, “Fluorescence excitation-emission matrices of human tissue: a system for in vivo measurement and data analysis,” Appl. Spectrosc. 53, 302 (1999).
[CrossRef]

R. Richards-Kortum and E. Sevick-Muraca, “Quantitative optical spectroscopy for tissue diagnosis,” Annu. Rev. Phys. Chem. 47, 555(1996).
[CrossRef]

N. Ramanujam, M. F. Mitchell, A. Mahadevan, S. Thomsen, E. Silva, and R. Richards-Kortum, “Fluorescence spectroscopy: a diagnostic tool for cervical intraepithelial neoplasia,” Gynecol. Oncol. 52, 31 (1994).
[CrossRef]

Rogatsky, G. G.

A. Mayevsky and G. G. Rogatsky, “Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studies,” Am. J. Physiol. Lung Cell. Mol. Physiol. 292, 615 (2007).

Rohrscheib, M.

J. D. Maynard, M. Rohrscheib, J. F. Way, C. M. Nguyen, and M. N. Ediger, “Noninvasive type-2 diabetes screening, superior sensitivity to fasting plasma glucose and A1C,” Diabetes Care 30, 1120 (2007).
[CrossRef]

Rozsíval, P.

M. Beránek, D. Nováková, P. Rozsíval, J. Drsata, and V. Palicka, “Glycation and advanced glycation end-products in laboratory experiments in vivo and in vitro,” Acta Medica (Hradec Kralove) 49, No. 1, 35 (2006).

Schmidt, A. M.

A. Goldin, J. A. Beckman, A. M. Schmidt, and M. A. Creager, “Advanced glycation end-products sparking the development of diabetic vascular injury,” Circulation 114, 597 (2006).
[CrossRef]

Schomacker, K. T.

K. A. Horvath, K. T. Schomacker, C. C. Lee, and L. H. Cohn, “Intraoperative myocardial ischemia detection with laser-induced fluorescence,” J. Thorac. Cardiovasc. Surg. 107, 220 (1994).

Schottenfeld, D.

M. Mitchell, S. B. Cantor, C. Brookner, U. Utzinger, and D. Schottenfeld, “Fluorescence spectroscopy for diagnosis of squamous intraepithelial lesions of the cervix,” Obstet. Gynecol. 93, 462 (1999).
[CrossRef]

Schouten, J. P.

J. W. Hartog, S. Gross, L. H. Oterdoom, R. M. van Ree, A. P. de Vries, A. J. Smit, J. P. Schouten, P. P. Nawroth, R. O. Gans, W. J. van Son, A. Bierhaus, and S. J. Bakker, “Skin autofluorescence is an independent predictor of graft loss in renal transplant recipients,” Transplantation 87, 1069 (2009).
[CrossRef]

Sevick-Muraca, E.

R. Richards-Kortum and E. Sevick-Muraca, “Quantitative optical spectroscopy for tissue diagnosis,” Annu. Rev. Phys. Chem. 47, 555(1996).
[CrossRef]

Shahzad, A.

A. Shahzad and G. Koehler, “Fluorescence spectroscopy: an emerging excellent diagnostic tool in medical sciences,” Internet J. Med. Technol. 5, No. 1 (2010).

Silva, E.

N. Ramanujam, M. F. Mitchell, A. Mahadevan, S. Thomsen, E. Silva, and R. Richards-Kortum, “Fluorescence spectroscopy: a diagnostic tool for cervical intraepithelial neoplasia,” Gynecol. Oncol. 52, 31 (1994).
[CrossRef]

Smirnov, V. V.

N. N. Zharkova, D. N. Kozlov, Yu. N. Polivanov, R. L. Pykhov, and V. V. Smirnov, “Laser-excited fluorescence spectrometric system for tissue diagnostics,” Proc. SPIE 2328, 196 (1994).
[CrossRef]

Smit, A. J.

M. Koetsier, E. Nur, H. Chunmao, H. L. Lutgers, T. P. Links, A. J. Smit, G. Rakhorst, and R. Graaff, “Skin-color-independent assessment of aging using skin autofluorescence,” Opt. Express 18, 14416 (2010).
[CrossRef]

J. W. Hartog, S. Gross, L. H. Oterdoom, R. M. van Ree, A. P. de Vries, A. J. Smit, J. P. Schouten, P. P. Nawroth, R. O. Gans, W. J. van Son, A. Bierhaus, and S. J. Bakker, “Skin autofluorescence is an independent predictor of graft loss in renal transplant recipients,” Transplantation 87, 1069 (2009).
[CrossRef]

R. Meervaldt, H. L. Lutgers, T. P. Links, R. Graaff, J. W. Baynes, R. Gans, and A. J. Smit, “Skin AF is a strong predictor of cardiac mortality in diabetes,” Diabetes Care 30, 107 (2007).
[CrossRef]

H. L. Lutgers, R. Graaff, T. P. Links, L. J. Ubink-Veltmaat, H. J. Bilo, R. O. Gans, and A. J. Smit, “Skin autofluorescence as a noninvasive marker of vascular damage in patients with type-2 diabetes,” Diabetes Care 29, 2654 (2006).
[CrossRef]

R. Meerwaldt, T. P. Links, R. Graaff, K. Hoogenberg, J. D. Lefrandt, J. W. Baynes, R. O. Gans, and A. J. Smit, “Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy,” Diabetologia 48, 1637 (2005).
[CrossRef]

R. Meerwaldt, J. W. Hartog, R. Graaff, R. J. Huisman, T. P. Links, N. C. den Hollander, S. R. Thorpe, J. W. Baynes, G. Navis, R. O. Gans, and A. J. Smit, “Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products mortality in hemodialysis patients,” J. Am. Soc. Nephrol. 16, 3687 (2005).
[CrossRef]

Smit, L.

R. Graaff, R. Meerwaldt, H. Lutgers, R. Baptist, E. de Jong, T. Andries, L. Smit, and G. Rakhorst, “Instrumentation for the measurement of autofluorescence in human skin,” Proc. SPIE 5692, 111 (2005).
[CrossRef]

Stroman, M.

Thomsen, S.

N. Ramanujam, M. F. Mitchell, A. Mahadevan, S. Thomsen, E. Silva, and R. Richards-Kortum, “Fluorescence spectroscopy: a diagnostic tool for cervical intraepithelial neoplasia,” Gynecol. Oncol. 52, 31 (1994).
[CrossRef]

Thorniley, M. S.

R. S. Bradley and M. S. Thorniley, “A review of attenuation correction techniques for tissue fluorescence,” J. R. Soc., Interface 3, 1 (2006).
[CrossRef]

Thorpe, S. R.

R. Meerwaldt, J. W. Hartog, R. Graaff, R. J. Huisman, T. P. Links, N. C. den Hollander, S. R. Thorpe, J. W. Baynes, G. Navis, R. O. Gans, and A. J. Smit, “Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products mortality in hemodialysis patients,” J. Am. Soc. Nephrol. 16, 3687 (2005).
[CrossRef]

Ubink-Veltmaat, L. J.

H. L. Lutgers, R. Graaff, T. P. Links, L. J. Ubink-Veltmaat, H. J. Bilo, R. O. Gans, and A. J. Smit, “Skin autofluorescence as a noninvasive marker of vascular damage in patients with type-2 diabetes,” Diabetes Care 29, 2654 (2006).
[CrossRef]

Uk, K.

K. Uk, G. V. Papayan, D. A. Makarov, S. Y. Lee, and S. J. Bae, “Illuminator for photodynamic therapy and fluorescence diagnosis with lightguide output of the radiation,” Opt. Zh. 75, No. 12, 16 (2008) [J. Opt. Technol.75, 772 (2008)].
[CrossRef]

K. Uk, G. V. Papayan, S.-J. Bae, V. B. Berezin, and S. Kim, “Fluorescence video dermatoscope,” Opt. Zh. 75, No. 1, 32 (2008) [J. Opt. Technol.75, 24 (2008)].
[CrossRef]

N. N. Petrishchev, G. V. Papayan, A. M. Esayan, E. N. Grineva, and K. Uk, “Study of glycation end-products by fluorescence spectroscopy of the skin. Photodynamic therapy and fluorescence diagnosis,” in Collection of Scientific Works, ed. N. N. Petrishcheva (Lan’, St. Petersburg, 2011), pp. 222–230.

Unione, A.

Utzinger, U.

M. Mitchell, S. B. Cantor, C. Brookner, U. Utzinger, and D. Schottenfeld, “Fluorescence spectroscopy for diagnosis of squamous intraepithelial lesions of the cervix,” Obstet. Gynecol. 93, 462 (1999).
[CrossRef]

A. Zuluaga, U. Utzinger, A. Durkin, H. Fuchs, A. Gillenwater, R. Jacob, B. Kemp, J. Fan, and R. Richards-Kortum, “Fluorescence excitation-emission matrices of human tissue: a system for in vivo measurement and data analysis,” Appl. Spectrosc. 53, 302 (1999).
[CrossRef]

van Ree, R. M.

J. W. Hartog, S. Gross, L. H. Oterdoom, R. M. van Ree, A. P. de Vries, A. J. Smit, J. P. Schouten, P. P. Nawroth, R. O. Gans, W. J. van Son, A. Bierhaus, and S. J. Bakker, “Skin autofluorescence is an independent predictor of graft loss in renal transplant recipients,” Transplantation 87, 1069 (2009).
[CrossRef]

van Son, W. J.

J. W. Hartog, S. Gross, L. H. Oterdoom, R. M. van Ree, A. P. de Vries, A. J. Smit, J. P. Schouten, P. P. Nawroth, R. O. Gans, W. J. van Son, A. Bierhaus, and S. J. Bakker, “Skin autofluorescence is an independent predictor of graft loss in renal transplant recipients,” Transplantation 87, 1069 (2009).
[CrossRef]

Way, J. F.

J. D. Maynard, M. Rohrscheib, J. F. Way, C. M. Nguyen, and M. N. Ediger, “Noninvasive type-2 diabetes screening, superior sensitivity to fasting plasma glucose and A1C,” Diabetes Care 30, 1120 (2007).
[CrossRef]

Zharkova, N. N.

N. N. Zharkova, D. N. Kozlov, Yu. N. Polivanov, R. L. Pykhov, and V. V. Smirnov, “Laser-excited fluorescence spectrometric system for tissue diagnostics,” Proc. SPIE 2328, 196 (1994).
[CrossRef]

Zuluaga, A.

Acta Medica (Hradec Kralove)

M. Beránek, D. Nováková, P. Rozsíval, J. Drsata, and V. Palicka, “Glycation and advanced glycation end-products in laboratory experiments in vivo and in vitro,” Acta Medica (Hradec Kralove) 49, No. 1, 35 (2006).

Am. J. Physiol. Lung Cell. Mol. Physiol.

A. Mayevsky and G. G. Rogatsky, “Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studies,” Am. J. Physiol. Lung Cell. Mol. Physiol. 292, 615 (2007).

Annu. Rev. Phys. Chem.

R. Richards-Kortum and E. Sevick-Muraca, “Quantitative optical spectroscopy for tissue diagnosis,” Annu. Rev. Phys. Chem. 47, 555(1996).
[CrossRef]

Appl. Spectrosc.

Circulation

A. Goldin, J. A. Beckman, A. M. Schmidt, and M. A. Creager, “Advanced glycation end-products sparking the development of diabetic vascular injury,” Circulation 114, 597 (2006).
[CrossRef]

Diabetes Care

J. D. Maynard, M. Rohrscheib, J. F. Way, C. M. Nguyen, and M. N. Ediger, “Noninvasive type-2 diabetes screening, superior sensitivity to fasting plasma glucose and A1C,” Diabetes Care 30, 1120 (2007).
[CrossRef]

H. L. Lutgers, R. Graaff, T. P. Links, L. J. Ubink-Veltmaat, H. J. Bilo, R. O. Gans, and A. J. Smit, “Skin autofluorescence as a noninvasive marker of vascular damage in patients with type-2 diabetes,” Diabetes Care 29, 2654 (2006).
[CrossRef]

R. Meervaldt, H. L. Lutgers, T. P. Links, R. Graaff, J. W. Baynes, R. Gans, and A. J. Smit, “Skin AF is a strong predictor of cardiac mortality in diabetes,” Diabetes Care 30, 107 (2007).
[CrossRef]

Diabetologia

R. Meerwaldt, T. P. Links, R. Graaff, K. Hoogenberg, J. D. Lefrandt, J. W. Baynes, R. O. Gans, and A. J. Smit, “Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy,” Diabetologia 48, 1637 (2005).
[CrossRef]

Gynecol. Oncol.

N. Ramanujam, M. F. Mitchell, A. Mahadevan, S. Thomsen, E. Silva, and R. Richards-Kortum, “Fluorescence spectroscopy: a diagnostic tool for cervical intraepithelial neoplasia,” Gynecol. Oncol. 52, 31 (1994).
[CrossRef]

Internet J. Med. Technol.

A. Shahzad and G. Koehler, “Fluorescence spectroscopy: an emerging excellent diagnostic tool in medical sciences,” Internet J. Med. Technol. 5, No. 1 (2010).

J. Am. Soc. Nephrol.

R. Meerwaldt, J. W. Hartog, R. Graaff, R. J. Huisman, T. P. Links, N. C. den Hollander, S. R. Thorpe, J. W. Baynes, G. Navis, R. O. Gans, and A. J. Smit, “Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products mortality in hemodialysis patients,” J. Am. Soc. Nephrol. 16, 3687 (2005).
[CrossRef]

J. Biomed. Opt.

S. K. Chang, Y. N. Mirabal, E. N. Atkinson, D. Cox, A. Malpica, M. Follen, and R. Richards-Kortum, “Combined reflectance and fluorescence spectroscopy for in vivo detection of cervical pre-cancer,” J. Biomed. Opt. 10, 024031 (2005).
[CrossRef]

J. R. Soc., Interface

R. S. Bradley and M. S. Thorniley, “A review of attenuation correction techniques for tissue fluorescence,” J. R. Soc., Interface 3, 1 (2006).
[CrossRef]

J. Thorac. Cardiovasc. Surg.

K. A. Horvath, K. T. Schomacker, C. C. Lee, and L. H. Cohn, “Intraoperative myocardial ischemia detection with laser-induced fluorescence,” J. Thorac. Cardiovasc. Surg. 107, 220 (1994).

Laser Phys.

V. B. Loschenov, V. I. Konov, and A. M. Prokhorov, “Photodynamic therapy and fluorescence diagnostics,” Laser Phys. 10, 1188 (2000).

Obstet. Gynecol.

M. Mitchell, S. B. Cantor, C. Brookner, U. Utzinger, and D. Schottenfeld, “Fluorescence spectroscopy for diagnosis of squamous intraepithelial lesions of the cervix,” Obstet. Gynecol. 93, 462 (1999).
[CrossRef]

Opt. Express

Opt. Zh. J. Opt. Technol.

K. Uk, G. V. Papayan, S.-J. Bae, V. B. Berezin, and S. Kim, “Fluorescence video dermatoscope,” Opt. Zh. 75, No. 1, 32 (2008) [J. Opt. Technol.75, 24 (2008)].
[CrossRef]

K. Uk, G. V. Papayan, D. A. Makarov, S. Y. Lee, and S. J. Bae, “Illuminator for photodynamic therapy and fluorescence diagnosis with lightguide output of the radiation,” Opt. Zh. 75, No. 12, 16 (2008) [J. Opt. Technol.75, 772 (2008)].
[CrossRef]

Physiol. Meas.

O. Kim, J. McMurdy, C. Lines, S. Duffy, G. Crawford, and M. Alber, “Reflectance spectrometry of normal and bruised human skins: experiments and modeling,” Physiol. Meas. 33, 159 (2012).
[CrossRef]

Proc. SPIE

N. N. Zharkova, D. N. Kozlov, Yu. N. Polivanov, R. L. Pykhov, and V. V. Smirnov, “Laser-excited fluorescence spectrometric system for tissue diagnostics,” Proc. SPIE 2328, 196 (1994).
[CrossRef]

G. V. Papayan and I. Ya. Barsky, “Contact luminescence spectrophotometry for biomedical studies,” Proc. SPIE 4515, 125 (2001).
[CrossRef]

R. Graaff, R. Meerwaldt, H. Lutgers, R. Baptist, E. de Jong, T. Andries, L. Smit, and G. Rakhorst, “Instrumentation for the measurement of autofluorescence in human skin,” Proc. SPIE 5692, 111 (2005).
[CrossRef]

Transplantation

J. W. Hartog, S. Gross, L. H. Oterdoom, R. M. van Ree, A. P. de Vries, A. J. Smit, J. P. Schouten, P. P. Nawroth, R. O. Gans, W. J. van Son, A. Bierhaus, and S. J. Bakker, “Skin autofluorescence is an independent predictor of graft loss in renal transplant recipients,” Transplantation 87, 1069 (2009).
[CrossRef]

Other

V. V. Tuchin, ed., Optical Biomedical Diagnostics, vol. 2 (Fizmatlit, Moscow, 2007).

N. N. Petrishchev, G. V. Papayan, A. M. Esayan, E. N. Grineva, and K. Uk, “Study of glycation end-products by fluorescence spectroscopy of the skin. Photodynamic therapy and fluorescence diagnosis,” in Collection of Scientific Works, ed. N. N. Petrishcheva (Lan’, St. Petersburg, 2011), pp. 222–230.

N. N. Petrishchev and G. V. Papayan, “Autofluorescence organoscopy. Photodynamic therapy and fluorescence diagnosis,” in Collection of Scientific Works, ed. N. N. Petrishcheva (Lan’, St. Petersburg, 2011), pp. 261–273.

M. N. Ediger, R. D. Johnson, E. L. Hull, and C. D. Brown, “Determination of a measure of a glycation end-product or disease state using tissue fluorescence,” U.S. Patent No. 8078243 (2011).

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