Abstract

Optical mapping of the internal signal is a unique method of studying the brain and makes it possible to investigate the functional anatomy of the cerebral cortex with high spatial resolution. Modern modifications of this method make it possible to shorten the time to obtain individual functional maps, and this opens up new prospects of using the given approach in neurophysiological experiments. It is shown to be possible in principle to use optical mapping of the internal signal to objectively test the visual function: As the contrast of the visual stimulus changes, changes have been observed in both the amplitude of the metabolic response in the cortex and in the structure of the functional maps.

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  1. I. A. Shevelev and N. A. Lazareva, “Characteristics of the responses of visual cortex neurons with sensitivity to bars or cross-shaped figures in cats,” Neurosci. Behav. Physiol. 37, 311 (2007).
    [CrossRef] [PubMed]
  2. A. Grinvald, “Imaging input and output dynamics of neocortical networks in vivo: exciting times ahead,” Proc. Natl. Acad. Sci. U.S.A. 102, 14125 (2005).
    [CrossRef] [PubMed]
  3. V. A. Kalatsky and M. P. Stryker, “New paradigm for optical imaging: temporally encoded maps of intrinsic signal,” Neuron 38, 529 (2003).
    [CrossRef] [PubMed]
  4. A. Grinvald, R. D. Frostig, E. Lieke, and R. Hildesheim, “Optical imaging of neuronal activity,” Physiol. Rev. 68, No. 4, 1285 (1988).
    [PubMed]
  5. J. E. Mayhew, S. Askew, Y. Zheng, J. Porrill, G. W. Westby, P. Redgrave, D. M. Rector, and R. M. Harper, “Cerebral vasomotion: a 0.1-Hz oscillation in reflected light imaging of neural activity,” Neuroimage 4, No. 3, 183 (1996).
    [CrossRef] [PubMed]
  6. M. P. Vanni, J. Provost, C. Casanova, and F. Lesage, “Bimodal modulation and continuous stimulation in optical imaging to map direction selectivity,” Neuroimage 49, 1416 (2010).
    [CrossRef]

2010

M. P. Vanni, J. Provost, C. Casanova, and F. Lesage, “Bimodal modulation and continuous stimulation in optical imaging to map direction selectivity,” Neuroimage 49, 1416 (2010).
[CrossRef]

2007

I. A. Shevelev and N. A. Lazareva, “Characteristics of the responses of visual cortex neurons with sensitivity to bars or cross-shaped figures in cats,” Neurosci. Behav. Physiol. 37, 311 (2007).
[CrossRef] [PubMed]

2005

A. Grinvald, “Imaging input and output dynamics of neocortical networks in vivo: exciting times ahead,” Proc. Natl. Acad. Sci. U.S.A. 102, 14125 (2005).
[CrossRef] [PubMed]

2003

V. A. Kalatsky and M. P. Stryker, “New paradigm for optical imaging: temporally encoded maps of intrinsic signal,” Neuron 38, 529 (2003).
[CrossRef] [PubMed]

1996

J. E. Mayhew, S. Askew, Y. Zheng, J. Porrill, G. W. Westby, P. Redgrave, D. M. Rector, and R. M. Harper, “Cerebral vasomotion: a 0.1-Hz oscillation in reflected light imaging of neural activity,” Neuroimage 4, No. 3, 183 (1996).
[CrossRef] [PubMed]

1988

A. Grinvald, R. D. Frostig, E. Lieke, and R. Hildesheim, “Optical imaging of neuronal activity,” Physiol. Rev. 68, No. 4, 1285 (1988).
[PubMed]

Askew, S.

J. E. Mayhew, S. Askew, Y. Zheng, J. Porrill, G. W. Westby, P. Redgrave, D. M. Rector, and R. M. Harper, “Cerebral vasomotion: a 0.1-Hz oscillation in reflected light imaging of neural activity,” Neuroimage 4, No. 3, 183 (1996).
[CrossRef] [PubMed]

Casanova, C.

M. P. Vanni, J. Provost, C. Casanova, and F. Lesage, “Bimodal modulation and continuous stimulation in optical imaging to map direction selectivity,” Neuroimage 49, 1416 (2010).
[CrossRef]

Frostig, R. D.

A. Grinvald, R. D. Frostig, E. Lieke, and R. Hildesheim, “Optical imaging of neuronal activity,” Physiol. Rev. 68, No. 4, 1285 (1988).
[PubMed]

Grinvald, A.

A. Grinvald, “Imaging input and output dynamics of neocortical networks in vivo: exciting times ahead,” Proc. Natl. Acad. Sci. U.S.A. 102, 14125 (2005).
[CrossRef] [PubMed]

A. Grinvald, R. D. Frostig, E. Lieke, and R. Hildesheim, “Optical imaging of neuronal activity,” Physiol. Rev. 68, No. 4, 1285 (1988).
[PubMed]

Harper, R. M.

J. E. Mayhew, S. Askew, Y. Zheng, J. Porrill, G. W. Westby, P. Redgrave, D. M. Rector, and R. M. Harper, “Cerebral vasomotion: a 0.1-Hz oscillation in reflected light imaging of neural activity,” Neuroimage 4, No. 3, 183 (1996).
[CrossRef] [PubMed]

Hildesheim, R.

A. Grinvald, R. D. Frostig, E. Lieke, and R. Hildesheim, “Optical imaging of neuronal activity,” Physiol. Rev. 68, No. 4, 1285 (1988).
[PubMed]

Kalatsky, V. A.

V. A. Kalatsky and M. P. Stryker, “New paradigm for optical imaging: temporally encoded maps of intrinsic signal,” Neuron 38, 529 (2003).
[CrossRef] [PubMed]

Lazareva, N. A.

I. A. Shevelev and N. A. Lazareva, “Characteristics of the responses of visual cortex neurons with sensitivity to bars or cross-shaped figures in cats,” Neurosci. Behav. Physiol. 37, 311 (2007).
[CrossRef] [PubMed]

Lesage, F.

M. P. Vanni, J. Provost, C. Casanova, and F. Lesage, “Bimodal modulation and continuous stimulation in optical imaging to map direction selectivity,” Neuroimage 49, 1416 (2010).
[CrossRef]

Lieke, E.

A. Grinvald, R. D. Frostig, E. Lieke, and R. Hildesheim, “Optical imaging of neuronal activity,” Physiol. Rev. 68, No. 4, 1285 (1988).
[PubMed]

Mayhew, J. E.

J. E. Mayhew, S. Askew, Y. Zheng, J. Porrill, G. W. Westby, P. Redgrave, D. M. Rector, and R. M. Harper, “Cerebral vasomotion: a 0.1-Hz oscillation in reflected light imaging of neural activity,” Neuroimage 4, No. 3, 183 (1996).
[CrossRef] [PubMed]

Porrill, J.

J. E. Mayhew, S. Askew, Y. Zheng, J. Porrill, G. W. Westby, P. Redgrave, D. M. Rector, and R. M. Harper, “Cerebral vasomotion: a 0.1-Hz oscillation in reflected light imaging of neural activity,” Neuroimage 4, No. 3, 183 (1996).
[CrossRef] [PubMed]

Provost, J.

M. P. Vanni, J. Provost, C. Casanova, and F. Lesage, “Bimodal modulation and continuous stimulation in optical imaging to map direction selectivity,” Neuroimage 49, 1416 (2010).
[CrossRef]

Rector, D. M.

J. E. Mayhew, S. Askew, Y. Zheng, J. Porrill, G. W. Westby, P. Redgrave, D. M. Rector, and R. M. Harper, “Cerebral vasomotion: a 0.1-Hz oscillation in reflected light imaging of neural activity,” Neuroimage 4, No. 3, 183 (1996).
[CrossRef] [PubMed]

Redgrave, P.

J. E. Mayhew, S. Askew, Y. Zheng, J. Porrill, G. W. Westby, P. Redgrave, D. M. Rector, and R. M. Harper, “Cerebral vasomotion: a 0.1-Hz oscillation in reflected light imaging of neural activity,” Neuroimage 4, No. 3, 183 (1996).
[CrossRef] [PubMed]

Shevelev, I. A.

I. A. Shevelev and N. A. Lazareva, “Characteristics of the responses of visual cortex neurons with sensitivity to bars or cross-shaped figures in cats,” Neurosci. Behav. Physiol. 37, 311 (2007).
[CrossRef] [PubMed]

Stryker, M. P.

V. A. Kalatsky and M. P. Stryker, “New paradigm for optical imaging: temporally encoded maps of intrinsic signal,” Neuron 38, 529 (2003).
[CrossRef] [PubMed]

Vanni, M. P.

M. P. Vanni, J. Provost, C. Casanova, and F. Lesage, “Bimodal modulation and continuous stimulation in optical imaging to map direction selectivity,” Neuroimage 49, 1416 (2010).
[CrossRef]

Westby, G. W.

J. E. Mayhew, S. Askew, Y. Zheng, J. Porrill, G. W. Westby, P. Redgrave, D. M. Rector, and R. M. Harper, “Cerebral vasomotion: a 0.1-Hz oscillation in reflected light imaging of neural activity,” Neuroimage 4, No. 3, 183 (1996).
[CrossRef] [PubMed]

Zheng, Y.

J. E. Mayhew, S. Askew, Y. Zheng, J. Porrill, G. W. Westby, P. Redgrave, D. M. Rector, and R. M. Harper, “Cerebral vasomotion: a 0.1-Hz oscillation in reflected light imaging of neural activity,” Neuroimage 4, No. 3, 183 (1996).
[CrossRef] [PubMed]

Neuroimage

J. E. Mayhew, S. Askew, Y. Zheng, J. Porrill, G. W. Westby, P. Redgrave, D. M. Rector, and R. M. Harper, “Cerebral vasomotion: a 0.1-Hz oscillation in reflected light imaging of neural activity,” Neuroimage 4, No. 3, 183 (1996).
[CrossRef] [PubMed]

M. P. Vanni, J. Provost, C. Casanova, and F. Lesage, “Bimodal modulation and continuous stimulation in optical imaging to map direction selectivity,” Neuroimage 49, 1416 (2010).
[CrossRef]

Neuron

V. A. Kalatsky and M. P. Stryker, “New paradigm for optical imaging: temporally encoded maps of intrinsic signal,” Neuron 38, 529 (2003).
[CrossRef] [PubMed]

Neurosci. Behav. Physiol.

I. A. Shevelev and N. A. Lazareva, “Characteristics of the responses of visual cortex neurons with sensitivity to bars or cross-shaped figures in cats,” Neurosci. Behav. Physiol. 37, 311 (2007).
[CrossRef] [PubMed]

Physiol. Rev.

A. Grinvald, R. D. Frostig, E. Lieke, and R. Hildesheim, “Optical imaging of neuronal activity,” Physiol. Rev. 68, No. 4, 1285 (1988).
[PubMed]

Proc. Natl. Acad. Sci. U.S.A.

A. Grinvald, “Imaging input and output dynamics of neocortical networks in vivo: exciting times ahead,” Proc. Natl. Acad. Sci. U.S.A. 102, 14125 (2005).
[CrossRef] [PubMed]

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