Abstract

The high variability of the specimens creates problems in the formation of both a representative model of the ambient medium and stable algorithms for the automatic microscopic analysis of biomaterials. When the MECOS-C2 analyzer is being developed and maintained, the technology of reference virtual slides formed with the participation of the users and available during operation from laboratories in the service center is used to obtain a model of the ambient medium. The structure of the MECOS-C2, adjusted to use virtual slides, makes it possible to largely automate the development of new versions of the software, taking into account the data on the ambient medium. Another key principle of the development is to use robust analysis algorithms adapted to a given specimen. The combination of these principles made it possible to create the medical-class MECOS-C2 automatic analyzer suitable for analyzing blood smears in a commercial laboratory.

© 2011 OSA

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  1. V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, and V. L. Dem’yanov, "Structure of the MECOS-C2 automatic microscopy system and techniques for testing it," Medits. Tekhnika (4), 36 (2006).
  2. V. S. Medovyĭ, A. A. Parpara, B. Z. Sokolinskiĭ, and V. L. Dem’yanov, "Combining the equipment and a system platform of automatic microscopy complexes," Medits. Tekhnika (2), 29 (2007).
  3. B. Swolin and P. Simonsson, et al., "Differential counting of blood leukocytes using automated microscopy and a decision support system based on artificial neural networks—evaluation of DiffMaster Octavia," Clin. Lab. Haematol. 25(3), 139 (2003).
    [CrossRef]
  4. "National Committee for Clinical Laboratory Standards," Reference Leukocyte Differential Count and Evaluation of Instrumental Methods: Approved Standards, NCCLS H20-A, Villanova, PA, 1992.
  5. M. Lundin, J. Lundin, and J. Isola, "Virtual microscopy," J. Clin. Pathology (57), 1250 (2004).
    [CrossRef]
  6. A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. S. Medovyĭ, and V. L. Dem’yanov, "Navigation over a blood smear during the automatic calculation of the leukocyte formula and erythrocytometry," Zdravookhran. Medits. Tekhnika (7(21)), 37 (2005).
  7. J. P. Greer, J. Foerster, and J. N. Lukens, ed., Wintrobe’s Clinical Hematology, Lippincot Williams & Wilkins, 2003.
  8. S. A. Plyasunova, R. Sh. Balugyan, K. E. Khmel’nitskiĭ, V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, and D. S. Nikolaenko, "Automatic techniques for microscopic analyses of blood smears–medical tests of the MECOS-C2 complex," Klin. Lab. Diagnostika (10), 22 (2006).
  9. V. C. Medovyĭ, D. S. Nikolaenko, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, T. V. Zhurkina, and I. B. Pal’chunova, "Automation of microscopic analyses of blood smears and quality control with the use of reference virtual slides," Klin. Lab. Diagnostika (6), 46 (2008).

2008 (1)

V. C. Medovyĭ, D. S. Nikolaenko, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, T. V. Zhurkina, and I. B. Pal’chunova, "Automation of microscopic analyses of blood smears and quality control with the use of reference virtual slides," Klin. Lab. Diagnostika (6), 46 (2008).

2007 (1)

V. S. Medovyĭ, A. A. Parpara, B. Z. Sokolinskiĭ, and V. L. Dem’yanov, "Combining the equipment and a system platform of automatic microscopy complexes," Medits. Tekhnika (2), 29 (2007).

2006 (2)

V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, and V. L. Dem’yanov, "Structure of the MECOS-C2 automatic microscopy system and techniques for testing it," Medits. Tekhnika (4), 36 (2006).

S. A. Plyasunova, R. Sh. Balugyan, K. E. Khmel’nitskiĭ, V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, and D. S. Nikolaenko, "Automatic techniques for microscopic analyses of blood smears–medical tests of the MECOS-C2 complex," Klin. Lab. Diagnostika (10), 22 (2006).

2005 (1)

A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. S. Medovyĭ, and V. L. Dem’yanov, "Navigation over a blood smear during the automatic calculation of the leukocyte formula and erythrocytometry," Zdravookhran. Medits. Tekhnika (7(21)), 37 (2005).

2004 (1)

M. Lundin, J. Lundin, and J. Isola, "Virtual microscopy," J. Clin. Pathology (57), 1250 (2004).
[CrossRef]

2003 (1)

B. Swolin and P. Simonsson, et al., "Differential counting of blood leukocytes using automated microscopy and a decision support system based on artificial neural networks—evaluation of DiffMaster Octavia," Clin. Lab. Haematol. 25(3), 139 (2003).
[CrossRef]

Balugyan, R. Sh.

S. A. Plyasunova, R. Sh. Balugyan, K. E. Khmel’nitskiĭ, V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, and D. S. Nikolaenko, "Automatic techniques for microscopic analyses of blood smears–medical tests of the MECOS-C2 complex," Klin. Lab. Diagnostika (10), 22 (2006).

Dem’yanov, V. L.

V. C. Medovyĭ, D. S. Nikolaenko, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, T. V. Zhurkina, and I. B. Pal’chunova, "Automation of microscopic analyses of blood smears and quality control with the use of reference virtual slides," Klin. Lab. Diagnostika (6), 46 (2008).

V. S. Medovyĭ, A. A. Parpara, B. Z. Sokolinskiĭ, and V. L. Dem’yanov, "Combining the equipment and a system platform of automatic microscopy complexes," Medits. Tekhnika (2), 29 (2007).

V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, and V. L. Dem’yanov, "Structure of the MECOS-C2 automatic microscopy system and techniques for testing it," Medits. Tekhnika (4), 36 (2006).

S. A. Plyasunova, R. Sh. Balugyan, K. E. Khmel’nitskiĭ, V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, and D. S. Nikolaenko, "Automatic techniques for microscopic analyses of blood smears–medical tests of the MECOS-C2 complex," Klin. Lab. Diagnostika (10), 22 (2006).

A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. S. Medovyĭ, and V. L. Dem’yanov, "Navigation over a blood smear during the automatic calculation of the leukocyte formula and erythrocytometry," Zdravookhran. Medits. Tekhnika (7(21)), 37 (2005).

Isola, J.

M. Lundin, J. Lundin, and J. Isola, "Virtual microscopy," J. Clin. Pathology (57), 1250 (2004).
[CrossRef]

Khmel’nitskii, K. E.

S. A. Plyasunova, R. Sh. Balugyan, K. E. Khmel’nitskiĭ, V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, and D. S. Nikolaenko, "Automatic techniques for microscopic analyses of blood smears–medical tests of the MECOS-C2 complex," Klin. Lab. Diagnostika (10), 22 (2006).

Lundin, J.

M. Lundin, J. Lundin, and J. Isola, "Virtual microscopy," J. Clin. Pathology (57), 1250 (2004).
[CrossRef]

Lundin, M.

M. Lundin, J. Lundin, and J. Isola, "Virtual microscopy," J. Clin. Pathology (57), 1250 (2004).
[CrossRef]

Medovyi, V. C.

V. C. Medovyĭ, D. S. Nikolaenko, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, T. V. Zhurkina, and I. B. Pal’chunova, "Automation of microscopic analyses of blood smears and quality control with the use of reference virtual slides," Klin. Lab. Diagnostika (6), 46 (2008).

Medovyi, V. S.

V. S. Medovyĭ, A. A. Parpara, B. Z. Sokolinskiĭ, and V. L. Dem’yanov, "Combining the equipment and a system platform of automatic microscopy complexes," Medits. Tekhnika (2), 29 (2007).

V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, and V. L. Dem’yanov, "Structure of the MECOS-C2 automatic microscopy system and techniques for testing it," Medits. Tekhnika (4), 36 (2006).

S. A. Plyasunova, R. Sh. Balugyan, K. E. Khmel’nitskiĭ, V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, and D. S. Nikolaenko, "Automatic techniques for microscopic analyses of blood smears–medical tests of the MECOS-C2 complex," Klin. Lab. Diagnostika (10), 22 (2006).

A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. S. Medovyĭ, and V. L. Dem’yanov, "Navigation over a blood smear during the automatic calculation of the leukocyte formula and erythrocytometry," Zdravookhran. Medits. Tekhnika (7(21)), 37 (2005).

Nikolaenko, D. S.

V. C. Medovyĭ, D. S. Nikolaenko, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, T. V. Zhurkina, and I. B. Pal’chunova, "Automation of microscopic analyses of blood smears and quality control with the use of reference virtual slides," Klin. Lab. Diagnostika (6), 46 (2008).

S. A. Plyasunova, R. Sh. Balugyan, K. E. Khmel’nitskiĭ, V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, and D. S. Nikolaenko, "Automatic techniques for microscopic analyses of blood smears–medical tests of the MECOS-C2 complex," Klin. Lab. Diagnostika (10), 22 (2006).

Pal’chunova, I. B.

V. C. Medovyĭ, D. S. Nikolaenko, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, T. V. Zhurkina, and I. B. Pal’chunova, "Automation of microscopic analyses of blood smears and quality control with the use of reference virtual slides," Klin. Lab. Diagnostika (6), 46 (2008).

Parpara, A. A.

V. C. Medovyĭ, D. S. Nikolaenko, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, T. V. Zhurkina, and I. B. Pal’chunova, "Automation of microscopic analyses of blood smears and quality control with the use of reference virtual slides," Klin. Lab. Diagnostika (6), 46 (2008).

V. S. Medovyĭ, A. A. Parpara, B. Z. Sokolinskiĭ, and V. L. Dem’yanov, "Combining the equipment and a system platform of automatic microscopy complexes," Medits. Tekhnika (2), 29 (2007).

V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, and V. L. Dem’yanov, "Structure of the MECOS-C2 automatic microscopy system and techniques for testing it," Medits. Tekhnika (4), 36 (2006).

S. A. Plyasunova, R. Sh. Balugyan, K. E. Khmel’nitskiĭ, V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, and D. S. Nikolaenko, "Automatic techniques for microscopic analyses of blood smears–medical tests of the MECOS-C2 complex," Klin. Lab. Diagnostika (10), 22 (2006).

A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. S. Medovyĭ, and V. L. Dem’yanov, "Navigation over a blood smear during the automatic calculation of the leukocyte formula and erythrocytometry," Zdravookhran. Medits. Tekhnika (7(21)), 37 (2005).

Plyasunova, S. A.

S. A. Plyasunova, R. Sh. Balugyan, K. E. Khmel’nitskiĭ, V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, and D. S. Nikolaenko, "Automatic techniques for microscopic analyses of blood smears–medical tests of the MECOS-C2 complex," Klin. Lab. Diagnostika (10), 22 (2006).

Pyatnitskii, A. M.

V. C. Medovyĭ, D. S. Nikolaenko, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, T. V. Zhurkina, and I. B. Pal’chunova, "Automation of microscopic analyses of blood smears and quality control with the use of reference virtual slides," Klin. Lab. Diagnostika (6), 46 (2008).

S. A. Plyasunova, R. Sh. Balugyan, K. E. Khmel’nitskiĭ, V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, and D. S. Nikolaenko, "Automatic techniques for microscopic analyses of blood smears–medical tests of the MECOS-C2 complex," Klin. Lab. Diagnostika (10), 22 (2006).

V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, and V. L. Dem’yanov, "Structure of the MECOS-C2 automatic microscopy system and techniques for testing it," Medits. Tekhnika (4), 36 (2006).

A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. S. Medovyĭ, and V. L. Dem’yanov, "Navigation over a blood smear during the automatic calculation of the leukocyte formula and erythrocytometry," Zdravookhran. Medits. Tekhnika (7(21)), 37 (2005).

Simonsson, P.

B. Swolin and P. Simonsson, et al., "Differential counting of blood leukocytes using automated microscopy and a decision support system based on artificial neural networks—evaluation of DiffMaster Octavia," Clin. Lab. Haematol. 25(3), 139 (2003).
[CrossRef]

Sokolinskii, B. Z.

V. C. Medovyĭ, D. S. Nikolaenko, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, T. V. Zhurkina, and I. B. Pal’chunova, "Automation of microscopic analyses of blood smears and quality control with the use of reference virtual slides," Klin. Lab. Diagnostika (6), 46 (2008).

V. S. Medovyĭ, A. A. Parpara, B. Z. Sokolinskiĭ, and V. L. Dem’yanov, "Combining the equipment and a system platform of automatic microscopy complexes," Medits. Tekhnika (2), 29 (2007).

V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, and V. L. Dem’yanov, "Structure of the MECOS-C2 automatic microscopy system and techniques for testing it," Medits. Tekhnika (4), 36 (2006).

S. A. Plyasunova, R. Sh. Balugyan, K. E. Khmel’nitskiĭ, V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, and D. S. Nikolaenko, "Automatic techniques for microscopic analyses of blood smears–medical tests of the MECOS-C2 complex," Klin. Lab. Diagnostika (10), 22 (2006).

A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. S. Medovyĭ, and V. L. Dem’yanov, "Navigation over a blood smear during the automatic calculation of the leukocyte formula and erythrocytometry," Zdravookhran. Medits. Tekhnika (7(21)), 37 (2005).

Swolin, B.

B. Swolin and P. Simonsson, et al., "Differential counting of blood leukocytes using automated microscopy and a decision support system based on artificial neural networks—evaluation of DiffMaster Octavia," Clin. Lab. Haematol. 25(3), 139 (2003).
[CrossRef]

Zhurkina, T. V.

V. C. Medovyĭ, D. S. Nikolaenko, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, T. V. Zhurkina, and I. B. Pal’chunova, "Automation of microscopic analyses of blood smears and quality control with the use of reference virtual slides," Klin. Lab. Diagnostika (6), 46 (2008).

Clin. Lab. Haematol. (1)

B. Swolin and P. Simonsson, et al., "Differential counting of blood leukocytes using automated microscopy and a decision support system based on artificial neural networks—evaluation of DiffMaster Octavia," Clin. Lab. Haematol. 25(3), 139 (2003).
[CrossRef]

J. Clin. Pathology (1)

M. Lundin, J. Lundin, and J. Isola, "Virtual microscopy," J. Clin. Pathology (57), 1250 (2004).
[CrossRef]

Klin. Lab. Diagnostika (2)

S. A. Plyasunova, R. Sh. Balugyan, K. E. Khmel’nitskiĭ, V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, and D. S. Nikolaenko, "Automatic techniques for microscopic analyses of blood smears–medical tests of the MECOS-C2 complex," Klin. Lab. Diagnostika (10), 22 (2006).

V. C. Medovyĭ, D. S. Nikolaenko, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. L. Dem’yanov, T. V. Zhurkina, and I. B. Pal’chunova, "Automation of microscopic analyses of blood smears and quality control with the use of reference virtual slides," Klin. Lab. Diagnostika (6), 46 (2008).

Medits. Tekhnika (2)

V. S. Medovyĭ, A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, and V. L. Dem’yanov, "Structure of the MECOS-C2 automatic microscopy system and techniques for testing it," Medits. Tekhnika (4), 36 (2006).

V. S. Medovyĭ, A. A. Parpara, B. Z. Sokolinskiĭ, and V. L. Dem’yanov, "Combining the equipment and a system platform of automatic microscopy complexes," Medits. Tekhnika (2), 29 (2007).

Zdravookhran. Medits. Tekhnika (1)

A. A. Parpara, A. M. Pyatnitskiĭ, B. Z. Sokolinskiĭ, V. S. Medovyĭ, and V. L. Dem’yanov, "Navigation over a blood smear during the automatic calculation of the leukocyte formula and erythrocytometry," Zdravookhran. Medits. Tekhnika (7(21)), 37 (2005).

Other (2)

J. P. Greer, J. Foerster, and J. N. Lukens, ed., Wintrobe’s Clinical Hematology, Lippincot Williams & Wilkins, 2003.

"National Committee for Clinical Laboratory Standards," Reference Leukocyte Differential Count and Evaluation of Instrumental Methods: Approved Standards, NCCLS H20-A, Villanova, PA, 1992.

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