Abstract

Mercury and halogen lamps that possess mutually supplementary spectral responses are used simultaneously in an illuminator intended for phototherapy and fluorescence diagnosis. Their radiation is summed and delivered to an object through a liquid lightguide. Two summation methods--spectral and angular--are tested experimentally. The best results are given by the latter method, in which convergent beams from the lamps are directed into the lightguide at different angles. The total optical power at the lightguide output is 14.5W in the 300-800-nm range. The working spectral interval is selected by means of switchable interference filters on command from a built-in processor. The influence of the spectral width of the radiation on the efficiency with which the radiant flux is used is estimated.

© 2008 Optical Society of America

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  1. T. J. Dougherty, C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan, and Q. Peng, “Photodynamic therapy,” J. Natl. Cancer Inst. 90, 889 (1998).
    [CrossRef]
  2. M. Leonhard, “New incoherent autofluorescence/fluorescence system for early detection of lung cancer,” Diag. Therap. Endos. 5, 71 (1999).
  3. G. V. Papayan and Kang Uk, “Fluorescence endoscopic video system,” Opt. Zh. 64, No. 10, 94 (2006) G. V. Papayan and Kang Uk[J. Opt. Technol. 64, 739 (2006)].
  4. J. Hewett, V. Nadeau, J. Ferguson, H. Moseley, S. Ibbotson, J. W. Allen, W. Sibbett, and M. Padgett, “The application of compact multispectral imaging system with integrated excitation source to in-vivo monitoring of fluorescence during topical photodynamic therapy of superficial skin cancer,” Photochem. Photobiol. 73, No. 30, 278 (2001).
    [CrossRef]
  5. Kang Uk, G. V. Papayan, Bae Soo-Jin, V. B. Berezin, and S. Kim, “Fluorescence video dermatoscope,” Opt. Zh. 75, No. 1, 32 (2008) Kang Uk, G. V. Papayan, Bae Soo-Jin, V. B. Berezin, and S. Kim[J. Opt. Technol. 75, 24 (2008)].
  6. R. Richards-Kortum and E. Sevick-Muraca, “Quantitative optical spectroscopy for tissue diagnosis,” Annu. Rev. Phys. Chem. 47, No. 1, 555 (1996).
    [CrossRef]
  7. G. A. Wagnieres, W. M. Star, and B. C. Wilson, “In-vivo fluorescence spectroscopy and imaging for oncological applications,” Photochem. Photobiol. 68, 603 (1998).
    [CrossRef]
  8. G. V. Papayan and I. Ya. Barsky, “Contact luminescence spectrophotometry for biomedical studies,” Proc. SPIE 4515, 125 (2001).
    [CrossRef]
  9. V. I. Karandashov, E. B. Petukhov, and V. S. Zrodnikov, Phototherapy (Light Therapy) (ed.) N.R.Paleeva (Meditisina, Moscow, 2001).
  10. Kang Uk, G. Papayan, Bae Soo Jin, and Rim Geun Hie, “Light source for fluorescence diagnosis and photodynamic therapy,” Patent KR10-0798486.
  11. Kang Uk, G. Papayan, D. Makarov, Lee Seung Yup, and Bae Soo Jin, “Light-source system for phototherapy of skin disease,” Patent appl. KR20070101398.
  12. P. Papageorgiou, A. Katsambas, and A. Chu, “Phototherapy with blue (415nm) and red (660nm) light in the treatment of acne vulgaris,” British J. Dermat. No. 142, 973 (2000).

2008 (1)

Kang Uk, G. V. Papayan, Bae Soo-Jin, V. B. Berezin, and S. Kim, “Fluorescence video dermatoscope,” Opt. Zh. 75, No. 1, 32 (2008) Kang Uk, G. V. Papayan, Bae Soo-Jin, V. B. Berezin, and S. Kim[J. Opt. Technol. 75, 24 (2008)].

2006 (1)

G. V. Papayan and Kang Uk, “Fluorescence endoscopic video system,” Opt. Zh. 64, No. 10, 94 (2006) G. V. Papayan and Kang Uk[J. Opt. Technol. 64, 739 (2006)].

2001 (2)

J. Hewett, V. Nadeau, J. Ferguson, H. Moseley, S. Ibbotson, J. W. Allen, W. Sibbett, and M. Padgett, “The application of compact multispectral imaging system with integrated excitation source to in-vivo monitoring of fluorescence during topical photodynamic therapy of superficial skin cancer,” Photochem. Photobiol. 73, No. 30, 278 (2001).
[CrossRef]

G. V. Papayan and I. Ya. Barsky, “Contact luminescence spectrophotometry for biomedical studies,” Proc. SPIE 4515, 125 (2001).
[CrossRef]

1999 (1)

M. Leonhard, “New incoherent autofluorescence/fluorescence system for early detection of lung cancer,” Diag. Therap. Endos. 5, 71 (1999).

1998 (2)

T. J. Dougherty, C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan, and Q. Peng, “Photodynamic therapy,” J. Natl. Cancer Inst. 90, 889 (1998).
[CrossRef]

G. A. Wagnieres, W. M. Star, and B. C. Wilson, “In-vivo fluorescence spectroscopy and imaging for oncological applications,” Photochem. Photobiol. 68, 603 (1998).
[CrossRef]

1996 (1)

R. Richards-Kortum and E. Sevick-Muraca, “Quantitative optical spectroscopy for tissue diagnosis,” Annu. Rev. Phys. Chem. 47, No. 1, 555 (1996).
[CrossRef]

Allen, J. W.

J. Hewett, V. Nadeau, J. Ferguson, H. Moseley, S. Ibbotson, J. W. Allen, W. Sibbett, and M. Padgett, “The application of compact multispectral imaging system with integrated excitation source to in-vivo monitoring of fluorescence during topical photodynamic therapy of superficial skin cancer,” Photochem. Photobiol. 73, No. 30, 278 (2001).
[CrossRef]

Barsky, I. Ya.

G. V. Papayan and I. Ya. Barsky, “Contact luminescence spectrophotometry for biomedical studies,” Proc. SPIE 4515, 125 (2001).
[CrossRef]

Berezin, V. B.

Kang Uk, G. V. Papayan, Bae Soo-Jin, V. B. Berezin, and S. Kim, “Fluorescence video dermatoscope,” Opt. Zh. 75, No. 1, 32 (2008) Kang Uk, G. V. Papayan, Bae Soo-Jin, V. B. Berezin, and S. Kim[J. Opt. Technol. 75, 24 (2008)].

Chu, A.

P. Papageorgiou, A. Katsambas, and A. Chu, “Phototherapy with blue (415nm) and red (660nm) light in the treatment of acne vulgaris,” British J. Dermat. No. 142, 973 (2000).

Dougherty, T. J.

T. J. Dougherty, C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan, and Q. Peng, “Photodynamic therapy,” J. Natl. Cancer Inst. 90, 889 (1998).
[CrossRef]

Ferguson, J.

J. Hewett, V. Nadeau, J. Ferguson, H. Moseley, S. Ibbotson, J. W. Allen, W. Sibbett, and M. Padgett, “The application of compact multispectral imaging system with integrated excitation source to in-vivo monitoring of fluorescence during topical photodynamic therapy of superficial skin cancer,” Photochem. Photobiol. 73, No. 30, 278 (2001).
[CrossRef]

Gomer, C. J.

T. J. Dougherty, C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan, and Q. Peng, “Photodynamic therapy,” J. Natl. Cancer Inst. 90, 889 (1998).
[CrossRef]

Henderson, B. W.

T. J. Dougherty, C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan, and Q. Peng, “Photodynamic therapy,” J. Natl. Cancer Inst. 90, 889 (1998).
[CrossRef]

Hewett, J.

J. Hewett, V. Nadeau, J. Ferguson, H. Moseley, S. Ibbotson, J. W. Allen, W. Sibbett, and M. Padgett, “The application of compact multispectral imaging system with integrated excitation source to in-vivo monitoring of fluorescence during topical photodynamic therapy of superficial skin cancer,” Photochem. Photobiol. 73, No. 30, 278 (2001).
[CrossRef]

Hie, Rim Geun

Kang Uk, G. Papayan, Bae Soo Jin, and Rim Geun Hie, “Light source for fluorescence diagnosis and photodynamic therapy,” Patent KR10-0798486.

Ibbotson, S.

J. Hewett, V. Nadeau, J. Ferguson, H. Moseley, S. Ibbotson, J. W. Allen, W. Sibbett, and M. Padgett, “The application of compact multispectral imaging system with integrated excitation source to in-vivo monitoring of fluorescence during topical photodynamic therapy of superficial skin cancer,” Photochem. Photobiol. 73, No. 30, 278 (2001).
[CrossRef]

Jin, Bae Soo

Kang Uk, G. Papayan, Bae Soo Jin, and Rim Geun Hie, “Light source for fluorescence diagnosis and photodynamic therapy,” Patent KR10-0798486.

Kang Uk, G. Papayan, D. Makarov, Lee Seung Yup, and Bae Soo Jin, “Light-source system for phototherapy of skin disease,” Patent appl. KR20070101398.

Jori, G.

T. J. Dougherty, C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan, and Q. Peng, “Photodynamic therapy,” J. Natl. Cancer Inst. 90, 889 (1998).
[CrossRef]

Karandashov, V. I.

V. I. Karandashov, E. B. Petukhov, and V. S. Zrodnikov, Phototherapy (Light Therapy) (ed.) N.R.Paleeva (Meditisina, Moscow, 2001).

Katsambas, A.

P. Papageorgiou, A. Katsambas, and A. Chu, “Phototherapy with blue (415nm) and red (660nm) light in the treatment of acne vulgaris,” British J. Dermat. No. 142, 973 (2000).

Kessel, D.

T. J. Dougherty, C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan, and Q. Peng, “Photodynamic therapy,” J. Natl. Cancer Inst. 90, 889 (1998).
[CrossRef]

Kim, S.

Kang Uk, G. V. Papayan, Bae Soo-Jin, V. B. Berezin, and S. Kim, “Fluorescence video dermatoscope,” Opt. Zh. 75, No. 1, 32 (2008) Kang Uk, G. V. Papayan, Bae Soo-Jin, V. B. Berezin, and S. Kim[J. Opt. Technol. 75, 24 (2008)].

Korbelik, M.

T. J. Dougherty, C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan, and Q. Peng, “Photodynamic therapy,” J. Natl. Cancer Inst. 90, 889 (1998).
[CrossRef]

Leonhard, M.

M. Leonhard, “New incoherent autofluorescence/fluorescence system for early detection of lung cancer,” Diag. Therap. Endos. 5, 71 (1999).

Makarov, D.

Kang Uk, G. Papayan, D. Makarov, Lee Seung Yup, and Bae Soo Jin, “Light-source system for phototherapy of skin disease,” Patent appl. KR20070101398.

Moan, J.

T. J. Dougherty, C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan, and Q. Peng, “Photodynamic therapy,” J. Natl. Cancer Inst. 90, 889 (1998).
[CrossRef]

Moseley, H.

J. Hewett, V. Nadeau, J. Ferguson, H. Moseley, S. Ibbotson, J. W. Allen, W. Sibbett, and M. Padgett, “The application of compact multispectral imaging system with integrated excitation source to in-vivo monitoring of fluorescence during topical photodynamic therapy of superficial skin cancer,” Photochem. Photobiol. 73, No. 30, 278 (2001).
[CrossRef]

Nadeau, V.

J. Hewett, V. Nadeau, J. Ferguson, H. Moseley, S. Ibbotson, J. W. Allen, W. Sibbett, and M. Padgett, “The application of compact multispectral imaging system with integrated excitation source to in-vivo monitoring of fluorescence during topical photodynamic therapy of superficial skin cancer,” Photochem. Photobiol. 73, No. 30, 278 (2001).
[CrossRef]

Padgett, M.

J. Hewett, V. Nadeau, J. Ferguson, H. Moseley, S. Ibbotson, J. W. Allen, W. Sibbett, and M. Padgett, “The application of compact multispectral imaging system with integrated excitation source to in-vivo monitoring of fluorescence during topical photodynamic therapy of superficial skin cancer,” Photochem. Photobiol. 73, No. 30, 278 (2001).
[CrossRef]

Papageorgiou, P.

P. Papageorgiou, A. Katsambas, and A. Chu, “Phototherapy with blue (415nm) and red (660nm) light in the treatment of acne vulgaris,” British J. Dermat. No. 142, 973 (2000).

Papayan, G.

Kang Uk, G. Papayan, D. Makarov, Lee Seung Yup, and Bae Soo Jin, “Light-source system for phototherapy of skin disease,” Patent appl. KR20070101398.

Kang Uk, G. Papayan, Bae Soo Jin, and Rim Geun Hie, “Light source for fluorescence diagnosis and photodynamic therapy,” Patent KR10-0798486.

Papayan, G. V.

Kang Uk, G. V. Papayan, Bae Soo-Jin, V. B. Berezin, and S. Kim, “Fluorescence video dermatoscope,” Opt. Zh. 75, No. 1, 32 (2008) Kang Uk, G. V. Papayan, Bae Soo-Jin, V. B. Berezin, and S. Kim[J. Opt. Technol. 75, 24 (2008)].

G. V. Papayan and Kang Uk, “Fluorescence endoscopic video system,” Opt. Zh. 64, No. 10, 94 (2006) G. V. Papayan and Kang Uk[J. Opt. Technol. 64, 739 (2006)].

G. V. Papayan and I. Ya. Barsky, “Contact luminescence spectrophotometry for biomedical studies,” Proc. SPIE 4515, 125 (2001).
[CrossRef]

Peng, Q.

T. J. Dougherty, C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan, and Q. Peng, “Photodynamic therapy,” J. Natl. Cancer Inst. 90, 889 (1998).
[CrossRef]

Petukhov, E. B.

V. I. Karandashov, E. B. Petukhov, and V. S. Zrodnikov, Phototherapy (Light Therapy) (ed.) N.R.Paleeva (Meditisina, Moscow, 2001).

Richards-Kortum, R.

R. Richards-Kortum and E. Sevick-Muraca, “Quantitative optical spectroscopy for tissue diagnosis,” Annu. Rev. Phys. Chem. 47, No. 1, 555 (1996).
[CrossRef]

Sevick-Muraca, E.

R. Richards-Kortum and E. Sevick-Muraca, “Quantitative optical spectroscopy for tissue diagnosis,” Annu. Rev. Phys. Chem. 47, No. 1, 555 (1996).
[CrossRef]

Sibbett, W.

J. Hewett, V. Nadeau, J. Ferguson, H. Moseley, S. Ibbotson, J. W. Allen, W. Sibbett, and M. Padgett, “The application of compact multispectral imaging system with integrated excitation source to in-vivo monitoring of fluorescence during topical photodynamic therapy of superficial skin cancer,” Photochem. Photobiol. 73, No. 30, 278 (2001).
[CrossRef]

Soo-Jin, Bae

Kang Uk, G. V. Papayan, Bae Soo-Jin, V. B. Berezin, and S. Kim, “Fluorescence video dermatoscope,” Opt. Zh. 75, No. 1, 32 (2008) Kang Uk, G. V. Papayan, Bae Soo-Jin, V. B. Berezin, and S. Kim[J. Opt. Technol. 75, 24 (2008)].

Star, W. M.

G. A. Wagnieres, W. M. Star, and B. C. Wilson, “In-vivo fluorescence spectroscopy and imaging for oncological applications,” Photochem. Photobiol. 68, 603 (1998).
[CrossRef]

Uk, Kang

Kang Uk, G. V. Papayan, Bae Soo-Jin, V. B. Berezin, and S. Kim, “Fluorescence video dermatoscope,” Opt. Zh. 75, No. 1, 32 (2008) Kang Uk, G. V. Papayan, Bae Soo-Jin, V. B. Berezin, and S. Kim[J. Opt. Technol. 75, 24 (2008)].

G. V. Papayan and Kang Uk, “Fluorescence endoscopic video system,” Opt. Zh. 64, No. 10, 94 (2006) G. V. Papayan and Kang Uk[J. Opt. Technol. 64, 739 (2006)].

Kang Uk, G. Papayan, Bae Soo Jin, and Rim Geun Hie, “Light source for fluorescence diagnosis and photodynamic therapy,” Patent KR10-0798486.

Kang Uk, G. Papayan, D. Makarov, Lee Seung Yup, and Bae Soo Jin, “Light-source system for phototherapy of skin disease,” Patent appl. KR20070101398.

Wagnieres, G. A.

G. A. Wagnieres, W. M. Star, and B. C. Wilson, “In-vivo fluorescence spectroscopy and imaging for oncological applications,” Photochem. Photobiol. 68, 603 (1998).
[CrossRef]

Wilson, B. C.

G. A. Wagnieres, W. M. Star, and B. C. Wilson, “In-vivo fluorescence spectroscopy and imaging for oncological applications,” Photochem. Photobiol. 68, 603 (1998).
[CrossRef]

Yup, Lee Seung

Kang Uk, G. Papayan, D. Makarov, Lee Seung Yup, and Bae Soo Jin, “Light-source system for phototherapy of skin disease,” Patent appl. KR20070101398.

Zrodnikov, V. S.

V. I. Karandashov, E. B. Petukhov, and V. S. Zrodnikov, Phototherapy (Light Therapy) (ed.) N.R.Paleeva (Meditisina, Moscow, 2001).

Annu. Rev. Phys. Chem. (1)

R. Richards-Kortum and E. Sevick-Muraca, “Quantitative optical spectroscopy for tissue diagnosis,” Annu. Rev. Phys. Chem. 47, No. 1, 555 (1996).
[CrossRef]

Diag. Therap. Endos. (1)

M. Leonhard, “New incoherent autofluorescence/fluorescence system for early detection of lung cancer,” Diag. Therap. Endos. 5, 71 (1999).

J. Natl. Cancer Inst. (1)

T. J. Dougherty, C. J. Gomer, B. W. Henderson, G. Jori, D. Kessel, M. Korbelik, J. Moan, and Q. Peng, “Photodynamic therapy,” J. Natl. Cancer Inst. 90, 889 (1998).
[CrossRef]

Opt. Zh. (2)

Kang Uk, G. V. Papayan, Bae Soo-Jin, V. B. Berezin, and S. Kim, “Fluorescence video dermatoscope,” Opt. Zh. 75, No. 1, 32 (2008) Kang Uk, G. V. Papayan, Bae Soo-Jin, V. B. Berezin, and S. Kim[J. Opt. Technol. 75, 24 (2008)].

G. V. Papayan and Kang Uk, “Fluorescence endoscopic video system,” Opt. Zh. 64, No. 10, 94 (2006) G. V. Papayan and Kang Uk[J. Opt. Technol. 64, 739 (2006)].

Photochem. Photobiol. (2)

J. Hewett, V. Nadeau, J. Ferguson, H. Moseley, S. Ibbotson, J. W. Allen, W. Sibbett, and M. Padgett, “The application of compact multispectral imaging system with integrated excitation source to in-vivo monitoring of fluorescence during topical photodynamic therapy of superficial skin cancer,” Photochem. Photobiol. 73, No. 30, 278 (2001).
[CrossRef]

G. A. Wagnieres, W. M. Star, and B. C. Wilson, “In-vivo fluorescence spectroscopy and imaging for oncological applications,” Photochem. Photobiol. 68, 603 (1998).
[CrossRef]

Proc. SPIE (1)

G. V. Papayan and I. Ya. Barsky, “Contact luminescence spectrophotometry for biomedical studies,” Proc. SPIE 4515, 125 (2001).
[CrossRef]

Other (4)

V. I. Karandashov, E. B. Petukhov, and V. S. Zrodnikov, Phototherapy (Light Therapy) (ed.) N.R.Paleeva (Meditisina, Moscow, 2001).

Kang Uk, G. Papayan, Bae Soo Jin, and Rim Geun Hie, “Light source for fluorescence diagnosis and photodynamic therapy,” Patent KR10-0798486.

Kang Uk, G. Papayan, D. Makarov, Lee Seung Yup, and Bae Soo Jin, “Light-source system for phototherapy of skin disease,” Patent appl. KR20070101398.

P. Papageorgiou, A. Katsambas, and A. Chu, “Phototherapy with blue (415nm) and red (660nm) light in the treatment of acne vulgaris,” British J. Dermat. No. 142, 973 (2000).

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