Abstract

An optical method of measuring hematocrit noninvasively is presented. An LED Light with multiple wavelengths was irradiated on fingernail and transmitted light from the finger was measured to predict hematocrit. A finger probe contained an LED array and detector. Our previous experience showed that prediction accuracy was sensitive to reliability of the finger probe hardware and we optimized the finger probe parameters such as the internal color, detector area and the emission area of a light source based on Design of Experiment. Using the optimized finger probe, we developed a hematocrit monitoring system and tested with 549 persons. For the calibration model with 368 persons, a regression coefficient of 0.74 and a standard deviation of 3.67 and the mean percent error of <TEX>$8\%$</TEX> were obtained. Hematocrits for 181 persons were predicted. We achieved a mean percent error of <TEX>$8.2\%$</TEX> where the regression coefficient was 0.68 and the standard deviation was 3.69.

© 2005 Optical Society of Korea

PDF Article

References

  • View by:
  • |
  • |

  1. R. McNichols and G. L. Cote, "Optical glucose sensing in biological fluids : an overview," J. Biomedical Optics, vol. 5, no. 1, pp. 5-16, 2000
    [Crossref]
  2. J.G. Webster ed., Design of Pulse Oximeters, (Institute of Physics Publishing, Bristol and Philadelphia, 1997), pp. 124-143
  3. S. Yasuda, S. Itoh, K. Isobe, et al., "New transcutaneous jaundice device with two optical paths," J. Perinat. Med., vol. 31, pp. 81-88, 2003
    [Crossref]
  4. K.J. Jeon, S-J Kim, K.K. Park, J-W Kim, and G. Yoon, "Noninvasive total hemoglobin measurement," J. of Biomedical Optics, vol. 7, no. 1, pp. 45-50, 2001
    [Crossref]
  5. S. Hahn, G. Yoon, G. Kim, and S-H Park, "Reagentless determination of human serum components using infrared absorption spectroscopy," Journal of the Optical Society of Korea, vol. 7, no. 4, pp. 240-244, 2003
    [Crossref]
  6. C. Choi, K-S Soh, S.M. Lee, and G. Yoon, "Propagation of light along an Acupuncture meridian," Journal of the Optical Society of Korea, vol. 7, no. 4, pp. 245-248, 2003
    [Crossref]
  7. R. F. Schmidt and G. Thews eds. Human Physiology, (Springer-Verlag Berlin Heidelberg, 1993), Chapt. 18
  8. S. M. Hopfer, F.L. Nadeau, M. Sundra, and G. S. Makowski, "Effect of protein on hemoglobin and hematocrit assays with a conductivitity-based point-of-care testing device : comparison with optical methods," Annals of clinical & Laboratory Science, vol. 34, pp. 75- 82, 2004
  9. H. Kanashima, T. Yamane, T. Takubo, T. Kamitani, and M. Hino, "Evaluation of noninvasive hemoglobin monitoring for hematological disorders," J. of Clin. Lab. Anal., vol. 19, pp. 1-5, 2005
    [Crossref]
  10. D. Dvir, D. Geva, O. Amir, I. Fine, E. Moanshkin, G. Fostick, and E. Segal, "Evaluation of a noninvasive hemoglobin and hematocrit monitoring device," Critical Care, vol. 9, suppl 1, P333, 2005
    [Crossref]
  11. G. Yoon, S-J Kim, K. J. Jeon, "Robust design of finger probe in non-invasive total haemoglobin monitor," Medical & Biological Engineering & Computing, vol. 43, no. 1, pp. 121-125, 2005
    [Crossref]
  12. O.Wieben, Saturation versus normalized ratio, J.G. Webster ed., Design of Pulse Oximeters, (Institute of Physics Publishing, Bristol and Philadelphia, 1997), chapter 4.4
  13. V. Twersky, "Absorption and multiple scattering by biological suspensions," J. Opt. Soc. Am., vol. 60, pp. 1084-1093, 1970
    [Crossref]

2005 (3)

H. Kanashima, T. Yamane, T. Takubo, T. Kamitani, and M. Hino, "Evaluation of noninvasive hemoglobin monitoring for hematological disorders," J. of Clin. Lab. Anal., vol. 19, pp. 1-5, 2005
[Crossref]

D. Dvir, D. Geva, O. Amir, I. Fine, E. Moanshkin, G. Fostick, and E. Segal, "Evaluation of a noninvasive hemoglobin and hematocrit monitoring device," Critical Care, vol. 9, suppl 1, P333, 2005
[Crossref]

G. Yoon, S-J Kim, K. J. Jeon, "Robust design of finger probe in non-invasive total haemoglobin monitor," Medical & Biological Engineering & Computing, vol. 43, no. 1, pp. 121-125, 2005
[Crossref]

2004 (1)

S. M. Hopfer, F.L. Nadeau, M. Sundra, and G. S. Makowski, "Effect of protein on hemoglobin and hematocrit assays with a conductivitity-based point-of-care testing device : comparison with optical methods," Annals of clinical & Laboratory Science, vol. 34, pp. 75- 82, 2004

2003 (3)

S. Hahn, G. Yoon, G. Kim, and S-H Park, "Reagentless determination of human serum components using infrared absorption spectroscopy," Journal of the Optical Society of Korea, vol. 7, no. 4, pp. 240-244, 2003
[Crossref]

C. Choi, K-S Soh, S.M. Lee, and G. Yoon, "Propagation of light along an Acupuncture meridian," Journal of the Optical Society of Korea, vol. 7, no. 4, pp. 245-248, 2003
[Crossref]

S. Yasuda, S. Itoh, K. Isobe, et al., "New transcutaneous jaundice device with two optical paths," J. Perinat. Med., vol. 31, pp. 81-88, 2003
[Crossref]

2002 (1)

K.J. Jeon, S-J Kim, K.K. Park, J-W Kim, and G. Yoon, "Noninvasive total hemoglobin measurement," J. of Biomedical Optics, vol. 7, no. 1, pp. 45-50, 2001
[Crossref]

2000 (1)

R. McNichols and G. L. Cote, "Optical glucose sensing in biological fluids : an overview," J. Biomedical Optics, vol. 5, no. 1, pp. 5-16, 2000
[Crossref]

1997 (2)

J.G. Webster ed., Design of Pulse Oximeters, (Institute of Physics Publishing, Bristol and Philadelphia, 1997), pp. 124-143

O.Wieben, Saturation versus normalized ratio, J.G. Webster ed., Design of Pulse Oximeters, (Institute of Physics Publishing, Bristol and Philadelphia, 1997), chapter 4.4

1993 (1)

R. F. Schmidt and G. Thews eds. Human Physiology, (Springer-Verlag Berlin Heidelberg, 1993), Chapt. 18

1970 (1)

V. Twersky, "Absorption and multiple scattering by biological suspensions," J. Opt. Soc. Am., vol. 60, pp. 1084-1093, 1970
[Crossref]

Annals of clinical & Laboratory Science (1)

S. M. Hopfer, F.L. Nadeau, M. Sundra, and G. S. Makowski, "Effect of protein on hemoglobin and hematocrit assays with a conductivitity-based point-of-care testing device : comparison with optical methods," Annals of clinical & Laboratory Science, vol. 34, pp. 75- 82, 2004

Critical Care (1)

D. Dvir, D. Geva, O. Amir, I. Fine, E. Moanshkin, G. Fostick, and E. Segal, "Evaluation of a noninvasive hemoglobin and hematocrit monitoring device," Critical Care, vol. 9, suppl 1, P333, 2005
[Crossref]

J. Biomedical Optics (2)

R. McNichols and G. L. Cote, "Optical glucose sensing in biological fluids : an overview," J. Biomedical Optics, vol. 5, no. 1, pp. 5-16, 2000
[Crossref]

K.J. Jeon, S-J Kim, K.K. Park, J-W Kim, and G. Yoon, "Noninvasive total hemoglobin measurement," J. of Biomedical Optics, vol. 7, no. 1, pp. 45-50, 2001
[Crossref]

Journal of Clinical Laboratory Analysis (1)

H. Kanashima, T. Yamane, T. Takubo, T. Kamitani, and M. Hino, "Evaluation of noninvasive hemoglobin monitoring for hematological disorders," J. of Clin. Lab. Anal., vol. 19, pp. 1-5, 2005
[Crossref]

Journal of Perinatal Medicine (1)

S. Yasuda, S. Itoh, K. Isobe, et al., "New transcutaneous jaundice device with two optical paths," J. Perinat. Med., vol. 31, pp. 81-88, 2003
[Crossref]

Journal of the Optical Society of America (1)

V. Twersky, "Absorption and multiple scattering by biological suspensions," J. Opt. Soc. Am., vol. 60, pp. 1084-1093, 1970
[Crossref]

Journal of the Optical Society of Korea (2)

S. Hahn, G. Yoon, G. Kim, and S-H Park, "Reagentless determination of human serum components using infrared absorption spectroscopy," Journal of the Optical Society of Korea, vol. 7, no. 4, pp. 240-244, 2003
[Crossref]

C. Choi, K-S Soh, S.M. Lee, and G. Yoon, "Propagation of light along an Acupuncture meridian," Journal of the Optical Society of Korea, vol. 7, no. 4, pp. 245-248, 2003
[Crossref]

Medical and Biological Engineering and Computing (1)

G. Yoon, S-J Kim, K. J. Jeon, "Robust design of finger probe in non-invasive total haemoglobin monitor," Medical & Biological Engineering & Computing, vol. 43, no. 1, pp. 121-125, 2005
[Crossref]

Other (3)

O.Wieben, Saturation versus normalized ratio, J.G. Webster ed., Design of Pulse Oximeters, (Institute of Physics Publishing, Bristol and Philadelphia, 1997), chapter 4.4

R. F. Schmidt and G. Thews eds. Human Physiology, (Springer-Verlag Berlin Heidelberg, 1993), Chapt. 18

J.G. Webster ed., Design of Pulse Oximeters, (Institute of Physics Publishing, Bristol and Philadelphia, 1997), pp. 124-143

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.