Abstract

This study investigated, using the Orbscan II topography system, the influence of age and sex related changes on the corneal thickness and anterior corneal curvature, more specifically the fine structure of the cornea, in a Korean young population. The Orbscan II topography system is a computer-assisted slit-beam scanning technology that can map the anterior section of the cornea. The mean central corneal thickness of all subjects was 547.532±44.529 µm. There was no statistical difference (p>0.5) in the mean central corneal thickness between males and females. Sex and age related changes in the mean central corneal thickness had no specific statistical difference (P>0.5). There was a negative correlation between the anterior corneal curvature and the central corneal thickness in all subjects, except for the twenty year olds. However, the thickness relationship between the mean central corneal and the eight paracentral corneal thicknesses had strong statistical differences in all subjects. Also age and sex related changes in the central corneal thickness and the anterior corneal curvature in all subjects had no statistically significant difference, except from 20-26 years old (p>0.05). This information could be a suitable reference basis for future studies in the young population of Asia and for the development of examination tools for corneal refractive surgery.

© 2011 Optical Society of Korea

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  1. K. R. Wilhelmus, J. Sugar, R. A. Hyndiuk, and R. D. Stulting,“Corneal thickness changes during herpes simplex virusdisciform keratitis,” Cornea 23, 154-157 (2004).
    [CrossRef]
  2. A. M. Bron, C. Creuzot-Garcher, S. Goudeau-Boutillon, andP. d’Athis, “Falsely elevated IOP due to increased CCT,”Graefes Arch. Clin. Exp. Ophthalmol. 227, 220-224 (1999).
  3. M. M. Marsich and M. A. Bullimore, “The repeatibility ofcorneal thickness measures,” Cornea 19, 792-795 (2000).
    [CrossRef]
  4. A. K. Lam and W. A. Douthwaite, “The corneal-thicknessprofile in Hong Kong Chinese,” Cornea 17, 384-388 (1998).
    [CrossRef]
  5. C. B. Cosar and A. B. Sener, “Orbscan corneal topographysystem in evaluating the anterior structures of the humaneye,” Cornea 22, 118-121 (2003).
    [CrossRef]
  6. Z. Liu and S. C. Pflugfelder, “Corneal thickness is reducedin dry eye,” Cornea 18, 403-407 (1999).
  7. Z. Liu, A. J. Huang, and S. C. Pflugfelder, “Evaluation ofcorneal thickness and topography in normal eyes using theOrbscan corneal system,” Br. J. Ophthalmol. 83, 774-778 (1999).
    [CrossRef]
  8. C. Sorrention, P. Affinito, F. M. Raso, M. Loffredo, P.Merlino, A. Loffredo, S. Palomba, and C. Nappi, “Effect ofhormone replacement therapy on postmenopausal ocular function,”Minerva Ginecol. 50, 19-24 (1998).
  9. S.-G. Juan A, L.-P. Antonio, A. Luis, M. S. Rahhal, andM.-S. Franciso, “Anatomic study of the corneal thicknessof young emmetropic subjects,” Cornea 23, 669-673 (2004).
    [CrossRef]
  10. M. Bohnke, P. Chavanne, R. Gianotti, and R. P. Salathe,“Continuous non-contact corneal pachymetry with a highspeed reflectometer,” J. Refract. Surg. 14, 140-146 (1998).
  11. Y. Feng, J. Varikooty, and T. L. Simpson, “Diurnal variationof corneal and corneal epithelial measured using opticalcoherence tomography,” Cornea 20, 480-483 (2001).
    [CrossRef]
  12. R. Florian, S. Anke, B. Christine, and E. Carl, “Age-relatedchanges in central and peripheral corneal thickness-determinationof normal values with the Orbscan II topography system,”Cornea 26, 1-5 (2007).
    [CrossRef]
  13. P. Cho and S. W. Cheung, “Repeatability of corneal thicknessmeasurements made by a scanning slit topography system,”Ophthalmic Physiol. Opt. 22, 505-510 (2002).
    [CrossRef]
  14. M. A. Hussein, E. A. Paysse, N. P. Bell, D. K. Coats, K.M. B. McCreery, D. D. Koch, S. Orengo-Nania, D. Baskin,and K. R. Wilhelmus, “Corneal thickness in children,” Am.J. Ophthalmol. 138, 744-748 (2004).
    [CrossRef]
  15. H. Akiko, S. Miho, T. Kinnichi, M. K. Yuka, A. Ryo, andH. Yoshihiro, “Central corneal thickness in Japanese children,”Jpn. J. Ophthalmol. 53, 7-11 (2009).
    [CrossRef]
  16. T. Autzen and L. Bjornstrom, “Central corneal thickness infull-term newborns,” Acta Ophthalmol. (copenh) 67, 719-720(1989).
  17. T. Autzen and L. Bjornstrom, “Central corneal thickness infull-term newborns,” Acta Ophthalmol. (copenh) 69, 251-252(1991).
  18. M. Sawa, “Measurement of corneal thickness,” Jap. Rev.Clin. Ophthalmol. (Ganka Rinsho Iho) 80, 177-184 (1986).
  19. K. W. Muir, J. Jin, and S. F. Freedman, “Central cornealthickness and its relationship to intraocular pressure in children,”Ophthalmology 111, 2220-2223 (2004).
    [CrossRef]
  20. L. Jr. Modis, A. Langenbucher, and B. Seitz, “Evaluationof normal cornea using the scanning-slit topography/pachymetrysystem,” Cornea 23, 689-694 (2004).
    [CrossRef]
  21. P. J. Foster, J. Baasanhu, P. H. Alsbirk, D. Munkhbayer,D. Uranchimeg, and G. J. Johnson, “Central corneal thicknessand intraocular pressure in Mongolian population,” Ophthalmology105, 969-973 (1998).
    [CrossRef]
  22. F. W. Price, D. L. Koller, and M. O. Price, “Central cornealpachymetry in patients undergoing laser in situ keratomileusis,”Ophthalmology 106, 2216-2220 (1999).
    [CrossRef]
  23. F. A. La Rosa, R. L. Gross, and S. Orengo-Nania, “Centralcorneal thickness of Caucasian and African Americans inglaucomatous and nonglaucomatous populations,” ArchOphthalmol. 119, 23-27 (2001).
  24. M. J. Doughty and M. L. Zaman, “Human corneal thicknessand its impact on intraocular pressure measures: a reviewand meta-analysis approach,” Surv. Ophthalmol. 44, 367-408(2000).
    [CrossRef]
  25. P. Erickson, T. L. Comstock, and S. G. Zantos, “Is thesuperior cornea continuously swollen?,” Clin. Exp. Optom.85, 168-171 (2002).
    [CrossRef]
  26. M. J. G. Fernandez, A. D. Rey, A. Cervino, and E. Yebra-Pimentel, “A comparison of corneal of two pachymetricsystems: slit-scanning and ultrasonic,” CLAO J. 28, 221-223(2002).

2009

H. Akiko, S. Miho, T. Kinnichi, M. K. Yuka, A. Ryo, andH. Yoshihiro, “Central corneal thickness in Japanese children,”Jpn. J. Ophthalmol. 53, 7-11 (2009).
[CrossRef]

2007

R. Florian, S. Anke, B. Christine, and E. Carl, “Age-relatedchanges in central and peripheral corneal thickness-determinationof normal values with the Orbscan II topography system,”Cornea 26, 1-5 (2007).
[CrossRef]

2004

S.-G. Juan A, L.-P. Antonio, A. Luis, M. S. Rahhal, andM.-S. Franciso, “Anatomic study of the corneal thicknessof young emmetropic subjects,” Cornea 23, 669-673 (2004).
[CrossRef]

M. A. Hussein, E. A. Paysse, N. P. Bell, D. K. Coats, K.M. B. McCreery, D. D. Koch, S. Orengo-Nania, D. Baskin,and K. R. Wilhelmus, “Corneal thickness in children,” Am.J. Ophthalmol. 138, 744-748 (2004).
[CrossRef]

K. R. Wilhelmus, J. Sugar, R. A. Hyndiuk, and R. D. Stulting,“Corneal thickness changes during herpes simplex virusdisciform keratitis,” Cornea 23, 154-157 (2004).
[CrossRef]

K. W. Muir, J. Jin, and S. F. Freedman, “Central cornealthickness and its relationship to intraocular pressure in children,”Ophthalmology 111, 2220-2223 (2004).
[CrossRef]

L. Jr. Modis, A. Langenbucher, and B. Seitz, “Evaluationof normal cornea using the scanning-slit topography/pachymetrysystem,” Cornea 23, 689-694 (2004).
[CrossRef]

2003

C. B. Cosar and A. B. Sener, “Orbscan corneal topographysystem in evaluating the anterior structures of the humaneye,” Cornea 22, 118-121 (2003).
[CrossRef]

2002

P. Cho and S. W. Cheung, “Repeatability of corneal thicknessmeasurements made by a scanning slit topography system,”Ophthalmic Physiol. Opt. 22, 505-510 (2002).
[CrossRef]

P. Erickson, T. L. Comstock, and S. G. Zantos, “Is thesuperior cornea continuously swollen?,” Clin. Exp. Optom.85, 168-171 (2002).
[CrossRef]

M. J. G. Fernandez, A. D. Rey, A. Cervino, and E. Yebra-Pimentel, “A comparison of corneal of two pachymetricsystems: slit-scanning and ultrasonic,” CLAO J. 28, 221-223(2002).

2001

F. A. La Rosa, R. L. Gross, and S. Orengo-Nania, “Centralcorneal thickness of Caucasian and African Americans inglaucomatous and nonglaucomatous populations,” ArchOphthalmol. 119, 23-27 (2001).

Y. Feng, J. Varikooty, and T. L. Simpson, “Diurnal variationof corneal and corneal epithelial measured using opticalcoherence tomography,” Cornea 20, 480-483 (2001).
[CrossRef]

2000

M. M. Marsich and M. A. Bullimore, “The repeatibility ofcorneal thickness measures,” Cornea 19, 792-795 (2000).
[CrossRef]

M. J. Doughty and M. L. Zaman, “Human corneal thicknessand its impact on intraocular pressure measures: a reviewand meta-analysis approach,” Surv. Ophthalmol. 44, 367-408(2000).
[CrossRef]

1999

F. W. Price, D. L. Koller, and M. O. Price, “Central cornealpachymetry in patients undergoing laser in situ keratomileusis,”Ophthalmology 106, 2216-2220 (1999).
[CrossRef]

A. M. Bron, C. Creuzot-Garcher, S. Goudeau-Boutillon, andP. d’Athis, “Falsely elevated IOP due to increased CCT,”Graefes Arch. Clin. Exp. Ophthalmol. 227, 220-224 (1999).

Z. Liu and S. C. Pflugfelder, “Corneal thickness is reducedin dry eye,” Cornea 18, 403-407 (1999).

Z. Liu, A. J. Huang, and S. C. Pflugfelder, “Evaluation ofcorneal thickness and topography in normal eyes using theOrbscan corneal system,” Br. J. Ophthalmol. 83, 774-778 (1999).
[CrossRef]

1998

C. Sorrention, P. Affinito, F. M. Raso, M. Loffredo, P.Merlino, A. Loffredo, S. Palomba, and C. Nappi, “Effect ofhormone replacement therapy on postmenopausal ocular function,”Minerva Ginecol. 50, 19-24 (1998).

A. K. Lam and W. A. Douthwaite, “The corneal-thicknessprofile in Hong Kong Chinese,” Cornea 17, 384-388 (1998).
[CrossRef]

M. Bohnke, P. Chavanne, R. Gianotti, and R. P. Salathe,“Continuous non-contact corneal pachymetry with a highspeed reflectometer,” J. Refract. Surg. 14, 140-146 (1998).

P. J. Foster, J. Baasanhu, P. H. Alsbirk, D. Munkhbayer,D. Uranchimeg, and G. J. Johnson, “Central corneal thicknessand intraocular pressure in Mongolian population,” Ophthalmology105, 969-973 (1998).
[CrossRef]

1991

T. Autzen and L. Bjornstrom, “Central corneal thickness infull-term newborns,” Acta Ophthalmol. (copenh) 69, 251-252(1991).

1989

T. Autzen and L. Bjornstrom, “Central corneal thickness infull-term newborns,” Acta Ophthalmol. (copenh) 67, 719-720(1989).

1986

M. Sawa, “Measurement of corneal thickness,” Jap. Rev.Clin. Ophthalmol. (Ganka Rinsho Iho) 80, 177-184 (1986).

Acta Ophthalmol. (copenh)

T. Autzen and L. Bjornstrom, “Central corneal thickness infull-term newborns,” Acta Ophthalmol. (copenh) 67, 719-720(1989).

T. Autzen and L. Bjornstrom, “Central corneal thickness infull-term newborns,” Acta Ophthalmol. (copenh) 69, 251-252(1991).

Am. J. Ophthalmol.

M. A. Hussein, E. A. Paysse, N. P. Bell, D. K. Coats, K.M. B. McCreery, D. D. Koch, S. Orengo-Nania, D. Baskin,and K. R. Wilhelmus, “Corneal thickness in children,” Am.J. Ophthalmol. 138, 744-748 (2004).
[CrossRef]

Arch Ophthalmol.

F. A. La Rosa, R. L. Gross, and S. Orengo-Nania, “Centralcorneal thickness of Caucasian and African Americans inglaucomatous and nonglaucomatous populations,” ArchOphthalmol. 119, 23-27 (2001).

Br. J. Ophthalmol.

Z. Liu, A. J. Huang, and S. C. Pflugfelder, “Evaluation ofcorneal thickness and topography in normal eyes using theOrbscan corneal system,” Br. J. Ophthalmol. 83, 774-778 (1999).
[CrossRef]

CLAO J.

M. J. G. Fernandez, A. D. Rey, A. Cervino, and E. Yebra-Pimentel, “A comparison of corneal of two pachymetricsystems: slit-scanning and ultrasonic,” CLAO J. 28, 221-223(2002).

Clin. Exp. Optom.

P. Erickson, T. L. Comstock, and S. G. Zantos, “Is thesuperior cornea continuously swollen?,” Clin. Exp. Optom.85, 168-171 (2002).
[CrossRef]

Cornea

L. Jr. Modis, A. Langenbucher, and B. Seitz, “Evaluationof normal cornea using the scanning-slit topography/pachymetrysystem,” Cornea 23, 689-694 (2004).
[CrossRef]

K. R. Wilhelmus, J. Sugar, R. A. Hyndiuk, and R. D. Stulting,“Corneal thickness changes during herpes simplex virusdisciform keratitis,” Cornea 23, 154-157 (2004).
[CrossRef]

M. M. Marsich and M. A. Bullimore, “The repeatibility ofcorneal thickness measures,” Cornea 19, 792-795 (2000).
[CrossRef]

A. K. Lam and W. A. Douthwaite, “The corneal-thicknessprofile in Hong Kong Chinese,” Cornea 17, 384-388 (1998).
[CrossRef]

C. B. Cosar and A. B. Sener, “Orbscan corneal topographysystem in evaluating the anterior structures of the humaneye,” Cornea 22, 118-121 (2003).
[CrossRef]

Z. Liu and S. C. Pflugfelder, “Corneal thickness is reducedin dry eye,” Cornea 18, 403-407 (1999).

S.-G. Juan A, L.-P. Antonio, A. Luis, M. S. Rahhal, andM.-S. Franciso, “Anatomic study of the corneal thicknessof young emmetropic subjects,” Cornea 23, 669-673 (2004).
[CrossRef]

Y. Feng, J. Varikooty, and T. L. Simpson, “Diurnal variationof corneal and corneal epithelial measured using opticalcoherence tomography,” Cornea 20, 480-483 (2001).
[CrossRef]

R. Florian, S. Anke, B. Christine, and E. Carl, “Age-relatedchanges in central and peripheral corneal thickness-determinationof normal values with the Orbscan II topography system,”Cornea 26, 1-5 (2007).
[CrossRef]

Graefes Arch. Clin. Exp. Ophthalmol.

A. M. Bron, C. Creuzot-Garcher, S. Goudeau-Boutillon, andP. d’Athis, “Falsely elevated IOP due to increased CCT,”Graefes Arch. Clin. Exp. Ophthalmol. 227, 220-224 (1999).

J. Refract. Surg.

M. Bohnke, P. Chavanne, R. Gianotti, and R. P. Salathe,“Continuous non-contact corneal pachymetry with a highspeed reflectometer,” J. Refract. Surg. 14, 140-146 (1998).

Jap. Rev. Clin. Ophthalmol. (Ganka Rinsho Iho)

M. Sawa, “Measurement of corneal thickness,” Jap. Rev.Clin. Ophthalmol. (Ganka Rinsho Iho) 80, 177-184 (1986).

Jpn. J. Ophthalmol.

H. Akiko, S. Miho, T. Kinnichi, M. K. Yuka, A. Ryo, andH. Yoshihiro, “Central corneal thickness in Japanese children,”Jpn. J. Ophthalmol. 53, 7-11 (2009).
[CrossRef]

Minerva Ginecol.

C. Sorrention, P. Affinito, F. M. Raso, M. Loffredo, P.Merlino, A. Loffredo, S. Palomba, and C. Nappi, “Effect ofhormone replacement therapy on postmenopausal ocular function,”Minerva Ginecol. 50, 19-24 (1998).

Ophthalmic Physiol. Opt.

P. Cho and S. W. Cheung, “Repeatability of corneal thicknessmeasurements made by a scanning slit topography system,”Ophthalmic Physiol. Opt. 22, 505-510 (2002).
[CrossRef]

Ophthalmology

K. W. Muir, J. Jin, and S. F. Freedman, “Central cornealthickness and its relationship to intraocular pressure in children,”Ophthalmology 111, 2220-2223 (2004).
[CrossRef]

P. J. Foster, J. Baasanhu, P. H. Alsbirk, D. Munkhbayer,D. Uranchimeg, and G. J. Johnson, “Central corneal thicknessand intraocular pressure in Mongolian population,” Ophthalmology105, 969-973 (1998).
[CrossRef]

F. W. Price, D. L. Koller, and M. O. Price, “Central cornealpachymetry in patients undergoing laser in situ keratomileusis,”Ophthalmology 106, 2216-2220 (1999).
[CrossRef]

Surv. Ophthalmol.

M. J. Doughty and M. L. Zaman, “Human corneal thicknessand its impact on intraocular pressure measures: a reviewand meta-analysis approach,” Surv. Ophthalmol. 44, 367-408(2000).
[CrossRef]

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