Abstract

We introduce a novel contrast mechanism for imaging superparamagnetic iron oxide (SPIO) nanoparticles (average diameter <TEX>${\sim}100nm$</TEX>) using magneto-motive optical Doppler tomography (MM-ODT), which combines an externally applied temporally oscillating high-strength magnetic field with ODT to detect the nanoparticles flowing through a glass capillary tube. A solenoid cone-shaped ferrite core extensively increased the magnetic field strength (<TEX>$B_{max}=1\;T,\;{\Delta}|B|^2=220T^2/m$</TEX>) at the tip of the core and also focused the magnetic force on targeted samples. Nanoparticle contrast was demonstrated in a capillary tube filled with the SPIO solution by imaging the Doppler frequency shift which was observed independent of the flow rate and direction. Results suggest that MM-ODT may be a promising technique to enhance SPIO nanoparticle contrast for imaging fluid flow.

© 2006 Optical Society of Korea

PDF Article

References

  • View by:
  • |
  • |

  1. A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, "Optical coherence tomography - principles and applications," Rep. Pro. Phys., vol. 66, pp. 239-303, 2003
    [CrossRef]
  2. B. H. Park, M. C. Pierce, B. Cense, and J. F. de Boer, "Real-time multi-functional optical coherence tomography," Opt. Express, vol. 11, pp. 782-793, 2003
    [CrossRef]
  3. N. J. Kemp, J. Park, H. N. Zaatari, H. G. Rylander, and T. E. Milner, "High-sensitivity determination of birefringence in turbid media with enhanced polarization-sensitive optical coherence tomography," J. Opt. Soc. Amer·. A, vol. 22, pp. 552-560, 2005
    [CrossRef]
  4. D. P. Dave, T. Akkin, and T. E. Milner, "Polarization-maintaining fiber-based optical low-coherence reflectometer for characterization and ranging of birefringence," Opt. Lett., vol. 28, pp. 1775-1777, 2003
    [CrossRef]
  5. C. G. Rylander, D. P. Dave, T. Akkin, T. E. Milner, K. R. Diller, and A. J. Welch, "Quantitative phasecontrast imaging of cells with phase-sensitive optical coherence microscopy," Opt. Lett., vol. 29, pp. 1509-1511, 2004
    [CrossRef]
  6. J. F. de Boer, T. E. Milner, M. G. Ducros, S. M. Srinivas, and J. S. Nelson, "Polarization-sensitive optical coherence tomography," in Handbook Of Optical Coherence Tomography., B. E. Bouma, and G. J. Tearney, eds. (Marcel Dekker, Inc, New York, 2002), pp. 237-274.
  7. Z. P. Chen, T. E. Milner, D. Dave, and J. S. Nelson, "Optical Doppler tomographic imaging of fluid flow velocity in highly scattering media," Opt. Lett., vol. 22, pp. 64-66, 1997
    [CrossRef]
  8. X. J. Wang, T. E. Milner, and J. S. Nelson, "Characterization of Fluid-Flow Velocity by Optical Doppler Tomography," Opt. Lett., vol. 20, pp. 1337-1339, 1995
    [CrossRef]
  9. Y. H. Zhao, Z. P. Chen, C. Saxer, S. H. Xiang, J. F. de Boer, and J. S. Nelson, "Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity," Opt. Lett., vol. 25, pp. 114-116, 2000
    [CrossRef]
  10. B. H. Park, M. C. Pierce, B. Cense, S. H. Yun, M. Mujat, G. J. Tearney, B. E. Bouma, and J. F. de Boer, "Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 <TEX>${\mu}m$</TEX>," Opt. Express, vol. 13, pp. 3931-3944, 2005
    [CrossRef]
  11. M. C. Pierce, B. H. Park, B. Cense, and J. F. de Boer, "Simultaneous intensity, birefringence, and flow measurements with high-speed fiber-based optical coherence tomography," Opt. Lett., vol. 27, 1534-1536, 2002
    [CrossRef]
  12. D. Q. Piao, and Q. Zhu, "Quantifying Doppler angle and mapping flow velocity by a combination of Doppler-shift and Doppler-bandwidth measurements in optical Doppler tomography," Appl. Opt., vol. 42, pp. 5158-5166, 2003
    [CrossRef]
  13. T. M. Lee, A. L. Oldenburg, S. Sitafalwalla, D. L. Marks, W. Luo, F. J. J. Toublan, K. S. Suslick, and S. A. Boppart, "Engineered microsphere contrast agents for optical coherence tomography," Opt. Lett., vol. 28, pp. 1546-1548, 2003
    [CrossRef]
  14. C. Loo, A. Lin, L. Hirsch, M. H. Lee, J. Barton, N. Halas, J. West, and R. Drezek, "Nanoshell-enabled photonics-based imaging and therapy of cancer," Technol. Cancer Res. Treat., vol. 3, pp. 33-40, 2004
  15. A. L. Oldenburg, J. R. Gunther, and S. A. Boppart, "Imaging magnetically labeled cells with magnetomotive optical coherence tomography," Opt. Lett., vol. 30, pp. 747-749, 2005
    [CrossRef]
  16. A. L. Oldenburg, F. J. J. Toublan, K. S. Suslick, A. Wei, and S. A. Boppart, "Magnetomotive contrast for in vivo optical coherence tomography," Opt. Express, vol. 13, pp. 6597-6614, 2005
    [CrossRef]
  17. Y. X. J. Wang, S. M. Hussain, and G. P. Krestin, "Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging," Eur. Radio., vol. 11, pp. 2319-2331, 2001
    [CrossRef]
  18. A. K. Fahlvik, J. Klaveness, and D. D. Stark, "Iron Oxides as Mr Imaging Contrast Agents," J. Magn. Reson. Imaging., vol. 3, pp. 187-194, 1993
    [CrossRef]
  19. R. Weissleder, A. Bogdanov, E. A. Neuwelt, and M. Papisov, "Long-Circulating Iron-Oxides for Mr-Imaging," Adv. Drug Deliv. Rev., vol. 16, pp. 321-334, 1995
    [CrossRef]

2005

N. J. Kemp, J. Park, H. N. Zaatari, H. G. Rylander, and T. E. Milner, "High-sensitivity determination of birefringence in turbid media with enhanced polarization-sensitive optical coherence tomography," J. Opt. Soc. Amer·. A, vol. 22, pp. 552-560, 2005
[CrossRef]

B. H. Park, M. C. Pierce, B. Cense, S. H. Yun, M. Mujat, G. J. Tearney, B. E. Bouma, and J. F. de Boer, "Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 <TEX>${\mu}m$</TEX>," Opt. Express, vol. 13, pp. 3931-3944, 2005
[CrossRef]

A. L. Oldenburg, J. R. Gunther, and S. A. Boppart, "Imaging magnetically labeled cells with magnetomotive optical coherence tomography," Opt. Lett., vol. 30, pp. 747-749, 2005
[CrossRef]

A. L. Oldenburg, F. J. J. Toublan, K. S. Suslick, A. Wei, and S. A. Boppart, "Magnetomotive contrast for in vivo optical coherence tomography," Opt. Express, vol. 13, pp. 6597-6614, 2005
[CrossRef]

2004

C. G. Rylander, D. P. Dave, T. Akkin, T. E. Milner, K. R. Diller, and A. J. Welch, "Quantitative phasecontrast imaging of cells with phase-sensitive optical coherence microscopy," Opt. Lett., vol. 29, pp. 1509-1511, 2004
[CrossRef]

C. Loo, A. Lin, L. Hirsch, M. H. Lee, J. Barton, N. Halas, J. West, and R. Drezek, "Nanoshell-enabled photonics-based imaging and therapy of cancer," Technol. Cancer Res. Treat., vol. 3, pp. 33-40, 2004

2003

D. P. Dave, T. Akkin, and T. E. Milner, "Polarization-maintaining fiber-based optical low-coherence reflectometer for characterization and ranging of birefringence," Opt. Lett., vol. 28, pp. 1775-1777, 2003
[CrossRef]

A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, "Optical coherence tomography - principles and applications," Rep. Pro. Phys., vol. 66, pp. 239-303, 2003
[CrossRef]

B. H. Park, M. C. Pierce, B. Cense, and J. F. de Boer, "Real-time multi-functional optical coherence tomography," Opt. Express, vol. 11, pp. 782-793, 2003
[CrossRef]

D. Q. Piao, and Q. Zhu, "Quantifying Doppler angle and mapping flow velocity by a combination of Doppler-shift and Doppler-bandwidth measurements in optical Doppler tomography," Appl. Opt., vol. 42, pp. 5158-5166, 2003
[CrossRef]

T. M. Lee, A. L. Oldenburg, S. Sitafalwalla, D. L. Marks, W. Luo, F. J. J. Toublan, K. S. Suslick, and S. A. Boppart, "Engineered microsphere contrast agents for optical coherence tomography," Opt. Lett., vol. 28, pp. 1546-1548, 2003
[CrossRef]

2002

M. C. Pierce, B. H. Park, B. Cense, and J. F. de Boer, "Simultaneous intensity, birefringence, and flow measurements with high-speed fiber-based optical coherence tomography," Opt. Lett., vol. 27, 1534-1536, 2002
[CrossRef]

J. F. de Boer, T. E. Milner, M. G. Ducros, S. M. Srinivas, and J. S. Nelson, "Polarization-sensitive optical coherence tomography," in Handbook Of Optical Coherence Tomography., B. E. Bouma, and G. J. Tearney, eds. (Marcel Dekker, Inc, New York, 2002), pp. 237-274.

2001

Y. X. J. Wang, S. M. Hussain, and G. P. Krestin, "Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging," Eur. Radio., vol. 11, pp. 2319-2331, 2001
[CrossRef]

2000

Y. H. Zhao, Z. P. Chen, C. Saxer, S. H. Xiang, J. F. de Boer, and J. S. Nelson, "Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity," Opt. Lett., vol. 25, pp. 114-116, 2000
[CrossRef]

1997

Z. P. Chen, T. E. Milner, D. Dave, and J. S. Nelson, "Optical Doppler tomographic imaging of fluid flow velocity in highly scattering media," Opt. Lett., vol. 22, pp. 64-66, 1997
[CrossRef]

1995

X. J. Wang, T. E. Milner, and J. S. Nelson, "Characterization of Fluid-Flow Velocity by Optical Doppler Tomography," Opt. Lett., vol. 20, pp. 1337-1339, 1995
[CrossRef]

R. Weissleder, A. Bogdanov, E. A. Neuwelt, and M. Papisov, "Long-Circulating Iron-Oxides for Mr-Imaging," Adv. Drug Deliv. Rev., vol. 16, pp. 321-334, 1995
[CrossRef]

1993

A. K. Fahlvik, J. Klaveness, and D. D. Stark, "Iron Oxides as Mr Imaging Contrast Agents," J. Magn. Reson. Imaging., vol. 3, pp. 187-194, 1993
[CrossRef]

Advanced Drug Delivery Reviews

R. Weissleder, A. Bogdanov, E. A. Neuwelt, and M. Papisov, "Long-Circulating Iron-Oxides for Mr-Imaging," Adv. Drug Deliv. Rev., vol. 16, pp. 321-334, 1995
[CrossRef]

Applied Optics

D. Q. Piao, and Q. Zhu, "Quantifying Doppler angle and mapping flow velocity by a combination of Doppler-shift and Doppler-bandwidth measurements in optical Doppler tomography," Appl. Opt., vol. 42, pp. 5158-5166, 2003
[CrossRef]

European Radiology

Y. X. J. Wang, S. M. Hussain, and G. P. Krestin, "Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging," Eur. Radio., vol. 11, pp. 2319-2331, 2001
[CrossRef]

Journal of Magnetic Resonance Imaging

A. K. Fahlvik, J. Klaveness, and D. D. Stark, "Iron Oxides as Mr Imaging Contrast Agents," J. Magn. Reson. Imaging., vol. 3, pp. 187-194, 1993
[CrossRef]

Journal of the Optical Society of America A

N. J. Kemp, J. Park, H. N. Zaatari, H. G. Rylander, and T. E. Milner, "High-sensitivity determination of birefringence in turbid media with enhanced polarization-sensitive optical coherence tomography," J. Opt. Soc. Amer·. A, vol. 22, pp. 552-560, 2005
[CrossRef]

Optics Express

B. H. Park, M. C. Pierce, B. Cense, and J. F. de Boer, "Real-time multi-functional optical coherence tomography," Opt. Express, vol. 11, pp. 782-793, 2003
[CrossRef]

A. L. Oldenburg, F. J. J. Toublan, K. S. Suslick, A. Wei, and S. A. Boppart, "Magnetomotive contrast for in vivo optical coherence tomography," Opt. Express, vol. 13, pp. 6597-6614, 2005
[CrossRef]

B. H. Park, M. C. Pierce, B. Cense, S. H. Yun, M. Mujat, G. J. Tearney, B. E. Bouma, and J. F. de Boer, "Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 <TEX>${\mu}m$</TEX>," Opt. Express, vol. 13, pp. 3931-3944, 2005
[CrossRef]

Optics Letters

M. C. Pierce, B. H. Park, B. Cense, and J. F. de Boer, "Simultaneous intensity, birefringence, and flow measurements with high-speed fiber-based optical coherence tomography," Opt. Lett., vol. 27, 1534-1536, 2002
[CrossRef]

T. M. Lee, A. L. Oldenburg, S. Sitafalwalla, D. L. Marks, W. Luo, F. J. J. Toublan, K. S. Suslick, and S. A. Boppart, "Engineered microsphere contrast agents for optical coherence tomography," Opt. Lett., vol. 28, pp. 1546-1548, 2003
[CrossRef]

A. L. Oldenburg, J. R. Gunther, and S. A. Boppart, "Imaging magnetically labeled cells with magnetomotive optical coherence tomography," Opt. Lett., vol. 30, pp. 747-749, 2005
[CrossRef]

Z. P. Chen, T. E. Milner, D. Dave, and J. S. Nelson, "Optical Doppler tomographic imaging of fluid flow velocity in highly scattering media," Opt. Lett., vol. 22, pp. 64-66, 1997
[CrossRef]

X. J. Wang, T. E. Milner, and J. S. Nelson, "Characterization of Fluid-Flow Velocity by Optical Doppler Tomography," Opt. Lett., vol. 20, pp. 1337-1339, 1995
[CrossRef]

Y. H. Zhao, Z. P. Chen, C. Saxer, S. H. Xiang, J. F. de Boer, and J. S. Nelson, "Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity," Opt. Lett., vol. 25, pp. 114-116, 2000
[CrossRef]

D. P. Dave, T. Akkin, and T. E. Milner, "Polarization-maintaining fiber-based optical low-coherence reflectometer for characterization and ranging of birefringence," Opt. Lett., vol. 28, pp. 1775-1777, 2003
[CrossRef]

C. G. Rylander, D. P. Dave, T. Akkin, T. E. Milner, K. R. Diller, and A. J. Welch, "Quantitative phasecontrast imaging of cells with phase-sensitive optical coherence microscopy," Opt. Lett., vol. 29, pp. 1509-1511, 2004
[CrossRef]

Reports on Progress in Physics

A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, "Optical coherence tomography - principles and applications," Rep. Pro. Phys., vol. 66, pp. 239-303, 2003
[CrossRef]

Technol Cancer Res. Treat.

C. Loo, A. Lin, L. Hirsch, M. H. Lee, J. Barton, N. Halas, J. West, and R. Drezek, "Nanoshell-enabled photonics-based imaging and therapy of cancer," Technol. Cancer Res. Treat., vol. 3, pp. 33-40, 2004

Other

J. F. de Boer, T. E. Milner, M. G. Ducros, S. M. Srinivas, and J. S. Nelson, "Polarization-sensitive optical coherence tomography," in Handbook Of Optical Coherence Tomography., B. E. Bouma, and G. J. Tearney, eds. (Marcel Dekker, Inc, New York, 2002), pp. 237-274.

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.