Abstract

M-mode imaging of the in vivo murine myocardium using optical coherence tomography (OCT) is described. Application of conventional techniques (e.g. MRI, Ultrasound imaging) for imaging the murine myocardium is problematic because the wall thickness is less than 1.5 mm (20 g mouse), and the heart rate can be as high as six hundred beats per minute. To acquire a real-time image of the murine myocardium, OCT can provide sufficient spatial resolution (<TEX>$10{\mu}m$</TEX>) and imaging speed (1000 A-scans/s). Strong light scattering by blood in the heart causes significant light attenuation, which makes delineation of the endocardium-chamber boundary problematic. To measure the thickness change of the myocardium during one heart beat cycle, a myocardium edge detection algorithm is developed and demonstrated.

© 2006 Optical Society of Korea

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    [CrossRef]
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    [CrossRef]
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    [CrossRef]
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    [CrossRef]
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    [CrossRef]
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    [CrossRef]
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2000 (1)

P. Patwari et al., "Assessment of coronary plaque with optical coherence tomography and high-frequency ultrasound," American Journal of Cardiology, vol. 85, no. 5, pp. 641-644, 2000
[CrossRef]

1999 (3)

A. Roggan et al., "Optical properties of circulating human blood in the wavelength range 400-2500 NM," Journal of Biomedical Optics, vol. 4, no. 1, pp. 36-46, 1999
[CrossRef]

M. G. Ducros et al., "Polarization sensitive optical coherence tomography of the rabbit eye," IEEE Journal of Selected Topics in Quantum Electronics, vol. 5, no. 4, pp. 1159-1167, 1999
[CrossRef]

J. G. Fujimoto et al., High resolution in vivo intraarterial imaging with optical coherence tomography," Heart, vol. 82 no. 2, pp. 128-133, 1999

1998 (2)

A. M. Rollins et al., "In vivo video rate optical coherence tomography," Optics Express, vol. 3, no. 6, pp. 219-229, 1998
[CrossRef]

S. Tsekeridou, C. K., and I. Pitas, "Morphological Signal Adaptive Filter for Still Image and Image Sequence Filtering," ISCAS "98, no. 4, pp. 21-24, 1998
[CrossRef]

1997 (2)

S. A. Boppart et al., "Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography," Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 9, pp. 4256-4261, 1997
[CrossRef]

Z. P. Chen et al., "Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography," Optics Letters, vol. 22, no. 14, pp. 1119-1121, 1997
[CrossRef]

1996 (1)

M. E. Brezinski et al., "Imaging of coronary artery microstructure (in vitro) with optical coherence tomography," American Journal of Cardiology, vol. 77, no. 1, pp. 92-93, 1996
[CrossRef]

1995 (2)

M. R. Hee et al., "Optical coherence tomography of the human retina," Archives of Ophthalmology, vol. 113, no. 3, pp. 323-332, 1995

J. M., Schmitt, M. J. Yadlowsky, and R. F. Bonner, "Subsurface Imaging of Living Skin with Optical Coherence Microscopy," Dermatology, vol. 191, no. 2, pp. 93-98, 1995
[CrossRef]

1993 (1)

T. Viero and Y. N., "3-D Median structures for image sequence filtering and coding," In Motion Analysis and Image Sequence Processing, 1993

1992 (1)

A. W. T. Lim, E. K. T., and D. P. Mital, "Edge Detection in Range Image with Multiple Window Operators," TENCON "92, no. 2, pp. 809-814, 1992
[CrossRef]

1991 (1)

D. Huang et al., "Optical coherence tomography," Science, vol. 254, no. 5035, pp. 1178-81, 1991
[CrossRef]

1986 (1)

J. M. Steinke and A. P. Shepherd, "Role of Light-Scattering in Whole-Blood Oximetry," IEEE Transactions on Biomedical Engineering, vol. 33, no. 3, pp. 294-301, 1986
[CrossRef]

1970 (1)

V. Twersky, "Absorption and Multiple Scattering by Biological Suspensions," Journal of the Optical Society of America, vol. 60, no. 8, pp. 1084-1089, 1970
[CrossRef]

1949 (1)

K. Kramer et al., "Spectrophotometric Studies on Whole Blood in the Red and near Infrared Regions," American Journal of Physiology, vol. 159, no. 3, pp. 577-577, 1949

American Journal of Physiology (1)

K. Kramer et al., "Spectrophotometric Studies on Whole Blood in the Red and near Infrared Regions," American Journal of Physiology, vol. 159, no. 3, pp. 577-577, 1949

Archives of Ophthalmology (1)

M. R. Hee et al., "Optical coherence tomography of the human retina," Archives of Ophthalmology, vol. 113, no. 3, pp. 323-332, 1995

Circuits and Systems, 1998. ISCAS '98. Proceedings of the 1998 IEEE International Symposium on (1)

S. Tsekeridou, C. K., and I. Pitas, "Morphological Signal Adaptive Filter for Still Image and Image Sequence Filtering," ISCAS "98, no. 4, pp. 21-24, 1998
[CrossRef]

Dermatology (1)

J. M., Schmitt, M. J. Yadlowsky, and R. F. Bonner, "Subsurface Imaging of Living Skin with Optical Coherence Microscopy," Dermatology, vol. 191, no. 2, pp. 93-98, 1995
[CrossRef]

Heart (1)

J. G. Fujimoto et al., High resolution in vivo intraarterial imaging with optical coherence tomography," Heart, vol. 82 no. 2, pp. 128-133, 1999

IEEE Journal of Selected Topics in Quantum Electronics (1)

M. G. Ducros et al., "Polarization sensitive optical coherence tomography of the rabbit eye," IEEE Journal of Selected Topics in Quantum Electronics, vol. 5, no. 4, pp. 1159-1167, 1999
[CrossRef]

IEEE Transactions on Biomedical Engineering (1)

J. M. Steinke and A. P. Shepherd, "Role of Light-Scattering in Whole-Blood Oximetry," IEEE Transactions on Biomedical Engineering, vol. 33, no. 3, pp. 294-301, 1986
[CrossRef]

In Motion Analysis and Image Sequence Processing (1)

T. Viero and Y. N., "3-D Median structures for image sequence filtering and coding," In Motion Analysis and Image Sequence Processing, 1993

Journal of Biomedical Optics (1)

A. Roggan et al., "Optical properties of circulating human blood in the wavelength range 400-2500 NM," Journal of Biomedical Optics, vol. 4, no. 1, pp. 36-46, 1999
[CrossRef]

Journal of the Optical Society of America (1)

V. Twersky, "Absorption and Multiple Scattering by Biological Suspensions," Journal of the Optical Society of America, vol. 60, no. 8, pp. 1084-1089, 1970
[CrossRef]

Optics Express (1)

A. M. Rollins et al., "In vivo video rate optical coherence tomography," Optics Express, vol. 3, no. 6, pp. 219-229, 1998
[CrossRef]

Optics Letters (1)

Z. P. Chen et al., "Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography," Optics Letters, vol. 22, no. 14, pp. 1119-1121, 1997
[CrossRef]

PNAS (1)

S. A. Boppart et al., "Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography," Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 9, pp. 4256-4261, 1997
[CrossRef]

Science (1)

D. Huang et al., "Optical coherence tomography," Science, vol. 254, no. 5035, pp. 1178-81, 1991
[CrossRef]

TENCON '92. Technology Enabling Tomorrow : Computers, Communications and Automation towards the 21st Century. 1992 IEEE Region 10 International Conference (1)

A. W. T. Lim, E. K. T., and D. P. Mital, "Edge Detection in Range Image with Multiple Window Operators," TENCON "92, no. 2, pp. 809-814, 1992
[CrossRef]

The American Journal of Cardiology (2)

M. E. Brezinski et al., "Imaging of coronary artery microstructure (in vitro) with optical coherence tomography," American Journal of Cardiology, vol. 77, no. 1, pp. 92-93, 1996
[CrossRef]

P. Patwari et al., "Assessment of coronary plaque with optical coherence tomography and high-frequency ultrasound," American Journal of Cardiology, vol. 85, no. 5, pp. 641-644, 2000
[CrossRef]

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