Abstract

We present an ultrahigh-resolution full-field optical coherence tomography (FF-OCT) implemented with a white-light interference microscope and a detector array as an alternative OCT technique. The use of detector array allows the capture of two-dimensional en-face images in parallel without taking any lateral scanning process. The phase shifting interferometric technique with the sinusoidal phase modulation (SPM) is utilized to get the demodulated OCT images. The configuration of the system and the resolution of the obtained image are presented. The topographic images, taken with the implemented system, of a coin, an integrated circuit chip, and the tomographic images of an onion epithelium are demonstrated also. Axial and lateral spatial resolution of <TEX>${\sim}1.0{\mu}m$</TEX> and <TEX>${\sim}2.0{\mu}m$</TEX> are achieved with the system respectively.

© 2007 Optical Society of Korea

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  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, pp. 1178-1181, 1991
    [CrossRef]
  2. J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med., vol. 1, no. 9, pp. 970-972, 1995
    [CrossRef]
  3. B. Bouma, G. J. Tearney, S. A. Boppart, M. R. Hee, M. E. Brezinski, and J. G. Fujimoto, "High-resolution optical coherence tomographic imaging using a modelocked Ti:<TEX>$Al_{2}O_{3}$</TEX> laser source," Opt. Lett., vol. 20, no. 13, pp. 1486-1488, 1995
  4. M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography of the human retina," Archiv. Ophthalmol., vol. 113, no. 3, pp. 325- 332, 1995
  5. R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of fourier domain vs. time domain optical coherence tomography," Opt. Express, vol. 11, no. 8, pp. 889-894, 2003
  6. J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-tonoise ratio in spectral-domain compared with timedomain optical coherence tomography," Opt. Lett., vol. 28, no. 21, pp. 2067-2069, 2003
    [CrossRef]
  7. A. Dubois, L. Vabre, A. C. Boccara, and E. Beaureparie, "High-resolution full-field optical coherence tomography with a Linnik microscope," Appl. Opt., vol. 41, no. 4, pp. 805-812, 2002
    [CrossRef]
  8. A. Dubois, K. Grieve, G. Moneron, R. Lecaque, L. Vabre, and C. Boccara, "Ultrahigh-resolution full-field optical coherence tomography," Appl. Opt., vol. 43, no. 14, pp. 2874-2883, 2004
    [CrossRef]
  9. K. Grieve, A. Dubois, M. Simonutti, M. Paques, J. Sahel, J. F. L. Gargasson, and C. Boccara, "In vivo anterior segment imaging in the rat eye with high speed white light full-field optical coherence tomography," Opt. Express, vol. 13, no. 16, pp. 6286-6295, 2005
    [CrossRef]
  10. S. Bourquin, P. Seitz, and R. P. Salathe, "Optical coherence topography based on a two-dimensional smart detector array," Opt. Lett., vol. 26, no. 8, pp. 512-514, 2001
    [CrossRef]
  11. M. Akiba, K. P. Chan, and N. Tanno, "Full-field optical coherence tomography by two-dimensional heterodyne detection with a pair of CCD cameras," Opt. Lett., vol. 28, no. 10, pp. 816-818, 2003
    [CrossRef]
  12. D. W. Phillion, "General methods for generating phaseshifting interferometry algorithms," Appl. Opt., vol. 36, no. 31, pp. 8098-8115, 1997
    [CrossRef]
  13. O. Sasaki and H. Okazaki, "Sinusoidal phase modulating interferometry for surface profile measurement," Appl. Opt., vol. 25, no. 18, pp. 3137-3140, 1986
    [CrossRef]
  14. A. Dubois, "Phase-map measurements by interferometry with sinusoidal phase modulation and four integrating buckets," J. Opt, Soc. Am. A, vol. 18, no. 8, pp. 1972-1979, 2001
    [CrossRef]
  15. F. L. Pedrotti and S. J. L. S. Pedrotti, Introduction to optics (Prentice Hall, 1993), pp. 323-338
  16. M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahighresolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express, vol. 12, no. 11, pp. 2404-2422, 2004
    [CrossRef]
  17. C. K. Hitzenberger, P. Trost, P. Lo, and Q. Zhou, "Three-dimensional imaging of the human retina by high-speed optical coherence tomgoraphy," Opt. Express, vol. 11, no. 21, pp. 2753-2761, 2003

2005 (1)

K. Grieve, A. Dubois, M. Simonutti, M. Paques, J. Sahel, J. F. L. Gargasson, and C. Boccara, "In vivo anterior segment imaging in the rat eye with high speed white light full-field optical coherence tomography," Opt. Express, vol. 13, no. 16, pp. 6286-6295, 2005
[CrossRef]

2004 (2)

A. Dubois, K. Grieve, G. Moneron, R. Lecaque, L. Vabre, and C. Boccara, "Ultrahigh-resolution full-field optical coherence tomography," Appl. Opt., vol. 43, no. 14, pp. 2874-2883, 2004
[CrossRef]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahighresolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express, vol. 12, no. 11, pp. 2404-2422, 2004
[CrossRef]

2003 (4)

C. K. Hitzenberger, P. Trost, P. Lo, and Q. Zhou, "Three-dimensional imaging of the human retina by high-speed optical coherence tomgoraphy," Opt. Express, vol. 11, no. 21, pp. 2753-2761, 2003

M. Akiba, K. P. Chan, and N. Tanno, "Full-field optical coherence tomography by two-dimensional heterodyne detection with a pair of CCD cameras," Opt. Lett., vol. 28, no. 10, pp. 816-818, 2003
[CrossRef]

R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of fourier domain vs. time domain optical coherence tomography," Opt. Express, vol. 11, no. 8, pp. 889-894, 2003

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-tonoise ratio in spectral-domain compared with timedomain optical coherence tomography," Opt. Lett., vol. 28, no. 21, pp. 2067-2069, 2003
[CrossRef]

2002 (1)

A. Dubois, L. Vabre, A. C. Boccara, and E. Beaureparie, "High-resolution full-field optical coherence tomography with a Linnik microscope," Appl. Opt., vol. 41, no. 4, pp. 805-812, 2002
[CrossRef]

2001 (2)

S. Bourquin, P. Seitz, and R. P. Salathe, "Optical coherence topography based on a two-dimensional smart detector array," Opt. Lett., vol. 26, no. 8, pp. 512-514, 2001
[CrossRef]

A. Dubois, "Phase-map measurements by interferometry with sinusoidal phase modulation and four integrating buckets," J. Opt, Soc. Am. A, vol. 18, no. 8, pp. 1972-1979, 2001
[CrossRef]

1997 (1)

D. W. Phillion, "General methods for generating phaseshifting interferometry algorithms," Appl. Opt., vol. 36, no. 31, pp. 8098-8115, 1997
[CrossRef]

1995 (3)

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med., vol. 1, no. 9, pp. 970-972, 1995
[CrossRef]

B. Bouma, G. J. Tearney, S. A. Boppart, M. R. Hee, M. E. Brezinski, and J. G. Fujimoto, "High-resolution optical coherence tomographic imaging using a modelocked Ti:<TEX>$Al_{2}O_{3}$</TEX> laser source," Opt. Lett., vol. 20, no. 13, pp. 1486-1488, 1995

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography of the human retina," Archiv. Ophthalmol., vol. 113, no. 3, pp. 325- 332, 1995

1993 (1)

F. L. Pedrotti and S. J. L. S. Pedrotti, Introduction to optics (Prentice Hall, 1993), pp. 323-338

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, pp. 1178-1181, 1991
[CrossRef]

1986 (1)

O. Sasaki and H. Okazaki, "Sinusoidal phase modulating interferometry for surface profile measurement," Appl. Opt., vol. 25, no. 18, pp. 3137-3140, 1986
[CrossRef]

Applied Optics (4)

A. Dubois, L. Vabre, A. C. Boccara, and E. Beaureparie, "High-resolution full-field optical coherence tomography with a Linnik microscope," Appl. Opt., vol. 41, no. 4, pp. 805-812, 2002
[CrossRef]

A. Dubois, K. Grieve, G. Moneron, R. Lecaque, L. Vabre, and C. Boccara, "Ultrahigh-resolution full-field optical coherence tomography," Appl. Opt., vol. 43, no. 14, pp. 2874-2883, 2004
[CrossRef]

D. W. Phillion, "General methods for generating phaseshifting interferometry algorithms," Appl. Opt., vol. 36, no. 31, pp. 8098-8115, 1997
[CrossRef]

O. Sasaki and H. Okazaki, "Sinusoidal phase modulating interferometry for surface profile measurement," Appl. Opt., vol. 25, no. 18, pp. 3137-3140, 1986
[CrossRef]

Archiv. Ophthalmol. (1)

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography of the human retina," Archiv. Ophthalmol., vol. 113, no. 3, pp. 325- 332, 1995

JOSA A (1)

A. Dubois, "Phase-map measurements by interferometry with sinusoidal phase modulation and four integrating buckets," J. Opt, Soc. Am. A, vol. 18, no. 8, pp. 1972-1979, 2001
[CrossRef]

Nature Medicine (1)

J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Boppart, B. E. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, "Optical biopsy and imaging using optical coherence tomography," Nat. Med., vol. 1, no. 9, pp. 970-972, 1995
[CrossRef]

Opt. Express (2)

Opt. Lett. (1)

Optics Express (2)

K. Grieve, A. Dubois, M. Simonutti, M. Paques, J. Sahel, J. F. L. Gargasson, and C. Boccara, "In vivo anterior segment imaging in the rat eye with high speed white light full-field optical coherence tomography," Opt. Express, vol. 13, no. 16, pp. 6286-6295, 2005
[CrossRef]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahighresolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express, vol. 12, no. 11, pp. 2404-2422, 2004
[CrossRef]

Optics Letters (3)

S. Bourquin, P. Seitz, and R. P. Salathe, "Optical coherence topography based on a two-dimensional smart detector array," Opt. Lett., vol. 26, no. 8, pp. 512-514, 2001
[CrossRef]

M. Akiba, K. P. Chan, and N. Tanno, "Full-field optical coherence tomography by two-dimensional heterodyne detection with a pair of CCD cameras," Opt. Lett., vol. 28, no. 10, pp. 816-818, 2003
[CrossRef]

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-tonoise ratio in spectral-domain compared with timedomain optical coherence tomography," Opt. Lett., vol. 28, no. 21, pp. 2067-2069, 2003
[CrossRef]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, pp. 1178-1181, 1991
[CrossRef]

Other (1)

F. L. Pedrotti and S. J. L. S. Pedrotti, Introduction to optics (Prentice Hall, 1993), pp. 323-338

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