Abstract

The electromagnetic resonances of optical microspheres—the so-called whispering gallery modes (WGMs)—can be used for refractometric sensing of surrounding fluids. Microspheres are attractive because they offer high sensitivity and can be utilized with fluorescent dyes or quantum dots. One issue with microspheres, however, is that they are difficult to integrate into microfluidic systems. Here, we develop a microfluidic structure that permits sensing applications using a single microsphere in a capillary. To achieve this, a microsphere formed on the end of a tapered fiber was first coated with fluorescent silicon quantum dots (QDs). The sphere was then inserted into a microcapillary and the fluorescence WGMs were monitored as different fluids were pumped through the channel. The sensitivity and detection limits for this sphere-in-a-capillary device were measured for several different QD film thicknesses and for two different microsphere sizes. Because of the relatively high-visibility mode structure, the sensitivity and detection limit can be defined by Fourier analysis of the free spectral range and WGM spectral shifts.

© 2012 Optical Society of America

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2012 (2)

Y. Zou, S. Chakravarty, W.-C. Lai, C.-Y. Lin, and R. T. Chen, “Methods to array photonic crystal microcavities for high throughput high sensitivity biosensing on a silicon-chip based platform,” Lab Chip 12, 2309–2312 (2012).
[CrossRef]

J. W. Silverstone, S. McFarlane, C. P. K. Manchee, and A. Meldrum, “Ultimate resolution for sensing with microcavities,” Opt. Express 20, 8284–8295 (2012).
[CrossRef]

2011 (2)

C. P. K. Manchee, V. Zamora, J. Silverstone, J. G. C. Veinot, and A. Meldrum, “Refractometric sensing with fluorescent-core microcavities,” Opt. Express 19, 21540–21551 (2011).
[CrossRef]

H. A. Huckabay and R. C. Dunn, “Whispering gallery mode imaging for the multiplexed detection of biomarkers,” Sens. Actuators B Chem. 160, 1262–1267 (2011).
[CrossRef]

2010 (3)

2009 (3)

G.-D. Kim, G.-S. Son, H.-S. Lee, K.-D. Kim, and S.-S. Lee, “Refractometric sensor utilizing a vertically coupled polymeric microdisk resonator incorporating a high refractive index overlay,” Opt. Lett. 34, 1048–1050 (2009).
[CrossRef]

H. T. Beier, G. L. Coté, and K. E. Meissner, “Whispering gallery mode biosensors consisting of quantum dot-embedded microspheres,” Ann. Biomed. Eng. 37, 1974–1983 (2009).
[CrossRef]

P. Bianucci, J. R. Rodríguez, C. Clements, C. M. Hessel, J. G. C. Veinot, and A. Meldrum, “Whispering gallery modes in silicon nanocrystal coated microcavities,” Phys. Status Solidi A 206, 973–975 (2009).
[CrossRef]

2008 (4)

F. Vollmer and S. Arnold, “Whispering-gallery-mode biosensing: label free detection down to single molecules,” Nat. Methods 5, 591–596 (2008).
[CrossRef]

J. Lutti, W. Langbein, and P. Borri, “A monolithic optical sensor based on whispering gallery modes in polystyrene microspheres,” Appl. Phys. A 93, 151103 (2008).
[CrossRef]

I. M. White and X. Fan, “On the performance quantification of resonant refractive index sensors,” Opt. Express 16, 1020–1028 (2008).
[CrossRef]

Y. Panitchob, G. S. Murugan, M. N. Zervas, P. Horak, S. Berneschi, S. Pelli, G. Nunzi Conti, and J. S. Wilkinson, “Whispering gallery mode spectra of channel waveguide coupled microspheres,” Opt. Express 16, 11066–11076(2008).
[CrossRef]

2007 (6)

I. Teraoka, and S. Arnold, “Whispering-gallery modes in a microsphere coated with a high-refractive index layer: polarization-dependent sensitivity enhancement of the resonance-shift sensor and TE-TM resonance matching,” J. Opt. Soc. Am. B 24, 653–659 (2007).
[CrossRef]

M. Daimon and A. Masumura, “Measurement of the refractive index of distilled water from the near-infrared region to the ultraviolet region,” Appl. Opt. 46, 3811–3820 (2007).
[CrossRef]

J. Lutti, W. Langbein, and P. Borri, “High Q optical resonances of polystyrene microspheres in water controlled by optical tweezers,” Appl. Phys. Lett. 91, 141116 (2007).
[CrossRef]

C. M. Hessel, E. J. Henderson, and J. G. C. Veinot, “An investigation of the formation and growth of oxide-embedded silicon nanocrystals in hydrogen silsesquioxane-derived nanocomposites,” J. Phys. Chem. C 111, 6956–6961 (2007).
[CrossRef]

C. M. Hessel, M. A. Summers, A. Meldrum, M. Malac, and J. G. C. Veinot, “Direct patterning, conformal coating, and erbium doping of luminescent nc-Si/SiO2 thin films from solution processable hydrogen silsesquioxane,” Adv. Mater. 19, 3513–3516 (2007).
[CrossRef]

L. Ferraioli, M. Wang, G. Pucker, D. Navarro-Urrios, N. Daldosso, C. Kompocholis, and L. Pavesi, “Photoluminescence of silicon nanocrystals in silicon oxide,” J. Nanomater. 2007, 43491(2007).
[CrossRef]

2006 (6)

J. V. Herráez and R. Belda, “Refractive indices, densities and excess molar volumes of monoalcohols+water,” J. Solution Chem. 35, 1315–1328 (2006).
[CrossRef]

A. Meldrum, A. Hryciw, A. N. MacDonald, C. Blois, K. Marsh, J. Wang, and Q. Li, “Photoluminescence in the silicon-oxygen system,” J. Vac. Sci. Technol. A 24, 713 (2006).
[CrossRef]

H. Zhu, J. D. Suter, I. M. White, and X. Fan, “Aptamer based microsphere biosensor for thrombin detection,” Sensors 6, 785–795 (2006).
[CrossRef]

P. S. Dittrich and A. Manz, “Lab-on-a-Chip: microfluidics in drug discovery,” Nat. Rev. Drug Discov. 5, 210–218 (2006).
[CrossRef]

I. M. White, H. Oveys, and X. Fan, “Liquid-core optical ring-resonator sensors,” Opt. Lett. 31, 1319–1321 (2006).
[CrossRef]

I. Teraoka and S. Arnold, “Enhancing sensitivity of a whispering gallery mode microsphere sensor by a high-refractive index surface layer,” J. Opt. Soc. Am. B 23, 1434–1441 (2006).
[CrossRef]

2005 (1)

N. M. Hanumegowda, C. J. Stica, B. C. Patel, I. White, and X. Fan, “Refractometric sensors based on microsphere resonators,” Appl. Phys. Lett. 87, 201107 (2005).
[CrossRef]

2004 (2)

H. A. Stone, A. D. Stroock, and A. Ajdari, “Engineering flows in small devices: microfluidics toward a Lab-on-a-Chip,” Annu. Rev. Fluid Mech. 36, 381–411 (2004).
[CrossRef]

S. Gotzinger, L. de, S. Menezes, O. Benson, D. V. Talapin, N. Gaponik, H. Weller, A. L. Rogach, and V. Sandoghdar, “Confocal microscopy and spectroscopy of nanocrystals on a high-Q microsphere resonator,” J. Opt. B 6, 154–158 (2004).
[CrossRef]

2003 (1)

2000 (1)

Adibi, A.

S. Yegnanarayanan, W. Roman, M. Soltani, G. Cremona, H. Lu, and A. Adibi, “On-chip Integration of Microfluidic Channels with Ultra-high Q Silicon microdisk resonators for Lab-on-a-Chip sensing applications,” in Lasers and Electro-Optics Society, The 20th Annual Meeting of the IEEE (IEEE, 2007), pp. 50–51.

Aitchison, J. S.

Ajdari, A.

H. A. Stone, A. D. Stroock, and A. Ajdari, “Engineering flows in small devices: microfluidics toward a Lab-on-a-Chip,” Annu. Rev. Fluid Mech. 36, 381–411 (2004).
[CrossRef]

Arnold, S.

Beier, H. T.

H. T. Beier, G. L. Coté, and K. E. Meissner, “Whispering gallery mode biosensors consisting of quantum dot-embedded microspheres,” Ann. Biomed. Eng. 37, 1974–1983 (2009).
[CrossRef]

Belda, R.

J. V. Herráez and R. Belda, “Refractive indices, densities and excess molar volumes of monoalcohols+water,” J. Solution Chem. 35, 1315–1328 (2006).
[CrossRef]

Benson, O.

S. Gotzinger, L. de, S. Menezes, O. Benson, D. V. Talapin, N. Gaponik, H. Weller, A. L. Rogach, and V. Sandoghdar, “Confocal microscopy and spectroscopy of nanocrystals on a high-Q microsphere resonator,” J. Opt. B 6, 154–158 (2004).
[CrossRef]

Berneschi, S.

Y. Panitchob, G. S. Murugan, M. N. Zervas, P. Horak, S. Berneschi, S. Pelli, G. Nunzi Conti, and J. S. Wilkinson, “Whispering gallery mode spectra of channel waveguide coupled microspheres,” Opt. Express 16, 11066–11076(2008).
[CrossRef]

G. Nunzi Conti, S. Berneschi, F. Cosi, S. Pelli, S. Soria, G. C. Righini, P.-H. Merrer, M. Dispenza, and A. Secchi, “Coupling of angle polished waveguides to high-Q whispering gallery mode resonators,” in CLEO Europe 2011 Lasers and Electro-Optics Europe (CLEO EUROPE/EQEC) and 12th European Quantum Electronics Conference (IEEE, 2011), p. 1.

Bianucci, P.

A. Meldrum, P. Bianucci, and F. Marsiglio, “Modification of ensemble emission rates and luminescence spectra for inhomogeneously broadened distributions of quantum dots coupled to optical microcavities,” Opt. Express 18, 10230–10246 (2010).
[CrossRef]

P. Bianucci, J. R. Rodríguez, C. Clements, C. M. Hessel, J. G. C. Veinot, and A. Meldrum, “Whispering gallery modes in silicon nanocrystal coated microcavities,” Phys. Status Solidi A 206, 973–975 (2009).
[CrossRef]

Blois, C.

A. Meldrum, A. Hryciw, A. N. MacDonald, C. Blois, K. Marsh, J. Wang, and Q. Li, “Photoluminescence in the silicon-oxygen system,” J. Vac. Sci. Technol. A 24, 713 (2006).
[CrossRef]

Borri, P.

J. Lutti, W. Langbein, and P. Borri, “A monolithic optical sensor based on whispering gallery modes in polystyrene microspheres,” Appl. Phys. A 93, 151103 (2008).
[CrossRef]

J. Lutti, W. Langbein, and P. Borri, “High Q optical resonances of polystyrene microspheres in water controlled by optical tweezers,” Appl. Phys. Lett. 91, 141116 (2007).
[CrossRef]

Chakravarty, S.

Y. Zou, S. Chakravarty, W.-C. Lai, C.-Y. Lin, and R. T. Chen, “Methods to array photonic crystal microcavities for high throughput high sensitivity biosensing on a silicon-chip based platform,” Lab Chip 12, 2309–2312 (2012).
[CrossRef]

Chen, R. T.

Y. Zou, S. Chakravarty, W.-C. Lai, C.-Y. Lin, and R. T. Chen, “Methods to array photonic crystal microcavities for high throughput high sensitivity biosensing on a silicon-chip based platform,” Lab Chip 12, 2309–2312 (2012).
[CrossRef]

Clements, C.

P. Bianucci, J. R. Rodríguez, C. Clements, C. M. Hessel, J. G. C. Veinot, and A. Meldrum, “Whispering gallery modes in silicon nanocrystal coated microcavities,” Phys. Status Solidi A 206, 973–975 (2009).
[CrossRef]

Cosi, F.

G. Nunzi Conti, S. Berneschi, F. Cosi, S. Pelli, S. Soria, G. C. Righini, P.-H. Merrer, M. Dispenza, and A. Secchi, “Coupling of angle polished waveguides to high-Q whispering gallery mode resonators,” in CLEO Europe 2011 Lasers and Electro-Optics Europe (CLEO EUROPE/EQEC) and 12th European Quantum Electronics Conference (IEEE, 2011), p. 1.

Coté, G. L.

H. T. Beier, G. L. Coté, and K. E. Meissner, “Whispering gallery mode biosensors consisting of quantum dot-embedded microspheres,” Ann. Biomed. Eng. 37, 1974–1983 (2009).
[CrossRef]

Cremona, G.

S. Yegnanarayanan, W. Roman, M. Soltani, G. Cremona, H. Lu, and A. Adibi, “On-chip Integration of Microfluidic Channels with Ultra-high Q Silicon microdisk resonators for Lab-on-a-Chip sensing applications,” in Lasers and Electro-Optics Society, The 20th Annual Meeting of the IEEE (IEEE, 2007), pp. 50–51.

Daimon, M.

Daldosso, N.

L. Ferraioli, M. Wang, G. Pucker, D. Navarro-Urrios, N. Daldosso, C. Kompocholis, and L. Pavesi, “Photoluminescence of silicon nanocrystals in silicon oxide,” J. Nanomater. 2007, 43491(2007).
[CrossRef]

de, L.

S. Gotzinger, L. de, S. Menezes, O. Benson, D. V. Talapin, N. Gaponik, H. Weller, A. L. Rogach, and V. Sandoghdar, “Confocal microscopy and spectroscopy of nanocrystals on a high-Q microsphere resonator,” J. Opt. B 6, 154–158 (2004).
[CrossRef]

Dispenza, M.

G. Nunzi Conti, S. Berneschi, F. Cosi, S. Pelli, S. Soria, G. C. Righini, P.-H. Merrer, M. Dispenza, and A. Secchi, “Coupling of angle polished waveguides to high-Q whispering gallery mode resonators,” in CLEO Europe 2011 Lasers and Electro-Optics Europe (CLEO EUROPE/EQEC) and 12th European Quantum Electronics Conference (IEEE, 2011), p. 1.

Dittrich, P. S.

P. S. Dittrich and A. Manz, “Lab-on-a-Chip: microfluidics in drug discovery,” Nat. Rev. Drug Discov. 5, 210–218 (2006).
[CrossRef]

Dunn, R. C.

H. A. Huckabay and R. C. Dunn, “Whispering gallery mode imaging for the multiplexed detection of biomarkers,” Sens. Actuators B Chem. 160, 1262–1267 (2011).
[CrossRef]

Fan, X.

Ferraioli, L.

L. Ferraioli, M. Wang, G. Pucker, D. Navarro-Urrios, N. Daldosso, C. Kompocholis, and L. Pavesi, “Photoluminescence of silicon nanocrystals in silicon oxide,” J. Nanomater. 2007, 43491(2007).
[CrossRef]

Gaponik, N.

S. Gotzinger, L. de, S. Menezes, O. Benson, D. V. Talapin, N. Gaponik, H. Weller, A. L. Rogach, and V. Sandoghdar, “Confocal microscopy and spectroscopy of nanocrystals on a high-Q microsphere resonator,” J. Opt. B 6, 154–158 (2004).
[CrossRef]

Gotzinger, S.

S. Gotzinger, L. de, S. Menezes, O. Benson, D. V. Talapin, N. Gaponik, H. Weller, A. L. Rogach, and V. Sandoghdar, “Confocal microscopy and spectroscopy of nanocrystals on a high-Q microsphere resonator,” J. Opt. B 6, 154–158 (2004).
[CrossRef]

Haeberle, S.

D. Mark, S. Haeberle, G. Roth, F. von Stetten, and R. Zengerle, “Microfluidic Lab-on-a-Chip platforms: requirements, characteristics and applications,” Chem. Soc. Rev. 39, 1153–1158(2010).
[CrossRef]

Hanumegowda, N. M.

N. M. Hanumegowda, C. J. Stica, B. C. Patel, I. White, and X. Fan, “Refractometric sensors based on microsphere resonators,” Appl. Phys. Lett. 87, 201107 (2005).
[CrossRef]

Henderson, E. J.

C. M. Hessel, E. J. Henderson, and J. G. C. Veinot, “An investigation of the formation and growth of oxide-embedded silicon nanocrystals in hydrogen silsesquioxane-derived nanocomposites,” J. Phys. Chem. C 111, 6956–6961 (2007).
[CrossRef]

Herráez, J. V.

J. V. Herráez and R. Belda, “Refractive indices, densities and excess molar volumes of monoalcohols+water,” J. Solution Chem. 35, 1315–1328 (2006).
[CrossRef]

Hessel, C. M.

P. Bianucci, J. R. Rodríguez, C. Clements, C. M. Hessel, J. G. C. Veinot, and A. Meldrum, “Whispering gallery modes in silicon nanocrystal coated microcavities,” Phys. Status Solidi A 206, 973–975 (2009).
[CrossRef]

C. M. Hessel, E. J. Henderson, and J. G. C. Veinot, “An investigation of the formation and growth of oxide-embedded silicon nanocrystals in hydrogen silsesquioxane-derived nanocomposites,” J. Phys. Chem. C 111, 6956–6961 (2007).
[CrossRef]

C. M. Hessel, M. A. Summers, A. Meldrum, M. Malac, and J. G. C. Veinot, “Direct patterning, conformal coating, and erbium doping of luminescent nc-Si/SiO2 thin films from solution processable hydrogen silsesquioxane,” Adv. Mater. 19, 3513–3516 (2007).
[CrossRef]

Holler, S.

Horak, P.

Hryciw, A.

A. Meldrum, A. Hryciw, A. N. MacDonald, C. Blois, K. Marsh, J. Wang, and Q. Li, “Photoluminescence in the silicon-oxygen system,” J. Vac. Sci. Technol. A 24, 713 (2006).
[CrossRef]

Huckabay, H. A.

H. A. Huckabay and R. C. Dunn, “Whispering gallery mode imaging for the multiplexed detection of biomarkers,” Sens. Actuators B Chem. 160, 1262–1267 (2011).
[CrossRef]

Khoshsima, M.

Kim, G.-D.

Kim, K.-D.

Kompocholis, C.

L. Ferraioli, M. Wang, G. Pucker, D. Navarro-Urrios, N. Daldosso, C. Kompocholis, and L. Pavesi, “Photoluminescence of silicon nanocrystals in silicon oxide,” J. Nanomater. 2007, 43491(2007).
[CrossRef]

Lacey, S.

Lai, W.-C.

Y. Zou, S. Chakravarty, W.-C. Lai, C.-Y. Lin, and R. T. Chen, “Methods to array photonic crystal microcavities for high throughput high sensitivity biosensing on a silicon-chip based platform,” Lab Chip 12, 2309–2312 (2012).
[CrossRef]

Langbein, W.

J. Lutti, W. Langbein, and P. Borri, “A monolithic optical sensor based on whispering gallery modes in polystyrene microspheres,” Appl. Phys. A 93, 151103 (2008).
[CrossRef]

J. Lutti, W. Langbein, and P. Borri, “High Q optical resonances of polystyrene microspheres in water controlled by optical tweezers,” Appl. Phys. Lett. 91, 141116 (2007).
[CrossRef]

Lee, H.-S.

Lee, S.-S.

Li, Q.

A. Meldrum, A. Hryciw, A. N. MacDonald, C. Blois, K. Marsh, J. Wang, and Q. Li, “Photoluminescence in the silicon-oxygen system,” J. Vac. Sci. Technol. A 24, 713 (2006).
[CrossRef]

Lin, C.-Y.

Y. Zou, S. Chakravarty, W.-C. Lai, C.-Y. Lin, and R. T. Chen, “Methods to array photonic crystal microcavities for high throughput high sensitivity biosensing on a silicon-chip based platform,” Lab Chip 12, 2309–2312 (2012).
[CrossRef]

Lu, H.

S. Yegnanarayanan, W. Roman, M. Soltani, G. Cremona, H. Lu, and A. Adibi, “On-chip Integration of Microfluidic Channels with Ultra-high Q Silicon microdisk resonators for Lab-on-a-Chip sensing applications,” in Lasers and Electro-Optics Society, The 20th Annual Meeting of the IEEE (IEEE, 2007), pp. 50–51.

Lutti, J.

J. Lutti, W. Langbein, and P. Borri, “A monolithic optical sensor based on whispering gallery modes in polystyrene microspheres,” Appl. Phys. A 93, 151103 (2008).
[CrossRef]

J. Lutti, W. Langbein, and P. Borri, “High Q optical resonances of polystyrene microspheres in water controlled by optical tweezers,” Appl. Phys. Lett. 91, 141116 (2007).
[CrossRef]

MacDonald, A. N.

A. Meldrum, A. Hryciw, A. N. MacDonald, C. Blois, K. Marsh, J. Wang, and Q. Li, “Photoluminescence in the silicon-oxygen system,” J. Vac. Sci. Technol. A 24, 713 (2006).
[CrossRef]

Malac, M.

C. M. Hessel, M. A. Summers, A. Meldrum, M. Malac, and J. G. C. Veinot, “Direct patterning, conformal coating, and erbium doping of luminescent nc-Si/SiO2 thin films from solution processable hydrogen silsesquioxane,” Adv. Mater. 19, 3513–3516 (2007).
[CrossRef]

Manchee, C. P. K.

J. W. Silverstone, S. McFarlane, C. P. K. Manchee, and A. Meldrum, “Ultimate resolution for sensing with microcavities,” Opt. Express 20, 8284–8295 (2012).
[CrossRef]

C. P. K. Manchee, V. Zamora, J. Silverstone, J. G. C. Veinot, and A. Meldrum, “Refractometric sensing with fluorescent-core microcavities,” Opt. Express 19, 21540–21551 (2011).
[CrossRef]

Y. Zhi, C. P. K. Manchee, J. W. Silverstone, Z. Zhang, and A. Meldrum, “Refractometric Sensing with Silicon Quantum Dots Coupled to a Microsphere,” Plasmonics doi: 10.1007/s11468-012-9423-8 (posted online 21 August 2012, to be published).

S. McFarlane, C. P. K. Manchee, J. W. Silverstone, J. G. C. Veinot, and A. Meldrum, “Development of fluorescent-core microcavity biosensors,” Sensor Letters (EMRS-2012 symposium Q, in review).

Manz, A.

P. S. Dittrich and A. Manz, “Lab-on-a-Chip: microfluidics in drug discovery,” Nat. Rev. Drug Discov. 5, 210–218 (2006).
[CrossRef]

Mark, D.

D. Mark, S. Haeberle, G. Roth, F. von Stetten, and R. Zengerle, “Microfluidic Lab-on-a-Chip platforms: requirements, characteristics and applications,” Chem. Soc. Rev. 39, 1153–1158(2010).
[CrossRef]

Marsh, K.

A. Meldrum, A. Hryciw, A. N. MacDonald, C. Blois, K. Marsh, J. Wang, and Q. Li, “Photoluminescence in the silicon-oxygen system,” J. Vac. Sci. Technol. A 24, 713 (2006).
[CrossRef]

Marsiglio, F.

Masumura, A.

McFarlane, S.

J. W. Silverstone, S. McFarlane, C. P. K. Manchee, and A. Meldrum, “Ultimate resolution for sensing with microcavities,” Opt. Express 20, 8284–8295 (2012).
[CrossRef]

S. McFarlane, C. P. K. Manchee, J. W. Silverstone, J. G. C. Veinot, and A. Meldrum, “Development of fluorescent-core microcavity biosensors,” Sensor Letters (EMRS-2012 symposium Q, in review).

Meissner, K. E.

H. T. Beier, G. L. Coté, and K. E. Meissner, “Whispering gallery mode biosensors consisting of quantum dot-embedded microspheres,” Ann. Biomed. Eng. 37, 1974–1983 (2009).
[CrossRef]

Meldrum, A.

J. W. Silverstone, S. McFarlane, C. P. K. Manchee, and A. Meldrum, “Ultimate resolution for sensing with microcavities,” Opt. Express 20, 8284–8295 (2012).
[CrossRef]

C. P. K. Manchee, V. Zamora, J. Silverstone, J. G. C. Veinot, and A. Meldrum, “Refractometric sensing with fluorescent-core microcavities,” Opt. Express 19, 21540–21551 (2011).
[CrossRef]

A. Meldrum, P. Bianucci, and F. Marsiglio, “Modification of ensemble emission rates and luminescence spectra for inhomogeneously broadened distributions of quantum dots coupled to optical microcavities,” Opt. Express 18, 10230–10246 (2010).
[CrossRef]

P. Bianucci, J. R. Rodríguez, C. Clements, C. M. Hessel, J. G. C. Veinot, and A. Meldrum, “Whispering gallery modes in silicon nanocrystal coated microcavities,” Phys. Status Solidi A 206, 973–975 (2009).
[CrossRef]

C. M. Hessel, M. A. Summers, A. Meldrum, M. Malac, and J. G. C. Veinot, “Direct patterning, conformal coating, and erbium doping of luminescent nc-Si/SiO2 thin films from solution processable hydrogen silsesquioxane,” Adv. Mater. 19, 3513–3516 (2007).
[CrossRef]

A. Meldrum, A. Hryciw, A. N. MacDonald, C. Blois, K. Marsh, J. Wang, and Q. Li, “Photoluminescence in the silicon-oxygen system,” J. Vac. Sci. Technol. A 24, 713 (2006).
[CrossRef]

Y. Zhi, C. P. K. Manchee, J. W. Silverstone, Z. Zhang, and A. Meldrum, “Refractometric Sensing with Silicon Quantum Dots Coupled to a Microsphere,” Plasmonics doi: 10.1007/s11468-012-9423-8 (posted online 21 August 2012, to be published).

S. McFarlane, C. P. K. Manchee, J. W. Silverstone, J. G. C. Veinot, and A. Meldrum, “Development of fluorescent-core microcavity biosensors,” Sensor Letters (EMRS-2012 symposium Q, in review).

Menezes, S.

S. Gotzinger, L. de, S. Menezes, O. Benson, D. V. Talapin, N. Gaponik, H. Weller, A. L. Rogach, and V. Sandoghdar, “Confocal microscopy and spectroscopy of nanocrystals on a high-Q microsphere resonator,” J. Opt. B 6, 154–158 (2004).
[CrossRef]

Merrer, P.-H.

G. Nunzi Conti, S. Berneschi, F. Cosi, S. Pelli, S. Soria, G. C. Righini, P.-H. Merrer, M. Dispenza, and A. Secchi, “Coupling of angle polished waveguides to high-Q whispering gallery mode resonators,” in CLEO Europe 2011 Lasers and Electro-Optics Europe (CLEO EUROPE/EQEC) and 12th European Quantum Electronics Conference (IEEE, 2011), p. 1.

Murugan, G. S.

Navarro-Urrios, D.

L. Ferraioli, M. Wang, G. Pucker, D. Navarro-Urrios, N. Daldosso, C. Kompocholis, and L. Pavesi, “Photoluminescence of silicon nanocrystals in silicon oxide,” J. Nanomater. 2007, 43491(2007).
[CrossRef]

Nunzi Conti, G.

Y. Panitchob, G. S. Murugan, M. N. Zervas, P. Horak, S. Berneschi, S. Pelli, G. Nunzi Conti, and J. S. Wilkinson, “Whispering gallery mode spectra of channel waveguide coupled microspheres,” Opt. Express 16, 11066–11076(2008).
[CrossRef]

G. Nunzi Conti, S. Berneschi, F. Cosi, S. Pelli, S. Soria, G. C. Righini, P.-H. Merrer, M. Dispenza, and A. Secchi, “Coupling of angle polished waveguides to high-Q whispering gallery mode resonators,” in CLEO Europe 2011 Lasers and Electro-Optics Europe (CLEO EUROPE/EQEC) and 12th European Quantum Electronics Conference (IEEE, 2011), p. 1.

Oveys, H.

Palinginis, P.

Panitchob, Y.

Patel, B. C.

N. M. Hanumegowda, C. J. Stica, B. C. Patel, I. White, and X. Fan, “Refractometric sensors based on microsphere resonators,” Appl. Phys. Lett. 87, 201107 (2005).
[CrossRef]

Pavesi, L.

L. Ferraioli, M. Wang, G. Pucker, D. Navarro-Urrios, N. Daldosso, C. Kompocholis, and L. Pavesi, “Photoluminescence of silicon nanocrystals in silicon oxide,” J. Nanomater. 2007, 43491(2007).
[CrossRef]

Pelli, S.

Y. Panitchob, G. S. Murugan, M. N. Zervas, P. Horak, S. Berneschi, S. Pelli, G. Nunzi Conti, and J. S. Wilkinson, “Whispering gallery mode spectra of channel waveguide coupled microspheres,” Opt. Express 16, 11066–11076(2008).
[CrossRef]

G. Nunzi Conti, S. Berneschi, F. Cosi, S. Pelli, S. Soria, G. C. Righini, P.-H. Merrer, M. Dispenza, and A. Secchi, “Coupling of angle polished waveguides to high-Q whispering gallery mode resonators,” in CLEO Europe 2011 Lasers and Electro-Optics Europe (CLEO EUROPE/EQEC) and 12th European Quantum Electronics Conference (IEEE, 2011), p. 1.

Pucker, G.

L. Ferraioli, M. Wang, G. Pucker, D. Navarro-Urrios, N. Daldosso, C. Kompocholis, and L. Pavesi, “Photoluminescence of silicon nanocrystals in silicon oxide,” J. Nanomater. 2007, 43491(2007).
[CrossRef]

Righini, G. C.

G. Nunzi Conti, S. Berneschi, F. Cosi, S. Pelli, S. Soria, G. C. Righini, P.-H. Merrer, M. Dispenza, and A. Secchi, “Coupling of angle polished waveguides to high-Q whispering gallery mode resonators,” in CLEO Europe 2011 Lasers and Electro-Optics Europe (CLEO EUROPE/EQEC) and 12th European Quantum Electronics Conference (IEEE, 2011), p. 1.

Rodríguez, J. R.

P. Bianucci, J. R. Rodríguez, C. Clements, C. M. Hessel, J. G. C. Veinot, and A. Meldrum, “Whispering gallery modes in silicon nanocrystal coated microcavities,” Phys. Status Solidi A 206, 973–975 (2009).
[CrossRef]

Rogach, A. L.

S. Gotzinger, L. de, S. Menezes, O. Benson, D. V. Talapin, N. Gaponik, H. Weller, A. L. Rogach, and V. Sandoghdar, “Confocal microscopy and spectroscopy of nanocrystals on a high-Q microsphere resonator,” J. Opt. B 6, 154–158 (2004).
[CrossRef]

Roman, W.

S. Yegnanarayanan, W. Roman, M. Soltani, G. Cremona, H. Lu, and A. Adibi, “On-chip Integration of Microfluidic Channels with Ultra-high Q Silicon microdisk resonators for Lab-on-a-Chip sensing applications,” in Lasers and Electro-Optics Society, The 20th Annual Meeting of the IEEE (IEEE, 2007), pp. 50–51.

Roth, G.

D. Mark, S. Haeberle, G. Roth, F. von Stetten, and R. Zengerle, “Microfluidic Lab-on-a-Chip platforms: requirements, characteristics and applications,” Chem. Soc. Rev. 39, 1153–1158(2010).
[CrossRef]

Ruda, H. E.

Sandoghdar, V.

S. Gotzinger, L. de, S. Menezes, O. Benson, D. V. Talapin, N. Gaponik, H. Weller, A. L. Rogach, and V. Sandoghdar, “Confocal microscopy and spectroscopy of nanocrystals on a high-Q microsphere resonator,” J. Opt. B 6, 154–158 (2004).
[CrossRef]

Secchi, A.

G. Nunzi Conti, S. Berneschi, F. Cosi, S. Pelli, S. Soria, G. C. Righini, P.-H. Merrer, M. Dispenza, and A. Secchi, “Coupling of angle polished waveguides to high-Q whispering gallery mode resonators,” in CLEO Europe 2011 Lasers and Electro-Optics Europe (CLEO EUROPE/EQEC) and 12th European Quantum Electronics Conference (IEEE, 2011), p. 1.

Silverstone, J.

Silverstone, J. W.

J. W. Silverstone, S. McFarlane, C. P. K. Manchee, and A. Meldrum, “Ultimate resolution for sensing with microcavities,” Opt. Express 20, 8284–8295 (2012).
[CrossRef]

S. McFarlane, C. P. K. Manchee, J. W. Silverstone, J. G. C. Veinot, and A. Meldrum, “Development of fluorescent-core microcavity biosensors,” Sensor Letters (EMRS-2012 symposium Q, in review).

Y. Zhi, C. P. K. Manchee, J. W. Silverstone, Z. Zhang, and A. Meldrum, “Refractometric Sensing with Silicon Quantum Dots Coupled to a Microsphere,” Plasmonics doi: 10.1007/s11468-012-9423-8 (posted online 21 August 2012, to be published).

Soltani, M.

S. Yegnanarayanan, W. Roman, M. Soltani, G. Cremona, H. Lu, and A. Adibi, “On-chip Integration of Microfluidic Channels with Ultra-high Q Silicon microdisk resonators for Lab-on-a-Chip sensing applications,” in Lasers and Electro-Optics Society, The 20th Annual Meeting of the IEEE (IEEE, 2007), pp. 50–51.

Son, G.-S.

Soria, S.

G. Nunzi Conti, S. Berneschi, F. Cosi, S. Pelli, S. Soria, G. C. Righini, P.-H. Merrer, M. Dispenza, and A. Secchi, “Coupling of angle polished waveguides to high-Q whispering gallery mode resonators,” in CLEO Europe 2011 Lasers and Electro-Optics Europe (CLEO EUROPE/EQEC) and 12th European Quantum Electronics Conference (IEEE, 2011), p. 1.

Stica, C. J.

N. M. Hanumegowda, C. J. Stica, B. C. Patel, I. White, and X. Fan, “Refractometric sensors based on microsphere resonators,” Appl. Phys. Lett. 87, 201107 (2005).
[CrossRef]

Stone, H. A.

H. A. Stone, A. D. Stroock, and A. Ajdari, “Engineering flows in small devices: microfluidics toward a Lab-on-a-Chip,” Annu. Rev. Fluid Mech. 36, 381–411 (2004).
[CrossRef]

Stroock, A. D.

H. A. Stone, A. D. Stroock, and A. Ajdari, “Engineering flows in small devices: microfluidics toward a Lab-on-a-Chip,” Annu. Rev. Fluid Mech. 36, 381–411 (2004).
[CrossRef]

Summers, M. A.

C. M. Hessel, M. A. Summers, A. Meldrum, M. Malac, and J. G. C. Veinot, “Direct patterning, conformal coating, and erbium doping of luminescent nc-Si/SiO2 thin films from solution processable hydrogen silsesquioxane,” Adv. Mater. 19, 3513–3516 (2007).
[CrossRef]

Suter, J. D.

H. Zhu, J. D. Suter, I. M. White, and X. Fan, “Aptamer based microsphere biosensor for thrombin detection,” Sensors 6, 785–795 (2006).
[CrossRef]

Talapin, D. V.

S. Gotzinger, L. de, S. Menezes, O. Benson, D. V. Talapin, N. Gaponik, H. Weller, A. L. Rogach, and V. Sandoghdar, “Confocal microscopy and spectroscopy of nanocrystals on a high-Q microsphere resonator,” J. Opt. B 6, 154–158 (2004).
[CrossRef]

Teraoka, I.

Veinot, J. G. C.

C. P. K. Manchee, V. Zamora, J. Silverstone, J. G. C. Veinot, and A. Meldrum, “Refractometric sensing with fluorescent-core microcavities,” Opt. Express 19, 21540–21551 (2011).
[CrossRef]

P. Bianucci, J. R. Rodríguez, C. Clements, C. M. Hessel, J. G. C. Veinot, and A. Meldrum, “Whispering gallery modes in silicon nanocrystal coated microcavities,” Phys. Status Solidi A 206, 973–975 (2009).
[CrossRef]

C. M. Hessel, E. J. Henderson, and J. G. C. Veinot, “An investigation of the formation and growth of oxide-embedded silicon nanocrystals in hydrogen silsesquioxane-derived nanocomposites,” J. Phys. Chem. C 111, 6956–6961 (2007).
[CrossRef]

C. M. Hessel, M. A. Summers, A. Meldrum, M. Malac, and J. G. C. Veinot, “Direct patterning, conformal coating, and erbium doping of luminescent nc-Si/SiO2 thin films from solution processable hydrogen silsesquioxane,” Adv. Mater. 19, 3513–3516 (2007).
[CrossRef]

S. McFarlane, C. P. K. Manchee, J. W. Silverstone, J. G. C. Veinot, and A. Meldrum, “Development of fluorescent-core microcavity biosensors,” Sensor Letters (EMRS-2012 symposium Q, in review).

Vollmer, F.

F. Vollmer and S. Arnold, “Whispering-gallery-mode biosensing: label free detection down to single molecules,” Nat. Methods 5, 591–596 (2008).
[CrossRef]

S. Arnold, M. Khoshsima, I. Teraoka, S. Holler, and F. Vollmer, “Shift of whispering-gallery modes in microspheres by protein adsorption,” Opt. Lett. 28, 272–274 (2003).
[CrossRef]

von Stetten, F.

D. Mark, S. Haeberle, G. Roth, F. von Stetten, and R. Zengerle, “Microfluidic Lab-on-a-Chip platforms: requirements, characteristics and applications,” Chem. Soc. Rev. 39, 1153–1158(2010).
[CrossRef]

Wang, H.

Wang, J.

A. Meldrum, A. Hryciw, A. N. MacDonald, C. Blois, K. Marsh, J. Wang, and Q. Li, “Photoluminescence in the silicon-oxygen system,” J. Vac. Sci. Technol. A 24, 713 (2006).
[CrossRef]

Wang, M.

L. Ferraioli, M. Wang, G. Pucker, D. Navarro-Urrios, N. Daldosso, C. Kompocholis, and L. Pavesi, “Photoluminescence of silicon nanocrystals in silicon oxide,” J. Nanomater. 2007, 43491(2007).
[CrossRef]

Weller, H.

S. Gotzinger, L. de, S. Menezes, O. Benson, D. V. Talapin, N. Gaponik, H. Weller, A. L. Rogach, and V. Sandoghdar, “Confocal microscopy and spectroscopy of nanocrystals on a high-Q microsphere resonator,” J. Opt. B 6, 154–158 (2004).
[CrossRef]

White, I.

N. M. Hanumegowda, C. J. Stica, B. C. Patel, I. White, and X. Fan, “Refractometric sensors based on microsphere resonators,” Appl. Phys. Lett. 87, 201107 (2005).
[CrossRef]

White, I. M.

Wilkinson, J. S.

Wosinski, L.

Xu, M. Y.-C.

Xu, T.

Yegnanarayanan, S.

S. Yegnanarayanan, W. Roman, M. Soltani, G. Cremona, H. Lu, and A. Adibi, “On-chip Integration of Microfluidic Channels with Ultra-high Q Silicon microdisk resonators for Lab-on-a-Chip sensing applications,” in Lasers and Electro-Optics Society, The 20th Annual Meeting of the IEEE (IEEE, 2007), pp. 50–51.

Zamora, V.

Zengerle, R.

D. Mark, S. Haeberle, G. Roth, F. von Stetten, and R. Zengerle, “Microfluidic Lab-on-a-Chip platforms: requirements, characteristics and applications,” Chem. Soc. Rev. 39, 1153–1158(2010).
[CrossRef]

Zervas, M. N.

Zhang, Z.

Y. Zhi, C. P. K. Manchee, J. W. Silverstone, Z. Zhang, and A. Meldrum, “Refractometric Sensing with Silicon Quantum Dots Coupled to a Microsphere,” Plasmonics doi: 10.1007/s11468-012-9423-8 (posted online 21 August 2012, to be published).

Zhi, Y.

Y. Zhi, C. P. K. Manchee, J. W. Silverstone, Z. Zhang, and A. Meldrum, “Refractometric Sensing with Silicon Quantum Dots Coupled to a Microsphere,” Plasmonics doi: 10.1007/s11468-012-9423-8 (posted online 21 August 2012, to be published).

Zhu, H.

H. Zhu, J. D. Suter, I. M. White, and X. Fan, “Aptamer based microsphere biosensor for thrombin detection,” Sensors 6, 785–795 (2006).
[CrossRef]

Zhu, N.

Zou, Y.

Y. Zou, S. Chakravarty, W.-C. Lai, C.-Y. Lin, and R. T. Chen, “Methods to array photonic crystal microcavities for high throughput high sensitivity biosensing on a silicon-chip based platform,” Lab Chip 12, 2309–2312 (2012).
[CrossRef]

Adv. Mater. (1)

C. M. Hessel, M. A. Summers, A. Meldrum, M. Malac, and J. G. C. Veinot, “Direct patterning, conformal coating, and erbium doping of luminescent nc-Si/SiO2 thin films from solution processable hydrogen silsesquioxane,” Adv. Mater. 19, 3513–3516 (2007).
[CrossRef]

Ann. Biomed. Eng. (1)

H. T. Beier, G. L. Coté, and K. E. Meissner, “Whispering gallery mode biosensors consisting of quantum dot-embedded microspheres,” Ann. Biomed. Eng. 37, 1974–1983 (2009).
[CrossRef]

Annu. Rev. Fluid Mech. (1)

H. A. Stone, A. D. Stroock, and A. Ajdari, “Engineering flows in small devices: microfluidics toward a Lab-on-a-Chip,” Annu. Rev. Fluid Mech. 36, 381–411 (2004).
[CrossRef]

Appl. Opt. (1)

Appl. Phys. A (1)

J. Lutti, W. Langbein, and P. Borri, “A monolithic optical sensor based on whispering gallery modes in polystyrene microspheres,” Appl. Phys. A 93, 151103 (2008).
[CrossRef]

Appl. Phys. Lett. (2)

J. Lutti, W. Langbein, and P. Borri, “High Q optical resonances of polystyrene microspheres in water controlled by optical tweezers,” Appl. Phys. Lett. 91, 141116 (2007).
[CrossRef]

N. M. Hanumegowda, C. J. Stica, B. C. Patel, I. White, and X. Fan, “Refractometric sensors based on microsphere resonators,” Appl. Phys. Lett. 87, 201107 (2005).
[CrossRef]

Chem. Soc. Rev. (1)

D. Mark, S. Haeberle, G. Roth, F. von Stetten, and R. Zengerle, “Microfluidic Lab-on-a-Chip platforms: requirements, characteristics and applications,” Chem. Soc. Rev. 39, 1153–1158(2010).
[CrossRef]

J. Nanomater. (1)

L. Ferraioli, M. Wang, G. Pucker, D. Navarro-Urrios, N. Daldosso, C. Kompocholis, and L. Pavesi, “Photoluminescence of silicon nanocrystals in silicon oxide,” J. Nanomater. 2007, 43491(2007).
[CrossRef]

J. Opt. B (1)

S. Gotzinger, L. de, S. Menezes, O. Benson, D. V. Talapin, N. Gaponik, H. Weller, A. L. Rogach, and V. Sandoghdar, “Confocal microscopy and spectroscopy of nanocrystals on a high-Q microsphere resonator,” J. Opt. B 6, 154–158 (2004).
[CrossRef]

J. Opt. Soc. Am. B (2)

J. Phys. Chem. C (1)

C. M. Hessel, E. J. Henderson, and J. G. C. Veinot, “An investigation of the formation and growth of oxide-embedded silicon nanocrystals in hydrogen silsesquioxane-derived nanocomposites,” J. Phys. Chem. C 111, 6956–6961 (2007).
[CrossRef]

J. Solution Chem. (1)

J. V. Herráez and R. Belda, “Refractive indices, densities and excess molar volumes of monoalcohols+water,” J. Solution Chem. 35, 1315–1328 (2006).
[CrossRef]

J. Vac. Sci. Technol. A (1)

A. Meldrum, A. Hryciw, A. N. MacDonald, C. Blois, K. Marsh, J. Wang, and Q. Li, “Photoluminescence in the silicon-oxygen system,” J. Vac. Sci. Technol. A 24, 713 (2006).
[CrossRef]

Lab Chip (1)

Y. Zou, S. Chakravarty, W.-C. Lai, C.-Y. Lin, and R. T. Chen, “Methods to array photonic crystal microcavities for high throughput high sensitivity biosensing on a silicon-chip based platform,” Lab Chip 12, 2309–2312 (2012).
[CrossRef]

Nat. Methods (1)

F. Vollmer and S. Arnold, “Whispering-gallery-mode biosensing: label free detection down to single molecules,” Nat. Methods 5, 591–596 (2008).
[CrossRef]

Nat. Rev. Drug Discov. (1)

P. S. Dittrich and A. Manz, “Lab-on-a-Chip: microfluidics in drug discovery,” Nat. Rev. Drug Discov. 5, 210–218 (2006).
[CrossRef]

Opt. Express (6)

Opt. Lett. (4)

Phys. Status Solidi A (1)

P. Bianucci, J. R. Rodríguez, C. Clements, C. M. Hessel, J. G. C. Veinot, and A. Meldrum, “Whispering gallery modes in silicon nanocrystal coated microcavities,” Phys. Status Solidi A 206, 973–975 (2009).
[CrossRef]

Sens. Actuators B Chem. (1)

H. A. Huckabay and R. C. Dunn, “Whispering gallery mode imaging for the multiplexed detection of biomarkers,” Sens. Actuators B Chem. 160, 1262–1267 (2011).
[CrossRef]

Sensors (1)

H. Zhu, J. D. Suter, I. M. White, and X. Fan, “Aptamer based microsphere biosensor for thrombin detection,” Sensors 6, 785–795 (2006).
[CrossRef]

Other (4)

G. Nunzi Conti, S. Berneschi, F. Cosi, S. Pelli, S. Soria, G. C. Righini, P.-H. Merrer, M. Dispenza, and A. Secchi, “Coupling of angle polished waveguides to high-Q whispering gallery mode resonators,” in CLEO Europe 2011 Lasers and Electro-Optics Europe (CLEO EUROPE/EQEC) and 12th European Quantum Electronics Conference (IEEE, 2011), p. 1.

S. Yegnanarayanan, W. Roman, M. Soltani, G. Cremona, H. Lu, and A. Adibi, “On-chip Integration of Microfluidic Channels with Ultra-high Q Silicon microdisk resonators for Lab-on-a-Chip sensing applications,” in Lasers and Electro-Optics Society, The 20th Annual Meeting of the IEEE (IEEE, 2007), pp. 50–51.

Y. Zhi, C. P. K. Manchee, J. W. Silverstone, Z. Zhang, and A. Meldrum, “Refractometric Sensing with Silicon Quantum Dots Coupled to a Microsphere,” Plasmonics doi: 10.1007/s11468-012-9423-8 (posted online 21 August 2012, to be published).

S. McFarlane, C. P. K. Manchee, J. W. Silverstone, J. G. C. Veinot, and A. Meldrum, “Development of fluorescent-core microcavity biosensors,” Sensor Letters (EMRS-2012 symposium Q, in review).

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