Abstract

Fluorescence molecular tomography (FMT) is an important in vivo molecular imaging technique and has been widely studied in preclinical research. Many methods perform well in the reconstruction of a single fluorescent target but may fail in reconstructing multiple targets because of the severe ill-posedness of the FMT inverse problem. In this paper the original synchronization-inspired clustering algorithm (OSC) is introduced into FMT for resolving multiple targets from the reconstruction result. Based on OSC, a synchronization-based clustering algorithm for FMT (SC-FMT) is developed to further improve location accuracy. Both algorithms utilize the minimum spanning tree to automatically identify the number of the reconstructed targets without prior information and human intervention. A serial of numerical simulation results demonstrates that SC-FMT and OSC can resolve multiple targets robustly and automatically, which also shows the potential of the proposed postprocessing algorithms in FMT reconstruction.

© 2018 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Improved sparse reconstruction for fluorescence molecular tomography with L1/2 regularization

Hongbo Guo, Jingjing Yu, Xiaowei He, Yuqing Hou, Fang Dong, and Shuling Zhang
Biomed. Opt. Express 6(5) 1648-1664 (2015)

Unmixing multiple adjacent fluorescent targets with multispectral excited fluorescence molecular tomography

Yuan Zhou, Huizhi Guang, Huangsheng Pu, Jiulou Zhang, and Jianwen Luo
Appl. Opt. 55(18) 4843-4849 (2016)

Novel l2,1-norm optimization method for fluorescence molecular tomography reconstruction

Shixin Jiang, Jie Liu, Yu An, Guanglei Zhang, Jinzuo Ye, Yamin Mao, Kunshan He, Chongwei Chi, and Jie Tian
Biomed. Opt. Express 7(6) 2342-2359 (2016)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (8)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Tables (3)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (10)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription