Abstract

Fluorescence molecular tomography (FMT) has been a promising imaging tool that provides convenience for accurate localization and quantitative analysis of the fluorescent probe. In this study, we present a reconstruction method combining sorted L-one penalized estimation with an iterative-shrinking permissible region strategy to reconstruct fluorescence targets. Both numerical simulation experiments on a three-dimensional digital mouse model and physical experiments on a cubic phantom were carried out to validate the accuracy, effectiveness, and robustness of the proposed method. The results indicate that the proposed method can produce better location and satisfactory fluorescent yield with computational efficiency, which makes it a practical and promising reconstruction method for FMT.

© 2015 Optical Society of America

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