Abstract

We combine diffuse optical tomography for detecting and localizing an inhomogeneity in a two-layered tissue and diffuse optical spectroscopy (DOS) for characterizing the spectrum of that inhomogeneity. For detecting and localizing an inhomogeneity, we reduce the number of unknowns substantially by seeking only the location and size of the inhomogeneity. Then, we seek to recover an unknown specific tumor component of that inhomogeneity from spectral data. In doing so, we develop a method for distinguishing between healthy and tumorous lesions. We demonstrate the utility of this theory with numerical simulations.

©2012 Optical Society of America

Optical mammography combined with fluorescence imaging: lesion detection using scatterplots

Anaïs Leproux, Marjolein van der Voort, Martin B. van der Mark, Rik Harbers, Stephanie M. W. Y. van de Ven, and Ton G. van Leeuwen
Biomed. Opt. Express 2(4) 1007-1020 (2011)

Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography

Giovanna Quarto, Lorenzo Spinelli, Antonio Pifferi, Alessandro Torricelli, Rinaldo Cubeddu, Francesca Abbate, Nicola Balestreri, Simona Menna, Enrico Cassano, and Paola Taroni
Biomed. Opt. Express 5(10) 3684-3698 (2014)

Analysis of skin lesions using laminar optical tomography

Timothy J. Muldoon, Sean A. Burgess, Brenda R. Chen, Désirée Ratner, and Elizabeth M. C. Hillman
Biomed. Opt. Express 3(7) 1701-1712 (2012)

Assessment of the size, position, and optical properties of breast tumors in vivo by noninvasive optical methods

Sergio Fantini, Scott A. Walker, Maria Angela Franceschini, Michael Kaschke, Peter M. Schlag, and K. Thomas Moesta
Appl. Opt. 37(10) 1982-1989 (1998)

Interlesion differences in the local photodynamic therapy response of oral cavity lesions assessed by diffuse optical spectroscopies

Daniel J. Rohrbach, Nestor Rigual, Erin Tracy, Andrew Kowalczewski, Kenneth L. Keymel, Michele T. Cooper, Weirong Mo, Heinz Baumann, Barbara W. Henderson, and Ulas Sunar
Biomed. Opt. Express 3(9) 2142-2153 (2012)