Abstract

We combine diffuse optical tomography for detecting and localizing an inhomogeneity in a two-layered tissue and diffuse optical spectroscopy (DOS) for characterizing the spectrum of that inhomogeneity. For detecting and localizing an inhomogeneity, we reduce the number of unknowns substantially by seeking only the location and size of the inhomogeneity. Then, we seek to recover an unknown specific tumor component of that inhomogeneity from spectral data. In doing so, we develop a method for distinguishing between healthy and tumorous lesions. We demonstrate the utility of this theory with numerical simulations.

© 2012 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Effect of contact force on breast tissue optical property measurements using a broadband diffuse optical spectroscopy handheld probe

Albert Cerussi, Sarah Siavoshi, Amanda Durkin, Cynthia Chen, Wendy Tanamai, David Hsiang, and Bruce J. Tromberg
Appl. Opt. 48(21) 4270-4277 (2009)

Coregistration of diffuse optical spectroscopy and magnetic resonance imaging in a rat tumor model

Sean Merritt, Frederic Bevilacqua, Anthony J. Durkin, David J. Cuccia, Ryan Lanning, Bruce J. Tromberg, Gultekin Gulsen, Hon Yu, Jun Wang, and Orhan Nalcioglu
Appl. Opt. 42(16) 2951-2959 (2003)

Effect of bile absorption coefficients on the estimation of liver tissue optical properties and related implications in discriminating healthy and tumorous samples

Rami Nachabé, Daniel J. Evers, Benno H. W. Hendriks, Gerald W. Lucassen, Marjolein van der Voort, Jelle Wesseling, and Theo J. M. Ruers
Biomed. Opt. Express 2(3) 600-614 (2011)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (8)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Tables (2)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (13)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription