We have developed a compact, multimodal instrument for simultaneous acquisition of en face quasi-confocal fundus images and adaptive-optics (AO) spectral-domain optical coherence tomography (SDOCT) cross-sectional images. The optical system including all AO and SDOCT components occupies a breadboard that can be readily transported for clinical applications. The AO component combines a Hartmann–Shack wavefront sensor and a microelectromechanical systems-based deformable mirror to sense and correct ocular aberrations at with a maximum stroke of . A broadband superluminescent diode source provides depth resolution for SDOCT imaging. In human volunteer testing, we observed up to an increase in OCT signal and a corresponding lateral resolution of as a result of AO correction.
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