Aging of the human lens: changes in lens shape at zero-diopter accommodation

Jane F. Koretz; Christopher A. Cook; Paul L. Kaufman

doi:10.1364/JOSAA.18.000265

Journal of the Optical Society of America A
Vol. 18,
Issue 2,
pp. 265-272
(2001)
•https://doi.org/10.1364/JOSAA.18.000265

Aging of the human lens: changes in lens shape at zero-diopter accommodation

Jane F. Koretz, Christopher A. Cook, and Paul L. Kaufman

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Jane F. Koretz, Christopher A. Cook, and Paul L. Kaufman, "Aging of the human lens: changes in lens shape at zero-diopter accommodation," J. Opt. Soc. Am. A 18, 265-272 (2001)

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Abstract

Scheimpflug photographs of the zero-diopter-accommodated anterior segments of 100 human subjects, aged 18 to 70 yr and evenly spaced over this range, were digitized and analyzed to characterize lens and lens nucleus shape as a function of age by the Hough transform and other image analysis methods. Anterior and posterior lens surface curves exhibit a decrease in radius of curvature with increasing age, in qualitative but not quantitative agreement with the earlier observations of Brown [Exp. Eye Res. 19, 175 (1974)]. In contrast, the shape of the lens nuclear boundaries changes little with age. Overall lens volume at zero diopters increases with age, but the volume of the lens nucleus remains unchanged. The lens center of mass moves anteriorly with increasing age, as does the central clear region of the lens. Although these data sets were found to be more variable than those of Brown, the complementary variability of other factors, such as anterior chamber depth, for each subject leads to a very high statistical correlation between lens shape and lens location relative to the cornea. This supports the finding of previous work that image formation on the retina for a given individual results from the multifactorial balancing of related factors.

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Surface or Boundary	Parameter
Surface or Boundary	Intercept	Slope	$σ_{1}$	$σ_{S}$	r	$χ^{2}$	p	$μ_{r}$	$σ_{r}$	$s_{r}$	$k_{r}$
COM	4.906	$- 7.069 \times 10^{- 3}$	$1.446 \times 10^{- 2}$	$3.763 \times 10^{- 4}$	-0.264	4763.6	0.019	$- 2.947 \times 10^{- 3}$	$2.848 \times 10^{- 1}$	0.114	-0.422
CS	4.915	$- 3.197 \times 10^{- 3}$	$3.427 \times 10^{- 1}$	$7.473 \times 10^{- 3}$	-0.146	8.35	0.165	$- 6.517 \times 10^{- 7}$	$3.063 \times 10^{- 1}$	0.279	-0.644

Surface or Boundary	Parameter
Surface or Boundary	Intercept	Slope	$σ_{1}$	$σ_{S}$	r	$χ^{2}$	p	$μ_{r}$	$σ_{r}$	$s_{r}$	$k_{r}$
COM	4.916	$- 7.376 \times 10^{- 3}$	$1.448 \times 10^{- 2}$	$4.058 \times 10^{- 4}$	-0.211	5379.5	0.097	$- 5.733 \times 10^{- 3}$	$3.033 \times 10^{- 1}$	0.123	-0.542
CS	4.932	$- 3.672 \times 10^{- 3}$	$7.952 \times 10^{- 2}$	$1.910 \times 10^{- 3}$	-0.144	133.85	0.207	$- 5.926 \times 10^{- 3}$	$3.019 \times 10^{- 1}$	0.184	-0.543

Surface or Boundary	Parameter
Surface or Boundary	Intercept	Slope	$σ_{1}$	$σ_{S}$	r	$χ^{2}$	p	$μ_{r}$	$σ_{r}$	$s_{r}$	$k_{r}$
LAS	11.155	$- 2.004 \times 10^{- 2}$	$1.729 \times 10^{- 2}$	$3.806 \times 10^{- 4}$	-0.204	48866.0	0.046	$4.247 \times 10^{- 1}$	1.254	0.784	0.880
LPS	-8.267	$2.025 \times 10^{- 2}$	$4.336 \times 10^{- 2}$	$1.148 \times 10^{- 3}$	0.228	3547.4	0.042	$1.226 \times 10^{- 2}$	1.052	-0.461	0.410
NAB	3.782	$- 5.996 \times 10^{- 3}$	$1.376 \times 10^{- 2}$	$2.798 \times 10^{- 4}$	-0.124	25885.1	0.231	$4.455 \times 10^{- 1}$	0.820	0.646	0.253
NPB	-3.500	$5.537 \times 10^{- 3}$	$1.947 \times 10^{- 2}$	$4.126 \times 10^{- 4}$	0.137	11461.2	0.199	$- 4.339 \times 10^{- 1}$	0.718	-0.588	-0.096

Surface or Boundary	Parameter
Surface or Boundary	Intercept	Slope	$σ_{1}$	$σ_{S}$	r	$χ^{2}$	p	$μ_{r}$	$σ_{r}$	$s_{r}$	$k_{r}$
LAS	11.645	$- 3.169 \times 10^{- 2}$	$1.568 \times 10^{- 2}$	$3.829 \times 10^{- 4}$	-0.227	52637.5	0.045	$3.382 \times 10^{- 1}$	1.304	0.756	0.974
LPS	-7.671	$2.692 \times 10^{- 3}$	$4.353 \times 10^{- 2}$	$1.263 \times 10^{- 3}$	0.019	3181.3	0.883	$- 7.335 \times 10^{- 2}$	0.954	-0.682	1.346
NAB	3.867	$- 7.561 \times 10^{- 3}$	$1.242 \times 10^{- 2}$	$2.757 \times 10^{- 4}$	-0.124	23386.3	0.281	$3.629 \times 10^{- 1}$	0.733	0.274	-0.296
NPB	-3.611	$7.604 \times 10^{- 3}$	$1.733 \times 10^{- 2}$	$3.959 \times 10^{- 4}$	0.120	11733.9	0.309	$- 3.106 \times 10^{- 1}$	0.718	-0.542	-0.045

Surface or Boundary	Parameter
Surface or Boundary	Intercept	Slope	$σ_{1}$	$σ_{S}$	r	$χ^{2}$	p	$μ_{r}$	$σ_{r}$	$s_{r}$	$k_{r}$
COM	4.906	$- 7.069 \times 10^{- 3}$	$1.446 \times 10^{- 2}$	$3.763 \times 10^{- 4}$	-0.264	4763.6	0.019	$- 2.947 \times 10^{- 3}$	$2.848 \times 10^{- 1}$	0.114	-0.422
CS	4.915	$- 3.197 \times 10^{- 3}$	$3.427 \times 10^{- 1}$	$7.473 \times 10^{- 3}$	-0.146	8.35	0.165	$- 6.517 \times 10^{- 7}$	$3.063 \times 10^{- 1}$	0.279	-0.644

Abstract

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Journal of the Optical Society of America A