Abstract

The spatial variation of the backscattering cross section is the primary source of contrast in present applications of optical coherence tomography (OCT). We introduce and analyze a technique for obtaining OCT images of the local concentration of an absorbing compound in biological tissues and other highly scattering media. A pair of light-emitting diodes, one emitting in a vibrational absorption band of the chemical compound of interest and the other emitting just outside this band, are used as sources at the input of the interferometer. The differential absorption of the probe beam is determined by Fourier transformation and ratiometric processing of the measured interference signals. The ability of the technique to distinguish lipid and water inclusions in a scattering material is demonstrated with an OCT system that uses a pair of light-emitting-diode sources with center wavelengths of 1.3 µm and 1.46 µm.

© 1998 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Simultaneous dual-band ultra-high resolution optical coherence tomography

Felix Spöler, Stefan Kray, Patrik Grychtol, Barbara Hermes, Jörg Bornemann, Michael Först, and Heinrich Kurz
Opt. Express 15(17) 10832-10841 (2007)

Measurement and imaging of water concentration in human cornea with differential absorption optical coherence tomography

Michael Pircher, Erich Götzinger, Rainer Leitgeb, Adolf F. Fercher, and Christoph K. Hitzenberger
Opt. Express 11(18) 2190-2197 (2003)

Dual-band Fourier domain optical coherence tomography with depth-related compensations

Miao Zhang, Lixin Ma, and Ping Yu
Biomed. Opt. Express 5(1) 167-182 (2014)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Figures (6)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Tables (1)

You do not have subscription access to this journal. Article tables are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Equations (20)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription

Metrics

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access OSA Member Subscription