Abstract

The patient of this study is a protanope who is afflicted with retinitis pigmentosa. As with other patients studied, an abnormality in Stiles’s pi-1 mechanism was found in the patient’s worse eye (20/35 visual acuity). From his rejection of monochromatic color matches, we inferred that the sensitivity of the short-wave cones is reduced, but their signals are not abnormally attenuated by the middle-wave cones. The patient’s pi-4 thresholds, however, were within the range of normal control values.

© 1982 Optical Society of America

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  1. M. F. Marmor, "Visual loss in retinitis pigmentosa," Am. J. Ophthalmol. 89, 692–698 (1980).
  2. R. S. L. Young and G. A. Fishman, "Color matches of patients with retinitis pigmentosa," Invest. Ophthalmol. Vis. Sci. 19, 967–972 (1980).
  3. M. A. Sandberg and E. L. Berson, "Blue and green cone mechanisms in retinitis pigmentosa," Invest. Ophthalmol. Visual Sci. 16, 149–157 (1977).
  4. R. S. L. Young and G. A. Fishman, "Sensitivity losses in a long wavelength sensitive mechanism of patients with retinitis pigmentosa," Vision Res. (to be published).
  5. E. L. Berson and E. A. Simonoff, "Dominant retinitis pigmentosa with reduced penetrance," Arch. Ophthalmol. 97, 1286–1291 (1979).
  6. W. S. Stiles, "Separation of the blue and green mechanisms of foveal vision by measurements of increment thresholds," Proc. R. Soc. London Ser. B 133, 418–434 (1946).
  7. D. Kirk, "Color discrimination at threshold," Invest. Ophthalmol. Vis. Sci. Suppl. 19, 135 (1980).
  8. V. C. Smith and J. Pokorny, "Spectral sensitivity of the foveal cone photopigments between 400 and 500 nm," Vision Res. 15, 161–171 (1975).
  9. E. N. Pugh, "The nature of the pi 1 colour mechanism of W. S. Stiles," J. Physiol. 257, 713–747 (1976).
  10. E. N. Pugh and J. D. Mollon, "A theory of the pi 1 and pi 3 color mechanisms of Stiles," Vision Res. 19, 293–312 (1979).
  11. H. Kolb and P. Gouras, "Electron microscopic observations of human retinitis pigmentosa, dominantly inherited," Invest. Ophthalmol. 13, 487–498 (1974).
  12. R. B. Szamier, E. L. Berson, R. Klein, and S. Meyers, "Sex-linked retinitis pigmentosa: ultrastructure of photoreceptors and pigment epithelium," Invest. Ophthalmol. Vis. Sci. 18, 145–160 (1979).
  13. G. Wyszecki and W. S. Stiles, Color Science: Concepts and Methods, Quantitative Data and Formulas (Wiley, New York, 1967), p. 408.
  14. F. Flamant and W. S. Stiles, "The directional and spectral sensitivities of the retinal rods to adapting fields of different wavelengths," J. Physiol. 107, 187–202 (1948).

1980 (3)

M. F. Marmor, "Visual loss in retinitis pigmentosa," Am. J. Ophthalmol. 89, 692–698 (1980).

R. S. L. Young and G. A. Fishman, "Color matches of patients with retinitis pigmentosa," Invest. Ophthalmol. Vis. Sci. 19, 967–972 (1980).

D. Kirk, "Color discrimination at threshold," Invest. Ophthalmol. Vis. Sci. Suppl. 19, 135 (1980).

1979 (3)

E. N. Pugh and J. D. Mollon, "A theory of the pi 1 and pi 3 color mechanisms of Stiles," Vision Res. 19, 293–312 (1979).

E. L. Berson and E. A. Simonoff, "Dominant retinitis pigmentosa with reduced penetrance," Arch. Ophthalmol. 97, 1286–1291 (1979).

R. B. Szamier, E. L. Berson, R. Klein, and S. Meyers, "Sex-linked retinitis pigmentosa: ultrastructure of photoreceptors and pigment epithelium," Invest. Ophthalmol. Vis. Sci. 18, 145–160 (1979).

1977 (1)

M. A. Sandberg and E. L. Berson, "Blue and green cone mechanisms in retinitis pigmentosa," Invest. Ophthalmol. Visual Sci. 16, 149–157 (1977).

1976 (1)

E. N. Pugh, "The nature of the pi 1 colour mechanism of W. S. Stiles," J. Physiol. 257, 713–747 (1976).

1975 (1)

V. C. Smith and J. Pokorny, "Spectral sensitivity of the foveal cone photopigments between 400 and 500 nm," Vision Res. 15, 161–171 (1975).

1974 (1)

H. Kolb and P. Gouras, "Electron microscopic observations of human retinitis pigmentosa, dominantly inherited," Invest. Ophthalmol. 13, 487–498 (1974).

1948 (1)

F. Flamant and W. S. Stiles, "The directional and spectral sensitivities of the retinal rods to adapting fields of different wavelengths," J. Physiol. 107, 187–202 (1948).

1946 (1)

W. S. Stiles, "Separation of the blue and green mechanisms of foveal vision by measurements of increment thresholds," Proc. R. Soc. London Ser. B 133, 418–434 (1946).

Berson, E. L.

E. L. Berson and E. A. Simonoff, "Dominant retinitis pigmentosa with reduced penetrance," Arch. Ophthalmol. 97, 1286–1291 (1979).

R. B. Szamier, E. L. Berson, R. Klein, and S. Meyers, "Sex-linked retinitis pigmentosa: ultrastructure of photoreceptors and pigment epithelium," Invest. Ophthalmol. Vis. Sci. 18, 145–160 (1979).

M. A. Sandberg and E. L. Berson, "Blue and green cone mechanisms in retinitis pigmentosa," Invest. Ophthalmol. Visual Sci. 16, 149–157 (1977).

Fishman, G. A.

R. S. L. Young and G. A. Fishman, "Color matches of patients with retinitis pigmentosa," Invest. Ophthalmol. Vis. Sci. 19, 967–972 (1980).

R. S. L. Young and G. A. Fishman, "Sensitivity losses in a long wavelength sensitive mechanism of patients with retinitis pigmentosa," Vision Res. (to be published).

Flamant, F.

F. Flamant and W. S. Stiles, "The directional and spectral sensitivities of the retinal rods to adapting fields of different wavelengths," J. Physiol. 107, 187–202 (1948).

Gouras, P.

H. Kolb and P. Gouras, "Electron microscopic observations of human retinitis pigmentosa, dominantly inherited," Invest. Ophthalmol. 13, 487–498 (1974).

Kirk, D.

D. Kirk, "Color discrimination at threshold," Invest. Ophthalmol. Vis. Sci. Suppl. 19, 135 (1980).

Klein, R.

R. B. Szamier, E. L. Berson, R. Klein, and S. Meyers, "Sex-linked retinitis pigmentosa: ultrastructure of photoreceptors and pigment epithelium," Invest. Ophthalmol. Vis. Sci. 18, 145–160 (1979).

Kolb, H.

H. Kolb and P. Gouras, "Electron microscopic observations of human retinitis pigmentosa, dominantly inherited," Invest. Ophthalmol. 13, 487–498 (1974).

Marmor, M. F.

M. F. Marmor, "Visual loss in retinitis pigmentosa," Am. J. Ophthalmol. 89, 692–698 (1980).

Meyers, S.

R. B. Szamier, E. L. Berson, R. Klein, and S. Meyers, "Sex-linked retinitis pigmentosa: ultrastructure of photoreceptors and pigment epithelium," Invest. Ophthalmol. Vis. Sci. 18, 145–160 (1979).

Mollon, J. D.

E. N. Pugh and J. D. Mollon, "A theory of the pi 1 and pi 3 color mechanisms of Stiles," Vision Res. 19, 293–312 (1979).

Pokorny, J.

V. C. Smith and J. Pokorny, "Spectral sensitivity of the foveal cone photopigments between 400 and 500 nm," Vision Res. 15, 161–171 (1975).

Pugh, E. N.

E. N. Pugh and J. D. Mollon, "A theory of the pi 1 and pi 3 color mechanisms of Stiles," Vision Res. 19, 293–312 (1979).

E. N. Pugh, "The nature of the pi 1 colour mechanism of W. S. Stiles," J. Physiol. 257, 713–747 (1976).

Sandberg, M. A.

M. A. Sandberg and E. L. Berson, "Blue and green cone mechanisms in retinitis pigmentosa," Invest. Ophthalmol. Visual Sci. 16, 149–157 (1977).

Simonoff, E. A.

E. L. Berson and E. A. Simonoff, "Dominant retinitis pigmentosa with reduced penetrance," Arch. Ophthalmol. 97, 1286–1291 (1979).

Smith, V. C.

V. C. Smith and J. Pokorny, "Spectral sensitivity of the foveal cone photopigments between 400 and 500 nm," Vision Res. 15, 161–171 (1975).

Stiles, W. S.

F. Flamant and W. S. Stiles, "The directional and spectral sensitivities of the retinal rods to adapting fields of different wavelengths," J. Physiol. 107, 187–202 (1948).

W. S. Stiles, "Separation of the blue and green mechanisms of foveal vision by measurements of increment thresholds," Proc. R. Soc. London Ser. B 133, 418–434 (1946).

G. Wyszecki and W. S. Stiles, Color Science: Concepts and Methods, Quantitative Data and Formulas (Wiley, New York, 1967), p. 408.

Szamier, R. B.

R. B. Szamier, E. L. Berson, R. Klein, and S. Meyers, "Sex-linked retinitis pigmentosa: ultrastructure of photoreceptors and pigment epithelium," Invest. Ophthalmol. Vis. Sci. 18, 145–160 (1979).

Wyszecki, G.

G. Wyszecki and W. S. Stiles, Color Science: Concepts and Methods, Quantitative Data and Formulas (Wiley, New York, 1967), p. 408.

Young, R. S. L.

R. S. L. Young and G. A. Fishman, "Color matches of patients with retinitis pigmentosa," Invest. Ophthalmol. Vis. Sci. 19, 967–972 (1980).

R. S. L. Young and G. A. Fishman, "Sensitivity losses in a long wavelength sensitive mechanism of patients with retinitis pigmentosa," Vision Res. (to be published).

Am. J. Ophthalmol. (1)

M. F. Marmor, "Visual loss in retinitis pigmentosa," Am. J. Ophthalmol. 89, 692–698 (1980).

Arch. Ophthalmol. (1)

E. L. Berson and E. A. Simonoff, "Dominant retinitis pigmentosa with reduced penetrance," Arch. Ophthalmol. 97, 1286–1291 (1979).

Invest. Ophthalmol. (1)

H. Kolb and P. Gouras, "Electron microscopic observations of human retinitis pigmentosa, dominantly inherited," Invest. Ophthalmol. 13, 487–498 (1974).

Invest. Ophthalmol. Vis. Sci. (2)

R. B. Szamier, E. L. Berson, R. Klein, and S. Meyers, "Sex-linked retinitis pigmentosa: ultrastructure of photoreceptors and pigment epithelium," Invest. Ophthalmol. Vis. Sci. 18, 145–160 (1979).

R. S. L. Young and G. A. Fishman, "Color matches of patients with retinitis pigmentosa," Invest. Ophthalmol. Vis. Sci. 19, 967–972 (1980).

Invest. Ophthalmol. Vis. Sci. Suppl. (1)

D. Kirk, "Color discrimination at threshold," Invest. Ophthalmol. Vis. Sci. Suppl. 19, 135 (1980).

Invest. Ophthalmol. Visual Sci. (1)

M. A. Sandberg and E. L. Berson, "Blue and green cone mechanisms in retinitis pigmentosa," Invest. Ophthalmol. Visual Sci. 16, 149–157 (1977).

J. Physiol. (2)

E. N. Pugh, "The nature of the pi 1 colour mechanism of W. S. Stiles," J. Physiol. 257, 713–747 (1976).

F. Flamant and W. S. Stiles, "The directional and spectral sensitivities of the retinal rods to adapting fields of different wavelengths," J. Physiol. 107, 187–202 (1948).

Proc. R. Soc. London Ser. B (1)

W. S. Stiles, "Separation of the blue and green mechanisms of foveal vision by measurements of increment thresholds," Proc. R. Soc. London Ser. B 133, 418–434 (1946).

Vision Res. (2)

V. C. Smith and J. Pokorny, "Spectral sensitivity of the foveal cone photopigments between 400 and 500 nm," Vision Res. 15, 161–171 (1975).

E. N. Pugh and J. D. Mollon, "A theory of the pi 1 and pi 3 color mechanisms of Stiles," Vision Res. 19, 293–312 (1979).

Other (2)

G. Wyszecki and W. S. Stiles, Color Science: Concepts and Methods, Quantitative Data and Formulas (Wiley, New York, 1967), p. 408.

R. S. L. Young and G. A. Fishman, "Sensitivity losses in a long wavelength sensitive mechanism of patients with retinitis pigmentosa," Vision Res. (to be published).

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