Abstract

The level of cholinesterase in the human blood is a very good indicator of liver function. In this study we desrcibe the relationship between cholinesterase values obtained with routine laboratory methods and near infrared (NIR) spectral data of 72 individuals with a wide range of cholinesterase levels. NIR spectra were measured with a SPECTRALYZER 10–25 (PMC) computerised research analyser. The relationship of laboratory data and values of the second derivative of the log (1/TF) spectra measured at different wavelengths was determined with multiple linear regression (MLR) analysis using three-term linear summation equations. A correlation coefficient (r) of 0.89 and a standard error of calibration (SEC) of 987 units L−1 (U/L) of the enzyme were obtained. Our results indicate that NIR measurements of cholinesterase in the human blood serum can be related to the analytical data obtained with routine laboratory methods. NIR spectroscopy is a rapid, accurate, and inexpensive method for determining various constituents in the human blood.

© 1998 NIR Publications

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  1. K.H. Norris, , “Possible Medical Applications of NIR”, in Making Light Work: Advances in Near Infrared Spectroscopy , Ed by I. Murray, and I.A. Cowe, VCH, Weinheim, pp. 596–602 (1992).
  2. J.W. Hall, and A. Pollard, , Clin. Chem.  38, 1623 (1992).
  3. J.W. Hall, and A. Pollard, , Clin. Biochem.  26, 483 (1993).
  4. M. Cope, and D.T. Delpy, , Med. Biol. Eng. Comput.  26, 289 (1988).
  5. A.W. van Toorenenbergen and B.G. Blijenberg, and B. Lejinse, , J. Clin. Chem. Clin. Biochem.  26, 209 (1988).
  6. E. Peuchant and C. Salles, and R. Jensen, , Anal. Chem.  59, 1816 (1987).
  7. R. Jensen and I. Lugan, and E. Peuchant, , Bull. Soc. Pharm. Bordeaux  125, 43 (1986).
  8. M.A. Arnold, and G.W. Small, , Anal. Chem.  62, 1457 (1990).
  9. G. Domján, K. Kaffka, J. Jákó, and I. Vályi-Nagy, , J. Near Infrared Spectrosc.  2, 67 (1994).
  10. I. Vályi-Nagy, J. Jákó, K. Kaffka, É. Gönczöl, and G. Domján, , Clin. Chim. Acta ,  264, 117 (1997).

1997 (1)

I. Vályi-Nagy, J. Jákó, K. Kaffka, É. Gönczöl, and G. Domján, , Clin. Chim. Acta ,  264, 117 (1997).

1994 (1)

1993 (1)

J.W. Hall, and A. Pollard, , Clin. Biochem.  26, 483 (1993).

J.W. Hall, and A. Pollard, , Clin. Biochem.  26, 483 (1993).

1992 (1)

J.W. Hall, and A. Pollard, , Clin. Chem.  38, 1623 (1992).

J.W. Hall, and A. Pollard, , Clin. Chem.  38, 1623 (1992).

1990 (1)

M.A. Arnold, and G.W. Small, , Anal. Chem.  62, 1457 (1990).

M.A. Arnold, and G.W. Small, , Anal. Chem.  62, 1457 (1990).

1988 (2)

M. Cope, and D.T. Delpy, , Med. Biol. Eng. Comput.  26, 289 (1988).

M. Cope, and D.T. Delpy, , Med. Biol. Eng. Comput.  26, 289 (1988).

A.W. van Toorenenbergen and B.G. Blijenberg, and B. Lejinse, , J. Clin. Chem. Clin. Biochem.  26, 209 (1988).

A.W. van Toorenenbergen and B.G. Blijenberg, and B. Lejinse, , J. Clin. Chem. Clin. Biochem.  26, 209 (1988).

1987 (1)

E. Peuchant and C. Salles, and R. Jensen, , Anal. Chem.  59, 1816 (1987).

E. Peuchant and C. Salles, and R. Jensen, , Anal. Chem.  59, 1816 (1987).

1986 (1)

R. Jensen and I. Lugan, and E. Peuchant, , Bull. Soc. Pharm. Bordeaux  125, 43 (1986).

R. Jensen and I. Lugan, and E. Peuchant, , Bull. Soc. Pharm. Bordeaux  125, 43 (1986).

Arnold, M.A.

M.A. Arnold, and G.W. Small, , Anal. Chem.  62, 1457 (1990).

Blijenberg, B.G.

A.W. van Toorenenbergen and B.G. Blijenberg, and B. Lejinse, , J. Clin. Chem. Clin. Biochem.  26, 209 (1988).

Cope, M.

M. Cope, and D.T. Delpy, , Med. Biol. Eng. Comput.  26, 289 (1988).

Delpy, D.T.

M. Cope, and D.T. Delpy, , Med. Biol. Eng. Comput.  26, 289 (1988).

Domján, G.

I. Vályi-Nagy, J. Jákó, K. Kaffka, É. Gönczöl, and G. Domján, , Clin. Chim. Acta ,  264, 117 (1997).

G. Domján, K. Kaffka, J. Jákó, and I. Vályi-Nagy, , J. Near Infrared Spectrosc.  2, 67 (1994).

Gönczöl, É.

I. Vályi-Nagy, J. Jákó, K. Kaffka, É. Gönczöl, and G. Domján, , Clin. Chim. Acta ,  264, 117 (1997).

Hall, J.W.

J.W. Hall, and A. Pollard, , Clin. Biochem.  26, 483 (1993).

J.W. Hall, and A. Pollard, , Clin. Chem.  38, 1623 (1992).

Jákó, J.

I. Vályi-Nagy, J. Jákó, K. Kaffka, É. Gönczöl, and G. Domján, , Clin. Chim. Acta ,  264, 117 (1997).

G. Domján, K. Kaffka, J. Jákó, and I. Vályi-Nagy, , J. Near Infrared Spectrosc.  2, 67 (1994).

Jensen, R.

E. Peuchant and C. Salles, and R. Jensen, , Anal. Chem.  59, 1816 (1987).

R. Jensen and I. Lugan, and E. Peuchant, , Bull. Soc. Pharm. Bordeaux  125, 43 (1986).

Kaffka, K.

I. Vályi-Nagy, J. Jákó, K. Kaffka, É. Gönczöl, and G. Domján, , Clin. Chim. Acta ,  264, 117 (1997).

G. Domján, K. Kaffka, J. Jákó, and I. Vályi-Nagy, , J. Near Infrared Spectrosc.  2, 67 (1994).

Lejinse, B.

A.W. van Toorenenbergen and B.G. Blijenberg, and B. Lejinse, , J. Clin. Chem. Clin. Biochem.  26, 209 (1988).

Lugan, I.

R. Jensen and I. Lugan, and E. Peuchant, , Bull. Soc. Pharm. Bordeaux  125, 43 (1986).

Norris, K.H.

K.H. Norris, , “Possible Medical Applications of NIR”, in Making Light Work: Advances in Near Infrared Spectroscopy , Ed by I. Murray, and I.A. Cowe, VCH, Weinheim, pp. 596–602 (1992).

Peuchant, E.

E. Peuchant and C. Salles, and R. Jensen, , Anal. Chem.  59, 1816 (1987).

R. Jensen and I. Lugan, and E. Peuchant, , Bull. Soc. Pharm. Bordeaux  125, 43 (1986).

Pollard, A.

J.W. Hall, and A. Pollard, , Clin. Biochem.  26, 483 (1993).

J.W. Hall, and A. Pollard, , Clin. Chem.  38, 1623 (1992).

Salles, C.

E. Peuchant and C. Salles, and R. Jensen, , Anal. Chem.  59, 1816 (1987).

Small, G.W.

M.A. Arnold, and G.W. Small, , Anal. Chem.  62, 1457 (1990).

Vályi-Nagy, I.

I. Vályi-Nagy, J. Jákó, K. Kaffka, É. Gönczöl, and G. Domján, , Clin. Chim. Acta ,  264, 117 (1997).

G. Domján, K. Kaffka, J. Jákó, and I. Vályi-Nagy, , J. Near Infrared Spectrosc.  2, 67 (1994).

van Toorenenbergen, A.W.

A.W. van Toorenenbergen and B.G. Blijenberg, and B. Lejinse, , J. Clin. Chem. Clin. Biochem.  26, 209 (1988).

Anal. Chem. (2)

E. Peuchant and C. Salles, and R. Jensen, , Anal. Chem.  59, 1816 (1987).

M.A. Arnold, and G.W. Small, , Anal. Chem.  62, 1457 (1990).

Bull. Soc. Pharm. Bordeaux (1)

R. Jensen and I. Lugan, and E. Peuchant, , Bull. Soc. Pharm. Bordeaux  125, 43 (1986).

Clin. Biochem. (1)

J.W. Hall, and A. Pollard, , Clin. Biochem.  26, 483 (1993).

Clin. Chem. (1)

J.W. Hall, and A. Pollard, , Clin. Chem.  38, 1623 (1992).

Clin. Chim. Acta (1)

I. Vályi-Nagy, J. Jákó, K. Kaffka, É. Gönczöl, and G. Domján, , Clin. Chim. Acta ,  264, 117 (1997).

J. Clin. Chem. Clin. Biochem. (1)

A.W. van Toorenenbergen and B.G. Blijenberg, and B. Lejinse, , J. Clin. Chem. Clin. Biochem.  26, 209 (1988).

J. Near Infrared Spectrosc. (1)

Med. Biol. Eng. Comput. (1)

M. Cope, and D.T. Delpy, , Med. Biol. Eng. Comput.  26, 289 (1988).

Other (1)

K.H. Norris, , “Possible Medical Applications of NIR”, in Making Light Work: Advances in Near Infrared Spectroscopy , Ed by I. Murray, and I.A. Cowe, VCH, Weinheim, pp. 596–602 (1992).

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