Abstract

The performance of an interferometric device based on integrated Bimodal Waveguides (BiMW) for sensing is demonstrated. The sensors are fabricated using standard silicon technology and can achieve a detection limit of 2.5 · 10<sup>-7</sup> RIU for homogeneous sensing, rendering in a very high sensitive device. The applicability of the bimodal waveguide interferometer as label-free biosensor has been demonstrated by the real-time monitoring of the biomolecular interaction of BSA and antiBSA. Due to their simplicity, the interferometric devices could be further integrated in complete lab-on-a-chip platforms for point-of-care diagnostics showing them as a powerful instrument for biochemical analysis.

© 2011 IEEE

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  1. F. Prieto, B. Sepúlveda, A. Calle, A. Llobera, C. Domínguez, A. Abad, A. Montoya, L. M. Lechuga, "An integrated optical interferometric nanodevice based on silicon technology for biosensor applications," Nanotechnology 14, 907-912 (2003).
  2. J. Homola, "Surface plasmon resonance sensors for detection of chemical and biological species," Chem. Rev. 108, 462-493 (2008).
  3. A. Ymeti, J. S. Kanger, R. Wijn, P. V. Lambeck, J. Greve, "Development of a multichannel integrated interferometer sensor," Sensors and Actuators B 83, 1-7 (2002).
  4. W. Lukosz, C. H. Stamm, "Integrated optical interferometer as relative humidity sensor and differential refractometer," Sensors and Actuators A 25–27, 185-188 (1991).
  5. N. Kato, L. Lee, R. Chandrawati, A. P. R. Johnston, F. Caruso, "Optically characterized DNA multilayered assemblies and phenomenological modeling of layer-by-layer hybridization," J. Phys. Chem. C 113, 21185-21195 (2009).
  6. M. Lohmeyer, L. Wilkens, O. Zhuromsky, H. Dötsch, P. Herte, "Integrated magnetooptic cross strip isolator," Optics Communications 189, 251-259 (2001).
  7. A. Irace, G. Breglio, "All-silicon optical temperature sensor based on multi-mode interference," Optics Express 11, 2807-2812 (2003).
  8. R. Levy, S. Ruschin, "Design of a single-channel modal interferometer waveguide sensor," IEEE Sensors 9, 146-153 (2009).
  9. K. Zinoviev, L. M. Lechuga, C. Dominguez, "Silicon nitride bimodal waveguides for high sensitivity biosensors," (ECIO) 2010, Proc. European Conference on Optical Integration (ECIO) (2010).
  10. Patent PCT/ES08/070142, 12/669307 (US).
  11. D. Dorfner, T. Zabel, T. Hürlimann, N. Hauke, L. Frandsen, U. Rant, G. Abstreiter, J. Finley, "Photonic crystal nanostructures for optical biosensing applications," Biosensors and Bioelectronics 24, 3688-3692 (2009).
  12. S. J. Choo, B.-C. Lee, S.-M. Lee, J. H. Park, H.-J. Shin, "Optimization of silicon oxynitrides by plasma-enhanced chemical vapor deposition for an interferometric biosensor," J. Micromech. Microeng. 19, 9 (2009).
  13. C. A. Barrios, M. J. Bañuls, V. González-Pedro, K. B. Gylfason, B. Sánchez, A. Griol, A. Maquieira, H. Sohlström, M. Holgado, R. Casquel, "Label-free optical biosensing with slot-waveguides," Optics Letters 33, 708-710 (2008).
  14. N. J. Freeman, L. L. Peel, M. J. Swann, G. H. Cross, A. Reeves, S. Brand, J. R. Lu, "Real time, high resolution studies of protein adsorption and structure at solid-liquid interface using dual polarization interferometry," J. Phys.; Condens. Matter 16, S2493-S2496 (2004).

2009 (4)

N. Kato, L. Lee, R. Chandrawati, A. P. R. Johnston, F. Caruso, "Optically characterized DNA multilayered assemblies and phenomenological modeling of layer-by-layer hybridization," J. Phys. Chem. C 113, 21185-21195 (2009).

R. Levy, S. Ruschin, "Design of a single-channel modal interferometer waveguide sensor," IEEE Sensors 9, 146-153 (2009).

D. Dorfner, T. Zabel, T. Hürlimann, N. Hauke, L. Frandsen, U. Rant, G. Abstreiter, J. Finley, "Photonic crystal nanostructures for optical biosensing applications," Biosensors and Bioelectronics 24, 3688-3692 (2009).

S. J. Choo, B.-C. Lee, S.-M. Lee, J. H. Park, H.-J. Shin, "Optimization of silicon oxynitrides by plasma-enhanced chemical vapor deposition for an interferometric biosensor," J. Micromech. Microeng. 19, 9 (2009).

2008 (2)

C. A. Barrios, M. J. Bañuls, V. González-Pedro, K. B. Gylfason, B. Sánchez, A. Griol, A. Maquieira, H. Sohlström, M. Holgado, R. Casquel, "Label-free optical biosensing with slot-waveguides," Optics Letters 33, 708-710 (2008).

J. Homola, "Surface plasmon resonance sensors for detection of chemical and biological species," Chem. Rev. 108, 462-493 (2008).

2004 (1)

N. J. Freeman, L. L. Peel, M. J. Swann, G. H. Cross, A. Reeves, S. Brand, J. R. Lu, "Real time, high resolution studies of protein adsorption and structure at solid-liquid interface using dual polarization interferometry," J. Phys.; Condens. Matter 16, S2493-S2496 (2004).

2003 (2)

F. Prieto, B. Sepúlveda, A. Calle, A. Llobera, C. Domínguez, A. Abad, A. Montoya, L. M. Lechuga, "An integrated optical interferometric nanodevice based on silicon technology for biosensor applications," Nanotechnology 14, 907-912 (2003).

A. Irace, G. Breglio, "All-silicon optical temperature sensor based on multi-mode interference," Optics Express 11, 2807-2812 (2003).

2002 (1)

A. Ymeti, J. S. Kanger, R. Wijn, P. V. Lambeck, J. Greve, "Development of a multichannel integrated interferometer sensor," Sensors and Actuators B 83, 1-7 (2002).

2001 (1)

M. Lohmeyer, L. Wilkens, O. Zhuromsky, H. Dötsch, P. Herte, "Integrated magnetooptic cross strip isolator," Optics Communications 189, 251-259 (2001).

1991 (1)

W. Lukosz, C. H. Stamm, "Integrated optical interferometer as relative humidity sensor and differential refractometer," Sensors and Actuators A 25–27, 185-188 (1991).

Biosensors and Bioelectronics (1)

D. Dorfner, T. Zabel, T. Hürlimann, N. Hauke, L. Frandsen, U. Rant, G. Abstreiter, J. Finley, "Photonic crystal nanostructures for optical biosensing applications," Biosensors and Bioelectronics 24, 3688-3692 (2009).

Chem. Rev. (1)

J. Homola, "Surface plasmon resonance sensors for detection of chemical and biological species," Chem. Rev. 108, 462-493 (2008).

IEEE Sensors (1)

R. Levy, S. Ruschin, "Design of a single-channel modal interferometer waveguide sensor," IEEE Sensors 9, 146-153 (2009).

J. Micromech. Microeng. (1)

S. J. Choo, B.-C. Lee, S.-M. Lee, J. H. Park, H.-J. Shin, "Optimization of silicon oxynitrides by plasma-enhanced chemical vapor deposition for an interferometric biosensor," J. Micromech. Microeng. 19, 9 (2009).

J. Phys. Chem. C (1)

N. Kato, L. Lee, R. Chandrawati, A. P. R. Johnston, F. Caruso, "Optically characterized DNA multilayered assemblies and phenomenological modeling of layer-by-layer hybridization," J. Phys. Chem. C 113, 21185-21195 (2009).

J. Phys.; Condens. Matter (1)

N. J. Freeman, L. L. Peel, M. J. Swann, G. H. Cross, A. Reeves, S. Brand, J. R. Lu, "Real time, high resolution studies of protein adsorption and structure at solid-liquid interface using dual polarization interferometry," J. Phys.; Condens. Matter 16, S2493-S2496 (2004).

Nanotechnology (1)

F. Prieto, B. Sepúlveda, A. Calle, A. Llobera, C. Domínguez, A. Abad, A. Montoya, L. M. Lechuga, "An integrated optical interferometric nanodevice based on silicon technology for biosensor applications," Nanotechnology 14, 907-912 (2003).

Optics Communications (1)

M. Lohmeyer, L. Wilkens, O. Zhuromsky, H. Dötsch, P. Herte, "Integrated magnetooptic cross strip isolator," Optics Communications 189, 251-259 (2001).

Optics Express (1)

A. Irace, G. Breglio, "All-silicon optical temperature sensor based on multi-mode interference," Optics Express 11, 2807-2812 (2003).

Optics Letters (1)

C. A. Barrios, M. J. Bañuls, V. González-Pedro, K. B. Gylfason, B. Sánchez, A. Griol, A. Maquieira, H. Sohlström, M. Holgado, R. Casquel, "Label-free optical biosensing with slot-waveguides," Optics Letters 33, 708-710 (2008).

Sensors and Actuators A (1)

W. Lukosz, C. H. Stamm, "Integrated optical interferometer as relative humidity sensor and differential refractometer," Sensors and Actuators A 25–27, 185-188 (1991).

Sensors and Actuators B (1)

A. Ymeti, J. S. Kanger, R. Wijn, P. V. Lambeck, J. Greve, "Development of a multichannel integrated interferometer sensor," Sensors and Actuators B 83, 1-7 (2002).

Other (2)

K. Zinoviev, L. M. Lechuga, C. Dominguez, "Silicon nitride bimodal waveguides for high sensitivity biosensors," (ECIO) 2010, Proc. European Conference on Optical Integration (ECIO) (2010).

Patent PCT/ES08/070142, 12/669307 (US).

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