Abstract
This paper presents a new label-free DNA optical sensor based on the
microgap structured Fabry–Perot interferometer. An optical cavity is
formed by a microgap sealed between a singlemode fiber and a well-cleaved
fiber end. The capture DNA is immobilized on the cavity end by layer-by-layer
electrostatic self-assembly. This sensor detects the hybridization of target
DNA with complementary capture DNA by observing the optical cavity thickness
variation. Experimental results demonstrate that this sensor has a sensitivity
of 6 nmol/ml and can identify a 2-bp mismatch.
© 2008 IEEE
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