Abstract

Indocyanine green (ICG) is a dye approved for use in clinical diagnostics. ICG remains in the intravascular space following intravenous administration, due to its ability to rapidly bind to the plasma proteins, and its therapeutic potential has been studied in well-vascularized cutaneous tumors. Here we have evaluated the clinical response of a subconjunctival tumor to photothermal therapy (PTT) using an ICG-enhanced near-infrared diode laser and its adverse effects, in a rabbit. 22 male New Zealand white rabbits with subconjunctival tumors were enrolled (control group 6, laser-only group 8, laser-with-ICG group 8). Rabbits in the laser-with-ICG group received ICG (twice, 2 mg/kg each time, intravenously) directly followed by irradiation with a diode laser (λ = 810 nm). Rabbits in the laser-only group were irradiated with the diode laser. ICG angiography, ultrasonography, and pathologic examination were performed to evaluate PTT response at specific time points (0, 2, and 4 weeks after PTT). Two weeks after initial treatment, the eight rabbits treated by laser with ICG showed a 100% response rate. There was no clinical response in both laser-only and control groups. ICG-PTT is a potential and effective palliative therapeutic modality for subconjunctival tumors.

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  1. S. S. Hwang, J. E. Kim, B.-K. Chun, S. Jung, E.-K. Park, H.-J. Lee, M. Jung, S.-J. Lee, G. M. Noh, R. Masanganise, C. Oak, and Y.-C. Ahn2013New model of subconjunctival tumor development in rabbitsJ. Biomed. Opt.18070501
  2. T. S. Chinogurei, R. Masanganise, S. Rusakaniko, and E. Sibanda2006Ocular surface squamous neoplasia (OSSN) and human immunodeficiency virus at Sekuru Kaguvi Eye Unit in Zimbabwe: the role of operational research studies in a resource poor environment?Cent. Afr. J. Med.525658
  3. C. Abels, S. Karrer, W. Bäumler, A. E. Goetz, M. Landthaler, and R.-M. Szeimies1998Indocyanine green and laser light for the treatment of AIDS-associated cutaneous Kaposi's sarcomaBr. J. Cancer7710211024
  4. J. Denekamp1993Angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapyBJR.66181196
  5. P. Babilas, G. Shafirstein, J. Baier, V. Schacht, R.-M. Szeimies, M. Landthaler, W. Bäumler, and C. Abels2007Photothermolysis of blood vessels using indocyanine green and pulsed diode laser irradiation in the dorsal skinfold chamber modelLasers Surg. Med.39341352
  6. S. Mordon, T. Desmettre, J.-M. Devoisselle, and V. Mitchell1997Selective laser photocoagulation of blood vessels in a hamster skin flap model using a specific ICG formulationLasers Surg. Med.21365373
  7. J. D. Wolfe and K. G. Csaky2004Indocyanine green enhanced retinal vessel laser closure in rats: histologic and immunohistochemical observationsExp. Eye Res.79631638
  8. M. A. Namvar, M. Vahedi, H. Abdolsamadi, A. Mirzaei, Y. Mohammadi, and F. A. Jalilian2019Effect of photodynamic therapy by 810 and 940 nm diode laser on Herpes Simplex Virus 1: An in vitro studyPhotodiagn. Photodyn. Ther.258791
  9. S. Long, Y. Xu, F. Zhou, B. Wang, Y. Yang, Y. Fu, N. Du, and X. Li2019Characteristics of temperature changes in photothermal therapy induced by combined application of indocyanine green and laserOncol. Lett.1739523959
  10. W. R. Chen, R. L. Adams, K. E. Bartels, and R. E. Nordquist1995Chromophore-enhanced in vivo tumor cell destruction using an 808-nm diode laserCancer Lett.94125131
  11. R. Pérez-Soler, A. Chachoua, L. A. Hammond, E. K. Rowinsky, M. Huberman, D. Karp, J. Rigas, G. M. Clark, P. Santabárbara, and P. Bonomi2004Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancerJ. Clin. Oncol.2232383247
  12. M. Reim, C. Redbrake, and N. Schrage2001Chemical and thermal injuries of the eyes. Surgical and medical treatment based on clinical and pathophysiological findingsArch. Soc. Esp. Oftalmol.7679124
  13. F. Codère, S. Brownstein, J. L. Garwood, and S. C. Dresner1988Carbon dioxide laser treatment of the conjunctiva and the corneaOphthalmology953745
  14. K.-H. Shin, J.-H. Hwang, and J.-W. Kwon2013Argon laser photoablation of superficial conjunctival nevus: results of a 3-year studyAm. J. Ophthalmol.155823828.e2
  15. R. B. Neto, J. Isenberg, A. G. Castillejos, R. Sant'ana, and A. O. Romano2018Novel treatment of papillomatous conjunctival lesions using pattern scanning laser photocoagulation: 1-Year resultsOcul. Surf.16337340
  16. K. D. Nelson and J. J. McSoley2011Clinical findings and management of conjunctival intraepithelial neoplasiaOptometry821521

Other (16)

S. S. Hwang, J. E. Kim, B.-K. Chun, S. Jung, E.-K. Park, H.-J. Lee, M. Jung, S.-J. Lee, G. M. Noh, R. Masanganise, C. Oak, and Y.-C. Ahn2013New model of subconjunctival tumor development in rabbitsJ. Biomed. Opt.18070501

T. S. Chinogurei, R. Masanganise, S. Rusakaniko, and E. Sibanda2006Ocular surface squamous neoplasia (OSSN) and human immunodeficiency virus at Sekuru Kaguvi Eye Unit in Zimbabwe: the role of operational research studies in a resource poor environment?Cent. Afr. J. Med.525658

C. Abels, S. Karrer, W. Bäumler, A. E. Goetz, M. Landthaler, and R.-M. Szeimies1998Indocyanine green and laser light for the treatment of AIDS-associated cutaneous Kaposi's sarcomaBr. J. Cancer7710211024

J. Denekamp1993Angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapyBJR.66181196

P. Babilas, G. Shafirstein, J. Baier, V. Schacht, R.-M. Szeimies, M. Landthaler, W. Bäumler, and C. Abels2007Photothermolysis of blood vessels using indocyanine green and pulsed diode laser irradiation in the dorsal skinfold chamber modelLasers Surg. Med.39341352

S. Mordon, T. Desmettre, J.-M. Devoisselle, and V. Mitchell1997Selective laser photocoagulation of blood vessels in a hamster skin flap model using a specific ICG formulationLasers Surg. Med.21365373

J. D. Wolfe and K. G. Csaky2004Indocyanine green enhanced retinal vessel laser closure in rats: histologic and immunohistochemical observationsExp. Eye Res.79631638

M. A. Namvar, M. Vahedi, H. Abdolsamadi, A. Mirzaei, Y. Mohammadi, and F. A. Jalilian2019Effect of photodynamic therapy by 810 and 940 nm diode laser on Herpes Simplex Virus 1: An in vitro studyPhotodiagn. Photodyn. Ther.258791

S. Long, Y. Xu, F. Zhou, B. Wang, Y. Yang, Y. Fu, N. Du, and X. Li2019Characteristics of temperature changes in photothermal therapy induced by combined application of indocyanine green and laserOncol. Lett.1739523959

W. R. Chen, R. L. Adams, K. E. Bartels, and R. E. Nordquist1995Chromophore-enhanced in vivo tumor cell destruction using an 808-nm diode laserCancer Lett.94125131

R. Pérez-Soler, A. Chachoua, L. A. Hammond, E. K. Rowinsky, M. Huberman, D. Karp, J. Rigas, G. M. Clark, P. Santabárbara, and P. Bonomi2004Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancerJ. Clin. Oncol.2232383247

M. Reim, C. Redbrake, and N. Schrage2001Chemical and thermal injuries of the eyes. Surgical and medical treatment based on clinical and pathophysiological findingsArch. Soc. Esp. Oftalmol.7679124

F. Codère, S. Brownstein, J. L. Garwood, and S. C. Dresner1988Carbon dioxide laser treatment of the conjunctiva and the corneaOphthalmology953745

K.-H. Shin, J.-H. Hwang, and J.-W. Kwon2013Argon laser photoablation of superficial conjunctival nevus: results of a 3-year studyAm. J. Ophthalmol.155823828.e2

R. B. Neto, J. Isenberg, A. G. Castillejos, R. Sant'ana, and A. O. Romano2018Novel treatment of papillomatous conjunctival lesions using pattern scanning laser photocoagulation: 1-Year resultsOcul. Surf.16337340

K. D. Nelson and J. J. McSoley2011Clinical findings and management of conjunctival intraepithelial neoplasiaOptometry821521

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