Abstract

The rodent model has been used frequently to understand stroke pathophysiology, due to its low cost and the large spectrum of genetic strains available. Here, we present a diffuse speckle contrast analysis system (DSCA) with a 1 × 2 optical switch that was used to non-invasively assess cerebral blood flow (CBF) changes in the rat during intraluminal suturing for middle cerebral artery occlusion (MCAO) surgery. The blood flow index (BFI) in the left hemisphere was lower than that in the right hemisphere because the left middle cerebral artery was occluded. Furthermore, the performance of the DSCA system was compared with that of commercial laser Doppler flowmetry. The changes in the BFI measured by the two systems were correlated strongly. The DSCA system was less sensitive to motion artifacts and able to measure relatively deep tissue flow in the rat’s brain. In conclusion, the DSCA system secured CBF monitoring during surgery in a rodent model without craniotomy.

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  33. M. Ren, Z. Lin, H. Qian, G. R. Choudhury, R. Liu, H. Liu, and S. YangEmbolic middle cerebral artery occlusion model using thrombin and fibrinogen composed clots in ratJ. Neurosci. Methods20122112296304
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  35. J. Dong, K. Lee, and P. M. GrantMulti-channel deep tissue flowmetry based on temporal diffuse speckle contrast analysisOpt. Express201321192285422861
  36. C. Yeo, H. C. Park, K. Lee, and C. SongAvian embryo monitoring during incubation using multi-channel diffuse speckle contrast analysisBiomed. Opt. Express2016719398
  37. C. Yeo and C. SongDiffuse speckle contrast analysis with novel fiber-lens detectionProc. of SPIE20171000591005904
  38. R. L. Yeager, J. A. Franzosa, D. S. Millsap, J. L. Angell-Yeager, S. S. Heise, P. Wakhungu, J. Lim, H. T. Whelan, J. T. Eells, and D. S. HenshelEffects of 670-nm phototherapy on developmentPhotomed. Laser Surg.2005233268272
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Other (40)

J. V. Gijn and M. S. DennisIssues and answers in stroke careLancet1998352Suppl. 3SIII2327

G. Pignataro, A. Scorziello, G. Di Renzo, and L. AnnunziatoPost-ischemic brain damage: effect of ischemic preconditioning and postconditioning and identification of potential candidates for stroke therapyFEBS J.200927614657

T. KirinoIschemic toleranceJ. Cereb. Blood Flow Metab.2002221112831296

A. Durukan, D. Strbian, and T. TatlisumakRodent models of ischemic stroke: a useful tool for stroke drug developmentCurr. Pharm. Des.2008144359370

H. Memezawa, M. L. Smith, and B. K. SiesjöPenumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in ratsStroke1992234552559

H. Nagasawa and K. KogureCorrelation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusionStroke198920810371043

B. Schaller and R. GrafCerebral ischemic preconditioningJ. Neurol.20022491115031511

M. I. MacraeNew models of focal cerebral ischaemiaBr. J. Clin. Pharmacol.1992344302308

R. M. K. W. LeeMorphology of cerebral arteriesPharmac. Ther.199566149173

M. Boquillon, J. P. Boquillon, and J. BraletPhotochemically induced, graded cerebral infarction in the mouse by laser irradiation evolution of brain edemaJ. Pharmacol. Toxicol. Methods199227116

A. H. Hainsworth and H. S. MarkusDo in vivo experimental models reflect human cerebral small vessel disease? A systematic reviewJ. Cereb. Blood Flow Metab.2008281218771891

Q. Liu, Y. Li, H. Lu, and S. TongReal-time high resolution laser speckle imaging of cerebral vascular changes in a rodent photothrombosis modelBiomed. Opt. Express20145514831493

J. Sharkey and S. P. ButcherCharacterisation of an experimental model of stroke produced by intracerebral microinjection of endothelin-1 adjacent to the rat middle cerebral arteryJ. Neurosci. Methods1995601-2125131

S. K. McCann, G. J. Dusting, and C. L. RoulstonEarly increase of Nox4 NADPH oxidase and superoxide generation following endothelin-1-induced stroke in conscious ratsJ. Neurosci. Res.2008861125242534

J. Koizumi, Y. Yoshida, T. Nakazawa, and G. OonedaExperimental studies of ischemic brain edema, I: a new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic areaJpn. J. Stroke1986818

E. Z. Longa, P. R. Weinstein, S. Carlson, and R. CumminsReversible middle cerebral artery occlusion without craniectomy in ratsStroke19892018491

K. Uluç, A. Miranpuri, G. C. Kujoth, E. Aktüre, and M. K. BaşkayaFocal cerebral ischemia model by endovascular suture occlusion of the middle cerebral artery in the ratJ. Vis. Exp.201148e1978

E. Toyota, D. C. Warltier, T. Brock, E. Ritman, C. Kolz, P. O’Malley, P. Rocic, M. Focardi, and W. M. ChilianVascular endothelial growth factor is required for coronary collateral growth in the ratCirculation20051121421082113

K. H. Bockhorst, P. A. Narayana, R. Liu, P. Ahobila-Vijjula, J. Ramu, M. Kamel, J. Wosik, T. Bockhorst, K. Hahn, K. M. Hasan, and J. R. Perez-PoloEarly postnatal development of rat brain: in vivo diffusion tensor imagingJ. Neurosci. Res.200886715201528

P. R. Allegrini and D. SauerApplication of magnetic resonance imaging to the measurement of neurodegeneration in rat brain: MRI data correlate strongly with histology and enzymatic analysisMagn. Reson. Imaging1992105773778

Y. F. Wang, S. E. Tsirka, S. Strickland, P. E. Stieg, S. G. Soriano, and S. A. LiptonTissue plasminogen activator (tPA) increase neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient miceNat. Med.199842228231

S. Rajdev, K. Hara, Y. Kokubo, R. Mestril, W. Dillmann, P. R. Weinstein, and F. R. SharpMice overexpressing rat heat shock protein 70 are protected against cerebral infarctionAnn Neurol.2000476782791

N. E. Stagliano, M. A. Pérez-Pinzón, M. A. Moskowitz, and P. L. HuangFocal ischemic preconditioning induces rapid tolerance to middle cerebral artery occlusion in miceJ. Cereb. Blood Flow Metab.1999197757761

J. Ma, C. Ayata, P. L. Huang, M. C. Fishman, and M. A. MoskowitzRegional cerebral blood flow response to vibrissal stimulation in mice lacking type I NOS gene expressionAm. J. Physiol.19962703H1085H1090

A. Y Shih, J. D Driscoll, P. J Drew, N. Nishimura, C. B Schaffer, and D. KleinfeldTwo-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brainJ. Cereb. Blood Flow Metab.201232712771309

A. Cho, C. Yeon, D. Kim, and E. ChungLaser speckle contrast imaging for measuring cerebral blood flow changes caused by electrical sensory stimulationJ. Opt. Soc. Korea20162018893

T. Durdurana and A. G. YodhDiffuse correlation spectro-scopy for non-invasive, micro-vascular cerebral blood flow measurementNeuroimage201485015163

Y. Shang, L. Chen, M. Toborek, and G. YuDiffuse optical monitoring of repeated cerebral ischemia in miceOpt. Express201119212030120315

S. Ansari, H. Azari, D. J. McConnell, A. Afzal, and J MoccoIntraluminal Middle Cerebral Artery Occlusion (MCAO)model for ischemic stroke with laser doppler flowmetryguidance in miceJ. Vis. Exp.201151e2879

H. Harada, Y. Wang, Y. Mishima, N. Uehara, T. Makaya, and T. KanoA novel method of detecting rCBF with laser-Doppler flowmetry without cranial window through the skull for a MCAO rat modelBrain Res. Protoc.2005143165170

P. Li and T. H. MurphyTwo-photon imaging during prolonged middle cerebral artery occlusion in mice reveals recovery of dendritic structure after reperfusionJ. Neurosci.200828461197011979

Q. Guo, G. Wang, and S. NamuraFenofibrate improves cerebral blood flow after middle cerebral artery occlusion in miceJ. Cereb. Blood Flow Metab.20103017078

M. Ren, Z. Lin, H. Qian, G. R. Choudhury, R. Liu, H. Liu, and S. YangEmbolic middle cerebral artery occlusion model using thrombin and fibrinogen composed clots in ratJ. Neurosci. Methods20122112296304

R. Bi, J. Dong, and K. LeeDeep tissue flowmetry based on diffuse speckle contrast analysisOpt. Lett.201338914011403

J. Dong, K. Lee, and P. M. GrantMulti-channel deep tissue flowmetry based on temporal diffuse speckle contrast analysisOpt. Express201321192285422861

C. Yeo, H. C. Park, K. Lee, and C. SongAvian embryo monitoring during incubation using multi-channel diffuse speckle contrast analysisBiomed. Opt. Express2016719398

C. Yeo and C. SongDiffuse speckle contrast analysis with novel fiber-lens detectionProc. of SPIE20171000591005904

R. L. Yeager, J. A. Franzosa, D. S. Millsap, J. L. Angell-Yeager, S. S. Heise, P. Wakhungu, J. Lim, H. T. Whelan, J. T. Eells, and D. S. HenshelEffects of 670-nm phototherapy on developmentPhotomed. Laser Surg.2005233268272

G. Yu, T. Durduran, C. Zhou, R. Cheng, and A. G. YodhHandbook of Biomedical Optics2011195216Near-infrared diffuse correlation spectroscopy for assessment of tissue blood flow

M. J. Leahy, F. F. M. de Mul, G. E. Nilsson, and R. ManiewskiPrinciples and practice of the laser-Dopplerper fusion techniqueTechnol Health Care.199972-3143162

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