Abstract

Conformations of surface atoms in various stages of nanogold-based genechip testing are scanned by the atomic force and scanning tunneling microscope. We intuitively observe the process and differences in probe combination, nucleic acid hybridization, and silver staining, which might be useful to validate the assay method of genechip. We hope to use this technology to make the other invisible chemical or biochemical reaction become visible and convincible in the future.

© 2010 Chinese Optics Letters

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2009 (2)

C.-H. Yeh, H.-H. Huang, T.-C. Chang, H.-P. Lin, and Y.-C. Lin, Biosens. Bioelectron. 24, 1661 (2009).

H. Li, Y. Tang, and L. Hu, Chinese J. Lasers (in Chinese)36, 472 (2009).

2008 (4)

T. Huang, S. Zhou, H. Teng, H. Lin, and J. Wang, Acta Opt. Sin. (in Chinese) 28, 1420 (2008).

Y. Wang, H. Meng, Y. Wang, and W. Wang, Acta Opt. Sin. (in Chinese) 28, 804 (2008).

H. J. Lee, A. W. Wark, and R. M. Corn, Analyst 133, 596 (2008).

D. Gu, W. Lu, H. Wang, and Y. Zhou, Chin. J. Nosocomiol. (in Chinese) 18, 29 (2008).

2007 (2)

D. Gu, W. Lu, H. Wang, and Y. Zhou, Chin. J. Nosocomiol. (in Chinese) 17, 143 (2007).

G. Peng, X. Yang, H. Xin, J. Liu, and X. Li, Chin. J. Mech. Eng. (in Chinese) 43, 127 (2007).

2006 (1)

G. He, Z. Zhang, G. Peng, H. Bai, and X. Yang, J. Chin. Electron Microsc. Soc. (in Chinese) 25, 26 (2006).

2005 (1)

D. Gu, W. Lu, and Y. Zhou, Foreign Medical Biomedical Engineering Foreign Medical Sciences (in Chinese) 28, 75 (2005).

2003 (2)

Y. F. Dufr?ene, Curr. Opin. Microbiol. 6, 317 (2003).

J. L. Alonso and W. H. Goldmann, Life Sci. 72, 2553(2003).

2001 (1)

X. Yang, A. Chen, G. He, X. Feng, Y. Wang, J. Zhan, and Z. Tang, J. Chongqing Univ. (Natural Sci. Ed.) (in Chinese) 24, 137 (2001).

1986 (1)

G. Binnig, C. F. Quate, and Ch. Gerber, Phys. Rev. Lett. 56, 930 (1986).

Alonso, J. L.

J. L. Alonso and W. H. Goldmann, Life Sci. 72, 2553(2003).

Bai, H.

G. He, Z. Zhang, G. Peng, H. Bai, and X. Yang, J. Chin. Electron Microsc. Soc. (in Chinese) 25, 26 (2006).

Binnig, G.

G. Binnig, C. F. Quate, and Ch. Gerber, Phys. Rev. Lett. 56, 930 (1986).

Chang, T.-C.

C.-H. Yeh, H.-H. Huang, T.-C. Chang, H.-P. Lin, and Y.-C. Lin, Biosens. Bioelectron. 24, 1661 (2009).

Chen, A.

X. Yang, A. Chen, G. He, X. Feng, Y. Wang, J. Zhan, and Z. Tang, J. Chongqing Univ. (Natural Sci. Ed.) (in Chinese) 24, 137 (2001).

Corn, R. M.

H. J. Lee, A. W. Wark, and R. M. Corn, Analyst 133, 596 (2008).

Dufr?ene, Y. F.

Y. F. Dufr?ene, Curr. Opin. Microbiol. 6, 317 (2003).

Feng, X.

X. Yang, A. Chen, G. He, X. Feng, Y. Wang, J. Zhan, and Z. Tang, J. Chongqing Univ. (Natural Sci. Ed.) (in Chinese) 24, 137 (2001).

Gerber, Ch.

G. Binnig, C. F. Quate, and Ch. Gerber, Phys. Rev. Lett. 56, 930 (1986).

Goldmann, W. H.

J. L. Alonso and W. H. Goldmann, Life Sci. 72, 2553(2003).

Gu, D.

D. Gu, W. Lu, H. Wang, and Y. Zhou, Chin. J. Nosocomiol. (in Chinese) 18, 29 (2008).

D. Gu, W. Lu, H. Wang, and Y. Zhou, Chin. J. Nosocomiol. (in Chinese) 17, 143 (2007).

D. Gu, W. Lu, and Y. Zhou, Foreign Medical Biomedical Engineering Foreign Medical Sciences (in Chinese) 28, 75 (2005).

He, G.

G. He, Z. Zhang, G. Peng, H. Bai, and X. Yang, J. Chin. Electron Microsc. Soc. (in Chinese) 25, 26 (2006).

X. Yang, A. Chen, G. He, X. Feng, Y. Wang, J. Zhan, and Z. Tang, J. Chongqing Univ. (Natural Sci. Ed.) (in Chinese) 24, 137 (2001).

Hu, L.

H. Li, Y. Tang, and L. Hu, Chinese J. Lasers (in Chinese)36, 472 (2009).

Huang, H.-H.

C.-H. Yeh, H.-H. Huang, T.-C. Chang, H.-P. Lin, and Y.-C. Lin, Biosens. Bioelectron. 24, 1661 (2009).

Huang, T.

T. Huang, S. Zhou, H. Teng, H. Lin, and J. Wang, Acta Opt. Sin. (in Chinese) 28, 1420 (2008).

Lee, H. J.

H. J. Lee, A. W. Wark, and R. M. Corn, Analyst 133, 596 (2008).

Li, H.

H. Li, Y. Tang, and L. Hu, Chinese J. Lasers (in Chinese)36, 472 (2009).

Li, X.

G. Peng, X. Yang, H. Xin, J. Liu, and X. Li, Chin. J. Mech. Eng. (in Chinese) 43, 127 (2007).

Lin, H.

T. Huang, S. Zhou, H. Teng, H. Lin, and J. Wang, Acta Opt. Sin. (in Chinese) 28, 1420 (2008).

Lin, H.-P.

C.-H. Yeh, H.-H. Huang, T.-C. Chang, H.-P. Lin, and Y.-C. Lin, Biosens. Bioelectron. 24, 1661 (2009).

Lin, Y.-C.

C.-H. Yeh, H.-H. Huang, T.-C. Chang, H.-P. Lin, and Y.-C. Lin, Biosens. Bioelectron. 24, 1661 (2009).

Liu, J.

G. Peng, X. Yang, H. Xin, J. Liu, and X. Li, Chin. J. Mech. Eng. (in Chinese) 43, 127 (2007).

Lu, W.

D. Gu, W. Lu, H. Wang, and Y. Zhou, Chin. J. Nosocomiol. (in Chinese) 18, 29 (2008).

D. Gu, W. Lu, H. Wang, and Y. Zhou, Chin. J. Nosocomiol. (in Chinese) 17, 143 (2007).

D. Gu, W. Lu, and Y. Zhou, Foreign Medical Biomedical Engineering Foreign Medical Sciences (in Chinese) 28, 75 (2005).

Meng, H.

Y. Wang, H. Meng, Y. Wang, and W. Wang, Acta Opt. Sin. (in Chinese) 28, 804 (2008).

Peng, G.

G. Peng, X. Yang, H. Xin, J. Liu, and X. Li, Chin. J. Mech. Eng. (in Chinese) 43, 127 (2007).

G. He, Z. Zhang, G. Peng, H. Bai, and X. Yang, J. Chin. Electron Microsc. Soc. (in Chinese) 25, 26 (2006).

Quate, C. F.

G. Binnig, C. F. Quate, and Ch. Gerber, Phys. Rev. Lett. 56, 930 (1986).

Tang, Y.

H. Li, Y. Tang, and L. Hu, Chinese J. Lasers (in Chinese)36, 472 (2009).

Tang, Z.

X. Yang, A. Chen, G. He, X. Feng, Y. Wang, J. Zhan, and Z. Tang, J. Chongqing Univ. (Natural Sci. Ed.) (in Chinese) 24, 137 (2001).

Teng, H.

T. Huang, S. Zhou, H. Teng, H. Lin, and J. Wang, Acta Opt. Sin. (in Chinese) 28, 1420 (2008).

Wang, H.

D. Gu, W. Lu, H. Wang, and Y. Zhou, Chin. J. Nosocomiol. (in Chinese) 18, 29 (2008).

D. Gu, W. Lu, H. Wang, and Y. Zhou, Chin. J. Nosocomiol. (in Chinese) 17, 143 (2007).

Wang, J.

T. Huang, S. Zhou, H. Teng, H. Lin, and J. Wang, Acta Opt. Sin. (in Chinese) 28, 1420 (2008).

Wang, W.

Y. Wang, H. Meng, Y. Wang, and W. Wang, Acta Opt. Sin. (in Chinese) 28, 804 (2008).

Wang, Y.

Y. Wang, H. Meng, Y. Wang, and W. Wang, Acta Opt. Sin. (in Chinese) 28, 804 (2008).

Y. Wang, H. Meng, Y. Wang, and W. Wang, Acta Opt. Sin. (in Chinese) 28, 804 (2008).

X. Yang, A. Chen, G. He, X. Feng, Y. Wang, J. Zhan, and Z. Tang, J. Chongqing Univ. (Natural Sci. Ed.) (in Chinese) 24, 137 (2001).

Wark, A. W.

H. J. Lee, A. W. Wark, and R. M. Corn, Analyst 133, 596 (2008).

Xin, H.

G. Peng, X. Yang, H. Xin, J. Liu, and X. Li, Chin. J. Mech. Eng. (in Chinese) 43, 127 (2007).

Yang, X.

G. Peng, X. Yang, H. Xin, J. Liu, and X. Li, Chin. J. Mech. Eng. (in Chinese) 43, 127 (2007).

G. He, Z. Zhang, G. Peng, H. Bai, and X. Yang, J. Chin. Electron Microsc. Soc. (in Chinese) 25, 26 (2006).

X. Yang, A. Chen, G. He, X. Feng, Y. Wang, J. Zhan, and Z. Tang, J. Chongqing Univ. (Natural Sci. Ed.) (in Chinese) 24, 137 (2001).

Yeh, C.-H.

C.-H. Yeh, H.-H. Huang, T.-C. Chang, H.-P. Lin, and Y.-C. Lin, Biosens. Bioelectron. 24, 1661 (2009).

Zhan, J.

X. Yang, A. Chen, G. He, X. Feng, Y. Wang, J. Zhan, and Z. Tang, J. Chongqing Univ. (Natural Sci. Ed.) (in Chinese) 24, 137 (2001).

Zhang, Z.

G. He, Z. Zhang, G. Peng, H. Bai, and X. Yang, J. Chin. Electron Microsc. Soc. (in Chinese) 25, 26 (2006).

Zhou, S.

T. Huang, S. Zhou, H. Teng, H. Lin, and J. Wang, Acta Opt. Sin. (in Chinese) 28, 1420 (2008).

Zhou, Y.

D. Gu, W. Lu, H. Wang, and Y. Zhou, Chin. J. Nosocomiol. (in Chinese) 18, 29 (2008).

D. Gu, W. Lu, H. Wang, and Y. Zhou, Chin. J. Nosocomiol. (in Chinese) 17, 143 (2007).

D. Gu, W. Lu, and Y. Zhou, Foreign Medical Biomedical Engineering Foreign Medical Sciences (in Chinese) 28, 75 (2005).

Acta Opt. Sin. (in Chinese) (2)

T. Huang, S. Zhou, H. Teng, H. Lin, and J. Wang, Acta Opt. Sin. (in Chinese) 28, 1420 (2008).

Y. Wang, H. Meng, Y. Wang, and W. Wang, Acta Opt. Sin. (in Chinese) 28, 804 (2008).

Analyst (1)

H. J. Lee, A. W. Wark, and R. M. Corn, Analyst 133, 596 (2008).

Biosens. Bioelectron. (1)

C.-H. Yeh, H.-H. Huang, T.-C. Chang, H.-P. Lin, and Y.-C. Lin, Biosens. Bioelectron. 24, 1661 (2009).

Chin. J. Mech. Eng. (in Chinese) (1)

G. Peng, X. Yang, H. Xin, J. Liu, and X. Li, Chin. J. Mech. Eng. (in Chinese) 43, 127 (2007).

Chin. J. Nosocomiol. (in Chinese) (2)

D. Gu, W. Lu, H. Wang, and Y. Zhou, Chin. J. Nosocomiol. (in Chinese) 18, 29 (2008).

D. Gu, W. Lu, H. Wang, and Y. Zhou, Chin. J. Nosocomiol. (in Chinese) 17, 143 (2007).

Chinese J. Lasers (in (1)

H. Li, Y. Tang, and L. Hu, Chinese J. Lasers (in Chinese)36, 472 (2009).

Curr. Opin. Microbiol. (1)

Y. F. Dufr?ene, Curr. Opin. Microbiol. 6, 317 (2003).

Foreign Medical Biomedical Engineering Foreign Medical Sciences (in Chinese) (1)

D. Gu, W. Lu, and Y. Zhou, Foreign Medical Biomedical Engineering Foreign Medical Sciences (in Chinese) 28, 75 (2005).

J. Chin. Electron Microsc. Soc. (in Chinese) (1)

G. He, Z. Zhang, G. Peng, H. Bai, and X. Yang, J. Chin. Electron Microsc. Soc. (in Chinese) 25, 26 (2006).

J. Chongqing Univ. (Natural Sci. Ed.) (in Chinese) (1)

X. Yang, A. Chen, G. He, X. Feng, Y. Wang, J. Zhan, and Z. Tang, J. Chongqing Univ. (Natural Sci. Ed.) (in Chinese) 24, 137 (2001).

Life Sci. (1)

J. L. Alonso and W. H. Goldmann, Life Sci. 72, 2553(2003).

Phys. Rev. Lett. (1)

G. Binnig, C. F. Quate, and Ch. Gerber, Phys. Rev. Lett. 56, 930 (1986).

Other (2)

Y. Zhou, D. Gu, W. Lu, R. Xiong, X. Liu, H. Shen, and X. Chen, "A nano-amplifying detection method for bio-chip" (in Chinese) Chinese Patent: ZL 02 1 33538.9 (May 25, 2005).

Y. Zhou,W. Lu, D. Gu, and H.Wang, "A gene-chip based on nanogold reporting system for rapid pathogens detection" (in Chinese) Chinese Patent: ZL 2004 2 0034442.X (May 11, 2005).

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