Abstract

We report the design and fabrication of a novel and fully integrated polymer-based centrifugal microfluidic disc for rapid automatic allergens detection. All essential steps for a single test including flow valving, sequencing, mixing, separation, extraction, and sedimentation for final detection are automatically conducted within 30 min on a centrifugal microfluidic disc. Our design features a siphon-based valving and analyte extraction structure where the released analyte is separated and subsequently extracted by a siphon valve into the detection chamber. Incorporating the siphon valve and a series of capillary valves, we realize automated detection of allergic reaction on a centrifugal microfluidic disc.

© 2010 Chinese Optics Letters

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  1. C. C. Lin, J. H. Wang, H. W. Wu, and G. B. Lee, J. Assoc. Lab. Autom. 15, 253 (2010).
  2. http://www.gyros.com/en/home/index.html.
  3. N. Honda, U. Lindberg, P. Andersson, S. Hoffmann, and H. Takei, Clin. Chem. 51, 1955 (2005).
  4. J. Steigert, T. Brenner, M. Grumann, L. Riegger, S. Lutz, R. Zengerle, and J. Ducr'ee, Biomed. Microdevices 9, 675(2007).
  5. S. Y. Lai, S. N. Wang, J. Luo, L. J. Lee, S. T. Yang, and M. J. Madou, Anal. Chem. 76, 1832 (2004).
  6. J. M. Chen, P. C. Huang, and M. G. Lin, Microfluid. Nanofluid. 4, 427 (2008).

2010 (1)

C. C. Lin, J. H. Wang, H. W. Wu, and G. B. Lee, J. Assoc. Lab. Autom. 15, 253 (2010).

2008 (1)

J. M. Chen, P. C. Huang, and M. G. Lin, Microfluid. Nanofluid. 4, 427 (2008).

2007 (1)

J. Steigert, T. Brenner, M. Grumann, L. Riegger, S. Lutz, R. Zengerle, and J. Ducr'ee, Biomed. Microdevices 9, 675(2007).

2005 (1)

N. Honda, U. Lindberg, P. Andersson, S. Hoffmann, and H. Takei, Clin. Chem. 51, 1955 (2005).

2004 (1)

S. Y. Lai, S. N. Wang, J. Luo, L. J. Lee, S. T. Yang, and M. J. Madou, Anal. Chem. 76, 1832 (2004).

Andersson, P.

N. Honda, U. Lindberg, P. Andersson, S. Hoffmann, and H. Takei, Clin. Chem. 51, 1955 (2005).

Brenner, T.

J. Steigert, T. Brenner, M. Grumann, L. Riegger, S. Lutz, R. Zengerle, and J. Ducr'ee, Biomed. Microdevices 9, 675(2007).

Chen, J. M.

J. M. Chen, P. C. Huang, and M. G. Lin, Microfluid. Nanofluid. 4, 427 (2008).

Ducr'ee, J.

J. Steigert, T. Brenner, M. Grumann, L. Riegger, S. Lutz, R. Zengerle, and J. Ducr'ee, Biomed. Microdevices 9, 675(2007).

Grumann, M.

J. Steigert, T. Brenner, M. Grumann, L. Riegger, S. Lutz, R. Zengerle, and J. Ducr'ee, Biomed. Microdevices 9, 675(2007).

Hoffmann, S.

N. Honda, U. Lindberg, P. Andersson, S. Hoffmann, and H. Takei, Clin. Chem. 51, 1955 (2005).

Honda, N.

N. Honda, U. Lindberg, P. Andersson, S. Hoffmann, and H. Takei, Clin. Chem. 51, 1955 (2005).

Huang, P. C.

J. M. Chen, P. C. Huang, and M. G. Lin, Microfluid. Nanofluid. 4, 427 (2008).

Lai, S. Y.

S. Y. Lai, S. N. Wang, J. Luo, L. J. Lee, S. T. Yang, and M. J. Madou, Anal. Chem. 76, 1832 (2004).

Lee, G. B.

C. C. Lin, J. H. Wang, H. W. Wu, and G. B. Lee, J. Assoc. Lab. Autom. 15, 253 (2010).

Lee, L. J.

S. Y. Lai, S. N. Wang, J. Luo, L. J. Lee, S. T. Yang, and M. J. Madou, Anal. Chem. 76, 1832 (2004).

Lin, C. C.

C. C. Lin, J. H. Wang, H. W. Wu, and G. B. Lee, J. Assoc. Lab. Autom. 15, 253 (2010).

Lin, M. G.

J. M. Chen, P. C. Huang, and M. G. Lin, Microfluid. Nanofluid. 4, 427 (2008).

Lindberg, U.

N. Honda, U. Lindberg, P. Andersson, S. Hoffmann, and H. Takei, Clin. Chem. 51, 1955 (2005).

Luo, J.

S. Y. Lai, S. N. Wang, J. Luo, L. J. Lee, S. T. Yang, and M. J. Madou, Anal. Chem. 76, 1832 (2004).

Lutz, S.

J. Steigert, T. Brenner, M. Grumann, L. Riegger, S. Lutz, R. Zengerle, and J. Ducr'ee, Biomed. Microdevices 9, 675(2007).

Madou, M. J.

S. Y. Lai, S. N. Wang, J. Luo, L. J. Lee, S. T. Yang, and M. J. Madou, Anal. Chem. 76, 1832 (2004).

Riegger, L.

J. Steigert, T. Brenner, M. Grumann, L. Riegger, S. Lutz, R. Zengerle, and J. Ducr'ee, Biomed. Microdevices 9, 675(2007).

Steigert, J.

J. Steigert, T. Brenner, M. Grumann, L. Riegger, S. Lutz, R. Zengerle, and J. Ducr'ee, Biomed. Microdevices 9, 675(2007).

Takei, H.

N. Honda, U. Lindberg, P. Andersson, S. Hoffmann, and H. Takei, Clin. Chem. 51, 1955 (2005).

Wang, J. H.

C. C. Lin, J. H. Wang, H. W. Wu, and G. B. Lee, J. Assoc. Lab. Autom. 15, 253 (2010).

Wang, S. N.

S. Y. Lai, S. N. Wang, J. Luo, L. J. Lee, S. T. Yang, and M. J. Madou, Anal. Chem. 76, 1832 (2004).

Wu, H. W.

C. C. Lin, J. H. Wang, H. W. Wu, and G. B. Lee, J. Assoc. Lab. Autom. 15, 253 (2010).

Yang, S. T.

S. Y. Lai, S. N. Wang, J. Luo, L. J. Lee, S. T. Yang, and M. J. Madou, Anal. Chem. 76, 1832 (2004).

Zengerle, R.

J. Steigert, T. Brenner, M. Grumann, L. Riegger, S. Lutz, R. Zengerle, and J. Ducr'ee, Biomed. Microdevices 9, 675(2007).

Anal. Chem. (1)

S. Y. Lai, S. N. Wang, J. Luo, L. J. Lee, S. T. Yang, and M. J. Madou, Anal. Chem. 76, 1832 (2004).

Biomed. Microdevices (1)

J. Steigert, T. Brenner, M. Grumann, L. Riegger, S. Lutz, R. Zengerle, and J. Ducr'ee, Biomed. Microdevices 9, 675(2007).

Clin. Chem. (1)

N. Honda, U. Lindberg, P. Andersson, S. Hoffmann, and H. Takei, Clin. Chem. 51, 1955 (2005).

J. Assoc. Lab. Autom. (1)

C. C. Lin, J. H. Wang, H. W. Wu, and G. B. Lee, J. Assoc. Lab. Autom. 15, 253 (2010).

Microfluid. Nanofluid. (1)

J. M. Chen, P. C. Huang, and M. G. Lin, Microfluid. Nanofluid. 4, 427 (2008).

Other (1)

http://www.gyros.com/en/home/index.html.

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