Abstract

Singlet oxygen (<sup>1</sup>O<sub>2</sub>) is widely considered to play a major role in photodynamic therapy (PDT), and thus an increasing attention has been focused on the direct detection of <sup>1</sup>O<sub>2</sub> near-infrared luminescence around 1270 nm for PDT dosimetry. A new sensitive detection system is developed to directly measure the temporal and spectral resolved <sup>1</sup>O<sub>2</sub> luminescence spectra. The triplet state and <sup>1</sup>O<sub>2</sub> lifetimes of Rose Bengal as a model photosensitizer in different solvents are determined, and the obtained results agree well with the published data. Our detection system has the potential application in <sup>1</sup>O<sub>2</sub> luminescence-based PDT dosimetry.

© 2010 Chinese Optics Letters

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