Abstract

A novel structure of fiber optic biosensor and its principle are introduced. The sample is detected in microchannels of several microns diameter in fiber optic biosensors. The relation between the optic fiber tapered angle and the fluorescence incident angle is calculated in signal receiving part. As the sensor is a zero-order system, calculating formula of the static sensitivity is derived. When ZnSe nano-crystalline cluster is used for marking the molecules, the static sensitivity for fiber optic biosensors is calculated. At the same time, the relation between the static sensitivity and the ratio of exciting wavelength to fluorescence wavelength is presented.

© 2008 Chinese Optics Letters

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  1. L. Rindorf, P. E. Hoiby, J. B. Jensen, L. H. Pedersen, O. Bang, and O. Geschke, Anal. Bioanal. Chem. 385, 1370 (2006).
  2. L. Deng and Y. Feng, Chinese J. Sensors and Actuators (in Chinese) 18, 353 (2005).
  3. Y. Yang, Y. Wang, K. Xiong, B. Liu, Y. Tan, H. Tan, and R. Chen, Acta Photon. Sin. (in Chinese) 34, 121 (2005).
  4. M. D. Marazuela and M. C. Moreno-Bondi, Anal Bioanal. Chem. 372, 664 (2002).
  5. N. T. T. Ha, D. K. An, and P. V. Phong, Sensors and Actuators B 66, 200 (2000).
  6. W. C. Hui, L. Yobas, V. D. Samper, C.-K. Heng, S. Liw, H. Ji, Y. Chen, L. Cong, J. Li, and T. M. Lim, Sensors and Actuators A 133, 335 (2007).
  7. J. Yang, Y. Zhao, and X. Ni, Acta Opt. Sin. (in Chinese) 27, 1575 (2007).
  8. F. Liu, Q. Ye, J. Geng, R. Qu, and Z. Fang, Chin. Opt. Lett. 5, 267 (2007).
  9. Z.-C. Bai and S.-J. Qin, in Proceedings of Nanotech 2008 3, 331 (2008).
  10. C. Shan, Theoretical and Design Basis of Sensors and Their Applications (in Chinese) (National Defence Industry Press, Beijing, 1999) p.25.
  11. H.-S. Chen, B. Lo, J.-Y. Hwang, G.-Y. Chang, C.-M. Chen, S.-J. Tasi, and S.-J. J. Wang, J. Phys. Chem. B 108, 17119 (2004).
  12. D. A. Boehm and P. A. Gottlieb, Sensors and Actuators B 126, 508 (2007).
  13. Z. Wang, J. Wu, D. Li, and Y. Wang, Chinese J. Lasers (in Chinese) 33, 1003 (2006).
  14. S. Wormke, S. Mackowski, T. H. P. Brotosudarmo, and Ch. Br?uchle, Appl. Phys. Lett. 90, 193901 (2007).

2007 (5)

W. C. Hui, L. Yobas, V. D. Samper, C.-K. Heng, S. Liw, H. Ji, Y. Chen, L. Cong, J. Li, and T. M. Lim, Sensors and Actuators A 133, 335 (2007).

J. Yang, Y. Zhao, and X. Ni, Acta Opt. Sin. (in Chinese) 27, 1575 (2007).

F. Liu, Q. Ye, J. Geng, R. Qu, and Z. Fang, Chin. Opt. Lett. 5, 267 (2007).

D. A. Boehm and P. A. Gottlieb, Sensors and Actuators B 126, 508 (2007).

S. Wormke, S. Mackowski, T. H. P. Brotosudarmo, and Ch. Br?uchle, Appl. Phys. Lett. 90, 193901 (2007).

2006 (2)

Z. Wang, J. Wu, D. Li, and Y. Wang, Chinese J. Lasers (in Chinese) 33, 1003 (2006).

L. Rindorf, P. E. Hoiby, J. B. Jensen, L. H. Pedersen, O. Bang, and O. Geschke, Anal. Bioanal. Chem. 385, 1370 (2006).

2005 (2)

L. Deng and Y. Feng, Chinese J. Sensors and Actuators (in Chinese) 18, 353 (2005).

Y. Yang, Y. Wang, K. Xiong, B. Liu, Y. Tan, H. Tan, and R. Chen, Acta Photon. Sin. (in Chinese) 34, 121 (2005).

2004 (1)

H.-S. Chen, B. Lo, J.-Y. Hwang, G.-Y. Chang, C.-M. Chen, S.-J. Tasi, and S.-J. J. Wang, J. Phys. Chem. B 108, 17119 (2004).

2002 (1)

M. D. Marazuela and M. C. Moreno-Bondi, Anal Bioanal. Chem. 372, 664 (2002).

2000 (1)

N. T. T. Ha, D. K. An, and P. V. Phong, Sensors and Actuators B 66, 200 (2000).

An, D. K.

N. T. T. Ha, D. K. An, and P. V. Phong, Sensors and Actuators B 66, 200 (2000).

Bang, O.

L. Rindorf, P. E. Hoiby, J. B. Jensen, L. H. Pedersen, O. Bang, and O. Geschke, Anal. Bioanal. Chem. 385, 1370 (2006).

Boehm, D. A.

D. A. Boehm and P. A. Gottlieb, Sensors and Actuators B 126, 508 (2007).

Br?uchle, Ch.

S. Wormke, S. Mackowski, T. H. P. Brotosudarmo, and Ch. Br?uchle, Appl. Phys. Lett. 90, 193901 (2007).

Brotosudarmo, T. H. P.

S. Wormke, S. Mackowski, T. H. P. Brotosudarmo, and Ch. Br?uchle, Appl. Phys. Lett. 90, 193901 (2007).

Chang, G.-Y.

H.-S. Chen, B. Lo, J.-Y. Hwang, G.-Y. Chang, C.-M. Chen, S.-J. Tasi, and S.-J. J. Wang, J. Phys. Chem. B 108, 17119 (2004).

Chen, C.-M.

H.-S. Chen, B. Lo, J.-Y. Hwang, G.-Y. Chang, C.-M. Chen, S.-J. Tasi, and S.-J. J. Wang, J. Phys. Chem. B 108, 17119 (2004).

Chen, H.-S.

H.-S. Chen, B. Lo, J.-Y. Hwang, G.-Y. Chang, C.-M. Chen, S.-J. Tasi, and S.-J. J. Wang, J. Phys. Chem. B 108, 17119 (2004).

Chen, R.

Y. Yang, Y. Wang, K. Xiong, B. Liu, Y. Tan, H. Tan, and R. Chen, Acta Photon. Sin. (in Chinese) 34, 121 (2005).

Chen, Y.

W. C. Hui, L. Yobas, V. D. Samper, C.-K. Heng, S. Liw, H. Ji, Y. Chen, L. Cong, J. Li, and T. M. Lim, Sensors and Actuators A 133, 335 (2007).

Cong, L.

W. C. Hui, L. Yobas, V. D. Samper, C.-K. Heng, S. Liw, H. Ji, Y. Chen, L. Cong, J. Li, and T. M. Lim, Sensors and Actuators A 133, 335 (2007).

Deng, L.

L. Deng and Y. Feng, Chinese J. Sensors and Actuators (in Chinese) 18, 353 (2005).

Fang, Z.

Feng, Y.

L. Deng and Y. Feng, Chinese J. Sensors and Actuators (in Chinese) 18, 353 (2005).

Geng, J.

Geschke, O.

L. Rindorf, P. E. Hoiby, J. B. Jensen, L. H. Pedersen, O. Bang, and O. Geschke, Anal. Bioanal. Chem. 385, 1370 (2006).

Gottlieb, P. A.

D. A. Boehm and P. A. Gottlieb, Sensors and Actuators B 126, 508 (2007).

Ha, N. T. T.

N. T. T. Ha, D. K. An, and P. V. Phong, Sensors and Actuators B 66, 200 (2000).

Heng, C.-K.

W. C. Hui, L. Yobas, V. D. Samper, C.-K. Heng, S. Liw, H. Ji, Y. Chen, L. Cong, J. Li, and T. M. Lim, Sensors and Actuators A 133, 335 (2007).

Hoiby, P. E.

L. Rindorf, P. E. Hoiby, J. B. Jensen, L. H. Pedersen, O. Bang, and O. Geschke, Anal. Bioanal. Chem. 385, 1370 (2006).

Hui, W. C.

W. C. Hui, L. Yobas, V. D. Samper, C.-K. Heng, S. Liw, H. Ji, Y. Chen, L. Cong, J. Li, and T. M. Lim, Sensors and Actuators A 133, 335 (2007).

Hwang, J.-Y.

H.-S. Chen, B. Lo, J.-Y. Hwang, G.-Y. Chang, C.-M. Chen, S.-J. Tasi, and S.-J. J. Wang, J. Phys. Chem. B 108, 17119 (2004).

Jensen, J. B.

L. Rindorf, P. E. Hoiby, J. B. Jensen, L. H. Pedersen, O. Bang, and O. Geschke, Anal. Bioanal. Chem. 385, 1370 (2006).

Ji, H.

W. C. Hui, L. Yobas, V. D. Samper, C.-K. Heng, S. Liw, H. Ji, Y. Chen, L. Cong, J. Li, and T. M. Lim, Sensors and Actuators A 133, 335 (2007).

Li, D.

Z. Wang, J. Wu, D. Li, and Y. Wang, Chinese J. Lasers (in Chinese) 33, 1003 (2006).

Li, J.

W. C. Hui, L. Yobas, V. D. Samper, C.-K. Heng, S. Liw, H. Ji, Y. Chen, L. Cong, J. Li, and T. M. Lim, Sensors and Actuators A 133, 335 (2007).

Lim, T. M.

W. C. Hui, L. Yobas, V. D. Samper, C.-K. Heng, S. Liw, H. Ji, Y. Chen, L. Cong, J. Li, and T. M. Lim, Sensors and Actuators A 133, 335 (2007).

Liu, B.

Y. Yang, Y. Wang, K. Xiong, B. Liu, Y. Tan, H. Tan, and R. Chen, Acta Photon. Sin. (in Chinese) 34, 121 (2005).

Liu, F.

Liw, S.

W. C. Hui, L. Yobas, V. D. Samper, C.-K. Heng, S. Liw, H. Ji, Y. Chen, L. Cong, J. Li, and T. M. Lim, Sensors and Actuators A 133, 335 (2007).

Lo, B.

H.-S. Chen, B. Lo, J.-Y. Hwang, G.-Y. Chang, C.-M. Chen, S.-J. Tasi, and S.-J. J. Wang, J. Phys. Chem. B 108, 17119 (2004).

Mackowski, S.

S. Wormke, S. Mackowski, T. H. P. Brotosudarmo, and Ch. Br?uchle, Appl. Phys. Lett. 90, 193901 (2007).

Marazuela, M. D.

M. D. Marazuela and M. C. Moreno-Bondi, Anal Bioanal. Chem. 372, 664 (2002).

Moreno-Bondi, M. C.

M. D. Marazuela and M. C. Moreno-Bondi, Anal Bioanal. Chem. 372, 664 (2002).

Ni, X.

J. Yang, Y. Zhao, and X. Ni, Acta Opt. Sin. (in Chinese) 27, 1575 (2007).

Pedersen, L. H.

L. Rindorf, P. E. Hoiby, J. B. Jensen, L. H. Pedersen, O. Bang, and O. Geschke, Anal. Bioanal. Chem. 385, 1370 (2006).

Phong, P. V.

N. T. T. Ha, D. K. An, and P. V. Phong, Sensors and Actuators B 66, 200 (2000).

Qu, R.

Rindorf, L.

L. Rindorf, P. E. Hoiby, J. B. Jensen, L. H. Pedersen, O. Bang, and O. Geschke, Anal. Bioanal. Chem. 385, 1370 (2006).

Samper, V. D.

W. C. Hui, L. Yobas, V. D. Samper, C.-K. Heng, S. Liw, H. Ji, Y. Chen, L. Cong, J. Li, and T. M. Lim, Sensors and Actuators A 133, 335 (2007).

Tan, H.

Y. Yang, Y. Wang, K. Xiong, B. Liu, Y. Tan, H. Tan, and R. Chen, Acta Photon. Sin. (in Chinese) 34, 121 (2005).

Tan, Y.

Y. Yang, Y. Wang, K. Xiong, B. Liu, Y. Tan, H. Tan, and R. Chen, Acta Photon. Sin. (in Chinese) 34, 121 (2005).

Tasi, S.-J.

H.-S. Chen, B. Lo, J.-Y. Hwang, G.-Y. Chang, C.-M. Chen, S.-J. Tasi, and S.-J. J. Wang, J. Phys. Chem. B 108, 17119 (2004).

Wang, S.-J. J.

H.-S. Chen, B. Lo, J.-Y. Hwang, G.-Y. Chang, C.-M. Chen, S.-J. Tasi, and S.-J. J. Wang, J. Phys. Chem. B 108, 17119 (2004).

Wang, Y.

Z. Wang, J. Wu, D. Li, and Y. Wang, Chinese J. Lasers (in Chinese) 33, 1003 (2006).

Y. Yang, Y. Wang, K. Xiong, B. Liu, Y. Tan, H. Tan, and R. Chen, Acta Photon. Sin. (in Chinese) 34, 121 (2005).

Wang, Z.

Z. Wang, J. Wu, D. Li, and Y. Wang, Chinese J. Lasers (in Chinese) 33, 1003 (2006).

Wormke, S.

S. Wormke, S. Mackowski, T. H. P. Brotosudarmo, and Ch. Br?uchle, Appl. Phys. Lett. 90, 193901 (2007).

Wu, J.

Z. Wang, J. Wu, D. Li, and Y. Wang, Chinese J. Lasers (in Chinese) 33, 1003 (2006).

Xiong, K.

Y. Yang, Y. Wang, K. Xiong, B. Liu, Y. Tan, H. Tan, and R. Chen, Acta Photon. Sin. (in Chinese) 34, 121 (2005).

Yang, J.

J. Yang, Y. Zhao, and X. Ni, Acta Opt. Sin. (in Chinese) 27, 1575 (2007).

Yang, Y.

Y. Yang, Y. Wang, K. Xiong, B. Liu, Y. Tan, H. Tan, and R. Chen, Acta Photon. Sin. (in Chinese) 34, 121 (2005).

Ye, Q.

Yobas, L.

W. C. Hui, L. Yobas, V. D. Samper, C.-K. Heng, S. Liw, H. Ji, Y. Chen, L. Cong, J. Li, and T. M. Lim, Sensors and Actuators A 133, 335 (2007).

Zhao, Y.

J. Yang, Y. Zhao, and X. Ni, Acta Opt. Sin. (in Chinese) 27, 1575 (2007).

Acta Opt. Sin. (in Chinese) (1)

J. Yang, Y. Zhao, and X. Ni, Acta Opt. Sin. (in Chinese) 27, 1575 (2007).

Acta Photon. Sin. (in Chinese) (1)

Y. Yang, Y. Wang, K. Xiong, B. Liu, Y. Tan, H. Tan, and R. Chen, Acta Photon. Sin. (in Chinese) 34, 121 (2005).

Anal Bioanal. Chem. (1)

M. D. Marazuela and M. C. Moreno-Bondi, Anal Bioanal. Chem. 372, 664 (2002).

Anal. Bioanal. Chem. (1)

L. Rindorf, P. E. Hoiby, J. B. Jensen, L. H. Pedersen, O. Bang, and O. Geschke, Anal. Bioanal. Chem. 385, 1370 (2006).

Appl. Phys. Lett. (1)

S. Wormke, S. Mackowski, T. H. P. Brotosudarmo, and Ch. Br?uchle, Appl. Phys. Lett. 90, 193901 (2007).

Chin. Opt. Lett. (1)

Chinese J. Lasers (in Chinese) (1)

Z. Wang, J. Wu, D. Li, and Y. Wang, Chinese J. Lasers (in Chinese) 33, 1003 (2006).

Chinese J. Sensors and Actuators (in Chinese) (1)

L. Deng and Y. Feng, Chinese J. Sensors and Actuators (in Chinese) 18, 353 (2005).

J. Phys. Chem. B (1)

H.-S. Chen, B. Lo, J.-Y. Hwang, G.-Y. Chang, C.-M. Chen, S.-J. Tasi, and S.-J. J. Wang, J. Phys. Chem. B 108, 17119 (2004).

Sensors and Actuators A (1)

W. C. Hui, L. Yobas, V. D. Samper, C.-K. Heng, S. Liw, H. Ji, Y. Chen, L. Cong, J. Li, and T. M. Lim, Sensors and Actuators A 133, 335 (2007).

Sensors and Actuators B (2)

D. A. Boehm and P. A. Gottlieb, Sensors and Actuators B 126, 508 (2007).

N. T. T. Ha, D. K. An, and P. V. Phong, Sensors and Actuators B 66, 200 (2000).

Other (2)

Z.-C. Bai and S.-J. Qin, in Proceedings of Nanotech 2008 3, 331 (2008).

C. Shan, Theoretical and Design Basis of Sensors and Their Applications (in Chinese) (National Defence Industry Press, Beijing, 1999) p.25.

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