Abstract

We present a full three-dimensional, featured-data algorithm for time-domain fluorescence diffuse optical tomography that inverts the Laplace-transformed time-domain coupled diffusion equations and employs a pair of appropriate transform-factors to effectively separate the fluorescent yield and lifetime parameters. By use of a time-correlation single-photon counting system and the normalized Born formulation, we experimentally validate that the proposed scheme can achieve simultaneous reconstruction of the fluorescent yield and lifetime distributions with a reasonable accuracy.

© 2008 Chinese Optics Letters

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F. Yang, Y. Ma, F. Gao, and H. Zhao, Acta Opt. Sin. (in Chinese) 28, 1571 (2008).

L. Zhang, H. He, F. Gao, and H. Zhao, Acta Opt. Sin. (in Chinese) 28, 1262 (2008).

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L. Zhang, F. Gao, H. He, and H. J. Zhao, Opt. Express 16, 7214 (2008).

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A. Soubret, J. Ripoll, and V. Ntziachristos, IEEE Trans. Med. Imaging 24, 1377 (2005).

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F. Yang, Y. Ma, F. Gao, and H. Zhao, Acta Opt. Sin. (in Chinese) 28, 1571 (2008).

L. Zhang, H. He, F. Gao, and H. Zhao, Acta Opt. Sin. (in Chinese) 28, 1262 (2008).

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Zhao, H. J.

Acta Opt. Sin. (in Chinese) (2)

F. Yang, Y. Ma, F. Gao, and H. Zhao, Acta Opt. Sin. (in Chinese) 28, 1571 (2008).

L. Zhang, H. He, F. Gao, and H. Zhao, Acta Opt. Sin. (in Chinese) 28, 1262 (2008).

Appl. Opt. (2)

Chin. Opt. Lett. (1)

IEEE Trans. Med. Imaging (1)

A. Soubret, J. Ripoll, and V. Ntziachristos, IEEE Trans. Med. Imaging 24, 1377 (2005).

Nat. Med. (1)

V. Ntziachristos, C.-H. Tung, C. Bremer, and R. Weissleder, Nat. Med. 8, 757 (2002).

Opt. Express (5)

Opt. Lett. (4)

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