Abstract

For the eyeball composed of membrane and liquid, the contrast of ultrasound imaging is not high due to its small variance in acoustic impedance. As a new imaging modality, photoacoustic tomography combines the advantages of pure optical and ultrasonic imaging together and can provide high resolution, high contrast images. In this paper, the feasibility of photoacoustic tomography for ophthalmology is studied experimentally. A Q-switched Nd:YAG pulsed laser with 7-ns pulse width is used to generate photoacoustic signal of a porcine eyeball in vitro. The two-dimensional (2D) optical absorption image of the entire eyeball is reconstructed by time-domain spherical back projection algorithm. The imaging results agree well with the histological structure of the eyeball and show a high imaging contrast.

© 2007 Chinese Optics Letters

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M. Xu, Y. Xu, and L. V. Wang, IEEE Trans. Biomed. Eng. 50, 1086 (2003).

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M. Xu and L. V. Wang, IEEE Trans. Medical Imaging 21, 814 (2002).

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U. Oberheide, B. Jansen, I. Bruder, H. Lubatschowski, H. Welling, and W. Ertmer, Proc. SPIE 4434, 1 (2001).

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U. Oberheide, B. Jansen, I. Bruder, H. Lubatschowski, H. Welling, and W. Ertmer, Proc. SPIE 4434, 1 (2001).

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S. L. Jacques, R. D. Glickman, and J. A. Schwartz, Proc. SPIE 2681, 468 (1996).

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U. Oberheide, B. Jansen, I. Bruder, H. Lubatschowski, H. Welling, and W. Ertmer, Proc. SPIE 4434, 1 (2001).

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V. G. Andreev, A. A. Karabutov, and A. A. Oraevsky, IEEE Trans. Ultrasonics, Ferroelectrics and Frequency Control 50, 1383 (2003).

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R. A. Kruger, K. Stantz, and W. L. Kiser, Proc. SPIE 4682, 521 (2002).

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R. A. Kruger, K. Stantz, and W. L. Kiser, Proc. SPIE 4682, 521 (2002).

R. A. Kruger, W. L. Kiser, K. D. Miller, H. E. Reynolds, D. R. Reinecke, G. A. Kruger, and P. J. Hofacker, Proc. SPIE 3916, 150 (2000).

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G. Ku, X. Wang, G. Stoica, and L. V. Wang, Physics in Medicine and Biology 49, 1329 (2004).

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U. Oberheide, B. Jansen, I. Bruder, H. Lubatschowski, H. Welling, and W. Ertmer, Proc. SPIE 4434, 1 (2001).

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R. A. Kruger, W. L. Kiser, K. D. Miller, H. E. Reynolds, D. R. Reinecke, G. A. Kruger, and P. J. Hofacker, Proc. SPIE 3916, 150 (2000).

Oberheide, U.

U. Oberheide, B. Jansen, I. Bruder, H. Lubatschowski, H. Welling, and W. Ertmer, Proc. SPIE 4434, 1 (2001).

Oraevsky, A. A.

V. G. Andreev, A. A. Karabutov, and A. A. Oraevsky, IEEE Trans. Ultrasonics, Ferroelectrics and Frequency Control 50, 1383 (2003).

A. A. Karabutov, E. V. Savateeva, N. B. Podymova, and A. A. Oraevsky, J. Appl. Phys. 87, 2003 (2000).

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A. A. Karabutov, E. V. Savateeva, N. B. Podymova, and A. A. Oraevsky, J. Appl. Phys. 87, 2003 (2000).

Reinecke, D. R.

R. A. Kruger, W. L. Kiser, K. D. Miller, H. E. Reynolds, D. R. Reinecke, G. A. Kruger, and P. J. Hofacker, Proc. SPIE 3916, 150 (2000).

Reynolds, H. E.

R. A. Kruger, W. L. Kiser, K. D. Miller, H. E. Reynolds, D. R. Reinecke, G. A. Kruger, and P. J. Hofacker, Proc. SPIE 3916, 150 (2000).

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A. A. Karabutov, E. V. Savateeva, N. B. Podymova, and A. A. Oraevsky, J. Appl. Phys. 87, 2003 (2000).

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S. L. Jacques, R. D. Glickman, and J. A. Schwartz, Proc. SPIE 2681, 468 (1996).

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R. A. Kruger, K. Stantz, and W. L. Kiser, Proc. SPIE 4682, 521 (2002).

Stoica, G.

G. Ku, X. Wang, G. Stoica, and L. V. Wang, Physics in Medicine and Biology 49, 1329 (2004).

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Y. Su, F. Zhang, K. Xu, J. Yao, and R. K. Wang, J. Phys. D 38, 2640 (2005).

Wang, L. V.

L. V. Wang, Disease Markers 19, 123 (2004).

G. Ku, X. Wang, G. Stoica, and L. V. Wang, Physics in Medicine and Biology 49, 1329 (2004).

M. Xu, Y. Xu, and L. V. Wang, IEEE Trans. Biomed. Eng. 50, 1086 (2003).

M. Xu and L. V. Wang, IEEE Trans. Medical Imaging 21, 814 (2002).

Wang, R. K.

Y. Su, F. Zhang, K. Xu, J. Yao, and R. K. Wang, J. Phys. D 38, 2640 (2005).

Wang, X.

G. Ku, X. Wang, G. Stoica, and L. V. Wang, Physics in Medicine and Biology 49, 1329 (2004).

Wang, Y.

Welling, H.

U. Oberheide, B. Jansen, I. Bruder, H. Lubatschowski, H. Welling, and W. Ertmer, Proc. SPIE 4434, 1 (2001).

Xing, D.

Xu, K.

Y. Su, F. Zhang, K. Xu, J. Yao, and R. K. Wang, J. Phys. D 38, 2640 (2005).

Xu, M.

M. Xu, Y. Xu, and L. V. Wang, IEEE Trans. Biomed. Eng. 50, 1086 (2003).

M. Xu and L. V. Wang, IEEE Trans. Medical Imaging 21, 814 (2002).

Xu, Y.

M. Xu, Y. Xu, and L. V. Wang, IEEE Trans. Biomed. Eng. 50, 1086 (2003).

Yao, J.

Y. Su, F. Zhang, K. Xu, J. Yao, and R. K. Wang, J. Phys. D 38, 2640 (2005).

Yin, B.

Zeng, Y.

Zhang, F.

Y. Su, F. Zhang, K. Xu, J. Yao, and R. K. Wang, J. Phys. D 38, 2640 (2005).

Disease Markers

L. V. Wang, Disease Markers 19, 123 (2004).

IEEE Trans. Biomed. Eng.

M. Xu, Y. Xu, and L. V. Wang, IEEE Trans. Biomed. Eng. 50, 1086 (2003).

IEEE Trans. Medical Imaging

M. Xu and L. V. Wang, IEEE Trans. Medical Imaging 21, 814 (2002).

IEEE Trans. Ultrasonics, Ferroelectrics and Frequency Control

V. G. Andreev, A. A. Karabutov, and A. A. Oraevsky, IEEE Trans. Ultrasonics, Ferroelectrics and Frequency Control 50, 1383 (2003).

J. Appl. Phys.

A. A. Karabutov, E. V. Savateeva, N. B. Podymova, and A. A. Oraevsky, J. Appl. Phys. 87, 2003 (2000).

J. Phys. D

Y. Su, F. Zhang, K. Xu, J. Yao, and R. K. Wang, J. Phys. D 38, 2640 (2005).

Opt. Lett.

Physics in Medicine and Biology

G. Ku, X. Wang, G. Stoica, and L. V. Wang, Physics in Medicine and Biology 49, 1329 (2004).

Proc. SPIE

R. A. Kruger, W. L. Kiser, K. D. Miller, H. E. Reynolds, D. R. Reinecke, G. A. Kruger, and P. J. Hofacker, Proc. SPIE 3916, 150 (2000).

S. L. Jacques, R. D. Glickman, and J. A. Schwartz, Proc. SPIE 2681, 468 (1996).

R. A. Kruger, K. Stantz, and W. L. Kiser, Proc. SPIE 4682, 521 (2002).

U. Oberheide, B. Jansen, I. Bruder, H. Lubatschowski, H. Welling, and W. Ertmer, Proc. SPIE 4434, 1 (2001).

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