Abstract

Mitoxantrone, a clinically useful antitumour antibiotic for leukaemia and breast cancer, has received more attentions. In this paper, the interaction between mitoxantrone and calf thymus DNA is investigated by Raman and fluorescence spectroscopies, and the binding site of mitoxantrone to calf thymus DNA is explored. The results showed that mitoxantrone interacts with calf thymus DNA bases by the intercalation of anthracycline into the base pair plane of adenine (A) and thymine (T), and it results in the disruption of the hydrogen bonds between calf thymus DNA bases, and thus the calf thymus DNA double-strand can be disrupted into the B-form DNA double-strand segments.

© 2005 Chinese Optics Letters

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  1. D. W. Pang and H. D. Abruna, Analytical Chemistry 72, 4700 (2000).
  2. A. Erdem and M. Ozsoz, Analytica Chimica Acta 437, 107 (2001).
  3. H. Morjani, J. F. Riou, I. Nabiev, F. Lavelle, and M. Manfait, Cancer Research 53, 4784 (1993).
  4. J. M. Le Gal, H. Morjani, and M. Manfaint, Cancer Research 53, 3681 (1993).
  5. F. Seela and Y. Chen, Nucleic Acids Research 23, 2499 (1995).
  6. K. M. Guckian, T. R. Krugh, and E. T. Kool, Nature Structural Biology 5, 954 (1998).
  7. F. G. Loontiens, L. W. McLaughlin, S. Diekmann, and R. M. Clegg, Biochemistry 30, 182 (1991).
  8. J. A. Neidhart, D. Gochnour, and R. A. Roach, Journal of Clinical Oncology 4, 672 (1986).
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  10. Y. A. Mao, W. Z. Wei, and S. F. Zhang, Anal. Bioanal. Chem. 373, 215 (2002).
  11. S. F. Wang, T. Z. Peng, and C. F. Yang, Biophys. Chem. 104, 239 (2003).
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  17. P. Yang, M. L. Guo, and B. S. Yang, Chin. Sci. Bulletin (in Chinese) 38, 2049 (1993).
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2004

R. Dong, X. Yan, X. Pang, and S. Liu, Spectrochimica Acta Part A 60, 557 (2004).

2003

J. R. Chica, M. A. Medina, F. S. Jimenez, and F. J. Ramirez, Biochimica et Biophysica Acta 1628, 11 (2003).

S. F. Wang, T. Z. Peng, and C. F. Yang, Biophys. Chem. 104, 239 (2003).

2002

V. E. Semenov, V. D. Akamsin, V. S. Reznik, A. V. Chernova, G. M. Dorozhkina, Y. Y. Efremov, and A. A. Nafikova, Tetrahedron Lett. 43, 9683 (2002).

Y. A. Mao, W. Z. Wei, and S. F. Zhang, Anal. Bioanal. Chem. 373, 215 (2002).

2001

A. Erdem and M. Ozsoz, Analytica Chimica Acta 437, 107 (2001).

2000

D. W. Pang and H. D. Abruna, Analytical Chemistry 72, 4700 (2000).

Y. Ye, J. M. Hu, and Y. Zeng, Inorganica Chimica Acta 16, 6 (2000).

1999

T. Akira, H. Naoki, O. Junko, Y. Emiko, and T. Hideo, Journal of Raman Spectroscopy 30, 623 (1999).

H. Deng, V. A. Bloomfield, J. M. Benevides, and G. J. Thomas, Biopolymers 50, 656 (1999).

1998

E. Kocisova, L. Chinsky, and P. Miskovsky, Journal of Biomolecular Structure & Dynamics 15, 1147 (1998).

K. M. Guckian, T. R. Krugh, and E. T. Kool, Nature Structural Biology 5, 954 (1998).

1997

W. J. Jin, Y. S. Wei, C. S. Liu, G. L. Shen, and R. Q. Yu, Spectrochimica Acta Part A 53, 2701 (1997).

1996

Q. S. Li, P. Yang, H. F. Wang, and M. L. Guo, Journal of Inorganic Biochemistry 64, 181 (1996).

1995

F. Seela and Y. Chen, Nucleic Acids Research 23, 2499 (1995).

1993

H. Morjani, J. F. Riou, I. Nabiev, F. Lavelle, and M. Manfait, Cancer Research 53, 4784 (1993).

J. M. Le Gal, H. Morjani, and M. Manfaint, Cancer Research 53, 3681 (1993).

P. Yang, M. L. Guo, and B. S. Yang, Chin. Sci. Bulletin (in Chinese) 38, 2049 (1993).

1991

F. G. Loontiens, L. W. McLaughlin, S. Diekmann, and R. M. Clegg, Biochemistry 30, 182 (1991).

1987

F. Brito-Babapulle, D. Catovsky, G. Slocombe, A. C. Newland, R. E. Marcus, J. M. Goldman, and D. A. Galton, Cancer Treatment Reports 71, 161 (1987).

1986

J. A. Neidhart, D. Gochnour, and R. A. Roach, Journal of Clinical Oncology 4, 672 (1986).

C.-W. Ong, Inorganica Chimica Acta 123, 221 (1986).

Abruna, H. D.

D. W. Pang and H. D. Abruna, Analytical Chemistry 72, 4700 (2000).

Akamsin, V. D.

V. E. Semenov, V. D. Akamsin, V. S. Reznik, A. V. Chernova, G. M. Dorozhkina, Y. Y. Efremov, and A. A. Nafikova, Tetrahedron Lett. 43, 9683 (2002).

Akira, T.

T. Akira, H. Naoki, O. Junko, Y. Emiko, and T. Hideo, Journal of Raman Spectroscopy 30, 623 (1999).

Benevides, J. M.

H. Deng, V. A. Bloomfield, J. M. Benevides, and G. J. Thomas, Biopolymers 50, 656 (1999).

Bloomfield, V. A.

H. Deng, V. A. Bloomfield, J. M. Benevides, and G. J. Thomas, Biopolymers 50, 656 (1999).

Brito-Babapulle, F.

F. Brito-Babapulle, D. Catovsky, G. Slocombe, A. C. Newland, R. E. Marcus, J. M. Goldman, and D. A. Galton, Cancer Treatment Reports 71, 161 (1987).

Catovsky, D.

F. Brito-Babapulle, D. Catovsky, G. Slocombe, A. C. Newland, R. E. Marcus, J. M. Goldman, and D. A. Galton, Cancer Treatment Reports 71, 161 (1987).

Chen, Y.

F. Seela and Y. Chen, Nucleic Acids Research 23, 2499 (1995).

Chernova, A. V.

V. E. Semenov, V. D. Akamsin, V. S. Reznik, A. V. Chernova, G. M. Dorozhkina, Y. Y. Efremov, and A. A. Nafikova, Tetrahedron Lett. 43, 9683 (2002).

Chica, J. R.

J. R. Chica, M. A. Medina, F. S. Jimenez, and F. J. Ramirez, Biochimica et Biophysica Acta 1628, 11 (2003).

Chinsky, L.

E. Kocisova, L. Chinsky, and P. Miskovsky, Journal of Biomolecular Structure & Dynamics 15, 1147 (1998).

Clegg, R. M.

F. G. Loontiens, L. W. McLaughlin, S. Diekmann, and R. M. Clegg, Biochemistry 30, 182 (1991).

Deng, H.

H. Deng, V. A. Bloomfield, J. M. Benevides, and G. J. Thomas, Biopolymers 50, 656 (1999).

Diekmann, S.

F. G. Loontiens, L. W. McLaughlin, S. Diekmann, and R. M. Clegg, Biochemistry 30, 182 (1991).

Dong, R.

R. Dong, X. Yan, X. Pang, and S. Liu, Spectrochimica Acta Part A 60, 557 (2004).

Dorozhkina, G. M.

V. E. Semenov, V. D. Akamsin, V. S. Reznik, A. V. Chernova, G. M. Dorozhkina, Y. Y. Efremov, and A. A. Nafikova, Tetrahedron Lett. 43, 9683 (2002).

Efremov, Y. Y.

V. E. Semenov, V. D. Akamsin, V. S. Reznik, A. V. Chernova, G. M. Dorozhkina, Y. Y. Efremov, and A. A. Nafikova, Tetrahedron Lett. 43, 9683 (2002).

Emiko, Y.

T. Akira, H. Naoki, O. Junko, Y. Emiko, and T. Hideo, Journal of Raman Spectroscopy 30, 623 (1999).

Erdem, A.

A. Erdem and M. Ozsoz, Analytica Chimica Acta 437, 107 (2001).

Gal, J. M. Le

J. M. Le Gal, H. Morjani, and M. Manfaint, Cancer Research 53, 3681 (1993).

Galton, D. A.

F. Brito-Babapulle, D. Catovsky, G. Slocombe, A. C. Newland, R. E. Marcus, J. M. Goldman, and D. A. Galton, Cancer Treatment Reports 71, 161 (1987).

Gochnour, D.

J. A. Neidhart, D. Gochnour, and R. A. Roach, Journal of Clinical Oncology 4, 672 (1986).

Goldman, J. M.

F. Brito-Babapulle, D. Catovsky, G. Slocombe, A. C. Newland, R. E. Marcus, J. M. Goldman, and D. A. Galton, Cancer Treatment Reports 71, 161 (1987).

Guckian, K. M.

K. M. Guckian, T. R. Krugh, and E. T. Kool, Nature Structural Biology 5, 954 (1998).

Guo, M. L.

Q. S. Li, P. Yang, H. F. Wang, and M. L. Guo, Journal of Inorganic Biochemistry 64, 181 (1996).

P. Yang, M. L. Guo, and B. S. Yang, Chin. Sci. Bulletin (in Chinese) 38, 2049 (1993).

Hideo, T.

T. Akira, H. Naoki, O. Junko, Y. Emiko, and T. Hideo, Journal of Raman Spectroscopy 30, 623 (1999).

Hu, J. M.

Y. Ye, J. M. Hu, and Y. Zeng, Inorganica Chimica Acta 16, 6 (2000).

Jimenez, F. S.

J. R. Chica, M. A. Medina, F. S. Jimenez, and F. J. Ramirez, Biochimica et Biophysica Acta 1628, 11 (2003).

Jin, W. J.

W. J. Jin, Y. S. Wei, C. S. Liu, G. L. Shen, and R. Q. Yu, Spectrochimica Acta Part A 53, 2701 (1997).

Junko, O.

T. Akira, H. Naoki, O. Junko, Y. Emiko, and T. Hideo, Journal of Raman Spectroscopy 30, 623 (1999).

Kocisova, E.

E. Kocisova, L. Chinsky, and P. Miskovsky, Journal of Biomolecular Structure & Dynamics 15, 1147 (1998).

Kool, E. T.

K. M. Guckian, T. R. Krugh, and E. T. Kool, Nature Structural Biology 5, 954 (1998).

Krugh, T. R.

K. M. Guckian, T. R. Krugh, and E. T. Kool, Nature Structural Biology 5, 954 (1998).

Lavelle, F.

H. Morjani, J. F. Riou, I. Nabiev, F. Lavelle, and M. Manfait, Cancer Research 53, 4784 (1993).

Li, Q. S.

Q. S. Li, P. Yang, H. F. Wang, and M. L. Guo, Journal of Inorganic Biochemistry 64, 181 (1996).

Liu, C. S.

W. J. Jin, Y. S. Wei, C. S. Liu, G. L. Shen, and R. Q. Yu, Spectrochimica Acta Part A 53, 2701 (1997).

Liu, S.

R. Dong, X. Yan, X. Pang, and S. Liu, Spectrochimica Acta Part A 60, 557 (2004).

Loontiens, F. G.

F. G. Loontiens, L. W. McLaughlin, S. Diekmann, and R. M. Clegg, Biochemistry 30, 182 (1991).

Manfaint, M.

J. M. Le Gal, H. Morjani, and M. Manfaint, Cancer Research 53, 3681 (1993).

Manfait, M.

H. Morjani, J. F. Riou, I. Nabiev, F. Lavelle, and M. Manfait, Cancer Research 53, 4784 (1993).

Mao, Y. A.

Y. A. Mao, W. Z. Wei, and S. F. Zhang, Anal. Bioanal. Chem. 373, 215 (2002).

Marcus, R. E.

F. Brito-Babapulle, D. Catovsky, G. Slocombe, A. C. Newland, R. E. Marcus, J. M. Goldman, and D. A. Galton, Cancer Treatment Reports 71, 161 (1987).

McLaughlin, L. W.

F. G. Loontiens, L. W. McLaughlin, S. Diekmann, and R. M. Clegg, Biochemistry 30, 182 (1991).

Medina, M. A.

J. R. Chica, M. A. Medina, F. S. Jimenez, and F. J. Ramirez, Biochimica et Biophysica Acta 1628, 11 (2003).

Miskovsky, P.

E. Kocisova, L. Chinsky, and P. Miskovsky, Journal of Biomolecular Structure & Dynamics 15, 1147 (1998).

Morjani, H.

J. M. Le Gal, H. Morjani, and M. Manfaint, Cancer Research 53, 3681 (1993).

H. Morjani, J. F. Riou, I. Nabiev, F. Lavelle, and M. Manfait, Cancer Research 53, 4784 (1993).

Nabiev, I.

H. Morjani, J. F. Riou, I. Nabiev, F. Lavelle, and M. Manfait, Cancer Research 53, 4784 (1993).

Nafikova, A. A.

V. E. Semenov, V. D. Akamsin, V. S. Reznik, A. V. Chernova, G. M. Dorozhkina, Y. Y. Efremov, and A. A. Nafikova, Tetrahedron Lett. 43, 9683 (2002).

Naoki, H.

T. Akira, H. Naoki, O. Junko, Y. Emiko, and T. Hideo, Journal of Raman Spectroscopy 30, 623 (1999).

Neidhart, J. A.

J. A. Neidhart, D. Gochnour, and R. A. Roach, Journal of Clinical Oncology 4, 672 (1986).

Newland, A. C.

F. Brito-Babapulle, D. Catovsky, G. Slocombe, A. C. Newland, R. E. Marcus, J. M. Goldman, and D. A. Galton, Cancer Treatment Reports 71, 161 (1987).

Ong, C.-W.

C.-W. Ong, Inorganica Chimica Acta 123, 221 (1986).

Ozsoz, M.

A. Erdem and M. Ozsoz, Analytica Chimica Acta 437, 107 (2001).

Pang, D. W.

D. W. Pang and H. D. Abruna, Analytical Chemistry 72, 4700 (2000).

Pang, X.

R. Dong, X. Yan, X. Pang, and S. Liu, Spectrochimica Acta Part A 60, 557 (2004).

Peng, T. Z.

S. F. Wang, T. Z. Peng, and C. F. Yang, Biophys. Chem. 104, 239 (2003).

Ramirez, F. J.

J. R. Chica, M. A. Medina, F. S. Jimenez, and F. J. Ramirez, Biochimica et Biophysica Acta 1628, 11 (2003).

Reznik, V. S.

V. E. Semenov, V. D. Akamsin, V. S. Reznik, A. V. Chernova, G. M. Dorozhkina, Y. Y. Efremov, and A. A. Nafikova, Tetrahedron Lett. 43, 9683 (2002).

Riou, J. F.

H. Morjani, J. F. Riou, I. Nabiev, F. Lavelle, and M. Manfait, Cancer Research 53, 4784 (1993).

Roach, R. A.

J. A. Neidhart, D. Gochnour, and R. A. Roach, Journal of Clinical Oncology 4, 672 (1986).

Seela, F.

F. Seela and Y. Chen, Nucleic Acids Research 23, 2499 (1995).

Semenov, V. E.

V. E. Semenov, V. D. Akamsin, V. S. Reznik, A. V. Chernova, G. M. Dorozhkina, Y. Y. Efremov, and A. A. Nafikova, Tetrahedron Lett. 43, 9683 (2002).

Shen, G. L.

W. J. Jin, Y. S. Wei, C. S. Liu, G. L. Shen, and R. Q. Yu, Spectrochimica Acta Part A 53, 2701 (1997).

Slocombe, G.

F. Brito-Babapulle, D. Catovsky, G. Slocombe, A. C. Newland, R. E. Marcus, J. M. Goldman, and D. A. Galton, Cancer Treatment Reports 71, 161 (1987).

Thomas, G. J.

H. Deng, V. A. Bloomfield, J. M. Benevides, and G. J. Thomas, Biopolymers 50, 656 (1999).

Wang, H. F.

Q. S. Li, P. Yang, H. F. Wang, and M. L. Guo, Journal of Inorganic Biochemistry 64, 181 (1996).

Wang, S. F.

S. F. Wang, T. Z. Peng, and C. F. Yang, Biophys. Chem. 104, 239 (2003).

Wei, W. Z.

Y. A. Mao, W. Z. Wei, and S. F. Zhang, Anal. Bioanal. Chem. 373, 215 (2002).

Wei, Y. S.

W. J. Jin, Y. S. Wei, C. S. Liu, G. L. Shen, and R. Q. Yu, Spectrochimica Acta Part A 53, 2701 (1997).

Yan, X.

R. Dong, X. Yan, X. Pang, and S. Liu, Spectrochimica Acta Part A 60, 557 (2004).

Yang, B. S.

P. Yang, M. L. Guo, and B. S. Yang, Chin. Sci. Bulletin (in Chinese) 38, 2049 (1993).

Yang, C. F.

S. F. Wang, T. Z. Peng, and C. F. Yang, Biophys. Chem. 104, 239 (2003).

Yang, P.

Q. S. Li, P. Yang, H. F. Wang, and M. L. Guo, Journal of Inorganic Biochemistry 64, 181 (1996).

P. Yang, M. L. Guo, and B. S. Yang, Chin. Sci. Bulletin (in Chinese) 38, 2049 (1993).

Ye, Y.

Y. Ye, J. M. Hu, and Y. Zeng, Inorganica Chimica Acta 16, 6 (2000).

Yu, R. Q.

W. J. Jin, Y. S. Wei, C. S. Liu, G. L. Shen, and R. Q. Yu, Spectrochimica Acta Part A 53, 2701 (1997).

Zeng, Y.

Y. Ye, J. M. Hu, and Y. Zeng, Inorganica Chimica Acta 16, 6 (2000).

Zhang, S. F.

Y. A. Mao, W. Z. Wei, and S. F. Zhang, Anal. Bioanal. Chem. 373, 215 (2002).

Anal. Bioanal. Chem.

Y. A. Mao, W. Z. Wei, and S. F. Zhang, Anal. Bioanal. Chem. 373, 215 (2002).

Analytica Chimica Acta

A. Erdem and M. Ozsoz, Analytica Chimica Acta 437, 107 (2001).

Analytical Chemistry

D. W. Pang and H. D. Abruna, Analytical Chemistry 72, 4700 (2000).

Biochemistry

F. G. Loontiens, L. W. McLaughlin, S. Diekmann, and R. M. Clegg, Biochemistry 30, 182 (1991).

Biochimica et Biophysica Acta

J. R. Chica, M. A. Medina, F. S. Jimenez, and F. J. Ramirez, Biochimica et Biophysica Acta 1628, 11 (2003).

Biophys. Chem.

S. F. Wang, T. Z. Peng, and C. F. Yang, Biophys. Chem. 104, 239 (2003).

Biopolymers

H. Deng, V. A. Bloomfield, J. M. Benevides, and G. J. Thomas, Biopolymers 50, 656 (1999).

Cancer Research

H. Morjani, J. F. Riou, I. Nabiev, F. Lavelle, and M. Manfait, Cancer Research 53, 4784 (1993).

J. M. Le Gal, H. Morjani, and M. Manfaint, Cancer Research 53, 3681 (1993).

Cancer Treatment Reports

F. Brito-Babapulle, D. Catovsky, G. Slocombe, A. C. Newland, R. E. Marcus, J. M. Goldman, and D. A. Galton, Cancer Treatment Reports 71, 161 (1987).

Chin. Sci. Bulletin (in Chinese)

P. Yang, M. L. Guo, and B. S. Yang, Chin. Sci. Bulletin (in Chinese) 38, 2049 (1993).

Inorganica Chimica Acta

C.-W. Ong, Inorganica Chimica Acta 123, 221 (1986).

Y. Ye, J. M. Hu, and Y. Zeng, Inorganica Chimica Acta 16, 6 (2000).

Journal of Biomolecular Structure & Dynamics

E. Kocisova, L. Chinsky, and P. Miskovsky, Journal of Biomolecular Structure & Dynamics 15, 1147 (1998).

Journal of Clinical Oncology

J. A. Neidhart, D. Gochnour, and R. A. Roach, Journal of Clinical Oncology 4, 672 (1986).

Journal of Inorganic Biochemistry

Q. S. Li, P. Yang, H. F. Wang, and M. L. Guo, Journal of Inorganic Biochemistry 64, 181 (1996).

Journal of Raman Spectroscopy

T. Akira, H. Naoki, O. Junko, Y. Emiko, and T. Hideo, Journal of Raman Spectroscopy 30, 623 (1999).

Nature Structural Biology

K. M. Guckian, T. R. Krugh, and E. T. Kool, Nature Structural Biology 5, 954 (1998).

Nucleic Acids Research

F. Seela and Y. Chen, Nucleic Acids Research 23, 2499 (1995).

Spectrochimica Acta Part A

R. Dong, X. Yan, X. Pang, and S. Liu, Spectrochimica Acta Part A 60, 557 (2004).

W. J. Jin, Y. S. Wei, C. S. Liu, G. L. Shen, and R. Q. Yu, Spectrochimica Acta Part A 53, 2701 (1997).

Tetrahedron Lett.

V. E. Semenov, V. D. Akamsin, V. S. Reznik, A. V. Chernova, G. M. Dorozhkina, Y. Y. Efremov, and A. A. Nafikova, Tetrahedron Lett. 43, 9683 (2002).

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